Supervisor Project
Resume:
CURRICULUM VITAE
Galyna Dubinina, PhD
Department of Chemistry
University of Florida
PO Box 117200
Gainesville, FL 32611-7200
cell phone : 406-***-****
e-mail: ********@****.***.***
*********@*****.***
EDUCATION
Postdoc University of Florida, USA 2011- present
Specialization: Organic/Organometallic/Physical/Polymer/Material Chemistry
Postdoc SensoPath Technologies Inc., Montana, USA
2010- 2011Specialization: Organic Chemistry
Postdoc University of Hawaii at Manoa, USA, 2007-2010 Specialization: Organic/Organometallic Chemistry
Postdoc University of Arkansas, USA, 2007
Specialization: Organometallic Chemistry
PH.D National Taras Shevchenko University of Kiev
(Kyiv, Ukraine), 1995-2002 Specialization: Organic Chemistry. Dissertation: Synthesis of
The condensed heterocyclic systems by nucleophilic substitution of the vicynal dihalogenheterocycles. Supervisor: Professor Volovenko Yu. M.
M.A.+B.A National Taras Shevchenko University of Kiev
(Kyiv, Ukraine), 1988-1994 Specialization: Organic Chemistry. Title: Acylation of the 3,4-dihydro-4-oxo-2-quinazolinylacetonitrile.
Supervisor: Professor Volovenko Yu. M.
PROFESSIONAL
EXPERIENCE
August 2011- Present - Postdoctoral associate
Supervisor: Prof. Kirk S. Shanze (UF)
Prof. A. Rebane (Montana State University)
Department of Chemistry
University of Florida
PO Box 117200
Gainesville, FL 32611-7200
352-***-**** (office)
352-***-**** (fax)
********@****.***.***
http://www.chem.ufl.edu/~kschanze/
Research projects:
• Synthesis and Photophysical Properties of Pt-acetylides as Two-Photon Absorption Material (collaboration project between MSU and UF); polymer synthesis for NLA/solar cells, films preparation.
Achievements:
• 2 articles are preparing for publication
October 2010 – August 2011
SensoPath Technologies Inc.
920 Technology Blvd., suite B
Bozeman, Montana, 59718
work phone : 406-***-****
website: www.sensopath.com
e-mail : ******.********@*********.***
Postdoctoral research fellow
Supervisor: Prof. C. W. Spangler and Prof. B. D. Spangler (CEO)
Research projects:
• Synthesis of modified Porphyrins (~20-25 steps).
• Synthesis of the Imaging Agent (symmetrical and asymmetrical bis-1,1’-(4-sulfobutyl)-indo-dicarbo(and tricarbo)cyanine) with hexa-ethyleneglycole linkers.
• Synthesis of the Triad as a PDT anticancer agent by the sequential coupling of the Porphyrin with Imaging Agent and Targeting Peptide.
• Design and synthesis of Dendritic Tethers (monothiol and dithiol) for the immobilization of antibodies (5-10 steps).
Achievements:
• Modified Porphyrins and Triad (MW ~ 5,000; ~ 30 steps) has been synthesized, purified and characterized in enough amounts for biological testing on animals (I phase of the clinical trial).
• Dendritic Tethes continue to be synthesizing as custom syntheses on demand (client’s orders).
• 1 article was published
October 2009- October 2010
University of Hawai’i at Manoa, Department of Chemistry
2545 McCarthy Mall
Honolulu, Hawaii 96822
www.hawaii.edu
Postdoctoral research fellow
Supervisor: Prof. W. J. Chain
Research projects:
• Total synthesis of the natural compound Neostemofoline.
• Chelate-controlled Oxa-Michael Addition for construction of the naturally occurred cycles. Synthesis of azepinones, their isomerisation and alkylation.
Achievements:
• 2 articles have been published in a TL about Azepinones and their chemical conversions, including unexpected isomerisation and ring-contraction.
August 2007-October 2009
University of Hawai’i at Manoa, Department of Chemistry
2545 McCarthy Mall
Honolulu, Hawaii 96822
www2.hawaii.edu/~vicic/dvgroup.htm
Postdoctoral research fellow
Supervisor: Prof. David Vicic
Research projects:
• Development of the catalysts for cross-coupling perfluoroalkylation based on nickel and copper; new ligands synthesis.
