Cancer Research Molecular Biology

CV Adam Master p.*

AREAS OF EXPERTISE:

* ******** *** ******** ******, bioinformatics, AI-supported genomic data analysis to match cancer patients’ driver mutations with appropriate clinical and research trials. 2 Cancer research, drug development, pharmacogenomics, M.sc. and Postdoc. 3 Molecular biology, cancer cell biology, fluorescence microscopy, M.Sc. 4 Chemical technology, biotechnology of recombinant proteins, Eng. 5 Laboratory diagnostics, medical molecular diagnost. (license). 6 Forensic Sciences, court expert in genetics & biochemistry. 7 General nursing, license to practice the profession. SCIENTIFIC INTERESTS: 1 Translational control in diseases of civilization and aging. 2 Alternative translation initiation mechanisms activated by the integrated Stress Response (ISR) in cancer and cardiovascular diseases. 4 Dark transcriptome, lncRNA, transcriptomics, proteomics & integrative genomics. TECHNOLOGICAL INTERESTS: 1 Precision medicine: molecular diagnostics for targeted therapy, including small molecules, gene & cell therapy, ex-vivo genome editing, and immunotherapy. 2 A novel method for gene-specific enhancement of protein translation of tumor suppressors. 3 Nucleic acid -based next generation therapeutics: eRNA/dGoligo, ASO, siRNA, gRNA (CRISPR), ncRNA, circRNA, dsRNA, Z-RNA, self-transfecting and self-amplifying mRNA, cancer vaccines. 4 Development of precise targeting methods: protein-drug conjugates and bispecific antibodies. 5 Quantum biology in biological systems and its applications for controlling cellular processes. Date Academic

degree/title

Position/

function University/school/lab Field of study/work 2018 -2023 Postdoctoral Postdoctoral

Associate

followed by

Research

Scientist

The State University

of New York (SUNY)

at Stony Brook, New York, USA

Cancer research, cancer

prevention, ophthalmic

research, DED, inflammation,

pharmacogenomics, transcripto-

mics and bioinformatics

2010

-2016 Dr med. sc.

(Doctor of medical

sciences not physician

Research

Scientist

The Center of Postgraduate Medical

Education in Warsaw, Poland

in cooperation with DNAi Biotech Lab

and Imperial College London

Cancer research projects, grants,

papers followed by PhD public

defense

2005 -2010 PhD stud. The Center of Postgraduate Medical Education in Warsaw, Poland

Medical biology PhD progr.

cancer research, biochemistry

2001

-2004 Eng.

(Engineer)

Student Krakow University of Technology,

Poland

Chemical technology and

engineering, biotechnology of

recombinant proteins

1996 -2001 M.sc.

(Master of Science)

Student Jagiellonian University, Krakow,

Poland

Molecular biology,

cell biology, molecular genetics

1990 -1995 Student Medical High School in Wadowice, Poland General nursing, medical projects 1991 -1994 Student Music school in Wadowice Music instruments, alto saxophone EDUCATIONAL BACKGROUND

Collaborations:

1 The State University

of New York (SUNY)

at Stony Brook, suny.edu

Postdoctoral alumnus

2 Gednasa LLC, geDNAsa.com

Fields:

