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Curriculum Vitae

Bhanu Nirosha Yalamandala, PhD

Postdoctoral Researcher

Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University, Taiwan

Nationality: Indian,

Current Location: California, United States

Phone: +1-669-***-****

Email: ************@*****.***,

LinkedIn:linkedin.com/in/dr-bhanu-nirosha

ORCID: 0000-0003-3303-2183

Education

2017–2023 Ph.D.

Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan. 2010–2012 Master of Pharmacy

Department of Pharmaceutical Analysis, Acharya Nagarjuna University, India. 2006–2010 Bachelor of Pharmacy

Department of Pharmacy, Jawaharlal Nehru Technological University, India. Work Experience

2023–Present Postdoctoral Researcher, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan.

2012–2013 QA Chemist

Department of Tablets, SIRIS Pharmaceuticals, Vijayawada, India. 2011–2012 Trainee (R&D Department)

Aurobindo Pharmaceuticals, Hyderabad, India.

2009–2010 Trainee (Tablets Manufacturing)

Aurobindo Pharmaceuticals, Hyderabad, India.

Publications

2025

1. Beyond Borders: Engineering Organ-Targeted Immunotherapies to Overcome Site-Specific Barriers in Cancer.

Thrinayan Moorthy, Bhanu Nirosha Yalamandala, Thi My Hue Huynh, Hui-Wen Lien, Wan-Chi Pan, Hoi Man Iao, Yun-Hsuan Chang, Shang-Hsiu Hu.

Drug Delivery and Translational Research, 2025. (Under Review) 2. Wireless Chargeable Gold Yarnball-Mediated Mitochondrial Depolarization for Dendritic Cell Detainment in Programmed Brain Tumor Immunotherapy. Thrinayan Moorthy, Chia-Ko Chen, Zhuo-Hao Liu, Bhanu Nirosha Yalamandala, Thi My Hue Huynh, Hoi-Man Iao, Wan-Chi Pan, Hui-Wen Lien, Alan Yueh-Luen Lee, Wen-Hsuan Chiang, Ssu-Ju Li, You-Yin Chen, Shang-Hsiu Hu.

Nano Today, 2025, 65. (SCI: 13.2)

https://doi.org/10.1016/j.nantod.2025.102838

3. Advancing Brain Immunotherapy Through Functional Nanomaterials. Bhanu Nirosha Yalamandala, Thi My Hue Huynh, Hui-Wen Lien, Wan-Chi Pan, Hoi Man Iao, Thrinayan Moorthy, Yun-Hsuan Chang, Shang-Hsiu Hu. Drug Delivery and Translational Research, 2025. (SCI: 5.7) DOI: https://doi.org/10.1007/s13346-024-01778-5

2024

4. A Self-Cascading Catalytic Therapy and Antigen Capture Scaffold-Mediated T Cells Augments for Postoperative Brain Immunotherapy.

Bhanu Nirosha Yalamandala, Thrinayan Moorthy, Zhuo-Hao Liu, Thi My Hue Huynh, Hoi-Man Iao, Wan-Chi Pan, Kang-Li Wang, Chi-Shiun Chiang, Wen-Hsuan Chiang, Lun-De Liao, Yu-Chen Liu, Shang-Hsiu Hu.

Small, 2024, 2406178. (SCI: 13.0)

DOI: https://doi.org/10.1002/smll.202406178

5. A Self-Cascade Penetrating Brain Tumor Immunotherapy Mediated by Near-Infrared II Cell Membrane-Disrupting Nanoflakes via Detained Dendritic Cells. Bhanu Nirosha Yalamandala, Yu-Jen Chen, Ya-Hui Lin, Thi My Hue Huynh, Wen-Hsuan Chiang, Tsu-Chin Chou, Heng-Wei Liu, Chieh-Cheng Huang, Yu-Jen Lu, Chi-Shiun Chiang, Li-AnChu, and Shang-Hsiu Hu.

