Immunology Research Scientist with Translational Focus

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KAUSIK PAUL, Ph.D.

Los Angeles, CA *0004, USA

Email: **********@*****.***, ******.****@****.*** Phone: +1-213-***-**** Google Scholar Photography Portfolio

PROFILE SUMMARY

Biomedical scientist with experience in immunology, infectious diseases, and translational research across academic, collaborative industry settings. Proven track record in designing and executing preclinical studies, publishing in peer-reviewed international scientific journals, and presenting at international conferences. Adept in flow cytometry, immunology, anti-leishmania drug discovery, red blood cell alloimmunization, cancer biology, microfluidics, and in vivo disease models. CURRENT POSITION

Project Scientist, (2022 – Present), Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA

Investigating the role of type 1 and type 2 interferon signaling mechanisms to understand the cellular and molecular mechanisms of red blood cell (RBC) alloimmunization in the lupus mouse model using recombinant antibody therapy and transgenic mice.

ACADEMIC POSITIONS

Assistant Professor, Seacom Skills University, India (2021 – 2022) Assistant Professor, Glocal University, India (2018 – 2020)

(Taught and designed immunology and microbiology courses; mentored undergraduates for study-based research projects)

EDUCATION

Ph.D. Infectious Diseases & Immunology – CSIR-IICB & Jadavpur University, Kolkata, India Postgraduate (MS) in Biophysics- Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India Undergraduate (BS) in Microbiology- Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India POSTDOCTORAL EXPERIENCE:

Postdoctoral Fellow, Department of Medicine, University of Arizona, USA Postdoctoral Fellow, Department of Physics & Astronomy, University of Manitoba, Canada RESEARCH PUBLICATIONS/ CONTRIBUTION

1. Paul K, Hernandez-Armengol R, Lee JY, Chang C-Y, Shibata T, Yamashita M, Jefferies CA, Gibb DR. Distinct RBC alloantibody responses in type 1 interferon-dependent and -independent lupus mouse models. Front Immunol. 2024; 14:1304086.

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2. Chang CY, Hernández-Armengol R, Paul K, Lee JY, Nance K, Shibata T, Yue P, Stehlik C, Gibb DR. The Nrf2 Activator CDDO-Imidazole Suppresses Inflammation-Induced Red Blood Cell Alloimmunization. Antioxidants. 2025 Jun 3;14(6):678.

3. Manuscript reviewer for the journal “Transfusion” (RBC alloimmunization research) in 2025. 4. Paul K, Lee JY, Hernandez-Armengol R, Shibata T, Jefferies C, Gibb DR. Type 1 interferons promote anti- RBC antibody responses in interferon-dependent lupus mice. J Immunol. 2023. 210(S1): 247.12. 5. Hernandez-Armengol R, Lee JY, Paul K, Chang CY, Shibata T, Gibb DR. Identifying Inflammatory Pathways That Promote RBC Alloimmunization in Patients with Sickle Cell Disease. Blood. 2023 Nov 28;142: 2663. 6. Chang C-Y, Hernandez Armengol R, Paul K, Lee JY, Shibata T, Yue P, and Gibb DR. Antioxidant responses regulate RBC alloimmunization. Transfusion. 2024. Sept;64(S3) PL3-SN-25. Doi: 10.1111/trf.18002. 7. Li J, Nandagopal S, Wu D, Romanuik SF, Paul K, Thomson DJ, Lin F. Activated T lymphocytes migrate toward the cathode of DC electric fields in microfluidic devices. Lab on a Chip. 2011;11(7):1298-304. 8. Ganguly D, Paul K, Bagchi J, Rakshit S, Mandal L, Bandyopadhyay G, Bandyopadhyay S. Granulocyte- macrophage colony-stimulating factor drives monocytes to CD14low CD 83+ DCSIGN- interleukin- 10- producing myeloid cells with differential effects on T cell subsets. Immunology, 2007, August; 121(4): 499-507. (PMID: 17433076, ISSN: 1365-2567).

9. Pal C, Ganguly D, Paul K, Pal S. Dendritic cells and antigen trapping technology—a revolution in vaccine/ immunotherapy Strategy. Indian J Exp Biol. 2007, June; 45(6): 491-504. (PMID: 17585683, ISSN: 0019- 5189).