• Synthesis and development of conditions for reductive elimination for LL[Ni](Ar)(CF3) complexes.
• Synthesis of new heterocyclic chiral carbene ligands and their copper complexes;
• Synthesis of the paramagnetic LLNi(I)CF3 species as a source of CF3 groups.
Achievements:
• 5 articles have been published, including in a JACS Selected Collection, and in a Organometallics highlighted as the “Most Read” by ACS website (see Publication List for details). Poster presentation on ACS conf.
April 2007-August 2007
University of Arkansas
Department of Chemistry and Biochemistry
115 Chemistry Building
Fayetteville, AR 72701
Postdoctoral research fellow / research scholar:
Supervisor: Prof. David Vicic
The same project as mentioned above.
March 2004-April 2007
Enamine Ltd.
23 A. Matrosova st., Kiev, 01103, Ukraine (www.enamine.net)
Phone
Fax: +38-044-***-**-**
Project Leader:
(20-30 people involved in this project)
Supervisor: Prof. A. Tolmachov (President of Enamine Ltd.)
phone : +38-044-***-**-**
Email: *.********@*******.***
Research projects:
• Coordination of the Synthetic Chemistry, Molecular Modelling and Medicinal Chemistry groups’ activities.
• Leadership of the Medicinal Chemistry Group and 2 PhD works (in organic chemistry and drug design).
Achievements:
• 5 Articles have been published.
• 1 Patent, 1 Pat. Appl. (UA).
• 2 Poster conferences (ACS meeting; TAT-2005).
• Custom Designed Focused Libraries of compounds against different targets have been created and sold to the pharmaceutical companies.
• 2D filters (hinge-region–directed) have been created, which gave great benefits to the company in predicting activity and selling compounds.
February 2001–
February 2004
Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine (Kiev, Ukraine), Department of Combinatorial Cemistry
150 Zabolotny Str., Kiev - 143, 03143, Ukraine
Phone: +380-**-***-**-** (reception room)
Fax: +380-**-***-** www.imbg.org.ua
Scientific Researcher, Leader of Inhibitor Synthesis Group:
Advisor: Dr. Sergiy. M. Yarmoluk,
Phone: (380-44) 526-34-49; Fax: (380-44) 526-07-59.
E-mail: ******@********.***.**
web-sіtes: www.yarmoluk.org.ua
Research projects:
• Developing of the novel specific inhibitors for cyclin- dependent kinases based on maleimide and pyrrolo[2,3]pyrazine cores.
• Molecular Design, HTS of the newly synthesized compounds.
Achievements:
• 9 Articles have been published, 3 posters on conferences
• 3 Patents (UA).
TECHNICAL SKILLS /
EXPERTISE
In Organic/Organometallic chemistry
• Multistep synthesis, synthetic procedures development; synthesis of the air/water/light sensitive organic compounds and organometallic complexes (Schlenk technique, glovebox); microwave-assisted synthesis ect.
• Polymer synthesis, their purification (GPC) and identification. Films preparation (drop-coating, spin-coating etc.)
• Structure proof and purification of the newly synthesized compounds using spectral methods: IR, UV-VIS, NMR and X-Ray, also, elemental analysis, LC-MS, GC-MS, HPLC, SEC (Size Exclusion Chromatography)/GPC on Sephadex.
• Photophysical mesurements: UV-VIS, Emission spectra, Fluorescence/Phosphorescence Lifetimes, Quantum Yields, Singlet Oxygen Quantum Yield, TA spectra, Z-scans.
• Development new catalysts for cross-coupling reactions based on nickel, copper, palladium complexes, synthesis of the new chiral ligands;
• Electrochemistry: CV, redox-potentials for organo-metallic complexes.
• Atricle/presentation/report writing.
• Decoding NMR spectra (NUTS; MestRec etc.)
• PhD student/undergrads supervising.
In Medicinal/Computational chemistry and Drug Design
• Selection of attractive targets for developing new drugs; analysis of known inhibitors or activators for these targets, set-upping in vitro tests for kinase targets;
• Analysis of ADME parameters of the chemical databases (QikProp)
• Creation of ligand-based and receptor-based Targeted Libraries (PASS, Unity, QXP)
• Patentability checking of promising hits (SciFinder; Beilstein);
• SAR processing (PASS professional; PharmaExpert);
• Ligand-Based Training sets creations, Neural networks (PASS Professional) ;
• Development of novel bioisosteric scaffolds and synthesis routs (active analog approach);
• ISIS BASE; CheD – working with huge databases of the chemical compounds.
