Professor, physician and clinical researcher

J. Edward Lavine, MD PhD

*

Date of Preparation: June 8, 2024

Personal Data

Name: Joel Edward Lavine, M.D., Ph.D. F-AASLD, AGA-F Work address: Columbia University Medical Center

*** **** ***** ***eet, PH17

New York, NY 10032

<***********@*****.***>

Birthplace: Cleveland, Ohio

Citizenship: USA

Phone: 1-619-***-****

LinkedIn: linkedin.com/in/joel-lavine-943a0822

Twitter: @jl3553Columbia

ORCID: https://orcid/org/0000-0002-4340-4625

Academic Appointments

03/2023-present Department of Paediatrics, University of Nairobi Nairobi, Kenya Adjunct Professor (Honorary Faculty)

02/2010-present Department of Pediatrics, Columbia University New York, NY Professor of Pediatrics (with tenure)

Vice Chair of Pediatrics (Research) (2014-2019)

Chief, Gastroenterology, Hepatology & Nutrition

(2010 – 2020)

Professor of Pediatrics (in the Institute of Human Nutrition)

(11/2016-present)

07/2001 - 02/2010 Department of Pediatrics, University of California San Diego, CA Professor of Pediatrics (with tenure)

Vice Chair of Pediatrics (Faculty and Fellow Development)

(01/2002 – 12/2009)

Chief, Division of Gastroenterology, Hepatology & Nutrition

(10/1995-02/2010)

10/1995 - 06/2001 Department of Pediatrics, University of California San Diego, CA Associate Professor of Pediatrics

Chief, Division of Gastroenterology, Hepatology & Nutrition 09/1991 - 09/1995 Department of Pediatrics, Harvard Medical School Boston, MA Assistant Professor of Pediatrics

Director, Liver Research

04/1989 - 08/1991 Department of Pediatrics, University of California San Francisco, CA Assistant Professor of Pediatrics

J. Edward Lavine, MD PhD

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Hospital Appointments

2010 -2020 New York-Presbyterian New York, NY

Morgan Stanley Children’s Hospital

Attending Physician, Division Chief for Pediatric GI/Liver Director, Division of Gastroenterology, Hepatology and Nutrition 08/1995-01/2010 (Rady) Children’s Hospital San Diego, CA Senior Attending Physician

Director, Gastroenterology, Hepatology and Nutrition Director and Co-Founder, Liver Transplantation Program 09/1991– 07/1995 The Children’s Hospital, Boston Boston, MA Assistant Attending Physician

04/1989-08/1991 Department of Pediatrics, University of California San Francisco, CA Attending Physician

08/1987-08/1991 San Francisco General Hospital San Francisco, CA Attending Physician

Education

09/1980 - 06/1984 University of California San Diego, CA Doctor of Medicine

09/1976 - 12/1980 University of California Santa Barbara, CA PhD, Biological Sciences, awarded 12/1980

Thesis: Genetic and Biochemical Characterization of Tetrahymena Galactokinase

Advisor: Daniel Morse, PhD

09/1971 - 06/1975 University of California Berkeley, CA AB, Biochemistry, June 1975 (with honors)

Training

07/1986 - 03/1989 Department of Pediatrics, University of California San Francisco, CA Pediatric Gastroenterology, Hepatology & Nutrition Fellow Research Training in HHMI/Don Ganem and Harold Varmus 07/1985 - 06/1986 Department of Pediatrics, University of California, San Francisco, CA Pediatric Resident (short-tracked)

06/1984 - 06/1985 Department of Pediatrics, University of California, San Francisco, CA Pediatric Intern

Licensure and Board Certification

Licensure

2010-2021 Medical License, New York State (#256364, inactive) J. Edward Lavine, MD PhD

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1985 - 2012 Medical License, State of California (G56151, inactive) 1991- 1995 Medical License, State of Massachusetts (inactive) 1986-2022 Drug Enforcement Agency, USA

