Principal Investigator Scientific Writer

Dr. Herbert J. Tobias

1-510-***-**** www.linkedin.com/in/dr-herbert-j-tobias/ ****@*******.***

SUMMARY Pioneered novel analytical instrumentation, methods development and applications to unique measurements in order to advance research and monitoring in a wide variety of disciplines, such as the characterization of combustion engine emissions, atmospheric aerosols and global greenhouse VOC emissions, bio-aerosols, airborne pathogens, stable isotopes, biomolecules, sport anti-doping, microfabrication for analytic instrumentation, and environmental monitoring. Wrote many research articles for peer review Journals, proposals for research grants, and participated on panel reviews of proposals for NASA, (see details on last page below), EPA, and World Anti-Doping Agency (WADA). Successfully secured ~ >$1 million in research grants as lead P.I. since late 2016 for IRMS research. Previous to 2016, participated as co-P.I. in IRMS related projects for USADA & NIH and as Co-I on multi-million-$ funded projects supported by DARPA, TSWG, & Department of Homeland Security (DHS). I have led scientific projects and supervised junior and support staff and scientists, as well as participated in large multi-national collaborative scientific projects (see Nature, Physics, and some other LLNL publications below). Always open to learn, investigate, and apply new techniques to a broad range of scientific investigations.

EDUCATION

Cornell University, NY, Ph.D. (Analytical Chemistry, 1997)

Cornell University, NY, M.S. (Analytical Chemistry, 1994)

College of William & Mary, VA, B.S. (Chemistry, 1992)

OVERVIEW OF EXPERIENCE AND SKILLS

Instrument/Analytical Techniques: developed & applied analytical techniques with hands on experience:

Separations: gas & liquid chromatography (GC, LC), thermal desorption, and comprehensive 2D GC.

Ionization techniques: electron impact (EI), chemical (CI), and laser desorption ionization (LDI).

Mass spectrometry (MS) instrumentation: quadrupole (qMS), time-of-flight (TOF), and magnetic sector, including isotope ratio MS (IRMS), single particle aerosol MS (SPAMS), thermal desorption particle beam MS (TDPBMS), & GC-MS.

Aerosol generators, particle sizers, differential mobility analyzers, and particle collectors. Teamwork: Worked extensively in a results-oriented environment. This work was done alongside a multidisciplinary group of professionals on DARPA & DHS projects at LLNL.

Oral presentations: Research in seminars, conferences, funding reviews, invited talks, and group meetings.

Teaching & Guidance: Taught various courses at Cornell (Labs: 1992-1996; Lectures: 1996, 2008, 2010, 2012) and assisted in management & guidance over students and other scientists at UCR, LLNL, and Cornell.

EMPLOYMENT

09/01/23-Current Scientific/Technical Writer & Freelancer, Hours/week=Various.

During this time, I have been finishing writing up peer-reviewed research manuscript(s) from project(s) performed at my previous job at University of Texas. Just recently successfully publish in Analytical Chemistry in May 2024: Tobias et.al. Anal. Chem. 2024, 96, 19, 7348–7352. See details here & below.

https://testpubschina.acs.org/doi/full/10.1021/acs.analchem.3c03583

In addition, recently been learning to teach Artificial Intelligence (AI) in the subject of chemistry.

Then ultimately use these techniques to teach Outlier AI in Chemistry topics. Currently awaiting assignment to my first project.

4/01/17-8/31/23 Associate Professor, (Non-Tenure/Research Track) Dell Medical School, University of Texas at Austin. Hours work/week=40hr+ Full time.

Development of novel low temperature catalytic on-line combustion reactors in collaboration with industry for use in GC-combustion isotope ratio mass spectrometry (GC-C-IRMS) of 13C/12C by measurement of CO2 isotopes. This work resulted in a commercial product called the “ARC Isotope” reactor. with the following web link here: (https://www.activatedresearch.com/isotope-reactor/) for which we won the “Analytical Scientist Innovation Awards (TASIAs) 2018", for the ARC-i Isotope Low Temperature Catalytic Combustion Reactors. In house applications include detection of the use of exogenous anabolic steroids by athletes in sport; however, the technology can be applied to many areas of chemical sourcing in forensics and geochemistry. Other techniques used in the laboratory include biomolecule analysis such as gas chromatography quadrupole mass spectrometry (GC-MS). Development of coupling LC to IRMS using a novel rotating-catalytic disc interface employing laser-activated photo-catalytic oxidation to CO2. (https://dellmed.utexas.edu/directory/herbert-tobias/)

Duties & Responsibilities

Author, Co-Author grant proposals to fund research, salary.

