Experienced Analytical Toxicology Director and Lab Manager

Xiuping Sherry Liu

*** ***** *** **** ****** Hill, NC 27514

Phone: 919-***-****

Email: ******@*****.***

HIGHLIGHTS OF QUALIFICATIONS:

Experience in method development and/or validation for active ingredients, drugs and metabolites

Extensive hands-on experience with a wide array of analytical techniques: LC/UV, LC/MS, LC/MS/MS, UV/Vis, GC/FID, FT-IR, NMR

Deep understanding of separation science, with experience working with HIC, SEC, AEC, RPC chromatography

Knowledgeable in cGMP, cGLP requirements

Many years of experience in trouble shooting and maintenance for LCMSMS and some other instruments

SPE and LLE sample preparation techniques

Excellent interpersonal, verbal and written communication skills

Excellent troubleshooting, problem solving skills

Director Certification and Licensure:

National Registry of Certified Chemists (NRCC) - Toxicological Chemist

Florida State Licensure-Clinical Laboratory Director

EXPERIENCE:

General Laboratory Manager and Technical Supervisor (Aspirar Health, Cary, NC) 09/2015-11/2025

•Set up Aspirar Medical Lab from the start

•Develop and Validate quantitative Drug of Abuse methods for Urine and Saliva samples on LCMSMS

•Develop SPE method for Oral fluid samples for Quantitative analysis

•Review, prove and report LCMSMS Data to clients daily

•Maintenance and trouble shoot multiple LCMSMS instruments

•Manage toxicology lab and molecular lab.

•Supervise chemists and lab staff

•Perform QA and QC monthly according to CLIA and COLA guidelines

•Perform annual reviews for chemists and lab staff

Laboratory Supervisor (Premier Medical Laboratory, Fountain Inn, SC) 01/2014 – 12/2014

•Maintain and update current quantitative methods. Develop new methods when needed. Review data and generate reports. Troubleshoot instrumentation.

Laboratory Technical Consultant (Premier Medical Laboratory, Fountain Inn, SC) 02/2011- 01/2014

•Helped to plan the lab from scratch, including instrumentation, lab devices, reagents and methods. Provided scientific and technical advice for chemists on-site.

•Developed and validated quantitative analytical methods for drugs and metabolites. Prepare SOPs and review data as needed. Laboratory is under CLIA compliance.

Sr. Scientist (Catalent, Morrisville, NC) 02/2011-10/2011

•Worked on various projects from different customers on method validation, assay and purity analysis using HPLC-UV, UV-Vis, GC/FID under cGMP compliance.

•Developed HILIC-RI method for separation and quantitation of PEG and MPEG mixture.

Senior Scientist (PCLS, Charlotte, NC) 03/2009-10/2010

•Developed and validated quantitative LC-MS/MS (Positive ESI) method to analyze pain drugs, drugs of abuse (opioids, illicit drugs, cocaine, heroin, marijuana, amphetamines, benzodiazepines), and their metabolites in urine and saliva samples.

•Developed quantitative LC-MS/MS (negative ESI) method for Barbiturates analysis in urine samples.

•Analyzed and reviewed quantitative data to generate technical reports. Guided technician in SPE sample preparation procedures. Performed calibration, maintenance and troubleshooting of analytical instruments. Trained junior chemists. Wrote SOP for LC/MS/MS operation.

Senior Scientist (SSCI, Inc., West Lafayette, Indiana) 10/2007 – 6/2008

•Worked with other groups in formulation development and pre-formulation study. Developed HPLC-UV method for APIs, drug products and separation of enantiomers. Conducted assay and purity analysis by HPLC-UV, UV-Vis under cGMP requirements.

•Confirmed API with LC-MS/MS (3200 Q-TRAP). Conducted API stability testing and stress testing (pH, moisture, temperature, solvent, light etc.). Carried out dissolution study for drug products, all under cGMP requirements. Prepared scientific reports for clients.

EDUCATION:

Ph.D Degree, Analytical Chemistry December 2007, Purdue University, West Lafayette, IN

MS Degree, Organic Chemistry, July 1998, Xiamen University, Fujian, P.R.China

BS Degree, Chemistry, July 1995, Xiamen University, Fujian, P.R.China

Ph.D Thesis Research

Dissertation: Chromatographic Fractionation of Protein Complexes

•2-D LC-MS/MS Methodology Development for Protein Complexes Recognition:

•Developed proteomics methods for discovering protein quaternary structure as part of global proteomics in complex sample such as yeast lysate using multi-dimension liquid chromatography (hydrophobic interaction, size exclusion, strong anion and reversed-phase) and tandem mass spectrometry (MALDI-TOF-TOF, Trap XCT and QqTOF).

•Demonstrated method comparability to shot gun and two dimensional gel electrophoresis on resolution and speed with the added advantage of recognizing protein primary and quaternary structures.

•Synthesize New Labeling Agent:

Co-developed a series of new labeling reagents for amino acids detection and

quantification to increase the retention time of small hydrophilic amino acids in RPLC

and enhance the ionization in the ESI MS.

•2-D LC-MS/MS for Protein Identification in Complex Sample

•Peptide Mapping

Graduate Research (Xiamen University)

•Synthesized diasteromeric β,γ-disubstituted γ-lactones under nitrogen atmosphere.

•Confirmed or identified the structure of the intermediates and product and excess enantiomer by chiral chromatography, solid and liquid Infrared (IR), nuclear magnetic resonance (1H-NMR), mass spectrometry (CI-MS and EI-MS).

KEY PUBLICATIONS

•Coupling Protein Complex Analysis to Peptide Based Proteomics, Journal of Chromatography A, (2010), 1217 (49), 7661-7668. Qiang Gao, Ashraf G. Madian, Xiuping Liu, Jiri Adamec, Fred E. Regnier.

•Toward Chromatographic Analysis of Interacting Protein Networks, Journal of Chromatography A, (2008), 1178 (1-2), 24-32. Xiuping Liu, Wen-Chu Yang, Qiang Gao and Fred E. Regnier.

•Quaternary Structure Analysis As Part of Global Proteomics Strategies. MSB 2007: 20th International Symposium on Microscale Bioseparations, Fred E. Regnier, Xiuping Liu, Qiang Gao, and Hamid Mirzaei.

•Enhancement of amino acid detection and quantification by electrospray ionization mass spectrometry, Analytical Chemistry (2006), 78(13), 4702-4708. Wen-Chu Yang, Hamid Mirzaei, Xiuping Liu, Fred E. Regnier

•Asymmetric synthesis of β,γ-disubstituted γ-lactones, Huaxue Xuebao (2004), 62(18), 1794-1800, Pei-Qiang Huang, Xian-Yong Yu, Xiuping Liu

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