PUBLICATIONS
34 ARTICLES, 4 PATENTS (UA), 1 APPL., SELECTED PRESENTATIONS
34. Galyna G. Dubinina, Randi S. Price, M. Drobizhev, Aleksander Rebane, Kirk S. Schanze. Modified p-Phenylene Vinylene Platinum (II) Acetylides with Enhanced Nonlinear Absorption by Dual Mechanism, JACS, in preparation.
33. Russell W. Winkel, Galyna G. Dubinina, Khalil A. Abboud, Kirk S. Schanze. Synthesis and Photophysical Properties of trans-Platinum Acetylide Complexes Featuring NHC-Ligands, Organometallics, in preparation.
32. Charles W. Spangler, Jean R. Starkey, Galyna Dubinina, Carl Fahlstrom and Joyce Shepard, "Optimization of targeted two-photon PDT triads for the treatment of head and neck cancers", Proc. SPIE 8207, 820720 (2012); http://dx.doi.org/10.1117/12.909640
31. Galyna G. Dubinina#, William J. Chain. Reactions of azepinones with electrophiles. Tetrahedron Letters (2011), 52 (8), 939-942.
30. Galyna G. Dubinina#, Wesley Yoshida, William J. Chain. On the Preparation of Azepinones, Tetrahedron Letters (2010), 51, 5325-5327.
29. McReynolds, K. A.; Lewis, R. S.; Ackerman, L. K. G.; Dubinina, G. G. #; Brennessel, W. W.; Vicic, D. A. Decarboxylative Trifluoromethylation of Aryl Halides Using Well-Defined Copper-Trifluoroacetate and –Chlorodifluoroacetate Precursors, J. Fluor. Chem. 2010. DOI: 10.1016/j.jfluchem.2010.04.005
28*. Kieltsch, I.; Dubinina, G. G. #; Hamacher, C.; Kaiser, A.; Hutchison, J. M.; Klein, A.; Budnikova,Y.; Vicic, D. A. Magnitudes of Electron Withdrawing Effects of the Trifluoromethyl Ligand in Organometallic Complexes of Copper and Nickel. Organometallics (2010), 29(6), 1451-1456.
*This work has been listed as a "Most Read" (most downloaded) paper for the month of Feb-March by the ACS website.
27. Dubinina, G. G. #; Ogikubo, J.; Vicic, D. A. Structure of Bis(trifluoromethyl)cuprate and Its Role in Trifluoromethylation Reactions. Organometallics 2008, 27, 6233-6235.
26. Dubinina, G. G. #; Brennessel, W. W.; Miller, J. L.; Vicic, D. A. Exploring Trifluoromethylation Reactions at Nickel; A Structural and Reactivity Study. Organometallics 2008, 27, 3933-3938.
25*. Dubinina, G. G. #; Furutachi, H.; Vicic, D. A. Active Trifluoromethylating Agents from Well-defined Copper(I)-CF3 Complexes. J. Amer. Chem. Soc. 2008, 130, 8600-8601.
*This work was featured in a JACS Select collection (Issue 6) focused on diverse chemical applications of N-heterocyclic carbenes. The work was also highlighted as a JACS Image Challenge (#62).
24. Vicic, D. A.; Dubinina, Galyna; Furutachi, Hideki. Metal-mediated trifluoromethylation of organic electrophiles. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008), ORGN-027. CODEN: 69KXQ2 AN 2008:954066 CAPLUS
23. Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Dubinina, G. G. #; Tolmachev, A. A. Condensed isoquinolines. Part 30. Acylation and alkylation of 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one. Chemistry of Heterocyclic Compounds (New York, NY, United States) (2008), 44(5), 585-593. CODEN: CHCCAL ISSN:0009-3122. CAN 150:447850 AN 2008:1284387 CAPLUS
22. Dubinina G.G. #, Chupryna O.O., Platonov M.O., Borysko P.O., Ostrovska G.V., Tolmachov A.O., Shtil A. A. In Silico Design of Protein Kinase Inhibitors: Successes and Failures // Anti-Cancer Agents in Medicinal Chemistry (ACA-MC), 2007, 7(2), 171-188. CODEN: AAMCE4 ISSN:1871-5206. CAN 146:350349 AN 2007:206946 CAPLUS
21. Dubinina G.G. #, Platonov M.O., Golovach S.M., Borysko P.O., Tolmachov A.O., Volovenko YM. Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity // Eur J Med Chem. – 2006. - 41(6), P. 727-737.