Management, training, and guidance of students in research.

Conduct cutting-edge research in advanced low (Fast GC) separations coupled with MS and on-line combustion high precision isotope ratio mass spectrometry (IRMS) of urinary steroids for isotopic analysis. Also novel coupling of liquid chromatography to IRMS.

Build, maintain and troubleshoot laboratory separation and mass spectrometer systems, such as GC-MS, GC-C-IRMS, and GCxGC-C-MS/IRMS, LC-FID, LC-IRMS.

Key methodologies include GC, LC, EI, magnetic sector MS, on-line chemistry, microfabrication.

Procure laboratory consumables and equipment as needed.

Author manuscripts for peer review and publication (see all below).

Present research results at meetings and conferences (see all below).

1/02/07-3/05/17 Senior Research Associate (2010-2017); Research Associate (2007-2009), Division of Nutritional Sciences, Cornell University. Hours work/week=40hr+ Full time.

Development of isotopic standards and sample preparation & analysis techniques for the detection of the use of exogenous anabolic steroids from urine in sport doping, gas chromatography mass spectrometry (GC-MS), comprehensive 2D gas chromatography (GCxGC)-MS, GC-combustion stable isotope ratio mass spectrometry (GC-C-IRMS) measurements (GC-IRMS) of 13C/12C, novel instrumentation for fast GC and GCxGC separations coupled to IRMS. Micro-fabrication of micro-reactors, & assisted in external projects using aerosol mass spectrometry compared to X-ray free electron laser imaging of particles.

Duties & Responsibilities

Author, Co-Author grant proposals to fund research, salary.

Management, training, and guidance of students in research.

Conduct cutting-edge research in advanced 2D gas chromatography (GCxGC) separations coupled with MS and on-line combustion high precision isotope ratio mass spectrometry (IRMS) of urinary steroids, and microfabrication technology (using the Cornell NanoScale Science & Technology Facility) for combustion micro-reactor development for isotopic analysis.

Build, maintain and troubleshoot laboratory separation and mass spectrometer systems, such as GC-MS, GC-C-IRMS, and GCxGC-C-MS/IRMS.

Key methodologies include GC, EI, magnetic sector MS, on-line chemistry, microfabrication.

Procure laboratory consumables and equipment as needed.

Author manuscripts for peer review and publication (see all below).

Review grant proposals for NASA, WADA, and EPA, and review manuscripts submitted to a multitude of peer review journals.

Present research results at meetings and conferences (see all below).

11/01/01-12/01/06 Aerosol Chemist, Bio-Security & Nanoscience Laboratory (BSNL) in the Chemical & Material Sciences Division, Lawrence Livermore National Laboratory (LLNL), University of California. Hours work/week=40hrs+ Full time.

Development and application of Single Particle Aerosol Mass Spectrometry (using laser desorption ionization time-of-flight) for the rapid detection of bio-aerosols (microbiology of microbes & viruses) environmental monitoring & characterization of atmospheric particulates.

Duties & Responsibilities

Co-Authored grant proposals to fund research.

Conducted cutting edge research, in the development of analytical methodology (including mass spectrometry) for the detection of bio-aerosols of concern to national security and public health.

Built, maintained, and troubleshot lab built mass spectrometer systems, in this case advanced single particle aerosol mass spectrometers. Maintain and troubleshoot other equipment, such as particle sizers, advanced aerosol generators, particle collectors.

Key methodologies included LDI, MALDI, TOF-MS, particle sizing and sampling.

Managed large project subsection deliverables and finances.

Helped to lead instrument deployments to field sites and operations at government test beds for systems testing, such as SFO airport & Johns Hopkins Applied Physics Lab.

Managed, trained, and guided students in research.

Procured lab consumables and equipment as needed.

Authored manuscripts for peer review and publication (see all below).

Reviewed manuscripts for peer review journals and funding agencies.

Presented research results at meetings and conferences (see all below).

04/01//97-09/01/01 Postdoctoral Researcher, Air Pollution Research Center, University of California at Riverside (UCR). Hours work/week=40+ Full time.