Board Certification

2022-2023 recertification, Pediatric Gastroenterology, Hepatology, Nutrition, #150-****-**** Certificate of Added Qualification, Transplant Hepatology, ABP #52 2015- 2021 recertification, Pediatric Gastroenterology, Hepatology, Nutrition (#210608) 2011- 2015 recertification, Pediatrics and Pediatric Gastroenterology, Hepatology, Nutrition 2005 - 2011 recertification, Pediatrics and Pediatric Gastroenterology, Hepatology, Nutrition 1997 - 2004 recertification, Pediatrics and Pediatric Gastroenterology, Hepatology, Nutrition 1990-1997 initial certification, Pediatrics (ABP #210908) & Pediatric Gastroenterology ABP #150 Honors & Awards

2023-present Elected Fellow, American Gastroenterology Association; AGAF Recognizing AGA members making significant contributions to Gastroenterology and the AGA

2014-2024 “Who’s Who in America” (Marquis)

https://mbo.marquiswhoswho.com/

2022 Most cited co-author for top 2 of 3 articles in Hepatology, since journal inception 2021-2025 Ranked #1 for citations in Pediatrics and Child Health (at Columbia Univ., prior 6y) AD Scientific Index Rankings for Scientists

https://www.adscientificindex.com/scientist/joel-e-lavine/911-***-****-2023 Recognition for “Most Read Research” at Columbia University; per Research Gate 2020 Who’s Who Top Doctors Honoree (Marquis)

2020-2024 “Who’s Who in America” Lifetime Achievement Award (Marquis) http://www.24-7pressrelease.com/press-release-service/475-***-**** “GI Leader to Know” publication; Becker’s GI and Endoscopy https://www.beckersasc.com/gastroenterology-and-endoscopy/gi-leader-to-know-dr-joel- lavine-of-new-york-presbyterian.html

1998-2019 Best Doctors in America, (Woodward-White Polling and Research) 2013-2021 U.S. News/Castle-Connolly/New York Magazine; “Top Doctors in New York” 2011-2021 New York “Super Doctors” (Key Media/New York Times Magazine) 2019 Becker’s ASC Review, “117 GI Doctors to Know” 2019 Featured, Healio article, Stopping NASH in its tracks: Lifestyle intervention key” https://www.healio.com/news/hepatology/20190612/stopping-nash-in-its-tracks-lifestyle-intervention-key-from-day-1 2017 Featured Research, Nature article, “Childhood obesity: A growing concern” https://www.nature.com/articles/d41586-017-05868-y J. Edward Lavine, MD PhD

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2017 Featured, Gastroenterology and Endoscopy News, Hepatology in Focus, “Peds Group Updates NAFLD Guidelines”

2015 Featured Research, Science, “The Liver’s Weighty Problem”. 2015. 349: Issue 6243, July 14, 2015.

https://www.science.org/doi/10.1126/science.349.6243.18 2015 Featured Perspective, Nature Biotechnology, “Alexion pays big for Synageva’s rare disease drug candidate”. July 2015. 7: 679

Nat Biotechnol.33(7):679. doi: 10.1038/nbt0715-679. 2014-present Inaugural Fellow of the American Association for the Study of Liver Diseases Awarded to AASLD members who made significant contributions to Hepatology and the AASLD (F-AASLD)

2014-2017 Samberg Scholar at New York-Presbyterian Hospital ($500,000) Recognition of physician leadership in growth initiatives for children’s care 2013-2014 Awardee, American Pediatric Society “Success Story in Child Health Research” Chosen for one of three featured successes in pediatric health advances in America regarding research that led to successful therapy for nonalcoholic steatohepatitis in children (and adults).

