Manager Plant

Ranjit S. Verma, Ph.D.

**** * ******* ******, ***. # 6.

Milwaukee, WI 53211 ************@*****.***

Phone No. 414-***-****

Synthetic organic chemist, Process development chemist, medicinal chemist, Tech-transfer and Intellectual property.

15+ years of research experience in laboratory research, scale-ups and technology transfer to ensure optimal product quality in the plant for commercial production of API’s, Active Pharmaceutical intermediates and fine chemicals. Expertise in designing & implementation of medicinal chemistry and drug discovery projects. 4+ years experience of leading a team of 30+ highly motivated and result oriented researchers. Certified and capable to tackle Intellectual property right issues.

Core Competencies

Synthetic organic chemistry Chemical process development

Drug discovery Medicinal chemistry

Tech-transfer Scale-ups for commercialization

Trouble shooting Equipment design modification

Tailoring synthetic process Team motivator and builder

Plant audits

Employment profile

________________________________________

Cytometix Inc. Milwaukee WI. A start-up Pharmaceutical Company developing a novel class of pain therapeutic to treat pain. October 2011 to present.

Director of Operation.

• Successfully lead the process development of lead drug candidate CMX-020 by an external CRO. The over all yield increased from less than 10% to more than 23% in 9 steps. The costly Pd catalyst was replaced by a cheaper and easy to scale catalyst for the final step partial reduction of 3-triple bonds.

• Critically reviewed the CMC section of the IND application submitted to the FDA with the experts.

Most of the work was carried out by CRO’s; I had the opportunity to manage the key contracts and advisory relationships. Skillfully managed the laboratory resources to deliver timely results and converted them into technical reports for IND submission to FDA, before Phase-I a clinical trials.

University of Wisconsin. Milwaukee, WI. 2009-2011

Post Doctoral Research Fellow. Supervisor: Professor James M. Cook.

Synthesised Prodrugs to treat Schizophrenia and Drug addiction(NIH project),Cystine and cysteine related compounds. Developed a new class of potential anti-TB agents, synthesis & preliminary evaluation of novel acrylic acid ethyl esters. Conceptualized analogs of lead broad spectrum anti-biotic compound to enhance the biological activity, achieved 32-fold increase in activity.

Arch Pharmalabs limited,Taloja,(New Bombay) India. The business comprises manufacture and sale of API’s & Intermediates to innovator & generic pharmaceutical players globally. 11 manufacturing facilities across India employ over 2000+ employees. 2005-2009

Group Leader - R & D at Arch Pharmalabs Ltd.

• Awarded promotion as a Group leader within year of joining for successfully rescuing two important failing projects, DMPAC and Triflusal, for a valued customer in Italy, this improved the company’s image and resulted in new projects and business from the same customer.

• Guided and motivated the team to scale-up 10+ projects from bench level to plant scale.

• Managed, trained & carried out the performance appraisal of the scientists and chemists (18+12).

• Chaired the safety committee, successively for 3 years, implemented safe work environment through training, counseling and audits.

Enjoyed the opportunity to manage the FTE’s for customers and provided scientific guidance to solve the chemistry and process related challenges. Orchestred the smooth functioning of R & D and tech-transfer center. Reviewed project related documents such as DMF, TTD, CTD as per cGMP & ICH guidelines. Tailored the projects to fit plant requirements and limitations. Skillfully coordinated multi-disciplinary teams for planning and execution of projects during tech-transfer. Carried out facility audits(internal and external) Trained, guided and motivated scientists to build a synergistic & cohesive team. Active member of the literature survey, HAZOP and IP related decision making team.

Multi organics Pvt. Ltd, Mumbai, is the manufacturer of specialty chemical and pharma Intermediates, outsourcee to global chemical companies, 200+employees. 2004-2005

Asst. Manager- New product development.

• Headed and supervised the set-up of New R&D center, recruited and trained a team of chemists.

• Effectively managed external CRO & chemists to develop process technology for new products.

Coromandel Fertilizers India Limited, Mumbai. One of the leaders in fertilizers, specialty nutrients, and crop protection & markets around 2.9 million ton of products across the globe. CFL is second largest manufacturer of Malathion and Phenthoate. The Company turnover of $ 1.93 billion in 2012 & employs over 5000 people. 2002 -2004

Asst. Manager- R & D Centre. (Formerly EID Parry India Limited).

• Awarded a promotion from Scientist to Asst. Manager for successfully re-developing process for Phenthoate with 21% overall cost reduction and shorter time cycle. This product till date is being produced in the plant and CFL is the second largest producer.

• Successfully resolved the process difficulties in endosulfan and made the process very robust, this product was the core business, I was rewarded for this exceptional contribution.

• Volunteered to accept added responsibility to setup a new advanced formulation center. I attend a sponsored course titled “Newer formulation development” conducted by IPFT, Govt of India. Later developed formulations like Gels, micro-emulsions and WDG’s, one other notable product was water soluble packing of gels.

Calyx Chemical and Pharmaceuticals limited. Dombivali, India. A medium sized custom synthesis / manufacturing organization, employing about 200 people. 2002 (March-Aug)

Scientist – R & D.

• Successfully completed the n-1 intermediate for duloxtine for a Japanese company well before time, also collaborated with analytical team to develop a better method for HPLC analysis.

Nicholas Piramal India limited, Thane, India. It is a Part of Piramal health care & ranks 5th in list of top 10 pharmaceutical contract manufacturers globally as per UNCTD’s, World Investment Report, 2011, employs more than 400 scientists. 2000-2002

Junior Manager - R & D.

• Demonstrated, synthesized and scaled up Crotamiton to kilogram scale in the lab in record time.

• Skillfully completed impurity profiling for Verapamil hydrochloride and Bulaquin.

Collaborated with various teams and Completed laboratory work on Levobunolol, Valdecoxib and successfully introduced the process to manufacturing. Completed the plant trials of Gabapentin.

Education________________________________________

Intellectual Property Rights (IPR) Diploma. 2006

GNA Patent Gurukul(Institute), Mumbai, India.

Course covered: Indian Patent Law, TRIPS agreement, Patent reading, Patent writing and Claim drafting.

Ph.D. in Organic Chemistry 2002

Institute of Science, Mumbai, India. Advisor: Professor Madhukar S. Chande.

Thesis: "On the Chemistry of Spiro Compounds Containing N & S."

The project included synthesis of series of various novel heterocyclic, spiro compounds and spiro-crown ethers built on the oxindole nucleus. The compounds synthesized were characterized and scanned for their activity against mycobacterium tuberculosis.

Master of Science in Organic Chemistry 1996

Institute of Science, Mumbai, India. Advisor: Professor J. A. Patankar.

Thesis: "Synthesis of Some Phthalazinones and Isoquinolone Derivatives from 5,6,7-Trimethoxy isochroman-1,3-dione."

Bachelor of Science in Chemistry 1993

R. N. Ruia College, Bombay. India. Passed in 1st Class.

• Awarded outstanding students award for excellence in Academics and sports in 1992 and 1993.

• Was the Senior Under Officer (highest position) in National Cadet Crops of Ruia Platoon.

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