Development and application of Thermal Desorption Particle Beam Mass Spectrometry to fundamental laboratory studies of smog formation and the characterization of diesel engine exhaust.

Duties & Responsibilities

Conducted cutting edge research, in the development of analytical methodology for the study of organic aerosol formation and diesel exhaust nano-particle emissions of interest in air pollution.

Built, maintained, and troubleshot lab built mass spectrometer system, in this case a thermal desorption particle beam mass spectrometer, and other equipment, such as differential mobility analyzers, particle counters, and a 7000 liter environmental chamber.

Key methodologies included EI, thermal vaporization, quadrupole MS, particle sizing and sampling.

Procured lab consumables and equipment as needed.

Authored manuscripts for peer review and publication (see all below).

Presented research results at meetings and conferences (see all below).

SELECTED RECENT SPONSORED PROGRAMS (Grants: All awarded as Principal Investigator) All grants ~$150K to $270K over 1 to 2 years each.

2021 – 2023 “Liquid Chromatography Coupled to Isotope Ratio Mass Spectrometry Expanded to Include Organic Mobile Phases.” Evidence for the presence of non-natural pseudo-endogenous substances in doping control is currently provided almost exclusively by IRMS-based CIR methods and here we advance LC-IRMS from the current capability and apply to analysis of AICAR, an AMPK Activator.

2019 – 2021 “ARC Catalytic Combustion Reactors for Fast GCC-IRMS and GC GCC-IRMS of Urinary Steroids.” Advance ARC low temperature catalytic on-line combustion reactors with application to synthetic steroid detection using carbon isotope ratio (CIR) measurement. This enables more efficient, faster and more sensitive detection of exogenous sources of normally endogenous steroid use in sport for performance enhancement, such as testosterone and other anabolic steroids.

2018 – 2019 “Characterization of Novel Reactors to Enable Low Temperature Catalytic Combustion of Steroids for More Robust and Faster Gas Chromatography Combustion Isotope Ratio Mass Spectrometer Systems.” The gold standard method for confirming an adverse analytical finding of synthetic (exogenous) steroid use is the carbon isotope ratio (CIR) test (13C/12C). This technique was applied to analysis of anabolic steroids and their metabolites for the detection of testosterone and/or other normally endogenous anabolic androgenic steroid (EAAS) misuse from exogenous sources abused in muscle gain and sport.

2016 - 2017 “Novel Low Temperature Catalytic Combustion Reactor for Fast Gas Chromatography Combustion Isotope Ratio Mass Spectrometry.” Constructed a custom low temperature catalytic on-line reactor based on the commercial PolyARC reactor through small business industry partner Activated Research Company. It was designed as a more robust device for combustion in GCC-IRMS analysis of the carbon isotope ratio (CIR, 13C/12C) in organic (steroid) molecules.

PEER REVIEWED PUBLICATIONS (SUBTOPIC: STABLE ISOTOPE IRMS & GC-MS ANALYSIS)

Tobias, H.J.; Jones, A.; Saunders, T.; Brenna, J.T. “Liquid Chromatography Coupled to Isotope Ratio Mass Spectrometry Expanded to Include Organic Mobile Phases.” Analytical Chemistry, 2024, Anal. Chem. 2024, 96, 19, 7348–7352

Publication Date: May 2, 2024, https://doi.org/10.1021/acs.analchem.3c03583https://doi.org/10.1021/acs.analchem.3c03583.

Wang, D.; Wang, Z.; Martinez, S.; Tobias, H.J.; Brenna, J.T. “Fatty acid sentinels as covalently bound randomization standards for triacylglycerol (TAG) quantitative analysis.” Rapid Communications in Mass Spectrometry, 2020, DOI:10.1002/rcm.8891.

Wang, Z.; Wang, D.; Park, H.; Tobias, H.J.; Kothapalli, K.S.D.; Brenna, J.T. “Structural Identification of Monounsaturated Branched Chain Fatty Acid Methyl Esters by Combination of Electron Ionization and Acetonitrile Chemical Ionization Tandem Mass Spectrometry.” Analytical Chemistry, 2019, Dec 3;91(23):151**-*****. DOI: 10.1021/acs.analchem.9b03912.