ACS Nano, 2024, 18 (28), 187**-*****. (SCI:15.8) (Journal Cover) https://doi.org/10.1021/acsnano.4c06183

6. Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage-Wrapped NanoCubes-Mediated T Cell Infiltration. Kang-Li Wang, Cheng-Han Li, Pin-Xuan Huang, Hsiu-Ching Liu, Bhanu Nirosha Yalamandala, Wan- Chi Pan, Hoi Man Iao, and Shang-Hsiu Hu.

Small, 2024, 2406790. (SCI: 13.0)

DOI: https://doi.org/10.1002/smll.202406790

2023

7. Programmed antigen capture-harnessed dendritic cells by margination-hitchhiking lung delivery. Thi My Hue Huynh, Bhanu Nirosha Yalamandala, Min-Ren Chiang, Wei-Han Weng, Chien-Wen Chang, Wen-Hsuan Chiang, Lun-De Liao, Yu-Chen Liu, Shang-Hsiu Hu. Journal of Controlled Release, 2023, 358, 718-728. (SCI:11.467) https://doi.org/10.1016/j.jconrel.2023.05.028

2022

8. Programmed Catalytic Therapy and Antigen Capture-Mediated Dendritic Cells Harnessing Cancer Immunotherapies by In Situ-Forming Adhesive Nanoreservoirs. Bhanu Nirosha Yalamandala, Thi My Hue Huynh, Min-Ren Chiang, Wei-Han Weng, Chien-Wen Chang, Wen-Hsuan Chiang, Shang-Hsiu Hu.

Advanced Functional Materials, 2022, 2210644. (SCI:19.924) (Journal Cover) https://doi.org/10.1002/adfm.202210644

9. Programmed Catalytic Therapy-Mediated ROS Generation and T-Cell Infiltration in Lung Metastasis by a Dual Metal-Organic Framework (MOF) Nanoagent. Bhanu Nirosha Yalamandala, Pin-Hua Chen, Thrinayan Moorthy, Thi My Hue Huynh, Wen-Hsuan Chiang, Shang-Hsiu Hu.

Pharmaceutics, 2022, 14, 527. (SCI:6.321) (Journal Cover). https://doi.org/10.3390/pharmaceutics14030527

2021

10. Advances in Functional Metal-Organic Frameworks Based On-Demand Drug Delivery Systems for Tumor Therapeutics.

Bhanu Nirosha Yalamandala, Wei-Ting Shen, Sheng-Hao Min, Wen-Hsuan Chiang, Shing-Jyh Chang, and Shang- Hsiu Hu.

Advanced NanoBiomed Research, 2021, 2100014. (Invited Review, Journal Cover) https://doi.org/10.1002/anbr.202100014

2019

11. Polydopamine-coated gold nanostar for combined antitumor and antiangiogenic therapy in multidrug-resistant breast cancer.

You-Hong You, Yu-Feng Lin, Bhanu Nirosha, Huan-Tsung Chang and Yu-Fen Huang. Nanotheranostics, 2019, 3, 266. (SCI:5.28)

https://doi.org/10.7150/ntno.36842

2012

12. Analytical Method Development and Validation of Famciclovir in Bulk and Tablet Dosage Form by Using RP-HPLC Method.

Bhanu Nirosha Somavarapu, Venketeswararao. P, Sudhakar Babu A.M.S, Ramanjaneyulu. K.V. International Journal of Pharmacy & Therapeutics, 2012, 3, 306. Peer-Review Experience

Manuscript and Grant Reviewer, 2025

Journals:

1. Communications Biology (Nature Portfolio)

2. Drug Delivery and Translational Research (Springer Nature)

(Verified on ORCID: 0000-0003-3303-2183)

Selected Manuscripts Reviewed:

• NIR-II optogenetic CRISPR/Cas9 biomimetic nanoplatform for head and neck squamous cell carcinoma photoimmunotherapy

• Thermoresponsive solid lipid nanoparticles: Unlocking the potential for CNS tumor therapy

• Emerging Nano-derived Therapy for the Treatment of Dementia: A Comprehensive Review

• Crossing the Blood-Brain Barrier: Nanoparticle-Based Strategies for Neurodegenerative Disease Therapy.