Medical biology

Medical biotechnology

Molecular biology

Molecular medicine

Chemical technology

29 refereed publications

30> abstracts

4 patents

H-index range: 11-16

613-974 citating articles

5 citating patents industry

Curriculum Vitae

dr. med. sc. ADAM MASTER

65 Tompkins Ave 2H, Brooklyn, 11206 New York, USA

****.******.*******@*****.*** +1-516-***-****

CV Adam Master p.2

Date Position/function Institution Contact

2018 -2023 Postdoctoral Associate

followed by

Research Scientist

Research Foundation for The

State University of New York

(SUNY) at Stony Brook

100 Nicolls Rd S5422 Melville Library,

Stony Brook, 11794 NY, www.rfsuny.org

+1-631-***-****, *****.******@**********.***

2023 -2023 Research Scientist at the Department of Family, Population & Preventive Medicine, Division of Cancer Prevention, SUNY at Stony Brook Medicine (SBM), New York, USA. Specialized in cancer research, with a focus on the molecular mechanisms of paclitaxel-induced neuropathic pain (PIPN) in a mouse model. Conducted transcriptome analysis in mice, investigated neuronal differentiation, and studied axonal transport in cell cultures. Prioritized completing postdoctoral projects and publications (2018–2023: 7 articles, multiple transcriptome datasets and nucleotide records). 2021 -2023 Postdoctoral Associate at the Department of Family, Population & Preventive Medicine, Division of Cancer Prevention, SUNY at SBM. Specialized in cancer genetics and development of anti-cancer drugs (efficacy, toxicity, targets and molecular action). Conducted research using high-throughput next-generation technologies, transcriptomics, pharmacogenomics, bioinformatics, cell cultures, animal models (mouse, rat), Patient-Derived Xenografts (PDXs), and investigated the role of inflammation and immune response in PIPN. 2020 -2021 Postdoctoral Associate at the Department of Ophthalmology, Division of Cancer Prevention, SUNY at SBM. Specialized in medical biotechnology innovations for research on the molecular aspects of dry eye disease

(DED), including improved ocular impression cytology (IC), quantitative cell transfer from IC to microscope slides, and primary cornea, conjunctiva human cell cultures on nitrocellulose scaffolds for ex-vivo drug evaluation. Conducted studies on inflammation and immune responses in DED using animal models (rabbits), transcriptomics. 20018 -2020 Postdoctoral Associate at the Department of Medicine, Division of Cancer Prevention, SUNY at SBM. Specialized in cancer research and drug synthesis. Conducted large-scale data analysis, including kinome profiling, Whole Genome Sequencing (WGS), and Pharmacoscan, to identify alterations potentially contributing to drug resistance (pharmacogenomics). Chemical synthesis of drugs and their modifications, followed by analysis using spectroscopy, NMR, and mass spectrometry, subsequently tested in cell cultures, animal models (mouse), PDXs. 2005

-2016 PhD Student

followed by

Research Scientist

Centre of Postgraduate

Medical Education in

Warsaw (CMKP)

ul. Marymoncka 99/103, 01-813 Warsaw, Poland

+48-22-569****, ******.************@****.***.**

www.cmkp.edu.pl/about-cpme

2005 -2010 5-year full-time doctoral studies at Department of Biochemistry and Molecular Biology, CMKP in the field of medical biology, cancer research under the supervision of Professor Alicja Nauman, PhD. Doctoral dissertation: The Role of Untranslated Regions (UTRs) in the Expression of the T3-Dependent Nuclear Thyroid Hormone Receptor β1 (TRβ1) in Human Clear Cell Renal Cell Carcinoma (ccRCC). 2010 -2016 Research Scientist focused on managing multiple cancer research grants and authoring 11 scientific articles. Defended a doctoral dissertation, awarded the academic degree of Doctor of Medical Sciences in Medical Biology on 30/03/2016. 2001

-2004 Engineering Student Cracow University

of Technology (PK)

Warszawska 24, 31-155 Krakow, PL

+48-12-628-**-**, ******@**.***.**

www.chemia.pk.edu.pl

Four-year studies at Faculty of of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology of PK in collaboration with the Institute of Biotechnology and Antibiotics in Warsaw (now Institute of Industrial Chemistry). Engineer’s thesis: Engineering of a Plasmid-Based Genetic Construct Encoding the Fusion Protein: Ubiquitin-Ubiquitin Protease 4. The project was part of the purification method development for insulin production technology. Completed studies in Chemical Technology with a specialization in Light Organic Technology, graduating in 2004 and earning the title of Engineer. 1996

-2001 Master of Science

Student

Jagiellonian University in

Krakow (UJ), founded in

1364, ranked first in Poland

Golebia 24, 31-007 Krakow, PL

+48-12-664-**-**, ***********.*****@**.***.**

https://en.uj.edu.pl/en, https://zbk.wbbib.uj.edu.pl/en_GB Five-year full-time studies at the Faculty of Biochemistry, Biophysics, and Biotechnology (FBBB), Department of Cell Biology (CB), Jagiellonian University (UJ). Master's thesis: The Influence of Extracellular Calcium Ions on Contact-Mediated Acceleration of Migration of Mouse Melanoma B16 Cells. Completed in the field of Biology with a specialization in Molecular Biology, graduating in 2001 and earning the title of M.Sc.

