Medicinal Chemistry Organic

Location:

Fairfax, VA

Posted:

February 18, 2025

Contact this candidate

Resume:

Debatosh Majumdar, PhD, MBA

857-***-****

********.********@*****.***

https://www.linkedin.com/in/debatoshmajumdar/

Summary

■ Cross-functional collaboration with various scientists including cancer biologists, neuroscientists with an ability to apply specialized knowledge in medicinal chemistry, synthetic organic chemistry, computational chemistry, designed and synthesized inhibitors for proteins, enzymes, RNAs and modulators for G-protein coupled receptor (GPCR) implicated in cancer, CNS, and infectious diseases, as evidenced by 4 patents, 1 clinical candidate, several lead compounds, 8 peer-reviewed publications, 1 book chapter, and an article in preparation.

■ Taught chemistry to undergraduate students.

■ Excellent oral and written communication skills, multidisciplinary team collaborator, good presentation skills, as evidenced by 18 scientific presentations on related topics. Education

Ph.D. in Organic Chemistry, Department of Chemistry, University of Georgia, Athens, GA, USA (2004).

M.S. in Chemistry, Department of Chemistry, Indian Institute of Technology Kanpur (IIT), Kanpur, India (1996).

B.Sc. in Chemistry, University of Calcutta, Calcutta, India (1993). MBA, Master of Business Administration, Boston University, Questrom School of Business, Boston, MA, USA (2024).

Leadership Training

■ From the Laboratory to Leadership, The Leadership Edge Inc., La Jolla, CA, USA

(2017).

Course and Workshop Attended

■ Structure-Based Drug Design and Ligand Modification, Chemical Computing Group, Montreal, Canada (2017).

■ Pharmacokinetics for Chemists in Drug Discovery and Development, American Chemical Society, Washington, D.C., USA (2022).

Work Experience

Curia Global Inc. (Formerly Albany Molecular Research Inc), Rensselaer, NY Senior Research Scientist I - Medicinal Chemistry 7/2022 – 8/2024

■ Multidisciplinary team collaboration with various scientists including neurologists, designed, and synthesized orally active small molecule inhibitors for the main protease of SARS-COVID-2 and allosteric modulators of G-protein coupled receptor

(GPCR) implicated in COVID and CNS diseases such as neuropathic pain, and Parkinson’s disease, as evidenced by nomination of compounds for in vivo studies and preparation of draft for a peer-reviewed article.

■ Versatile researcher, designed and synthesized novel molecules for prostate cancer therapy by targeting prostate-specific membrane antigen, and Rho Kinase inhibitors implicated in spinal cord injury, evidenced by 3 lead compounds. 2

GlycoMimetics Inc., Rockville, MD

Research Scientist II - Medicinal Chemistry 7/2018 – 4/2022

■ Cross-functional collaboration with molecular biologists and computational chemists, to design and synthesize orally active small molecule inhibitors for the protein Galectin-3 for cancers and fibrosis, as evidenced by 3 patents and a clinical candidate.

■ A team player, worked with colleagues to develop methodology for alkylation of C-4 OH of sialic acid derivative for targeting CD-33 implicated in acute myeloid leukemia

(AML).

■ Conducted data analysis and analyzed chemistry data of phase 3 clinical trial of sickle cell anemia drug Rivipansel.

Center for Vaccine Development and Global Health (CVDGH), University of Maryland School of Medicine, Baltimore, MD

Research Specialist 3/2018 – 6/2018

■ Versatile scientist, analyzed bacterial polysaccharides, O-polysaccharides of Pseudomonas Aeruginosa, Klebsiella Pneumonia, and performed conjugation chemistry for vaccine development program, as evidenced by formation of a partnership with Affinivax Inc.

RaNA Therapeutics Inc. (acquired by Sanofi), Cambridge, MA Scientist - Medicinal Chemistry 9/2015 – 6/2017

■ Collaborated with RNA-biologists and pharmacologists, mentored junior chemists, designed, and synthesized novel nucleosides, oligonucleotides, oligonucleotide-ligand conjugates for targeting RNAs implicated in CNS, immuno-oncology, and liver diseases, as evidenced by a patent and advancement of RNA therapeutics program resulting acquisition by Sanofi.