Wang, D.; Wang, Z.; Le, K.; Cortright, J.R.; Park, H.; Tobias, H.J.; Brenna, J.T. “Conjugated Linolenic acids in Melon Seed Waste Streams.” Journal of Agricultural and Food Chemistry, 2019, 67, 37, 103**-*****. DOI: 10.1021/acs.jafc.9b04744.

Tobias, H.J.; Jones, A.; Spanjers, C.; Bowers, L.; Brenna, J.T. “Low Temperature Catalytic Combustion Reactors for High Precision Carbon Isotope Measurements in Gas Chromatography Combustion Isotope Ratio Mass Spectrometry.” Analytical Chemistry, 2019, 91, 4, 2901-2907. DOI: 10.1021/acs.analchem.8b05043.

Tobias, H.J.; Brenna, J.T. “Cryofocus Fast Gas Chromatography Combustion Isotope Ratio Mass Spectrometry for Rapid Detection of Synthetic Steroid Use in Sport Doping.” Analyst, 2018, 143, 1124-1132.

Tobias, H.J.; Brenna, J.T. “High Volume Steroid Isotopic Standards Developed as Working Standards for Gas Chromatography– Combustion–Isotope Ratio Mass Spectrometry.” Drug Testing and Analysis, 2018, 10, 781-785.

Nisbet, M.; Tobias, H.J.; Brenna, J.T.; Sacks, G.; Mansfield, A.K. “Quantifying the Contribution of Grape Hexoses to Wine Volatiles by High Precision [U13C]-glucose Tracer Studies." Journal of Agricultural and Food Chemistry, 2014, 62, 6820-6827.

Zhang, Y.; Tobias, H.J.; Sacks, G.L.; Brenna, J.T. “Calibration and Data Processing in Gas Chromatography Isotope Ratio Mass Spectrometry.” Drug Testing and Analysis, 2012, 4, 912-922.

Zhang, Y.; Tobias, H.J.; Brenna, J.T. “Highly Sensitive and Selective Analysis of Urinary Steroids by Comprehensive Two-Dimensional Gas Chromatography Combined with Positive Chemical Ionization Quadrupole Mass Spectrometry.” Analyst, 2012, 137, 3102-3110.

Zhang, Y.; Tobias, H.J.; Auchus, R.J.; Brenna, J.T. “Comprehensive Two Dimensional Gas Chromatography Fast Quadrupole Mass Spectrometry (GC GC-qMS) for Urinary Steroid Profiling. Mass Spectral Characteristics with Chemical Ionization.” Drug Testing and Analysis, 2011, 3, 857-867.

Tobias, H.J.; Zhang, Y.; Auchus, R.; Brenna, J.T. "Detection of Synthetic Testosterone Use by Novel Comprehensive Two-Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry (GC GCC-IRMS)," Analytical Chemistry, 2011, 83, 7158–7165.

Tobias, H.J.; Brenna, J.T. “Microfabrication of Micro-Reactors for Isotope Ratio Mass Spectrometry,” Microfluidics and Nanofluidics, 2010, 9, 461-470.

Zhang, Y; Tobias, H.J.; Brenna, J.T. “Uniform Steroid Isotopic Standards for Gas Chromatography Combustion Isotope Ratio Mass Spectrometry,” Steroids, 2009, 74, 369-378.

Tobias, H.J.; Sacks, G.L.; Zhang, Y.; Brenna, J.T. “Comprehensive Two-Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry,” Analytical Chemistry, 2008, 80, 8613-8621.

Zhang, Y; Tobias, H.J.; Brenna, J.T. “Uniform Isotopic Standards for Gas Chromatography Combustion Isotope Ratio Mass Spectrometry of Steroids,” Recent Advances in Doping Analysis, 2008, 16, 171-180.

Tobias, H.J.; Sacks, G.L.; Zhang, Y.; Brenna, J.T. “Progress Towards Comprehensive 2D Gas Chromatography Combustion Isotope Ratio Mass Spectrometry (GCxGC),” Recent Advances in Doping Analysis, 2008, 16, 153-162.

Brenna, J.T.; Corso, T.N.; Tobias, H.J.; Caimi, R.J. “High-Precision Continuous-Flow Isotope Ratio Mass Spectrometry.” Mass Spectrometry Reviews, 1997, 16, 227-258.

Tobias, H.J.; Brenna, J.T. “On-Line Pyrolysis as a Limitless Reduction Source for Isotopic Analysis of Organic Derived Hydrogen.”

