MIKA SHIMOJI
POTOMAC, MD *****
410-***-**** – MIKASHIMOJI@GMAILCOM
Professional Summary
Experienced preclinical scientist specializing in neurodegeneration, inflammation, immunotherapy, and targeted nanoparticle-based therapeutic delivery. Extensive expertise across in vitro, ex vivo, and in vivo biological models, including cells, tissues, and multiple animal species (invertebrates, rodents, felines, and non-human primates). Strong background in animal research compliance, with hands-on leadership in IACUC oversight and deep knowledge of AALAS and USDA guidelines.
Industry experience includes directing in vivo ear research at Otomagnetics, Inc., where I developed and validated models for magnetically guided nanoparticle drug delivery to the middle and inner ear, supporting FDA submissions. Most recently served as Principal Scientist at Autonomous Therapeutics, Inc., establishing and leading preclinical animal studies for respiratory diseases, oncology, and nanoparticle-based immunotherapies, with responsibility for study design, execution, and evaluation of efficacy, biodistribution, immune response, and safety.
SKILLS
GLP (certified), Nucleic acid purification/manipulations/sequencing/analysis, Molecular cloning, PCRs (rt-, di, q), Histology and tissue preparations, Tissue sectioning, Immunotherapy, Plaque assay, TCID 50, virus and antibody titrations, Virological assays, Virus amplification, Virus rescue and neutralization assays, Targeted drug delivery, Bacteria culturing, cloning, Cell /tissue cultures, 3D slice cultures, HPLC, ELISA, Protein purifications/assays, Microscopy
(light/confocal/fluorescent), Flow cytometry, Small animal imaging (MRI/ IVIS), Small animal Tumorigenesis, Small animal surgery/stereotaxic, Stereology, Nano-particle manipulations
/analysis/QC assays (DLS, ICP-MS), Data analysis, Statistical analysis. WORK EXPERIENCE
AUGUST 2021-AUGUST 2025
Principal Scientist of In vivo studies
Autonomous Therapeutics, Inc. Rockville, MD
• Responsible for setting up in vivo study facility (i.e. animal room, IACUC)
• In charge of designing, carrying out in vivo studies of virus infections, in vivo tumorigenesis, immuno-therapeutics delivery, evaluation of tissue distributions, efficacy, toxicity studies, various immunological assays, data analysis for presentations.
• Various cell and tissue cultures and assays and analysis
• Molecular cloning
• RT-, qPCR analysis of efficacy, tissue distribution sutdies
• Trained personnels at various levels of scientific backgrounds.
• Virus rescue and propagation
• Live animal imaging and targeted therapeutics delivery MIKA SHIMOJI
POTOMAC, MD 20854
410-***-**** – MIKASHIMOJI@GMAILCOM
OCTOBER 2013- AUGUST 2021
Director of Ear Research
Otomagnetics, Inc. Gaithersburg, MD (Univ. of MD, College Park, MD)
• Direct research and development of in vivo and in vitro testing and evaluations of targeted drug loaded nanoparticle delivery systems, efficacy and toxicity/safety assessment, and screening of candidate drug loaded nanoparticles prior to in vivo testing.
• Tissue extractions and preparations for immunohistology examinations.
• Ex vivo animal tissue studies magnetic nanoparticle delivery to a target tissue.
• Microscopies: light/fluorescent
• Responsibility included setting up in vivo study program and generating associate animal protocols for IACUC review and approvals, establishment of other in vitro, ex vivo evaluations and testing system for quality control and screening of drug loaded iron oxide nanoparticles.
• Government grant applications and scientific publications.
• Training of undergrad/graduate students and junior scientists SEPTEMBER 2007-DECEMBER 2015
Life Science consultant
Weinberg Medical Physics, Rockville, MD
• Biological sample preparations, bioscience consultant, and histology for Government grant applications.
• Tissue sample preparations and sectioning for immunobiological assays and examinations.
• Light microscopies
AUGUST 2012-AUGUST 2013
Contract Research Scientist & lecturer
University of the District of Columbia, Washington, D.C.
• Molecular biological investigation for prostate cancer signal transduction system using cell culture system with biochemical assays, molecular assays, and microscopy
(light/fluorescent/confocal) studies.
• Organized and taught a 4
th
year molecular biology course and lecture the course. APRIL 2007-JUNE 2012
Research Assistant Professor
Neuroscience, Georgetown University School of Medicine, Washington, D.C.