Glycosyn LLC, Medford, MA

Staff Scientist – Chemistry 2/2012 – 9/2015

■ Multidisciplinary research and development acumen, organic synthesis, and bio- conjugation chemistry, designed and synthesized glycoside derivatives; protein- carbohydrate conjugates, and carbohydrate-polymer conjugates as potential anti- infective agents against various pathogens, as evidenced by formation of partnerships with FrieslandCampina, Ginkgo Bioworks, and BASF.

Northeastern University, Nanomedicine Science and Technology Program, Boston, MA Associate Research Scientist 9/2011 – 12/2011

■ Strong grant writing and project development abilities, contributed to writing research proposal for developing a project on cancer nanomedicine combining expertise in medicinal chemistry, cancer biology, and nanotechnology. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA Research Associate (8/2008 – 8/2011)

Distinguished Research Fellow (1/2007 – 7/2008)

■ Product development expertise, synthesized conjugates of paclitaxel, EGFR-targeting peptides, polymers, and formulated anticancer nanoparticles, conducted in vitro and in vivo biological experiments using various cancer cell lines and tumor xenograft mouse model, as evidenced by 2 peer reviewed publications in Frontiers in Bioscience and Cancer Prevention Research.

University of Michigan, Department of Medicinal Chemistry, Ann Arbor, MI Research Fellow 9/2004 – 11/2006

■ Passionate chemistry researcher, collaborated with an enzymologist to design and synthesize inhibitors for the cysteine protease, γ-glutamyl hydrolase implicated in cancer, as evidenced by a peer reviewed publication in the Journal of Organic Chemistry.

University of Georgia, Department of Chemistry, Athens, GA Research Assistant 8/1999 – 7/2004

■ Creative synthetic organic chemist, designed and synthesized the tumor-associated antigen Lewis-X, and glycopeptides of Leishmania Major and Leishmania Mexicana; studied the role of stereo-directing solvents in glycosylation, as evidenced by 3 peer reviewed publications in the Organic Letters, Journal of Organic Chemistry, and Encyclopedia of Reagents for Organic Synthesis.

Teaching Experience

University of Georgia, Department of Chemistry, Athens, GA Graduate Teaching Assistant 8/1999 – 8/2000

■ Taught chemistry to undergraduate students.

Scientific and other Skills

Organic chemistry

Multi-step organic synthesis

Medicinal chemistry

Team coordination

Multidisciplinary collaboration

SAR data, PK, ADMET

2D NMR, LC-MS, HRMS

MALDI-TOF, GC-MS

RP-HPLC, TFF, SEC

HPAEC-PAD, SDS-PAGE

Data analysis

Oral communication

Written communication

Project management

Drug discovery

SBDD, CADD, PyMOL

Hit to Lead optimization

ChemDraw, LaTex

Research validation

Publications

■ Lu, D.; Ross, R., Lichtman, A.; Feng, T.; Herr, J.; Freeman, E.; Majumdar, D.; Selley, D et al. “Design and synthesis of small molecules for allosteric modulation of G- protein coupled receptor protein CB1 for CNS diseases” In preparation for the Journal of Medicinal Chemistry.

■ Jawaid, S.; Majumdar, D.; Banerjee, S.; Pramanik, S.; Mandal, S.; Chowdhury, I.; Khan, T.K. “Targeting integrin beta 1 using anti-tumorigenic quinazoline moiety in inhibition of glioblastoma cell invasion and survival” Biochemical and Biophysical Research Communications 2024 (submitted).

■ Majumdar, D.; Alexander, M. D.; Coward, J. K. “Synthesis of Isopeptide Epoxide Peptidomimetics.” Journal of Organic Chemistry 2009, 74, 617-27.