2014 “Quote of the Day”, New York Times (June 14) and front-page coverage of Dr. Lavine’s research (June).

https://www.nytimes.com/2014/06/14/pageoneplus/quotation-of-the-day-for-saturday-june-14- 2014.html?smid=em-share

2010 Presidential Plenary Keynote Address, American Association for the Study of Liver Disease, Boston, MA (3000 attendees)

2008 Congressional Citation in House of Representatives Congressional Record, May 21, 2008, for NIH Study for Fatty Liver in Children. Joel Lavine, multi-center study lead, PI, NASH Clinical Research Steering Committee Chair 2007 - 2018 Who’s Who in America (Marquis)

2006 Quality and Innovation Award; The Children’s Hospital, San Diego Single award per year for most improved access, available services and patient satisfaction scores for the Division of Gastroenterology and Hepatology 2003-10 Academy of Clinical Scholars, University of California, San Diego 1995 - 2001 Who’s Who in the West

1993 - 1997 Who’s Who in the East

1991 North American Society for Pediatric Gastroenterology and Nutrition Young Investigator Award Finalist

1988 American Association for the Study of Liver Disease Outstanding Pediatric Research Prize (singular awardee) J. Edward Lavine, MD PhD

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1984 Class of 1984, UCSD Medical School Graduation Speaker 1983 - 1984 A. Baird Hastings Medical Honor Society University of California, San Diego

1981 - 1983 Ruben Fleet Foundation Scholarship (UCSD Medical School) 1980 - 1983 B’nai Brith/Hillel Foundation Scholarship at UCSD School of Medicine 1975 Graduation with honors from UC Berkeley

Academic Service

Columbia University Medical Center

2020 Reviewer, Columbia Precision Medicine Initiative, Irving Institute for Clinical and Translational Sciences, Columbia University

2020 Reviewer, Pilot and Collaborative Studies Resource Grants, Irving Institute for Clinical and Translational Sciences, Columbia University

2020 Member, Internal Advisory Committee, Irving Institute for Clinical and Translational Sciences (U54 from NCATS)

2019-24 Mentor, T32 Training Grant in Pediatric Endocrinology and Diabetes, Department of Pediatrics, Columbia University

2019-24 Mentor, T32 Training Grant in Endocrinology and Diabetes, Russ Berrie Institute for Diabetes, Dept of Internal Medicine, Columbia University 2018-19 Steering Committee, Opioid Crisis Response, Irving Clinical and Translational Resource, https://www.irvinginstitute.columbia.edu/about-us/key-initiatives/opioid- crisis-response

2018 Scientific Reviewer, Pilots and Collaborative Resources, Irving Clinical and Translational Resource

2018 Symposium organizer, Irving CTRI for “Integrating Special Populations”, topic of

“Environmental Toxicants and Human Health Across the Lifespan” (May) 2018-2020 Director, Enrichment Core, NIDDK P30 Digestive Health Center Core Grant

(Precision Medicine Digestive Disease Research Center at Columbia University) In charge of quarterly work-in-progress meetings, visiting professor programs, annual symposia, invited lectureships, core enrichment activity and mini-sabbatical programs. 2018-2020 Member, Pilot and Feasibility Steering Committee, NIDDK P30 Digestive Health Center Core (Precision Medicine Digestive Disease Research at Columbia University) 2016-present Faculty, Institute of Human Nutrition (Professor) J. Edward Lavine, MD PhD

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2016-2020 Faculty Advisor, TRANSFORM (Irving CTRI for Training and Education) for interdisciplinary master’s, predoctoral, postdoctoral and career development programs 2017-2018 Member, Physician Scientist Development Committee for Burroughs Wellcome Award 2017-2020 Member, Dean’s Task Force on Opioid Intervention; Irving Clinical and Translational Research Institute

Co-Facilitator, Opioid Brainstorming Symposium on Therapeutic Interventions 2017- present Organizer/Liason, Continuing Medical Education regarding child health 2017-2018 Representative (Pediatrics), Basic Science Department Chairs Committee 2016-2020 Member, Steering Committee for Columbia Translational Therapeutics Resource Program, Irving Clinical Research and Translation Center 2016-2020 Inaugural member, Columbia Summer Research Institute (CSRI) Advisory Board 2016-2020 Inaugural member, Steering Committee for Translational Research Awards Pilot, Clinical and Translational Research Institute

2016-present Member, Columbia University Institute for Human Nutrition 2016-21 Director/Supervisor, Pediatric Hub for the Irving Clinical and Translational Science Research Institute, “Integrating Special Populations” 2016-2020 Judge/Abstract Reviewer, Annual Medical Student Research Day, Columbia College of Physicians and Surgeons