ACADEMIC EXPERIENCE 1996 - 2023

Postdoc

PhD

Eng.

M.sc.

CV Adam Master p.3

Date Position/function Institution Contact

2024 -pres. Member of the Scientific

Advisory Board,

Business Advisor

Gednasa LLC

244 Madison Ave 1554, 10016 NY, USA

+1-917-***-****, *******.***@*****.***

www.gednasa.com

Description of the Role: Non-work-related collaboration. Engaged in preparatory activities for the start-up GeDNAsa LLC, focusing on strategic planning, market research, and scientific discussions to establish operations. Key areas of interest include a) Genomic signatures for personalized medicine, aimed at recruiting cancer patients for clinical trials based on driver mutations through an AI-driven platform offering molecular diagnostics, targeted therapy identification, and trial matching using resources like clinicaltrials.gov. b) RNA-based therapeutics (eRNA). c) Quantum biology exploring ways to modulate cellular processes and drug metabolism using quantum phenomena. Additionally, collaborating with DNAi

– The Center of Genetic Information (PL) on EU-US consortium projects in precision medicine. 2018

-2023 Postdoctoral Associate

followed by

Research Scientist

Medical Scientist

SOC Code: 19-1042.00

Research Foundation for The

State University of New York

(SUNY) at Stony Brook

NAICS code: 541714

J-1 visa followed by H-1B

100 Nicolls Rd S5422 Melville Library,

Stony Brook, 11794 NY

+1-631-***-****, *****.******@**********.***

+1-631-***-****, ***@**********.***

www.rfsuny.org

2023 -2023 Conducted studies as a Research Scientist in the Department of Family, Population & Preventive Medicine, Division of Cancer Prevention, SUNY, Stony Brook Medicine (SBM). Focused on finalizing research projects and publications initiated during the postdoctoral period, including work in cancer research, ophthalmic research, and inflammation and immune response pathways. For further details, see Academic Experience. 2021 -2023 Postdoctoral Associate at the Department of Family, Population & Preventive Medicine, Division of Cancer Prevention, SUNY Stony Brook Medicine (SBM). Specialized in cancer genetics and drug development. 2020 -2021 Postdoctoral Associate, Department of Ophthalmology, SUNY, SBM. Conducted ophthalmic research, developed biotechnology innovations for dry eye disease (DED). See References for details. 2018 -2020 Postdoctoral Associate, Department of Medicine, SUNY, SBM. Cancer research, drug development, chemical synthesis of drugs, pharmacogenomics, in-vivo, in-vitro, ex-vivo studies. See Academic Experience. 2014

-2017 Scientific director of the

laboratory of genetics and

biochemistry

DNAi - The Centre of

Genetic Information

Baltycka 3, 31-214 Krakow, Poland, EU

+48-531-***-***, ***.****@*****.***

www.dnai.plus

https://web.archive.org/web/202***********/http://www.badanieojcostwa.pl Lab leader, geneticist, and court expert specializing in genetics and biochemistry, with expertise in forensic sciences and genetic diagnostics for precision molecular medicine. Conducted bioinformatic analyses of genetic data both on-site (2014–2017) and remotely as a scientific advisor (2018–2022, non-work-related activity). Collaborated with academia on scientific projects, including studies on translational control in cancer. Designed and led training programs and summer sessions in molecular biology, forensic genetics, medical biology, and medical biotechnology, mentoring student groups completing company fellowships funded by the Polish Ministry of Funds and Regional Policy and EU grants. 2005

-2016 PhD Student

followed by

Research Scientist

Centre of Postgraduate

Medical Education in

Warsaw (CMKP)

