Ph D medical Research

Lin Li

Lin Li, Ph.D.

Milwaukee, WI *****

Phone: +1-859-***-****

Email: ***.******@*******.***

LinkedIn: https://www.linkedin.com/in/lin-li-533325224/ PROFESSIONAL SUMMARY

Ph.D.-trained biomedical researcher with 10+ years of experience in molecular biology, immunology, and extracellular vesicle (EV) research. Proven success in leading projects, conducting advanced data analysis (R/Python), and collaborating in cross-functional teams. Seeking an industry role in translational research, biomarker discovery, or therapeutic development where I can apply my strong laboratory, data, and communication skills. CORE COMPETENCIES

• Bioinformatics & Multi-Omics RNA-seq Data Visualization (R, Python, GraphPad Prism)

• Clinical Sample Handling Translational Research Scientific Writing & Communication

• Flow Cytometry (MBFCM) TEM Cell Culture Ultracentrifugation PCR miRNA Profiling

• Molecular & Cellular Biology EV Purification Protein Expression & Purification EDUCATION

Ph.D. in Human Biology

Ludwig-Maximilians-University (LMU), Munich, Germany Apr 2023 M.S. in Integrated Traditional Chinese and Western Medicine Dalian Medical University, Dalian, China Sep 2018 B.Med. in Traditional Chinese Clinical Medicine

Bin Zhou Medical University, Yantai, China Sep 2014 INDUSTRY-RELEVANT EXPERIENCE

Postdoctoral Scholar – Platelet & EV Biology

Medical College of Wisconsin / Versiti Blood Research Institute, WI Mar 2025 – Present

• Investigating the role of integrins on platelet-derived EVs in cancer progression

• Designing and optimizing strep-tag protein purification and EV isolation protocols Postdoctoral Scholar – Gene Expression & CAR-T Therapy University of Kentucky, KY May 2023 – Mar 2025

• Studied gene expression of platelets and EVs following stem cell transplant and CAR-T infusion

• Collaborated in multi-disciplinary clinical research teams and presented at major conferences

Doctoral Researcher – EV Biomarkers & AML Immunotherapy LMU, Munich, Germany Sep 2018 – Apr 2023

• Characterized EV-derived miRNAs in AML patient samples as potential non- invasive biomarkers

• Developed and validated MBFCM-based profiling pipeline; led 9+ publications and 10+ posters

PUBLICATIONS

Li L, Görgens A, Mussack V, Pepeldjiyska E, Hartz AS, Aslan H, Rackl E, Baudrexler T, Rank A, Schmohl J, Krämer D, El Andaloussi S, Pfaffl MW, Schmetzer H. Role of extracellular vesicles (EVs) in the activation of leukemia-derived dendritic cells

(DCleu) and antileukemic immune response against AML. Oncology Reports. 2025 Mar 19. Aslan H, Hartz AS, Rackl E, Li L, Schwepcke C, Rejeski K, Schmid C, Rank A, Schmohl J, Krämer D, Bojko P, Schmetzer H.

Concentration-dependent effects of immunomodulatory cocktails on DCleu generation, T- cell activation, and on/off-target toxicity. Frontiers in Immunology. 2025 Jan 30;15:1527961. https://doi.org/10.3389/fimmu.2024.1527961 Rackl E, Hartz AS, Aslan H, Li L, Klauer L, Ugur S, Pepeldjiyska E, Amend C, Weinmann M, Doraneh-Gard F, Stein J, Reiter N, Seidel CL, Plett C, Amberger DC, Bojko P, Krämer D, Schmohl J, Rank A, Schmid C, Schmetzer HM.

TCRγδ-expressing APCs improve antileukemic activity ex vivo. Molecular Immunology. Accepted Sep 13, 2024.

Unterfrauner M, Aslan H, Hartz AS, Bohlscheid S, Baudrexler T, Feng X, Rackl E, Li L, Rank A, Velazquez GF, Schmid C, Schmohl J, Bojko P, Schmetzer H. GM-CSF + PGE1 generate DCleu from AML patient blood and marrow that mediate antileukemic activity. IJMS. Accepted Oct 31, 2023. Baudrexler T, Boeselt T, Li L, Bohlscheid S, Boas U, Schmid C, Rank A, Schmohl J, Koczulla R, Schmetzer HM.

Volatile profiling via eNose distinguishes supernatants from healthy and leukemic cultures. Biomolecules. Accepted May 30, 2023.