2011, 2015 Reviewer, Irving Institute for Clinical and Translational Research Awards for Collaborative and Multi-Disciplinary Pilot Research and K12 Awards 2015-2020 Member, Internal Advisory Board, Institute for Human Nutrition 2014-2015 Member, Children’s Health Strategic Planning 2013 - present Member, Women and Children’s Research Institute Steering Committee 2012 - present Member, Russ Berrie Diabetes Research Center 2012 - 2013 Member, Digestive Health Strategic Planning Initiative 2012 - 2013 Member, 2020 Vision/Strategic Planning Committee Department of Pediatrics, Columbia University Medical Center 2018 Member, Driscoll Scholar Selection Committee

2017-2018 Member, Irving Scholars Grant Review Committee 2016-2018 Chair, Search Committee for Chief of Hematology/Oncology/Bone Marrow Transplant J. Edward Lavine, MD PhD

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2016-2018 Chair, Underfunded Research Committee (for Career Development Awards) 2015-2018 Chair, Bridge Committee (for research funding) 2015 Member, Compensation Committee

2014-2017 Chair, Research Committee

Works with Chair of the Department to foster research development, facilities, space, core resources, information technology, translational conferences 2014-2018 Member, Chairman’s Cabinet

2014-15 Member, Search Committee for Infectious Disease Division Chief 2013 Chair, Ad hoc Promotion Committee for Hematology/Oncology Chief 2012 - 2013 Chair, Department of Pediatrics Clinical Operations Committee 2012 - 2013 Co-organizer, Junior Faculty Development Program 2011 - 2017 Member, Fellows Research Awards Committee 2011, 2014 Member, John Driscoll Award Selection Committee 2010-2018 Member, Fellowship Scientific Advisory Council Department of Pediatrics, University of California, San Diego 2007-2010 Member, Steering Committee, Digestive Disease Research Development Center

(NIDDK)

2005-2009 Member, School of Medicine Strategic Planning Initiative Primary coordination (with UCSD Department Chairman) for formation of Foundation joining UCSD Health Sciences, Faculty practices, and Rady Children’s Hospital. This effort formed the 5th largest academic Children’s Hospital in the US in 2010

2009 Organizer, Translational Initiatives in Child Health Symposia Brought together UCSD, Salk Institute, Scripps Research Institute, Burnham Institute for interdisciplinary lectures on child health to organize basic and clinical science collaborations in San Diego

2004-2009 Chair, Faculty and Fellow Development

2004-2009 Member, UCSD Research Space Allocation Committee 2007 Organizer/moderator, Young Faculty Research and Award Symposium 2005 - 2010 Member, Clinical Investigation Institute, University of California, San Diego 2002-2010 Member, Executive Committee, UCSD/Children’s Specialist’s Medical Group J. Edward Lavine, MD PhD

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1999-2010 Medical Director, Pediatric Liver Transplantation With the Director of Transplant Surgery, brought first liver and living–related donor transplant program to San Diego County and Arizona 2002 - 2005 Inaugural member, Academy of Clinician Scholars 2000-2002 Department representative, Academic Senate Department of Pediatrics, Harvard Medical School

1991 - 1995 Research Director, Hepatology

1991-1995 Member, Fellow Selection Committee

Professional Organizations and Societies

Membership and Positions:

2018- present Clinical Advisory Committee, NASH Alliance for Federal Policy 2018-present Lead Columbia Physician-Scientist- Coalition for Pediatric Medical Research 2018-2019 Professional member, New York Academy of Sciences 1991-2022 North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Lecturer, Post-Graduate Course for World Congress of GI/Nutrition (2016) Member, Nominating Committee (2014)

Member, Awards Committee (2008-2009)

Member, Committee on Training (2001-2004)

Co-Chair, Symposium on Pediatric Liver Diseases (1991) Member, (1991-2022)

1989-present American Association for the Study of Liver Diseases Abstract Reviewer, Topics on Pediatric Hepatology: Pediatric Liver Disease - Basic Science; Biliary Atresia and Cholestasis; Viral and Autoimmune Hepatitis; Metabolic and Genetic Diseases; Pediatric Liver Transplantation 2019 Moderator, Placebo Arm and Lifestyle Management in Clinical Trials Session, AASLD and EASL Symposium on “Clinical Endpoints in NASH Conference” Washington DC, July 2018