Marymoncka 99/103, 01-813 Warsaw, PL

+48-22-569*-***,

******.************@****.***.**

www.cmkp.edu.pl/about-cpme

2005 -2010 Conducted research as a PhD student at the Department of Biochemistry and Molecular Biology, CMKP, in the field of medical biology, focusing on renal cancer (ccRCC) genetics and translational control. 2010 -2016 Research Scientist (non-work related) focused on managing multiple cancer research grants and authoring scientific articles. Awarded the academic degree of Doctor of Medical Sciences in Medical Biology. See Academic Experience. 2005

-2014 The Founder & CEO,

Scientific Project

Director

BioTe21,

Laboratory of Molecular

Medical Biology,

NZOZ BioTe21 (Non-Public

Healthcare Institution)

Gronostajowa 7, 30-387 Krakow, PL

www.skillsforthefuture.iped.pl/pliki/BioTe21_EN_version.pdf

(case study of BioTe21)

*******.**********@*****.***

https://web.archive.org/web/200***********/http://biote21.com Organized BioTe21, a spin-off of the Jagiellonian University (UJ), affiliated with the Jagiellonian Center of Innovation and the Center for Technology Transfer UJ CITTRU. Secured funding through grant proposals, including the Integrated Regional Operational Program (IROP) and the 7th European Union Framework PROFESSIONAL EXPERIENCE & KEY COLLABORATIONS 2001-present CV Adam Master p.4

Programme (FP7). Designed the infrastructure for a genetic laboratory and a Non-Public Healthcare Institution (NZOZ). Developed innovative biotechnologies for molecular diagnostics, in vitro gene synthesis, a novel method for protein translation enhancement, and nucleotide-based next-generation therapeutics

(eRNA/dGoligo, see Patents). Conducted routine genetic and biochemical testing for molecular medicine, academia, and forensic sciences, including DNA/RNA synthesis, sequencing, genomics, and transcriptomics. The company was later restructured to align with evolving market demands, enabling me to focus on my PhD dissertation and 11 scientific publications (see References). 2005

-2008 Member of the Scientific

Advisory Board, and

Laboratory Designer

Nucleagena sp. z o.o

(now Synevo Sp. z o.o)

Pawinskiego 5A, 02-106 Warsaw, PL

https://web.archive.org/web/202***********/https://nucleagena.pl SYNEVO: +48-22-120-**-**,

*******@******.**, www.synevo.pl

The role involved designing and establishing a laboratory for molecular diagnostics and diagnostic devices, writing and managing scientific projects funded by European Structural Funds, and implementing advanced technologies for medical diagnostics, including genetic testing for microbiological infections such as HPV, Chlamydia, Legionella, and Toxoplasma, and cytology. 2003

-2005 Molecular Biologist

Laboratory Diagnostician

Institute for DNA

Research in Warsaw

Rakowiecka 36 lok. 30a, 02-532 Warsaw, PL

https://web.archive.org/web/200***********/http://ibdna.pl/ (2005) The role involved laboratory diagnostics, including DNA/RNA analysis, Sanger sequencing, genetic paternity testing, sorting of fetal erythroblasts, and preparing genetic constructs for recombinant proteins. 2002

2003 Biologist

Nencki Institute of

Experimental Biology

Pasteura 3, 02-093 Warsaw PL

+48-22-589-**-**, https://nencki.edu.pl

*.********@******.***.**

https://nencki.edu.pl/laboratories/laboratory-of-molecular-neurobiology Conducted research at the Laboratory of Transcription Regulation, applying various molecular biology methods such as gene cloning, gene expression analysis, and studies on TGF-β as a key regulator of glioblastoma invasion, with findings published in Oncogene (Nature). 2002

2002 Molecular Biologist Institute for DNA

Research in Warsaw

Rakowiecka 36 lok. 30a, 02-532 Warsaw, PL

https://web.archive.org/web/200***********/http://www.ibdna.pl/ (2002) The role involved supporting the organization of a molecular biology laboratory, including DNA sequencing, STR analysis, and genetic analyses for forensic sciences. 2001

-2002 Biologist

Institute of Farmacology of

Polish Academy of Science

Smetna 12, 31-343 Krakow, PL

+48-12-662-**-**, *****@**-***.******.**

http://if-pan.krakow.pl/en/

Conducted research at the Department of Molecular Neuropharmacology, utilizing molecular biology techniques, cell culture, and gene expression profiling, with a focus on drug abuse and neurobiology. Fields of expertise based on the North American Industry Classification System (NAICS): Research and Development in Biotechnology (541714), Research and Development in … Life Sciences (541715). Profession based on the Standard Occupational Classification (SOC): Medical Scientist (19-1042.00),

Research Scientist (19-1029.00, 19-1099.00),

Laboratory diagnostician (29-2011.00),

Chemical Engineer (17-2041.00).