Analytical Chemistry, 1997, 69, 3148-3152.

Tobias, H.J.; Brenna, J.T. “High-Precision D/H Measurement from Organic Mixtures by Gas Chromatography Continuous-Flow Isotope Ratio Mass Spectrometry Using a Palladium Filter.” Analytical Chemistry, 1996, 68, 3002-3007.

Tobias, H.J.; Brenna, J.T. “Correction of Ion Source Nonlinearities over a Wide Signal Range in Continuous-Flow Isotope Ratio Mass Spectrometry of Water Derived Hydrogen.” Analytical Chemistry, 1996, 68, 2281-2286.

Tobias, H.J.; Goodman, K.J.; Blacken, C.E.; Brenna, J.T. “High-Precision D/H Measurement from Hydrogen Gas and Water by Continuous-Flow Isotope Mass Spectrometry” Analytical Chemistry, 1995, 67, 2486-2492.

PEER REVIEWED PUBLICATIONS (SUBTOPIC: ATMOSPHERIC & BIOLOGICAL AEROSOL ANALYSIS)

Park, H.J.; et.al. “Toward Unsupervised Single-Shot Diffractive Imaging of Heterogeneous Particles using X-ray Free-Electron Lasers.”

Optics Express, 2013, 21, 28729.

Pedersoli, E.; et.al. “Mesoscale Morphology of Airborne Core-shell Nanoparticle Clusters: X-ray Laser Coherent Diffraction Imaging.”

Journal of Physics B: Atomic, Molecular & Optical Physics, 2013, 46, 164033.

Loh, N.D.; et.al. “Sensing the Wavefront of X-ray Free-electron Lasers using Aerosol Spheres.” Optics Express, 2013, 21, 12385.

Loh, N.D.; et.al. “Fractal Morphology, Imaging and Spectrometry of Single Aerosol Particles in Flight.” Nature, 2012,486, 513-517.

McJimpsey, E.L.; Jackson, W.M.; Lebrilla, C.B.; Tobias, H.J.; Bogan, M.J.; Gard, E.E.; Frank, M.; Steele, P.T. "Parameters Contributing to Efficient Ion Generation in Aerosol MALDI Mass Spectrometry," Journal of the American Society for Mass Spectrometry, 2008, 19, 315-324.

Farquar, G.R.; Steele, P.T.; McJimpsey, E.L.; Lebrilla, C.B.; Tobias, H.J.; Gard, E.E.; Frank, M.; Coffee, K.; Riot, V.; Fergenson, D.P. “Supramicrometer particle shadowgraph imaging in the ionization region of a single particle aerosol mass spectrometer.” Journal of Aerosol Science, 2008, 39, 10-18.

Bogan, M.J.; Patton, E.; Srivastava, A.; Martin, S.; Fergenson, D.P.; Steele, P.T.; Tobias, H.J.; Gard, E.E.; Frank, M. “Online aerosol mass spectrometry of single micrometer-sized particles containing poly(ethylene glycol).” Rapid Communications in Mass Spectrometry, 2007, 21, 1214-1220.

Tobias, H.J., Pitesky, M.; Fergenson, D.P.; Steele, P.T.; Horn, J.; Frank, M.; Gard, E.E. ”Following the biochemical and morphological changes of Bacillus atrophaeus cells during the sporulation process using Bioaerosol Mass Spectrometry.” Journal of Microbiological Methods, 2006, 67, 56-63.

Ferge, T.; Karg, E.; Schroppel, A.; Coffee, K.R.; Tobias, H.J.; Frank, M.; Gard, E.E.; Zimmerman, R. “Fast Determination of the Relative Elemental and Organic Carbon Content of Aerosol Samples by Single-Particle Aerosol Time-of-Flight Mass Spectrometry.” Environmental Science and Technology, 2005, 40, 3327-3335.

Steele, P.T.; Srivastava, A.; Pitesky, M.E.; Fergenson, D.P.; Tobias, H.J.; Gard, E.E.; Frank, M. “Desorption/Ionization Fluence Thresholds and Improved Mass Spectral Consistency Measured Using a Flattop Laser Profile in the Bioaerosol Mass Spectrometry of Single Bacillus Endospores.” Analytical Chemistry, 2005, 77, 7448-7454.