Guidelines Committee, Nonalcoholic Fatty Liver Disease, 2011-2021 Moderator, Clinical Workshop, Research in Children and Special Populations 2014 Inaugural Fellow of the American Association for the Study of Liver Diseases 2012- Presidential Plenary Speaker, 2010

Member, Grants and Awards Committee (2008-2010)

Moderator, Plenary Session for Young Investigators (2008) Reviewer, Liver Disease Research Agenda Committee for the NIH (2004) Member, Clinical Research Committee (2001-2004)

Member, Research Grant Selection Committee (1998)

Member, Basic Science Research Committee (1995-1998) Co-Chair, Plenary session on “Viral Hepatitis” (1994) Member, (1988-present)

J. Edward Lavine, MD PhD

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2003-present American Pediatric Society (elected)

Workshop Reviewer (2011)

Member, (2003-2023)

Emeritus (2023-present)

2003-present Society for Pediatric Research (elected) Member, (2003-present)

2008 American College of Gastroenterology

Member/sole pediatrician Task Force on Obesity, “Obesity, Do You Know Your Health Risks?” Physician and Patient Education Initiative Member, Physician Education Committee

2007- 2018 International Society for Pediatric Gastroenterology, Hepatology and Nutrition, Member, Working Group on Management of Obesity, Worldwide Consensus (2007) Member, Working Group on Management of Pediatric Acute Liver Failure (2005-2008) 1994 - present American Liver Foundation

Member, National Medical Advisory Committee (2019 commence) Member, Committee for Distinguished Lifetime Liver Research Award (1997) Member, Medical Advisory Board (1996-2010)

Member, Board of Directors (1996-2001)

Member, Grant Review Committee (1994-1997)

Member (1994 - present)

1992 - present American Association for the Advancement of Science Member

1990 - 2010 Western Society for Pediatric Research Member

1989 - present American Gastroenterological Association Academy of Education, member, 2023-2024

Nominee, Liver and Biliary Section Vice-Chair, 2020 Abstract Reviewer, Pediatric Liver Metabolic Diseases, 2020 Guidelines Committee, Nonalcoholic Fatty Liver Disease (2011-2016) Member/sole pediatrician, Task Force on Obesity (2004) Chair, Digestive Disease Week Symposium for North American Society for Gastroenterology and Nutrition (1991)

Member (1989 – present)

1989 - 2011 American Academy of Pediatrics

Member

Consultative:

National Institute of Health Research

2002-2020 Nonalcoholic Steatohepatitis Clinical Research Network (NIDDK) Principal Investigator, (2002-2018)

Member, Executive Committee (2002-2020)

Co-Chair, Steering Committee (2002-2020)

J. Edward Lavine, MD PhD

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Selected presenter, External Advisory Committee (2013, 2017) Co-chair and reviewer, Genetics Committee (2010-2020) Member, Ancillary Studies Committee (2010-2019)

Member, Radiology Committee (2009-2019),

Member, Publications and Presentations Committee (2009-2020) Member, Pilot and Feasibility Committee (2003-2009) Chair, Pediatric Committee (2002-2020)

Co-Chair, Database Committee (2002-2020)

2019 Member, Foundation for the National Institutes of Health (FNIH), NIMBLE Consortium

(Non-invasive Markers of Metabolic liver Disease)

2018 NIDDK Intramural Program for Hepatology Research Personnel Reviewer

2017 NIH/National Center for Advancing Translational Sciences; Special Emphasis Panel on Preclinical Research Based on Existing Repurposing Tools. Special Emphasis Panel/Scientific Review Group 05 ZTR1 DPI-2 (01)

Reviewer

2016 NIH/Scientific Review for Kidney, Nutrition, Obesity and Diabetes, Population Sciences and Epidemiology, Collaborations between NIH Intramural/Extramural Investigators; ZRG1 PSE-B 60 C, PAR15--287

