Clinical Testing Manager

Matthew S. Wells, B.S.

**** **** ****** **

Washington DC 20017

Email: *********@*****.***

Phone: 304-***-****

Summary

Extensive work experience in GCLP, GLP, GMP and FDA regulated laboratories

19 years of laboratory experience, including in-house developed ELISAs, Microneutralization, Pseudo neutralization, and Hemagglutination Inhibition Assays as well as Cell Culture

Extensive experience in Developing, Qualifying and Validating Immunological Assays

Managed up to 10 Research Assistants, scheduling testing and personnel responsibilities

Worked with Materials Management in order to be sure that the reagents and equipment required for testing were available

Excellent aseptic technique

Familiar with viral immunology methods

Experience culturing and working with a variety of mammalian cell lines, including human neuronal stem cells, bioreactors, luminescent assays, transfections and subcloning, as well as biochemical and immunohistochemistry techniques

Lab Coordination/Management

Experience in animal handling

Excellent written and verbal skills; familiar with a variety of scientific instruments such as centrifuges, laminar flow hoods, 96-well plate readers, incubators, microscopes and computer software including LIMS systems and Excel

Employment History

May 2012 – April 2025: Manager Clinical Immunology, Novavax Inc.

Managed sample testing of human serum samples collected from vaccine trials conducted around the world

October 2011 – December 2011: Scientist, Innovative Biosensors, Inc.

Novel cell line development, Expression vector construction, Cell signal

development, DNA isolation and transfection

May 2007 – September 2011: Research Associate II, Neuronascent, Inc.

Aseptic cell culture, Neurogenic and neurodegenerative drug discovery and development, Animal behavior studies

January 2011 – September 2011: Manufacturing Assistant, LifeLine Cell

Technology, LLC.

Laboratory Technician, Manufacturing Technician, Formulation Technician, Quality Assurance Technician

May 2006 – May 2007: Work study Internship at Neuronascent, Inc.

Skills and Experience

Immunological Assays:

Including many in-house developed ELISAs, MNTs, PNTs, and HAIs

Cell Culture:

MDCK cultures for use in Immunological Assays

Suspension cell culture: B cell Lymphoma M12.4 and M12.4.1

Adherent cell culture growth and maintenance: Human neuronal Progenitor Cells, Human embyonic stem cells, Human parthenogenic stem cells, Mitomycin C treated fibroblasts for feeder layers, Artic ground squirrel hippocampal stem cells

Biochemical Assays:

Lowry protein assay, Alamar blue metabolic determination, Lactate dehydrogenase assay, ELISA, ATP determination

Immunocytochemistry:

MAP-2, TUJ1, ERK, Nestin, Ki67, alpha Synuclein, Tau, GFAP, PCNA, BrdU

Animal Behavioral Models:

Modified Irwin Screen, Plus Maze, Open Field, Object Recognition, Water Maze, Rotorod

Manufacturing and QA:

Basal and Stock Chemical Formulation, Clean Room Product Production, Quality Assurance and SOP Compliance

Certifications and Accreditations:

HAZCOM, Bloodborne Pathogen,

Laboratory Safety Standard and HAZPOWER Awareness Level Certification

Computer Skills:

Microsoft Office (Word, Excel, PowerPoint), Cellomics Array Scan programs, Wallac Multilabel Assay Reader, Spot Advanced Microscopic Photography

Education

August 2002 - May 2007: Shepherd University, Shepherdstown, WV

Bachelor of Science – Biology Major, Chemistry Minor

Scientific Classes / Training

Microbiology, General Chemistry, Organic Chemistry, Biochemistry,

Mammalian Anatomy, Cell and Molecular Biology, Immunology, Genetics, Science Literacy, Advanced Cell and Molecular Lab Technique, Advanced Protein Chemistry.

Publications

Drew, K.L., Wells, M.S., Christian, S.L. and Kelleher-Andersson, J.A. (2006). Tolerance to oxygen glucose deprivation in differentiated adult hippocampal neuronal stem cells obtained from arctic ground squirrels (Spermophilus parryii). Stroke 38 (2): 558 (P341).

Drew KL, McGee RC, Wells MS, Kelleher-Andersson JA, 2011. Growth and differentiation of adult hippocampal arctic ground squirrel neural stem cells J Vis Exp 47: e2199

Contact this candidate