Research Scientist Lab
Resume:
Stephanie Hamill, PhD
** ****** ****, ***** *****, CT
*********.*.******@*****.***
linkedin.com/in/stephanie-hamill
Qualification Profile:
Determined and ethical professional, with broad-based experience in Biochemical research and product development. Stellar reputation in ability to lead and perform all phases of research. Expertise in analysis, documentation, research, complemented with effective writing and presentation skills. Efficiency in working with people of diverse cultures and organizational backgrounds by addressing their diverse needs. Excellence in collaborating and training team members while maintaining high quality standards, professional demeanor, and a cooperative attitude. Extremely capable of fast-paced environments with dedication to operational excellence.
Objective:
I am in search of a productive and talented research team that allows me to utilize my biochemistry and structural biology background in order to further explore the development of diagnostics and therapeutic targets through protein characterization and enzymology.
Education:
PhD: Columbia University; Biochemistry May 2006
BS: University of Connecticut; Cell Biology May 1998
Research Work Experience:
Yale University; Dept. of Cell Biology; New Haven, CT January 2025 – present
Research Scientist
Macromolecular structural analysis of lipid transport proteins.
Quantum-Si Branford, CT Staff Scientist March 2023 – December 2024
Senior Research Scientist December 2019 - March 2023
Research and development of a biotech platform for real time, next generation protein sequencing at the amino-acid level.
Yale University; Dept. of Molecular, Cellular and Develop Biology, August 2017- June 2018
New Haven, CT
Associate Research Scientist
Structural based studies of the group II ribozyme in complex with its helicase/maturase and the effect on splicing behavior.
Yale University; Dept. Of Pharmacology; New Haven, CT March 2011- April 2016
Associate Research Scientist
Biochemical and x-ray crystallographic studies of kinases involved in the progression of cancer. Macromolecular studies of substrate-bound kinases.
Yale University; Dept. of Cell Biology; New Haven, CT Nov 2006- March 2011
Postdoctoral Fellow
Macromolecular X-ray Crystallographic and functional studies of RNA-binding protein complexes targeted for aberrant RNA species degradation.
Columbia and Yale University; Dept. of Molecular Biology and Bio- August 2000- Nov 2006
Physics; New Haven, CT
Graduate Student
Structural and functional studies of group II intron ribozyme and effect on kinetic behavior.
Skillset:
Expertise in structural and functional characterization of proteins and nucleic acid complexes involved in targeting aberrant molecules for degradation or in the onset or progression of cancer.
Multiple years of experience in planning, designing and performing laboratory experiments, data analysis and communicating results and data through lectures, posters and peer-reviewed journals, supervising and mentoring graduate students in their dissertation research. Methods development for protein function and validation of molecular structure through biochemical tools.
Four years of recent industry experience with cutting-edge real-time protein-ligand binding kinetic assays, HTP and pilot scale protein downstream processing, QC analysis and assays.
Core Competencies:
Protein Biochemistry and crystallography: Protein Purification (high throughput and large-scale) Protein Expression using E. coli, baculovirus and Insect Cells, Development and trouble-shooting of in vitro assays to characterize kinases, polymerases, and GTPases by enzymatic function, pull-down assays, gel-shifts (EMSA), Biolayer Interferometry using Octet and BLITz. Cell-based assays including transient overexpression in mammalian cells. Western blots and IPs. Site-specific Modification – Phosphorylation and Glycosylation, Cell Culture, Radiography, X-ray crystallography (Crystallization – HTP using Mosquito and Hydra robots, Crystal Harvesting, CCP4, Phenix, HKL2000, solved structures by SAD and MR)
Molecular Biology and Cloning Techniques: PCR, Nucleic Acid Extraction, RNA Biochemistry, Large Scale Transcription and RNA Purification Techniques, RNA Footprinting and Interference Mapping, Ribozymology.
Technical Acumen: Proficient in Microsoft Office suite, data analysis using Prism, Excel and ImageQuant.
Awards:
Jane Coffin Childs Memorial: Genentech Fellow. $130,000-****-****
Total cost for postdoctoral research.
James Browne-Alexander Coxe Research Fund. $40,000 2007
Total cost for postdoctoral research.
Conferences:
Group II Intron Ribozyme Behavior with its Cognate Maturase Protein 2018
RNA, Berkely, California (poster presentation)
Structural Analyses of the TRAMP4 Complex: 2010
A story of a Non-canonical polymerase and its Substrate. ACA, Philadelphia, PA
Functional and Structural Studies of a Group II Intron Ribozyme 2004
RNA, Vienna, Austria (poster presentation)
Publications:
Reed BD et. al.; Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device; Science, 2022
Hamill, Lou, Turk and Boggon; Structural Basis for Non-canonical Substrate Recognition of Cofilin/ ADF proteins by Lim Kinase; Mol Cell, 2016.
Hamill, Wolin and Reinisch; Structure and Function of the Polymerase Core of TRAMP, an RNA Surveillance Complex; PNAS, 2010.
Hamill and Pyle; The Receptor for Branch-Site Docking within a Group II Intron Active Site; Mol Cell, 2006.
De Lencastre, Hamill and Pyle; A Single Active Site Region for a Group II Intron; Nature Structural and Molecular Biology, 2005.
Levine, Cloherty, Hamill and Carruthers; Molecular Determinants of Sugar Transport Regulation by ATP; Biochemistry, 2002.
Levine, Hamill, Cloherty and Carruthers; Alanine Scanning Mutagenesis of the Human Erythrocyte Glucose Transporter Putative ATP Binding Domain; Blood Cells, Molecules and Disease, 2001.
Cloherty, Levine, Hamill and Carruthers; Sugar Transporter Regulation by ATP and quaternary Structure; Blood Cells, Molecules and Disease, 2001.
Hamill, Cloherty and Carruthers; The Human Erythrocyte Sugar Transporter Presents 2 Sugar Import Sites; Biochemistry, 1999.
Hamill, Trevitt-Parker, Nowend, Carlson and Salamone; Nucleus Accumbens Dopamine Depletion and Time-Constrained Progressive Ratio Performance: Effects of Different Ratio Requirements; Pharmacology Biochem Behavior, 1999.
References:
Manjula Pandey; Director of Biochemistry at Quantum-Si
*******@*******-**.***
**********@*****.***
Brian Reed; Head of Research at Quantum-Si
*****@*******-**.***
*****.*******.****@*****.***
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