Reviewer

2016 NIH/National Center for Advancing Translational Sciences; Special Emphasis Panel on Preclinical Research Based on Existing Repurposing Tools. Reviewer

2015 NIH/NICHD, Expert Scientific Consultant Panel for Adolescent Bariatrics: Assessing Benefits and Risks (Teen LABS)

Chairperson and reviewer

2014 NIH R01 Ancillary Studies for Liver Diseases, 2014/10 ZDK1 GRB-C (O1) 1 Reviewer

2014 NIH/CSR Special Emphasis Panel, Population Sciences and Epidemiology Integrated Review Group, 2014/05 ZRG1 PSE-R (02) M

Reviewer

2013 NIH R01 Grant Review, Center for Scientific Review, Population Sciences and Epidemiology Integrated Review Group 2013/05 ZRG1 PSE-R (03) M Chairperson-Reviewer

2012-2013 NIH National Center for Advancing Translational Sciences, Therapeutics Discovery Section, ZTR1 CI-9 (01)

Reviewer

2012 NIH Population Sciences and Epidemiology, “Member Conflicts: Chronic Disease Epidemiology” ZRG1 PSE-P (02)

Reviewer

J. Edward Lavine, MD PhD

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2011 NIH Center for Scientific Review, Population Sciences and Epidemiology Integrated Review Group, Metabolic Disorders ZRG1 PSE H(02)

Reviewer

2011 NIDDK, Special Emphasis Panel (ZDK-GRB8-M3) Ancillary Studies to Major Ongoing Clinical Research Studies of Scientific Interest to the NIDDK (R01) Chairperson-Reviewer

2010 NIH/NICHD, Expert Scientific Consultant Panel for Adolescent Bariatrics: Assessing Benefits and Risks (Teen LABS)

Chairperson-Reviewer

2010 NIDDK, Grant Review Panel for T32, K24, and K23 applications (ZDK1 GRB-7), Chairperson-Reviewer

2010 NIDDK, Special Emphasis Review Panel, Acute Liver Failure (adults & children), ZDK1GRB-7(02)

Chairperson-Reviewer

2010 NIDDK, Mentored Applications for Digestive Diseases and Nutrition, ZDK1 GRB- 7(03)

Reviewer

2009 NIDDK, Special Emphasis Panel on Immunology in Liver Disease, Grant Review ZDK1 GRB-N (J2)

Chairperson-Reviewer

2007 NIDDK, Scientific Review Group NIH ZDK1GRB-N (M2) (1) Reviewer

2007 NIDDK Workshop on Nuclear Hormone Receptors in Digestive Diseases Co-organizer/Moderator/Lecturer

2006 NIDDK, Scientific Review Group, 2006/08 (ZDK GRB N(MI) Reviewer

2003 NIDDK, Scientific Review Group, (ADK1 GRB-7 04) Reviewer

2002 NIDDK, Scientific Review Group, (ZDK1GRB-2MIR) Reviewer

2002 NIDDK Review Branch C Committee (training programs and career development awards)

Reviewer

NIH Data Safety and Monitoring Boards

2019-2024 NIDDK, Surgical or Medical Treatment for Pediatric Type 2 Diabetes Member

2012-2017 NICHD, Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) J. Edward Lavine, MD PhD

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Chair/Reviewer

2009-2010 NIDDK, Cholestatic Liver Disease Research and Education Network (ChiLDREN) Chair/Reviewer

2004-2009 NIDDK, Biliary Atresia Research Consortium (BARC) Chair/Reviewer

1998-2003 NIDDK, Acute Liver Failure

Member; Chair for Pediatric ALF (PALF)

U.S. Food and Drug Administration

2013 American Association for the Study of Liver Diseases/Food and Drug Administration Public Workshop for Trial Designs and Endpoints for Liver Disease, “Pediatric Specific Trial Design and Endpoints” and “Trial Design Considerations and Endpoint for Development of Diagnostics for Pediatric Subjects” Invited lecturer, panelist, moderator