Awards and Honors

1. 2025, 2024 National Science and Technology, Award (Taipei, Taiwan) 2. 2024, 2023, National Tsing Hua University, Award (Hsinchu, Taiwan) 3. 2022, Oral Presenter Award, International conference, 7Th World Cancer Congress, Bangalore, India. 4. 2021, Doctoral Winner Award (Best Poster) won the Special Research Poster contest of Academy of Atomic Sciences- Doctoral Group College of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan

5. Licensed Pharmacist

Conferences and Presentations

1. “Injectable Adhesive MOF-Based Catalytic Nanogel as a Magnetothermal Derived Antigen Reservoir for Enhanced Immunotherapy”. (Oral conference) International conference, 7Th World cancer congress, 2022, Bangalore, India. Oral presenter award

2. “Programmed Catalytic Therapy and Antigen Capture-Mediated Dendritic Cells Harnessing Cancer Immunotherapies by In Situ-Forming Adhesive Nanoreservoirs”. (Poster) Thematic poster contest, College of nuclear science, National Tsing Hua University, 2022, Hsinchu, Taiwan. 3. “Injectable Adhesive MOF-Based Catalytic Nanogel as a Magnetothermal Derived Antigen Reservoir for Enhanced Immunotherapy”. (Oral Conference) (Drug delivery), BCRS Annual meeting of biomaterials and controlled release society, Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 2022, Hsinchu, Taiwan.

4. “Functional Metal-Organic Frameworks (MOF) based Fenton mediated Nanoagent for Lung Metastasis Therapy”. (Poster) Special Research Poster contest of Academy of Atomic Sciences- Doctoral Group College of Nuclear Science, National Tsing Hua University, 2021 Hsinchu, Taiwan. Winner award (Best poster award)

5. Qualified in PGCET (Post Graduate Common Entrance Test), 2010, India. 6. Presented a seminar in the international seminars, 2009, Jawaharlal Nehru Technological University, India. Technical Skills

• Microscopy: Confocal (Zeiss LSM-800), Fluorescence (Nikon TE2000-U)

• Flow Cytometry: BD FACSAriaTM II, FlowJo analysis

• Spectrometry & Analysis: UV-Vis, Fluorescence, FTIR, HPLC

• Material Characterization: DLS (Malvern), Zeta Potential, Calcination, SEM, Magnetic/NIR-II Imaging

• Spectroscopy & Separation Analysis: UV-Vis, Fluorescence, FTIR, HPLC

• Cellular Work: Cell culture, ROS detection, Antigen capture, ELISA, Immune cell profiling, Animal handling (mice)

• Nanomaterial Synthesis & Surface Chemistry: Hydrothermal and microwave assisted synthesis, Surface functionalization, Gel electrophoresis, ELISA

• Other Lab Skills: Quantitative image and Data Analysis Software Proficiency

MS Office Suite (Word, PowerPoint, Excel)

Data Analysis Tools: GraphPad Prism, Origin, FlowJO, Image J, ENDNOTE, ChemDraw Visualization: Biorender

Languages Known

English, Chinese, Telugu, Hindi

Postdoctoral Research

During my postdoctoral training in Professor Shang-Hsiu Hu’s lab, I focused on developing nanomaterial-based immunoengineering strategies to treat aggressive and poorly immunogenic tumors, including brain tumors, lung metastasis, and oral carcinoma. I led and co-authored multiple high-impact studies that merged nanotechnology with immune modulation to enhance CD8+ T cell infiltration, antigen presentation, and long-term immune memory. In one study (Small, 2024), I developed a self-cascading catalytic nanoplatform in brain tumor model embedded within a post-surgical antigen-capturing scaffold. This system promoted dendritic cell activation and robust T cell–mediated immunotherapy in glioblastoma models.