Biology: Medical biology, medical biotechnology, molecular biology, cancer research (in vitro, ex vivo and in vivo animal models), bioinformatics, genomics, transcriptomics, proteomics, laboratory diagnostics. Chemistry: chemical engineering, biotechnology of recombinant proteins, synthesis of anticancer drugs, molecular targeting.

CV Adam Master p.5

[1] Basu A, Yang JY, Tsirukis VE, Loiacono A, Koch G, Khwaja IA, Krishnamurthy M, Fazio N, White E, Jha A, Shah S, Takmil C, Bagdas D, Demirer A, Master A, Natke E, Honkanen R, Huang L, Rigas B. Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice. Front Neurosci. 2024 Jan 29;17:1240372. PDF https://www.ncbi.n lm.nih.gov /pmc/ artic les/PMC10860339/pdf/fn ins- 17-12 40372.pdf (ctrl+ click)

[2] Master A, Huang L, Tsirukis VE, Loiacono A, Khawja A, Takmil C, Tsioulias A, Honkanen R, Rigas B . Transcriptomic landscape of the Dorsal Root Ganglia (DRG) and the Sciatic Nerve (SN) in a mouse model of Paclitaxel-Induced Peripheral Neuropathy (PIPN). PLoS One in preparation (2025). Transcriptome datasets published on Dec 08 2023, NCBI GEO acc. no.: GSE249643. Link https://www.ncbi.n lm.nih.g ov/ge o/query/acc .c gi?acc=GSE249643

[3] Khwaja AI, Master A, Honkanen R, Rigas B. Ex Vivo Drug Evaluation Using Human Ocular Cells: A Contribution to Drug Discovery. Opht Res Rev Rep, April 01 2024, ISSN: 2754-4990, doi.org/10.47363/JORRR/2024(5)166. PDF https://www.on line scient ificresearch.com/articles/ex-vivo-drug-eval uation-u sing-hum an-ocu lar-cells-a-contribution-t o-drug-discovery.pdf

[4] Master A, Huang W, Huang L, Honkanen R, Rigas B. An Improved Ocular Impression Cytology Method: Quantitative Cell Transfer to Microscope Slides Using a Novel Polymer. Curr Eye Res. 2022 Jan;47(1):41-50. PDF https://pmc. ncbi.nlm.n ih.gov /articles/PMC8792174/pdf/nihms-1722348.pdf

[5] Master A, Huang W, Huang L, Li W, Saglam S, Honkanen R, Rigas B. Simplified ex-vivo drug evaluation in ocular surface cells: Culture on cellulose filters of cells obtained by impression cytology. Exp Eye Res. 2021 Dec;213:108827. link https://www.scie ncedirect.c om/ science/ article/abs/pii/S0014483521003936

[6] Huang W, Huang L, Li W, Saglam MS, Tourmouzis K, Goldstein SM, Master A, Honkanen R, Rigas B. Once-Daily Topical Phosphosulindac Is Efficacious in the Treatment of Dry Eye Disease: Studies in Rabbit Models of Its Main Clinical Subtypes. J Ocul Pharmacol Ther. 2021 Dec 29. PDF https://pmc.nc bi.nlm.ni h.gov/articles/PM C8817715/pdf/jo p.2021.00 50.pdf

[7] Master A, Kontzias A, Huang L, Huang W, Tsioulias A, Zarabi S, Wolek M, Wollocko BM, Honkanen R, Rigas B. The transcriptome of rabbit conjunctiva in dry eye disease: Large-scale changes and similarity to the human dry eye. PLoS One. 2021 Jul 29;16(7):e0254036. PDF https://pmc.nc bi.n lm.ni h.gov/articles/PMC 8321226/pdf/pone.02 54036.pdf