2012-2015 Endocrinology and Metabolism Section; External Advisory Committee Consultant/employee to provide recommendations on labeling of pharmaceuticals that affect metabolism/liver/obesity

2007 US Food & Drug Administration

Consultant regarding thiazolidinedione trials in children (a drug for type 2 diabetes) U.S. Department of State

2002 Civilian Research and Development Foundation

Grant Reviewer

International

2021, 2024 Qatar National Research Fund, Undergraduate and Graduate Research Experience Program

Grant Reviewer

2021 European International Liver Foundation, NAFLD Public Health Consensus Statement; Expert Consultant/co-author

2020 Research Foundation-Fonds Wetenschappelijk OnderzoekVlaanderen (FWO) Excellence Prizes; Brussels, Belgium

International Jury Reviewer, May

2018-21 NASH Alliance

Clinical Advisory Committee

2018-20 Chronic Liver Disease Foundation

Advisory Board

2017 European Science Foundation, University of Turin Grant Reviewer

J. Edward Lavine, MD PhD

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2016, 2018 Medical Research Councils, United Kingdom. Grant Reviewer

2016 Netherlands Organisation for Health Research and Development (ZonMw) Translational Research Programme

Grant Reviewer

2015-19 The Liver Forum: Facilitating Drug Development for the Treatment of Liver Disease European Association for the Study of Liver Disease and American Association for the Study of Liver Disease, in collaboration with pharmaceutical and regulatory agencies Invited Member and Section Leader on Pediatric Drug Development, Vienna, Austria Executive Committee for the Liver Forum (2015-2107) Chair, Pediatric Section (2015-2017)

2015 Czech Health Research Council, Ministry of the Czech Republic Grant Reviewer

2014-16 Global Pediatric Research Network Advisory Board Member

One of 25 members from academia, pharma, FDA and NIH to form a global network for pediatric clinical trials, to include Columbia University as an inaugural institution 2013 Health and Medical Research Fund under the Hong Kong Special Administrative Region

Grant Reviewer

2012-2018 Qatar National Research Fund, Undergraduate and Graduate Research Experience Program

Grant Reviewer

2012 Raine Medical Research Foundation (Australia) Grant Review Panel Grant Reviewer

2011-2018 Wellcome Trust Foundation (United Kingdom) Grant Reviewer

National, Non-federal

2018-20 Site Lead, Institute for Advanced Clinical Trials for Children (iACT) Best Practices, Education and Tools Committee

2017-18 Co-organizer, New York Academy of Sciences, Symposium on Therapeutic Developments in Fatty Liver Disease (Feb, 2018), NY, NY 2016 Chronic Liver Disease Foundation

Expert Committee Panel/Advisor <chronicliverdisease.org> 2008 Cystic Fibrosis Foundation, Grant Review panel Grant Reviewer

2007 Cincinnati Children’s Hospital Medical Center Board of Trustees, J. Edward Lavine, MD PhD

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Research Foundation and Research Committee

Scientific Advisory Committee, and Reviewer

2004 American Medical Foundation for Peer Review and Education Reviewer

Industry Consultant

2022-23 Thiogenesis Therapeutics, Corp. Toronto, Canada. Scientific Advisory Board 2022 Carmot Therapeutics, Berkeley, CA

2021-22 Merck Sharp and Dohme Corp., Kenilworth, NJ 2021-22 Mezzion Pharma Co. Ltd., Deerfield, IL

2021-22 Mirum Pharmaceuticals, Foster City, CA

2021-22 Prosciento, Chula Vista, CA

2021 Ascletis/Gannex LLC, Hong Kong

2020 Surrozen, Inc. South San Francisco, CA

2020-21 Intercept Pharmaceuticals, New York, NY

2019-21 Thetis Pharmaceuticals, Branford, CT (http://thetispharma.com/cms2/about/advisors/) Scientific Advisory Board