Tobias, H.J., Schafer, M.P., Pitesky, M. Fergenson, D.P., Horn, J., Frank, M., Gard, E.E. ”Bioaerosol Mass Spectrometry (BAMS) for the Rapid Detection of Individual Airborne Mycobacterium tuberculosis H37Ra Particles.” Applied and Environmental Microbiology, 2005, 71, 6086-6095.

Srivastava, A., Pitesky, M., Steele, P.T., Tobias, H.J., Fergenson, D.P., Horn, J.M., Russell, S.C., Czerwieniec, G.A., Lebrilla, C.B., Gard, E.E. and Frank, M. “Comprehensive Assignment of Mass Spectral Signatures from Individual Bacillus atrophaeus Spores in Matrix-free Laser Desorption/Ionization Bioaerosol Mass Spectrometry.” Analytical Chemistry, 2005, 77, 3315-3323.

Czerwieniec, G., Russell, S., Tobias, H.J., Pitesky, M., Fergenson, D., Steele, P.T., Srivastava, A., Horn, J., Frank, M., Gard, E.E. Lebrilla, C. ”Stable Isotope Labeling of Entire Bacillus atrophaeus Spores and Vegetative Cells Using Bioaerosol Mass Spectrometry.” Analytical Chemistry, 2005, 77, 1081-1087.

Russell, S., Czerwieniec, G., Tobias, H.J., Fergenson, D., Steele, P.T., Pitesky, M., Horn, J., Srivastava, A., Frank, M., Gard, E.E. Lebrilla, C. ”Toward Understanding the Ionization of Biomarkers from Micrometer Particles by Bio-Aerosol Mass Spectrometry.” Journal of the American Society for Mass Spectrometry, 2004, 15, 900-909.

Fergenson, D., Pitesky, M., Tobias, H.J., Steele, P.T., et. al., E.E. ”Detection and Classification of Individual Bioaerosol Particles.”

Analytical Chemistry, 2004, 76, 373-378.

Sakurai, H., Tobias, H.J., Park, K., M., Zarling, D., Docherty, K.S., Kittelson, D.B., McMurry, P.H.,

Ziemann, P.J. ”On-Line Measurements of Diesel Nanoparticle Composition, Volatility, and Hydroscopicity.” Atmospheric Environment, 2003, 37, 1199-1210.

Steele, P.T., Tobias, H.J., Fergenson, D.P., Pitesky, M., Horn, J., Czerwieniec, G., Russell, S., Lebrilla, C., Frank, M., Gard, E.E. “Laser Power Dependence of Mass Signatures from Individual Bacterial Spores in Bioaerosol Mass Spectrometry.” Analytical Chemistry, 2003, 75, 2480-2487.

Chattopadhyay, S.; Tobias, H.J.; Ziemann, P.J. "A Method for Measuring Vapor Pressures of Low-Volatility Organic Aerosol Compounds Using a Thermal Desorption Particle Beam Mass Spectrometer." Analytical Chemistry. 2001, 73, 3797-3803.

Tobias, H.J.; Ziemann, P.J. "Kinetics of the Gas-Phase Reactions of Alcohols, Aldehydes, Carboxylic Acids, and Water with the C13 Stabilized Criegee Intermediate formed from Ozonolysis of 1-Tetradecene." Journal of Physical Chemistry A, 2001, 105, 6129-6135.

Tobias, H.J., Beving, D.E., Ziemann, P.J., Sakurai, H., Zuk, M., McMurry, P.H., Zarling, D., Waytulonis, R., Kittelson, D.B. “Chemical Analysis of Diesel Engine Nanoparticles Using a Nano-DMA/Thermal Desorption Particle Beam Mass Spectrometer.” Environmental Science and Technology, 2001, 35, 2233-2243.

Tobias, H.J; Docherty, K.S.; Beving, D.E.; Ziemann, P.J. “Effect of Relative Humidity on the Chemical Composition of Secondary Organic Aerosol Formed from Reactions of 1-Tetradecene and Ozone.” Environmental Science and Technology, 2000, 34, 2116- 2125.

Tobias, H.J; Ziemann, P.J. “Thermal Desorption Mass Spectrometric Analysis of Organic Aerosol Formed from Reactions of 1- Tetradecene and Ozone in the Presence of Alcohols and Carboxylic Acids.” Environmental Science and Technology, 2000, 34, 2105-2115.