• Investigation of etiology and association between neuroinflammation due to head trauma and Parkinson’s disease using cell culture system, small animal model, and ex vivo human tissues samples. Light/fluorescent/confocal microscopy studies on animal and human tissue samples.
• Submit and acquire research fundings from private and governmental funding agencies.
• A voting member of Georgetown University’s Institutional Animal Care and Use Committee
(GUIACUC) to review animal protocols by other investigators within the university. MIKA SHIMOJI
POTOMAC, MD 20854
410-***-**** – MIKASHIMOJI@GMAILCOM
• Served the head of GUIACUC subcommittee for Non-human primate use review and advisory.
• A teaching faculty of a neuroanatomy lab course for the Georgetown medical school students.
FEBURARY 2004- FEBURARY 2007
Post-Doctoral Research Fellow
Laboratory of Neurogenetics, Transgenesis section, NIA/NIH, Bethesda, MD.
• Responsible for generation of a transgenic mouse model to investigate genetic components of Parkinson’s disease.
• Investigation of neuroinflammation and genetic components of Parkinson’s disease etiology intervention, and signaling pathway with cell culturing system.
• Microscopies (light/fluorescent/confocal) of immunohistochemistry and immune cytochemistry samples.
• Stereology sample preparations, sectioning, staining, and cell counting.
• Training of undergraduate/graduate students
DECEMBER 2000-FEBURARY 2004
Post-Doctoral Fellow
Department of Neurology, Institution of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD
• Responsible for setting up a several animal modeling systems for Parkinson’s disease for investigation of neurodegeneration and its etiology, neurotoxin administration, tissue harvest and evaluations.
• Stereology sample preparations, sectioning, staining, and cell counting.
• Microscopies (light/fluorescent/confocal) of immunohistochemistry and immune cytochemistry samples.
• Other responsibility included, cell culture and 2-D slice culture (ex vivo) system development for neuroinflammation and neurodegenerations cellular signaling system and intervention studies.
• Managing and maintenance of a transgenic mice colony for neurodegenerative disease signaling pathway studies.
• Training of undergraduate and graduate students
SEPTEMBER 1989-AUGUST 1994
Research Technologist
National Primate Research Center, University of Washington, Seattle, WA
• Responsible for daily primate visit for assessment on their basic health and well-beings.
• Setting up daily sample collections devices, sample collections, pre-processing of samples for endocrinology and blood testing.
• Setting up video recordings for animal behavior assessments and behavior coding.
• Assistance and anesthetization of primates for cardio monitoring device attachment and physical checkups.
MIKA SHIMOJI
POTOMAC, MD 20854
410-***-**** – MIKASHIMOJI@GMAILCOM
• Managing and maintenance of sample organizations and video recordings.
• Data collections and help analysis for peer reviewed scientific publications and governmental grant applications as well as attendance of professional conferences for data presentations.
• Training of undergraduate research students
EDUCATION
Ph.D.- Cellular and Clinical Neurobiology 12/2000
Wayne State University School of Medicine, Detroit, MI Dissertation topic: Gene Expression of GTP Cyclohydrolase in the hph-1 mouse and castrated rats
B.S. - Biology 08/1994
University of Washington, Seattle, WA
Emphasis on Molecular Biology
B.S. - Psychology 06/1990
University of Washington, Seattle, WA
Emphasis on Neuroscience
REFERENCES
Timothy Notton, Ph.D.
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Chief Scientific Officer, Autonomous Therapeutics, Inc Gregory Moore, Ph.D., MD
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Executive Board Member, Microsoft Health and Life Sciences Sayantan Bose, Ph.D.
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Director, Discovery Project Leader, GSK
Ted Dawson, Ph.D., MD
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Professor of Neurology, Director of Institute of Cell Engineering, Johns Hopkins University School of Medicine
Irving Weinberg, MD, Ph.D.
MIKA SHIMOJI
POTOMAC, MD 20854
410-***-**** – MIKASHIMOJI@GMAILCOM
**********@*****.***
CEO/President, Weinberg Medical Physics
Christopher Albanese, Ph.D.
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Professor/Director, Center for Translational Imaging, Department of Oncology, Pathology and Radiology, Georgetown University Medical Center
Didier Depireux, Ph.D.
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Founder/CSO, Otolith Labs
(Founder of Otomagnetics)