20. Dubinina, G. G. #; Golovach, S. M.; Kozlovs'kii, V. O.; Tolmachov, A. O.; Volovenko, Yu. M. Antiproliferative action of the new derivatives of 1-(4-R-benzyl)-3-R1-4-(R2-phenylamino)-1H-pyrrol-2,5-dione. Zhurnal Organichnoi ta Farmatsevtichnoi Khimii (2007), 5(1), 39-49. CODEN: ZOFKAM AN 2007:571890 CAPLUS
19. Mikhailiuk P.K., Afonin S., Chernega A.N., Rusanov E.B., Platonov M.O., 19. Dubinina G.G. #, Berditsch M., Ulrich A.S., Komarov I.V. Conformationally Rigid Trifluoromethyl-Substituted alpha-Amino Acid Designed for Peptide Structure Analysis by Solid-State (19)F NMR Spectroscopy. Angew Chem Int Ed Engl. 2006 Aug 25;45(34):5659-5661.
18. Yu. M. Volovenko, G. G. Dubinina#, A. N. Chernega. Interaction of 3,4-dichloro-N-R-maleimides with substituted thiouracils // Chemistry of Heterocyclic Compounds. - 2004. - N 1. - P. 100-106.
and other 17 articles and Patents.
#There are other variants of my name: Galina Dubinina, G.G. Dubinina
LANGUAGES Russian, Ukrainian (native speaker), English.
PROFESSIONAL
REFERENCES
1) Prof. Kirk S. Schanze – current supervisor
V.T. and Louise Jackson Professor of Chemistry
Editor-in-Chief, ACS Applied Materials & Interfaces
Head of Organic Division (University of Florida)
Department of Chemistry
University of Florida
P.O. Box 117200
Gainesville, Florida 32611-7200
352-***-**** (office)
352-***-**** (fax)
********@****.***.***
http://www.chem.ufl.edu/~kschanze/
2) Aleks Rebane, Professor of Physics - current supervisor
Montana State University
Bozeman, MT 59717 USA
tel. 406 994 783
fax 406 994 445
******@*******.*******.***
3) Prof. David Vicic
Associate Professor
Department of Chemistry
University of Hawaii
2545 McCarthy Mall
Honolulu, HI 96822
Phone: 808-***-****
Fax: 808-***-****
http://www2.hawaii.edu/~vicic/
e-mail: *****@******.***
4) Prof. Charles W. Spangler
SensoPath Technologies, Inc.
920 Technology Blvd, Suite B
Bozeman, MT 59718
Website: www.sensopath.com
e-mail : *******.********@*********.***
Phone : 406-***-****
Cell phone: 406-***-****
Fax: 406-***-****
5) Prof. W. J. Chain
Assistant Professor
Department of Chemistry
University of Hawaii
2545 McCarthy Mall
Honolulu, HI 96822
Phone: 808-***-****
Fax: 808-***-****
e-mail: *****@******.***
HONORS, MEMBERSHIP
1) ACS member since 2007
2) The article J. Amer. Chem. Soc. 2008, 130, 8600-8601 work was featured in a JACS Select collection (Issue 6) focused on diverse chemical applications of N-heterocyclic carbenes. The work was also highlighted as a JACS Image Challenge (#62).
3) The article Organometallics (2010), 29(6), 1451-1456 has been listed as a "Most Read" (most downloaded) paper for the month of Feb-March by the ACS website.
INTERNATIONAL TRAVELS
USA/NY/Arkansas/Hawaii/ (2007)
England, Turkey (2006)
Netherlands, France, Russia, Turkey (2005)
USA/Boston, Turkey (2004)
Russia, Romania, Poland, Germany, Egypt (1995-2003)
Contact this candidate