■ Majumdar, D.; Galal El Sayed.; Buskas, T.; Boons, G.J. “Synthesis of Proteophosphoglycans of Leishmania major and Leishmania mexicana A New Class of Glycosylated Phosphopeptides.” Journal of Organic Chemistry 2005, 70, 1691- 1697.

■ Majumdar, D.; Zhu, T.; Boons, G.J. “Synthesis of Oligosaccharides on Soluble High- Molecular-Weight Branched Polymers in Combination with Purification by Nanofiltration.” Organic Letters 2003, 5, 3591-3594.

■ Majumdar, D.; Rahman, Mohammad.A.; Chen, Z.G.; Shin, D.M. “Anticancer activity of drug conjugates in head and neck cancer cells.” Frontiers in Bioscience 2016, 8, 358-369.

■ Majumdar, D.; Boons, G.J. “Use of Solvent Acetonitrile in Stereoselective Glycosylations.” Encyclopedia of Reagents for Organic Synthesis 2004, 6.

■ Majumdar, D.; Jung, K-H.; Zhang, H.; Nannapaneni, S.; Wang, X.; Amin, A.R.M.; Chen, Z.; Chen, Z.G.; Shin, D.M. “Luteolin nanoparticle in cancer prevention- in vitro and in vivo anticancer activity.” Cancer Prevention Research 2014, 7, 65-73.

■ Majumdar, D.; Singhal, S. “Medicinal Chemistry and Nanomedicine for Reproductive Cancer Therapeutics.” Frontiers in Bioscience 2012, 4, 2029-2044.

■ Majumdar, D.; Peng, X-H; Shin, D. M. “The medicinal chemistry of theragnostics, multimodality imaging and applications of nanotechnology in cancer.” Current Topics in Medicinal Chemistry 2010, 10, 12, 1211-1226.

Book Chapter

■ Peng, X-H

; Majumdar, D.

; Shin, D. M. “Applications of Nanotechnology in Imaging and Therapy of Cancer.” Both authors contributed equally. Current Advances in the Medical Application of Nanotechnology 2011, Bentham Science Publishers Ltd, Oak Park, IL, USA.

Intellectual Property

■ J. L. Magnani, J. M. Peterson, Y. U. Vohra, I. Ghosh, J. Nogueira, A. K. Sarkar, D. Majumdar. Galectin-3 inhibiting C-glycosides ketones, ethers, and alcohols. WO 2021/1133924 A1.

■ J. L. Magnani, J. M. Peterson, Y. U. Vohra, I. Ghosh, D. Majumdar. Galectin-3 inhibiting C-glycosides oximes. WO 2022/ 250976 A1.

■ J. L. Magnani, J. M. Peterson, A. K. Sarkar, Y. U. Vohra, I. Ghosh, J. Nogueira, D. Majumdar. Galectin-3 inhibiting C-glycosides amides. WO 2022/241183 A1.

■ B. Bhat, S. Karmakar, D. Majumdar, J. Tay, N. Chau. Nucleic acid conjugates and uses thereof. US2019/0224326A1.

■ D. Majumdar, D. Shin, Mohammad. A. Rahman, Z.G. Chen. Synthesis of conjugate of paclitaxel, branched polymer, and EGFR-targeting peptide as prodrug, and study of its anticancer activity against head and neck cancer, Emory University Office of Technology Transfer, Atlanta, USA. 05/2011.

Member

■ Associate Chief Editor in “Frontiers in Medicinal and Pharmaceutical Chemistry”, Lausanne, Switzerland. (2014-2015).

■ “World Journal of Organic Chemistry”, DE, USA. (2012-Present).

■ Member, American Chemical Society.

Organizing Committee

■ International Conference on Medicinal Chemistry and Computer Aided Drug Designing. 2014, San Francisco, CA, USA.

Reviewer

■ 2011-2013: “PLoS ONE”, CA, USA.

■ 2010-2014: “Frontiers in Bioscience”, NY, USA.

■ 2012-Present: “World Journal of Organic Chemistry”, DE, USA.