[8] Koronowicz AA, Master A, Banks P, Piasna-Słupecka E, Domagała D, Drozdowska M, Leszczyńska T. PPAR Receptors Expressed from Vectors Containing CMV Promoter Can Enhance Self-Transcription in the Presence of Fatty Acids from CLA-Enriched Egg Yolks-A Novel Method for Studies of PPAR Ligands. Nutr Cancer. 2020;72(5):892-902. link https://www.tan dfon line.com/doi/ab s/1 0.1080 /01635581.2 019.165 2332? jou rnalCode=hnuc20 full article https:/ /drive. goog le.com/file/d/1szh3oQeSpys6Hhe-JcN4-7IBkmEqDN6g/view?usp=dr ive_link

[9] Aneta A. Koronowicz, Paula Banks, Adam Master, et al., “Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells,” PPAR Research, vol. 2017, Article ID 2865283, 12 pages, 2017. PDF https://pmc.nc bi.n lm.nih.g ov/ar ticle s/PMC5385215/pdf/PPAR2017-2 865283.pdf

[10] Master A, Wójcicka A, Giżewska K, Popławski P, Williams GR, Nauman A. A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5’UTRs of Selected Tumor Suppressors. PLoS ONE. 2016 May 12; 11(5): e0155359. PDF https://journals.plos.org/plosone/article/f ile? id=10.1371 /jo urnal.pone.0 155359&type =pr intable

[11] Koronowicz AA, Banks P, Domagała D, Master A, Leszczyńska T, Piasna E, Marynowska M, Laidler P. Fatty acid extract from CLA- enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation. Genes Nutri. 2016;11:22. PDF https://pmc.nc bi.nlm.n ih.gov/ artic les/PMC4968440/pdf/12263_2016_Art icle_537.pdf

[12] Koronowicz AA, Banks P, Szymczyk B, Leszczyńska T, Master A, Piasna E, Szczepański W, Domagała D, Kopeć A, Piątkowska E, Laidler P. Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens. Br Poult Sci. 2016 Jun 8. link https://www.ta ndfo nline.com/doi/ab s/10.1 080 /00071668.2 016.119 2280

[13] Koronowicz AA, Kopeć A, Master A, Smoleń S, Piątkowska E, Bieżanowska-Kopeć R, Ledwożyw-Smoleń I, Skoczylas Ł, Rakoczy R, Leszczyńska T, Kapusta-Duch J, Pysz M. Transcriptome Profiling of Caco-2 Cancer Cell Line following Treatment with Extracts from Iodine-Biofortified Lettuce (Lactuca sativa L.). PLoS One. 2016 Jan 22;11(1):e0147336. PDF https://journals.pl os.or g/plosone/article/file?id=10.1371/ journal.pone. 0147336&type=printable

[14] Wojcicka A, Piekielko-Witkowska A, Kedzierska H, Rybicka B,Poplawski P, Boguslawska J, Master A, Nauman A. Epigenetic regulation of thyroid hormone receptor Betain renal cancer. PLoS One. 2014 May 21;9(5):e97624. PDF https://pmc. ncbi.n lm.nih.gov /articles/PMC4029725/pdf/pone.009 7624.p df

[15] Master A, Nauman A. THRB (Thyroid Hormone Receptor, Beta). Atlas Genet Cytogenet Oncol Haematol. 2014; 18(6). PDF https://atl asge neticsoncology.org/gene/42554/thrb

[16] Master A, Nauman A. Molecular mechanisms of protein biosynthesis initiation - biochemical and biomedical implications of a new model of translation enhanced by the RNA hypoxia response element (rHRE) [Molekularne mechanizmy inicjacji biosyntezy białek - biochemiczne i biomedyczne implikacje nowego modelu translacji wzmacnianej przez element RNA odpowiedzi na hipoksję (rHRE)]. Postepy Biochem. 2014;60(1):39-54. Review. The Polish Biochemical Society has granted this work with Boleslaw Skarzynski Award for the best article published in a quarterly journal “Postepy Biochemii” published in year 2014. PDF [pl] https: //d rive.google.com/f ile /d/1OgyU43cClfCwLjGfOdM6ZG1KChOwdDqk/vie w, Machine translated PDF [en] https://d rive.google.com/f ile /d/1PEh X1629tN6MbP2kbqoI1emvjMMsV2gJ/view