Tobias, H.J.; Kooiman, P.M.; Docherty, K.S.; Ziemann, P.J. “Real-Time Chemical Analysis of Organic Aerosols Using a Thermal Desorption Particle Beam Mass Spectrometer.” Aerosol Science and Technology, 2000, 33, 170-190.

Tobias, H.J.; Ziemann, P.J. “Compound Identification in Organic Aerosols Using Temperature-Programmed Thermal Desorption Particle Beam Mass Spectrometry.” Analytical Chemistry, 1999, 71, 3428-3435.

BOOK CHAPTERS

Frank, M.; Gard, E.; J. Tobias, H.J.; et.al. “Single-Particle Aerosol Mass Spectrometry (SPAMS) for High-Throughput and Rapid Analysis of Biological Aerosols and Single Cells,” in Rapid Characterization of Microorganisms by Mass Spectrometry, Fenselau, C. (ed), ACS Symposium Series Vol. 1065; American Chemical Society: Washington, DC, 2011, Chapter 10, pp. 161-196. (Peer Reviewed Chapter).

Schaldach, C.M. ; deYoreo, J.J. ; Esposito, A. ; Fergenson, D.P. ; Gard, E. ; Hollars, C. ; Huser, Thomas; Lane, S.M. ; Malkin, A.J. ; Pitesky, M. ; Talley, C. ; Tobias, H.J. ; Woods, B. ; Bench, G. ; Grant, P. ; Kashgarian, M. ; Knezovich, J. ; Ferreira, J. ; Wu, K.-J.; Horn, J. ; Velsko, S.P. “Non-DNA Methods for Biological Signatures.” In Microbial Forensics. Breeze RG, Budowle B, Schutzer SE (Eds); Elsevier Academic Press, Burlington, 2005, pp. 262–295.

Brenna, J.T.; Tobias, H.J.; Corso, T.N. "High-Precision D/H Measurements from Organics and Position-Specific Carbon Isotope Analysis." in Stable Isotopes and the Integration of Biological, Ecological, and Geochemical Processes, Griffiths, H. (ed), Bios Scientific Publishers: Oxford, UK, 1998, Chapter 1, pp.1-12. ISBN: 1-85996-135-5.

ORAL PRESENTATIONS AT CONFERENCES

Tobias, H.J. “Advanced Detection of Steroids in Urine.” The 2019 Partnership for Clean Competition (PCC) Conference, London UK, April 16-18, 2019.

Tobias, H.J.; Zhang, Y.; Brenna, J.T. “Comprehensive Two Dimensional Gas Chromatography Coupled to IRMS: Considerations and Developments in Instrumentation and Analysis.” Joint European Stable Isotope Users Meeting, Leipzig Germany, Sept. 2-7, 2012.

Tobias, H.J.; Sacks, G.L.; Zhang, Y.; Brenna, J.T. “Coupling Comprehensive Two Dimensional Gas Chromatography to Isotope Ratio Mass Spectrometry.” Continuous Flow-Isotope Ratio M.S. Workshop, Ithaca NY, June 28-July 1, 2009.

Tobias, H.J., Pitesky, M.; Fergenson, D.P.; Horn, J.; Frank, M.; Gard, E.E. ”Following the biochemical and morphological changes of Bacillus atrophaeus cells during the sporulation process using Bioaerosol Mass Spectrometry.” ASMS Conference on Mass Spectrometry and Allied Topics, Seattle WA, May 28-June 1, 2006.

Tobias, H.J., Schafer, M.; Pitesky, M.; Fergenson, D.P.; Horn, J.; Frank, M.; Gard, E.E. ”Quantitative Evaluation of Bioaerosol Mass Spectrometry for the Real-Time Detection of Individual Airborne Mycobacterium tuberculosis H37Ra Particles.” ASMS Conference on Mass Spectrometry and Allied Topics, Nashville TN, May 23-27, 2004.

Tobias, H.J.; Docherty, K.S.; Beving, D.E.; Chattopadhyay, C.; Ziemann, P.J. “Relative Rates of the Aerosol Products Formed from the Ozonolysis of 1-Tetradecene in the Presence of Alcohols, Carboxylic Acids, and Water.” American Association for Aerosol Research 2000-19th Annual Conference. St. Louis, MO, Nov 6-10, 2000.