2019-20 Novo Nordisk, Denmark

2018-19 Cymabay Therapeutics

2017-19 TARGET PharmaSolutions, NC

2017-18 Pippin Therapeutics, Boston, MA

2017-18 Novartis, Basel, Switzerland

2017-19 Merck and Co., Inc., Kenilworth, NJ

2017-18 Janssen Inc. Jersey City, NJ

2017-18 Gilead, Foster City, CA

2017-18 Bristol Myers Squibb, Lebanon, NJ

2017-18 BASF/Pronova BioPharma, Lysaker, Norway

2017-19 Viking Therapeutics, San Diego, CA

J. Edward Lavine, MD PhD

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2016-17 Allergan Pharmaceuticals, Jersey City, NJ

2016-17 Albireo Pharmaceuticals, Sweden

2016 Takeda Pharmaceuticals, Chicago, IL

2016 Jefferies LLC, “Biotech Research and Development Summit”, New York, NY 2016-18 Humana Physician Advisory Board, Louisville, KY 2015-18 Merck Pharmaceuticals, Expert Input Forum Advisor, Lebanon, NJ 2015 Prestige Brands, New Brunswick, NJ

2015-2017 Alexion Pharmaceuticals, Boston, MA

2015-2019 Pfizer Pharmaceuticals, Rye Brook, NY

2015-20 Genfit Pharmaceuticals, Paris, France

2011-19 Somalogic, Inc. Boulder, CO

2013-2014 Immuron Ltd. Pharmaceuticals, Southbank, Australia 2013 Millenium (Takeda, re vedolizumab) Pharmaceuticals, Inc., Cambridge, MA 2013, 2017 Gilead Sciences, Foster City, CA

2013 Merck, Sharp and Dohme, Rahway, NJ

2013-2014 Crosscare/Colief, Dublin, Ireland

2011-2015 Synageva Pharmaceuticals, Lexington, MA

2011 Trinity Partners, Waltham, MA

2010 Quark Pharmaceuticals, Fremont, CA

2008 Takeda Pharmaceuticals, Chicago, IL

Journal Reviewer:

Journal of Clinical Investigation, Gastroenterology, Hepatology, Journal of Pediatric Gastroenterology and Nutrition, Pediatrics, Digestive Diseases and Sciences, Perinatal Diagnosis, Journal of Pediatrics, Teratology, Mayo Clinic Proceedings, Pediatric Research, American Journal of Gastroenterology, Diabetes Care, Gut, Clinical Gastroenterology and Hepatology, Journal of Clinical Gastroenterology, Journal of the American Medical Association, Journal of the American College of Nutrition, Alimentary Pharmacology and Therapeutics, Liver International, Diabetes/Metabolism Research and Reviews, New England Journal of Medicine, Metabolism-Clinical and Experimental, Hormone Research, International Journal of Pediatric Obesity, Annals Internal Medicine, Journal of Pediatric Endocrinology and Metabolism, European Journal of Gastroenterology and Hepatology, BioMed Central Gastroenterology, Metabolism, PLoS One, BMC Biochemistry, Endocrinology, Nature Reviews Gastroenterology and Hepatology, BMC Endocrine J. Edward Lavine, MD PhD

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Disorders, American Journal of Respiratory and Critical Medicine, Journal of Hepatology, Proceedings of the National Academy of Science (PNAS), European Medical Journal-Hepatology, Childhood Obesity, Journal of the American Medical Association-Internal Medicine; Nutrition, Metabolism and Cardiovascular Disease, British Medical Journal, Molecular and Cellular Endocrinology, Contemporary Clinical Trials, J Mol Diagnostics, BMC Pediatrics, BMC Medical Genetics, Yale Journal of Biology, Frontiers in Pharmacology, Frontiers in Medicine, Frontiers in Gastroenterology, BMC Nephrology, BMC Gastroenterology, Clinical and Translational Science, Frontiers in Endocrinology, Journal of Clinical Medicine, Nature (Communications Medicine).

Editorial Boards:

2023-present Journal of Clinical Medicine-Clinical Pediatric Section; Academic Editor https://www.mdpi.com/journal/jcm/editors?search=Lavine Frontiers in Medicine, Associate Editor, Hepatobiliary section Frontiers in Medicine, Associate Editor, Hepatology section Frontiers in Gastroenterology-Hepatology, Associate Editor 2022-present Frontiers in Pharmacology

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