Li L, Mussack V, Görgens A, Pepeldjiyska E, Hartz AS, Aslan H, Rackl E, Rank A, Schmohl J, Krämer D, El Andaloussi S, Pfaffl MW, Schmetzer H. Serum EV-derived small RNAs as non-invasive AML biomarkers. Nanoscale Advances. 2023 Feb 20;5:1691–1705.

https://doi.org/10.1039/D2NA00959E

Rackl E, Li L, Klauer LK, Ugur S, Pepeldjiyska E, Gunsilius C, Weinmann M, Doraneh- Gard F, Reiter N, Seidel C, Plett C, Amberger DC, Bojko P, Krämer D, Schmohl J, Rank A, Schmid C, Schmetzer HM.

Leukemia-specific integrin β7+ immune cells in DC-triggered immune activation. International Journal of Molecular Sciences. 2022 Dec. Pepeldjiyska E, Li L, Gao J, Blasi C, Özkaya E, Schmohl J, Schmid C, Rank A, Krämer D, Schmetzer HM. DCleu-mediated immune response correlates with reduced regulatory T cells in AML. Immunobiology. 2022 Jun 11.

https://doi.org/10.1016/j.imbio.2022.152237

Li L, Görgens A, Mussack V, Pepeldjiyska E, Hartz AS, Rank A, Schmohl J, Krämer D, El Andaloussi S, Pfaffl MW, Schmetzer H. Optimization of MBFCM for EV characterization in hematologic malignancy serum samples. Cancer Gene Therapy. 2022 Apr 27. https://doi.org/10.1038/s41417-022-00466-1

Li L, Sun Y, Feng M, Wang L, Liu J. Clinical value of blood-based miRNAs in NSCLC diagnosis. Oncology Letters. 2018;15(6):8915–8925. Sun Y, Li L, Liu J. Exosomes from body fluids: a novel diagnostic and therapeutic tool in lung cancer. Anti-Cancer Agents in Medicinal Chemistry (ACAMC). 2017;17(13):1734– 1740.

CONFERENCES & PRESENTATIONS

• Midwest Platelet Conference (MPC) – Oct 2024

Platelet function and gene expression after autologous or allogeneic stem cell transplantation (Poster)

• Society of Postdoctoral Scholars (SOPS), University of Kentucky – Sep 2024 Biochemical and morphological characterization of platelet-derived EVs after CAR-T cell infusion in lymphoma patients (Poster)

• Cardiovascular Research Day – 90-Second Poster Pitch – Sep 2024 Gene expression profiling of platelets post-stem cell transplantation (Poster Pitch Presentation)

• Gordon Research Conference – Extracellular Vesicles – Jul–Aug 2024 Characterization of platelet-derived extracellular vesicles after CAR-T therapy

(Poster)

• American Society of Hematology (ASH) – Dec 2023

Conference attendee

• Immunotherapy of Cancer (ITOC9) – 2022

Extracellular vesicle-derived small RNAs as non-invasive biomarkers in AML

(Poster #2022-A-34-ITOC, P0701)

• Immunotherapy of Cancer (ITOC9) – 2022

Volatile phase profiling using eNose to distinguish DC/MLC-derived samples from leukemia and healthy donors (Poster, JITC Suppl. 1)

• European Society for Blood and Marrow Transplantation (EBMT) – 2021 Serum EV-derived small RNAs as biomarkers in AML monitoring (Online Poster Presentation)

• Immunotherapy of Cancer (ITOC7) – 2020

Exosomes as promotors of DCleu-mediated antileukemic responses in AML (Poster P01.11; Journal for ImmunoTherapy of Cancer, Suppl. 2, A13–A14)

• European Society for Blood and Marrow Transplantation (EBMT) – 2020 Role of exosomes in activating leukemia-derived dendritic cells (Poster A392; Bone Marrow Transplantation Suppl. 1)

TECHNICAL SKILLS

• Programming: R, Python, GraphPad Prism

• Tools: FlowJo, ImageJ, NTA (Nanosight), BioRender, Adobe Illustrator

• Lab Techniques: SDS-PAGE, TEM, EV isolation, qPCR, sonication, affinity purification

AWARDS & CERTIFICATIONS

• Licensed Physician – China (2017)

• National Scholarship, Dalian Medical University (2016–2017)

• Senior Health Masseuse, CTT Certificate (2012–2013)

• GLP Training, KnowledgeTrak / Versiti (2024)

VOLUNTEER & ACTIVITIES

• DigiReta Project Participant – China Innovation & Entrepreneurship Competition, Munich (2023)

• Volunteer – Public lectures, Dalian Medical University (2017–2018)

• Blood Donor – National campaign, China (2014–2015)

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