Tobias, H.J.; Beving, D.E., Ziemann, P.J., Sakurai, H., Zuk, M., McMurry, P.H., Zarling, D., Waytulonis, R., Kittelson, D.B. “Nano- DMA/Thermal-Desorption Particle-Beam Mass Spectrometric Analysis of Nanoparticles Produced in Diesel Exhaust.” 220th ACS National Meeting. Washington DC, Aug. 20-24, 2000.

Tobias, H.J.; Docherty, K.S.; Beving, D.E.; Ziemann, P.J. “Thermal Desorption Particle Beam Mass Spectrometry as a Novel Tool for Secondary Organic Aerosol Analysis.” The 48th ASMS Conference on Mass Spectrometry and Allied Topics. Long Beach, CA, June 11-15, 2000.

Tobias, H.J.; Ziemann, P.J. American Association for Aerosol Research 1999-18th Annual Conference. “Identification and Real-Time Quantitative Analysis of Secondary Organic Aerosol Using Thermal Desorption Particle Beam Mass Spectrometry.” Tacoma, WA, Oct. 12-15, 1999.

Tobias, H.J.; Docherty, K.S.; Beving, D.E.; Ziemann, P.J. “Smog Chamber Studies of the Chemistry of Secondary Organic Aerosol Formation.” 35th ACS Western Regional Meeting. Ontario, CA, Oct. 6-8, 1999.

Tobias, H.J.; Kooiman, P.M.; Docherty, K.S.; Ziemann,P.J. “Identification and Quantification of Organic Aerosol Composition Using Thermal Desorption Particle Beam Mass Spectrometry.” 16th Annual Symposium on Kinetic and Photochemical Processes in the Atmosphere. Los Angeles, CA, Feb. 18, 1999.

Tobias, H.J.; Brenna, J.T. "Hydrogen Isotopic Analysis of H2O and Organic Mixtures Using Compound-Specific Continuous-Flow Isotope Ratio Mass Spectrometry." The 3rd Canadian CF-IRMS Workshop. Saskatoon, SK, Sept. 9-11, 1996.

Tobias, H.J.; Brenna,J.T. "High-Precision D/H Measurement From Organic Mixtures By Continuous-Flow IRMS Using A Pd Filter." The 44th ASMS Conference on Mass Spectrometry and Allied Topics. Portland, OR, May 12-16, 1996.

Tobias, H.J.; Goodman, K.J.; Blacken, C.E.; Brenna, J.T. "High Precision D/H Measurements From H2 Gas and H20 By Continuous- Flow IRMS." 210th ACS National Meeting. Chicago, IL, Aug. 20-24, 1995.

Tobias, H.J.; Goodman, K.J.; Blacken, C.E.; Brenna, J.T. "High-Precision Continuous-Flow D/H Measurement from Hydrogen Gas and Water." Proceedings: The 43rd ASMS Conference on Mass Spectrometry and Allied Topics. Atlanta, GA, May 21-26, 1995 p.46.

OTHER PRESENTATIONS AT CONFERENCES (Co-Authored PRESENTATIONS & POSTERS)

Tobias, H.J.; Saunders, T; Jones, A.; Brenna, J.T. " Liquid Chromatography Coupled to IRMS for use with Organic Mobile Phases.” Forensics Isotope Ratio Mass Spectrometry, Virtual, Oct 5-7, 2022.

Tobias, H.J.; Saunders, T; Jones, A.; Brenna, J.T. "Rotating Catalytic Disc Laser Combustion Interface for (U)HPLC-Isotope Ratio Mass Spectrometry for Detection of Performance Enhancing Drugs.” AOAC International Annual Meeting & Exposition, Scottsdale AZ, Aug 27–Sept 1, 2022.

Tobias, H.J.; Jones, A.; Brenna, J.T. " Potential for Liquid Chromatography Coupled to Isotope Ratio Mass Spectrometry Expanded to Include Organic Mobile Phases.” 69th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia PA, Oct 31 – Nov 4, 2021.

Lacombe, S.; Jones, A.; Brenna, J.T.; Tobias, H.J. “Cryofocus fast GC-IRMS featuring low temperature catalytic combustion reactors reduces analytical runtime for anabolic steroid testing” Partnership for Clean Competition (PCC) Virtual Poster Session, May 19, 2021.

Lacombe, S.; Jones, A.; Brenna, J.T.; Tobias, H.J. “Cryo-focus Fast Gas Chromatography

Contact this candidate