■ 2013-2014: “Drug Delivery Letters”, IL, USA.

Presentations

■ “The communion of medicinal chemistry and nanotechnology in anticancer therapeutics.” 2014, International Conference on Medicinal Chemistry and Computer Aided Drug Designing, CA, USA.

■ “Design and Synthesis of Cysteine Protease Inhibitors.” 2013, International Conference on Medicinal Chemistry and Computer Aided Drug Designing, NV, USA.

■ “Design and synthesis of biologically important carbohydrates and glycopeptides.” 2011, Astra Zeneca India, Bangalore, India.

■ “Design and synthesis of biologically important molecules and nanoparticles.” 2011, Indian Institute of Technology Kharagpur, Kharagpur, India.

■ “Development of nanoparticle and anticancer drug polymer conjugate, and their applications in cancer therapy.” 2011, Jawaharlal Nehru University, New Delhi, India.

■ “Design and synthesis of potential inhibitors of gama-glutamyl hydrolase.” 2011, Birla Institute of Technology and Science, Pilani, India.

■ “Towards the Synthesis of Tetrasaccharide on High Molecular Weight Branched Polymer.” 2001, Proctor and Gamble Symposium, University of Georgia, Athens, GA, USA.

■ “Synthesis of Tetrasaccharide on High Molecular Weight Branched Polymer in Combination with Membrane Nanofiltration for Product Purification.” 2002, Department of Chemistry, University of Georgia, Athens, GA, USA.

■ “Synthesis of Tumor Associated Antigen Lewis-X on High Molecular Weight Branched Polymer in Combination with Membrane Nanofiltration for Product Purification.” 2003, Proctor and Gamble Symposium, University of Georgia, Athens, GA, USA.

■ “Design and Synthesis of HIV Protease Inhibitor.” 2003, Department of Chemistry, University of Georgia, Athens, GA, USA.

■ “Synthesis of Tumor Associated Antigen Lewis-X on High Molecular Weight Branched Polymer in Combination with Membrane Nanofiltration for Product Purification.” 2003, Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, USA.

■ “The Synthesis of Oligosaccharide on High Molecular Weight Branched Polymer in Combination with Membrane Nanofiltration for Product Purification.” 2003, Carbohydrates Gordon Research Conference, Tilton, NH, USA.

■ “Design and Synthesis of Epoxide Peptidomimetics as Inhibitors of -Glutamyl Hydrolase.” 2005, Midwest Enzyme Chemistry Conference, Chicago, IL, USA.

■ “Design and Synthesis of Epoxide Peptidomimetics as Inhibitors of -Glutamyl Hydrolase.” 2006, National Meeting of the American Chemical Society, San Francisco, CA, USA.

■ “Nanotechnology in Cancer Therapy: Design and Synthesis of Nanoscale System for Targeted Delivery of Anti-Cancer Drug.” 2007, National Cancer Institute Nanotechnology Alliance Investigators Meeting, Chapel Hill, NC, USA.

■ “Nanotechnology in Cancer Therapy: Design and Synthesis of Nano-scale Systems for Diagnosis and Treatment of Prostate Cancer.” 2008, Emory Georgia Tech Frontiers of Cancer Nanotechnology Symposium, Callaway Gardens, GA, USA. 6

■ “Nanotechnology Based Chemoprevention and Cancer Therapy.” 2009, National Cancer Institute Nanotechnology Alliance Investigators Meeting, Los Angeles, CA, USA.

■ “Nanotechnology Based Chemoprevention and Cancer Therapy.” 2010, Particles 2010 International Conference in Nanotechnology, Lake Buena Vista, FL, USA. Reference

■ Prof. Dr. Indrajit Chowdhury, Ph.D.

Associate Professor

Morehouse School of Medicine

720 Westview Drive SW

Atlanta, GA 30310-1495

Email: **********@***.***

Phone: 404-***-****

Fax: 404-***-****

■ Dr. Amitava Adhikary, Ph.D.

Department of Radiation Oncology

University of Iowa

200 Hawkins Drive