[17] Master A, Nauman A. Gene expression regulation by long naturally occurring antisense transcripts [Regulacja ekspresji genów przez długie naturalnie występujące antysensowne transkrypty]. Post. Biol. Kom. 2014;41(1):3-28. Review. link, PDF [pl] https://www.p bkom. eu/site s/default/f ile s/REGULACJA%20E KSPRESJI%20GEN%C3%93W.p df, Machine translated by google PDF [en] https://d rive.google.com/f ile /d/1pzYDhr0g6yNLD7ksuJFEwdgGiWvZ36dz/v iew

[18] Master A, Nauman A. Genomic context and expression regulation of nuclear thyroid hormone receptors by long naturally occurring antisense transcripts [Genomowy kontekst i regulacja ekspresji receptorów hormonu tarczycy przez długie naturalnie występujące antysensowne transkrypty]. Post. Biol. Kom. 2014; 41(1):29-58. Review. link, PDF [pl] https://p bkom. eu/site s/default/f ile s/GEN OMOWY%20KONTEKST.pdf PDF [en] https://d rive.google.com/f ile /d/1hMpzRTqSeGYpPhPxwveVOASA5Jv6HFQd/view REFEREED PUBLICATIONS

CV Adam Master p.6

[19] Boguslawska J, Wojcicka A, Piekielko-Witkowska A, Master A, Nauman A. MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer. PLoS One. 2011;6(9):e24541. Epub 2011 Sep 2. PDF https://pmc.nc bi.n lm.ni h.gov/articles/PMC 3166326/pdf/pone.00 24541.pdf

[20] Master A, Wójcicka A, Piekiełko-Witkowska A, Bogusławska J, Popławski P, Tański Z, Darras VM, Williams GR, Nauman A. Untranslated regions of Thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma. Biochim Biophys Acta. 2010 Nov;1802(11):995-1005. Epub 2010 Aug 3. PDF https://www.sciencedirect.com/sc ience/a rticle/pii/S0925 443*********?v ia%3Dihub

[21] Piekielko-Witkowska A, Master A, Wojcicka A, Boguslawska J, Brozda I, Tanski Z, Nauman A. Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer. Thyroid. 2009 Oct;19(10):1105-13. PDF http:/ /online.liebertpub.com/doi/a bs/10.108 9/thy.2008.028 4

[22] Nauman A, Piekiełko – Witkowska A, Turowska O, Popławski P, Master A, Tański Z, Lampkowska J, Wójcicka A, Brózda I, Puzianowska

– Kuźnicka M. Disturbances of thyroid hormone signal pathway – in clear cell renal cell carcinoma [Zaburzenia szlaków sygnałowych hormonu tarczycy -trijodotyroniny - w raku nerki typu jasnokomórkowego]. Advances in Medical Sciences. 2008, 5: 268-278. Link [pl] http:/ /www.ksiaznica.h ome.pl/pnm /sp nm.php?kto ry=312 link [en] https://www-czytelniamedyczna-p l.tran sla te.goog/show.p hp?ktory= 2979&_x_tr_ sl=pl&_x_tr_t l=en&_x_tr_ hl=en&_x_t r_pto=wapp

[23] Wisniewski P, Master A, Kaminska B. Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli. Acta Biochim Pol. 2008;55(1):51-6. Epub 2008 Jan 18. PDF https://docs.go ogle.com/viewer?url=h ttps: //b ibliotekanauki.pl /articles/1 040813.pdf

[24] Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, Franciszkiewicz K, Chouaib S, Kaminska B. Microglia- derived TGF-beta as an important regulator of glioblastoma invasion—an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene (Nature). 2008 Feb 7;27(7):918-30. Epub 2007 Aug 6. link http://www.nat ure.c om/onc/journal/v27/n7/pdf/1210683a.pdf