10. Mallick S, Halder S, Dutta A, Dey S, Paul K, Maiti S, Bandyopadhyay C, Saha B, Pal C. Chromone linked nitrone derivative induces the expression of iNOS2 and Th1 cytokines but reduces the Th2 response in experimental visceral leishmaniasis. International Immunopharmacology. 2013 Apr 1;15(4):772-9. 11. Ghosh M, Mandal L, Maitra S, Rakshit S, Paul K, Bagchi J, Ganguly D, Pal C, Bandyopadhyay S. Leishmania donovani infection of human myeloid dendritic cells leads to a Th1 response in CD4+ T cells from healthy donors and patients with kala-azar. The Journal of Infectious Diseases. 2006 Aug 1;194(3):294-301.

12. Rakshit S, Bagchi J, Mandal L, Paul K, Ganguly D, Bhattacharjee S, Ghosh M, Biswas N, Chaudhuri U, Bandyopadhyay S. N-acetyl cysteine enhances imatinib-induced apoptosis of Bcr-Abl+ cells by endothelial nitric oxide synthase-mediated production of nitric oxide. Apoptosis. 2009 Mar;14(3):298-308. 13. Chakraborty JB, Mahato SK, Joshi K, Shinde V, Rakshit S, Biswas N, Choudhury Mukherjee I, Mandal L, Ganguly D, Chowdhury AA, Chaudhuri J, Paul K, Pal BC, Vinayagam J, Pal C, Manna A, Jaisankar P, Chaudhuri U, Konar A, Roy S, Bandyopadhyay S. Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance. Cancer Sci. 2012 Jan;103(1):88-99. Page 3 of 3

14. Bandyopadhyay S, Pal BC, Chakraborty JB, Rakshit S, Mandal L, Paul K, Biswas N, Manna A, inventors; Council of Scientific, Industrial Research CSIR, assignee. Extract of piper betel leaves for the treatment of human malignancies by inducing oxidative stress. United States patent application US 12/808,964. 2011 Jun 16. US Patent No. US 2011 O142969A1.

15. Bandyopadhyay S, Pal BC, Parasuraman J, Roy S, Chakrabotry JB, Mukherjee IC, Mahato SK, Konar A, Rakshit S, Mandal L, Ganguly D, Paul K, Manna A, Vinayagam J, Pal C. Inhibitors of phosphatidylinositol-3- kinase (PI3) and inducers of nitric oxide (NO). United States patent US 9,290,473. 2016 Mar 22. US Patent No. US009290473B2.

Full publication list: Google Scholar

HONORS & AWARDS

• Cedars-Sinai CTSI Core Voucher Award (2025) – Co-Investigator

• Senior Research Fellowship (CSIR, India, 2007)

• Senior Research Fellowship (DBT, India, 2006)

• Research Fellowship (DST, India, 2003)

LABORATORY SKILLS

• Immunology & Cell Biology: PBMC isolation, immune cell phenotyping, MACS, antigen detection, cytokine profiling, immune cells using Easy Sep Method of Stem Cell Technology, Cell survival and proliferation assays; cell viability assay, Preparation of Giemsa-stained smears of different cells for studying cell morphology, ELISA, BiolegendplexTM.

• Molecular Biology: Conversant with qPCR, western blot experiments.

• Microscopy: Conversant with Phase contrast, Immuno-fluorescence, and confocal microscopy.

• Flow cytometry: Conversant with using Cytek Spectral flow cytometer.

• Parasitology: Study of Visceral Leishmaniasis in animal (golden hamster & mouse balb/c) model.

• Animal Handling: Mouse models (C57BL/6, Balb/c, transgenic), hamster models, i.p (intraperitoneal) & RO (retro-orbital) injections, RO bleeding techniques.

• Software & Data Analysis: Conversant with the usage of Windows-based operating systems and software such as MS OfficeTM, Adobe PhotoShopTM, FlowJoTM, Graphpad PrismTM, etc. CONFERENCE PRESENTATIONS

Association for the Advancement of Blood & Biotherapies (AABB) Annual Meeting, 2025—Talk & Poster American Association of Immunologists (AAI) Annual Meeting, 2023 — Poster Immunology LA Annual Meetings, 2023–2025—Poster

UC Irvine Immunology Research Symposium, 2023-Poster CREWHS Symposia, Cedars-Sinai Medical Center 2023,2024, 2025—Lightning talk & Poster Cedars-Sinai Single Cell and Spatial Omics Symposium, 2025—Poster Annual Research Day Celebration, Cedars Sinai Medical Center, 2022, 2024-Poster CO-CURRICULAR ACTIVITIES

Internationally recognized photo artist with exhibitions and publications worldwide. Photography Portfolio

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