In another work (ACS Nano, 2024), I engineered NIR-II-activatable nanoflakes in brain tumor models capable of disrupting tumor cell membranes, facilitating sustained immune activation and localized delivery of immunostimulatory cargo to dendritic cells. These approaches significantly amplified antitumor T cell responses in brain tumor models and demonstrated translational potential for preventing post-surgical tumor recurrence. In a complementary review (Drug Delivery and Translational Research, 2025), I summarized recent advances in functional nanomaterials for brain immunotherapy, emphasizing their role in reshaping the tumor microenvironment and overcoming immune resistance. Collectively, my research integrates tumor microenvironment modulation, nanomedicine, and immune reprogramming, forming a strong foundation for extending this work to inflammation- associated cardiac diseases and immune checkpoint regulation in cancer. Ph.D Thesis Summary

Title: Programmed Catalytic Therapy and Antigen Capture-Mediated Cancer Immunotherapies by In Situ-Forming Adhesive Nanoreservoirs

Overview

My doctoral research focused on developing innovative nanomaterial-based immunotherapies to overcome tumor immune evasion, enhance immune cell infiltration, and suppress metastatic and brain tumors. Specifically, I designed functional Metal-Organic Frameworks (MOFs) and catalytic nanogels that improve tumor immunogenicity, generate reactive oxygen species (ROS), and sustain antigen presentation to elicit robust antitumor immune responses.My doctoral research focused on developing innovative nanomaterial-based immunotherapies to overcome tumor immune evasion, enhance immune cell infiltration, and suppress metastatic and brain tumors. Specifically, I designed functional Metal-Organic Frameworks (MOFs) and catalytic nanogels that improve tumor immunogenicity, generate reactive oxygen species (ROS), and sustain antigen presentation to elicit robust antitumor immune responses. The thesis is divided into two main parts:

Research Highlights:

Programmed Catalytic Immune Therapy for Lung Metastasis: I synthesized a dual-functional core-shell MOF nanocube integrating a Prussian blue-coated iron-containing MOF (MIL88) that acts as a peroxide mimic for sustained ROS generation in cancer cells. Combined with chloroquine-mediated autophagy inhibition via lysosomal deacidification, this dual MOF disrupts tumor self-defense mechanisms, enhances cytotoxicity, and promotes T cell recruitment. In vivo studies demonstrated a ~3-fold increase in T lymphocyte infiltration and over 90% suppression of lung metastatic tumor foci.

In Situ-Forming Adhesive Catalytic Nanogel for Enhanced Immunotherapy: I developed an adhesive catalytic nanogel (CN) incorporating manganese dioxide (MnO2) and catechol-functionalized magnetic MOF for magnetothermal-triggered antigen capture and delivery. The intravenously administered CN accumulates at metastatic tumor sites and forms a gel under magnetic hyperthermia, releasing Mn2+ to deplete glutathione and induce chemodynamic therapy. This process stimulates tumor-associated antigen and damage-associated molecular pattern release, which the catechol groups capture and present to dendritic cells, sustaining immune activation. This approach effectively inhibited lung metastasis progression over 60 days and significantly improved survival. Master’s Thesis Summary

The research involves Analytical Method Development and Validation of FAMCICLOVIR in Bulk and Tablet Dosage Form by using RP-HPLC Method. A reverse phase high-performance liquid chromatography method was developed for the estimation of Famciclovir in pure and pharmaceutical dosage form. Chromatography was carried out on a C18 column using a mixture of phosphate buffer and methanol (65:35) %v/v as a mobile phase at a flow rate of 1ml/min with detection at 310nm.The detector response was linear in the concentration of 30-110µg/ml. The method was validated by determining its precision, accuracy, linearity, ruggedness and robustness. The proposed method was found to be simple, precise, accurate, and quick.

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