[25] Nauman A, Turowska O, Poplawski P, Master A, Tanski Z, Puzianowska-Kuznicka M. Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequences. Acta Biochim Pol. 2007;54(3):595-602. Epub 2007 Aug 28. PDF https://docs.go ogle.com/v iewe r?ur l=https://bibliotekanauki.pl/art icles/1041047.p df

[26] Turowska O, Nauman A, Pietrzak M, Popławski P, Master A, Nygard M, Bondesson M, Tanski Z, Puzianowska-Kuznicka M. Overexpression of E2F1 in clear cell renal cell carcinoma: a potential impact of erroneous regulation by thyroid hormone nuclear receptors. Thyroid. 2007 Nov;17(11):1039-48. link https://w ww.l iebertpub.com/doi/ab s/10.1089/thy.20 07.0075

[27] Switaj K, Master A, Borkowski PK, Skrzypczak M, Wojciechowicz J, Zaborowski P., Association of ocular toxoplasmosis with type I Toxoplasma gondii strains: direct genotyping from peripheral blood samples, J Clin Microbiol. 2006 Nov;44(11):4262-4. PDF https://pmc.nc bi.n lm.ni h.gov/articles/PMC 1698313/pdf/1786- 06.pdf

[28] Switaj K, Master A, Skrzypczak M, Zaborowski P. Recent trends in molecular diagnostics for Toxoplasma gondii infections. Clin Microbiol Infect. 2005 Mar;11(3):170-6. Review. PDF https://www.c linicalmicrobiologyandinfection.c om/article/S1198- 743X( 14)620 70-X /pdf

[29] Madeja Z, Master A, Michalik M, Sroka J. Contact-mediated acceleration of migration of melanoma B16 cells depends on extracellular calcium ions. Folia Biol. 2001;49(3-4):113-24. link https://pubmed.ncbi.n lm.nih.g ov/11987446/ For additional papers see Orcid: http://orcid.org/0000-0001-9391-8846

[1] Master A, Huang L, Tsirukis VE, Loiacono A, Khawja A, Takmil C, Tsioulias A, Honkanen R, Rigas B . Transcriptomic landscape of the Dorsal Root Ganglia (DRG) and the Sciatic Nerve (SN) in a mouse model of Paclitaxel-Induced Peripheral Neuropathy (PIPN). PLoS One in preparation. Abstract published on Dec 08 2023, NCBI GEO acc. no.: GSE249643. link https://ww w.ncbi.nlm.n ih.gov/ geo /query /acc.c gi?acc=GSE249643

[2] Master A, Kontzias A, Huang L, Huang W, Tsioulias A, Zarabi S, Wolek M, Wollocko BM, Honkanen R, Rigas B . The transcriptome of rabbit conjunctiva in dry eye disease: Large-scale changes and similarity to the human dry eye. Abstract published on Mar 30 2021, NCBI GEO acc. no.: GSE171043. Link https://www.ncbi.n lm.nih.gov /geo/query/acc .c gi?acc=GSE171043

[3] Master, Adam; Wojcicka, Anna; Nauman, Alicja. Translation Enhancing Effects of Sequence Specific Oligonucleotides Targeting 5'UTRs of Selected Tumor Suppressors. Molecular Therapy Vol 26 No 5S1 May 2018 p 272-272. Chicago, IL. link https:/ /www.cell.com/pb- assets/mo lecular-therapy /AbstractFinal2018.pdf

[4] Adam Master 1, 2, Anna Wojcicka 2,3, Alicja Nauman 2 . Gene-specific enhancement of protein synthesis by targeting 5’UTRs -a novel oligonucleotide-based strategy for translational control of selected tumor suppressors. 1 DNAi - The Center of Genetic Information, Laboratory of Molecular Medical Biology, Krakow, PL, 2 Laboratory of Human Cancer Genetics, Centre of New Technologies, University of Warsaw, PL, 3 Genomic Medicine, Medical University of Warsaw, PL. 3rd International Conference and Expo on Drug Discovery & Designing. Volume 6, Issue 4(Suppl), p47, Drug Design Journal, ISSN: 2169-0138 DDO, October 02, 2017, Vienna, Austria. Link https

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