Naseem Ahmed, M.Phil., Ph.D.

Foxboro, MA *****. Ph.: +1-774-***-**** (cell), Email: adzvgv@r.postjobfree.com

SUMMARY

** ***** ** **** ********** as a research scientist and educator with solid foundation working in Biology/Biotechnology

Scientist (basic and clinical research) with excellent communication skills willing to work independently and with a team

5 years of HPLC and FPLC systems and protein crystallization experience

Taught a broad range of healthcare/Biology courses

EDUCATION

Ph.D. (Biological Sciences/Biotechnology) University of Wales, UK 1995 – 1999

M.Phil. (Clinical Biochemistry) M.Sc. (Biochemistry) 1988

B.Sc. (Biochemistry/Chemistry /Microbiology) 1982

RESEARCH/TEACHING EXPERIENCE

Siemens Healthineers, Walpole, MA 01/2022 – 05/2023

Senior Biochemist Technical Operations (TO)

Collaborative work with Quality Control, Manufacturing and Microbiology Departments

Leader, Sartoflow Advanced antigen/antibody recycling project in the aseptic environment, instrument validation in the GMP and GLP environment. The project will save billions of dollars for the company in the near future

Cell culture, protein purification and validation of purity

Expression of viral receptor protein molecules in CHO cells, E. coli and yeast cells. If the virus will not bind with the receptor molecules will not enter in the cell and multiply will be treatment of viral disease.

Actively involved in preparation of Installation Qualification (IQ), Operational Qualification (OQ), Performance Qualification (PQ) documents and Bioburden evaluation for FDA approval

Protein purification and validation of purity

Performing Immunoassays on Siemens’ cutting-edge Chemistry and Immunoassay Systems

Worked on application of Azure DevOps, SAP, ELN, TDMS, Documentum, Minitab, and Statistical Process Control/SCOPE

Evaluated product quality by analyzing purification reports, reviewing the nonconformances and solving problems related to product quality

Did product evaluation tools “SCOPE Alert Charts”, Lot to Lot variation analysis, QC analysis data collection, TO analysis from analytical clinical chemistry/immunology instruments (Centaur XP, CP, XPT and AIM) with patient’s specimens MDPs, Commercial controls and standards

Did trouble shooting and problem solving for developing and manufacturing organic synthetic compounds used as a raw material in the development of laboratory diagnostics assays reagents

Part of the team react and respond to CAPA (Corrective and Preventive Action) and NC (Non-Conformance) determinations as needed

Writing QNs and SCRAP QNs

Immunotrex Biologics Inc., Tyngsborough, MA 01/2017 –12/2018

Senior Scientific Consultant

Designed and interpreting preclinical and clinical pharmacology studies to bring the drugs from bench to bedside

Strategic planning of In vivo/In vitro experiments

Reviewed old SOPs and developed new SOPs to test new investigational drug molecules

Cell culture and apoptotic/toxicology assays development to test the efficacy of new investigational anticancer drugs

The development cancer therapeutics by targeting cancer cells and their ability to proliferate. The ribosome is the site of protein production within the cell and it is vital organelle for cellular survival

Ribosomal complexes form in response to the presence of mRNA and translates into proteins via ribosomal complexes. The approach was to inhibit the tRNA and the ribosomes within cancer cells.

Fisher College, Boston, MA 01/2011 –12/2017

Part Time Teaching Faculty

Taught Undergraduate Science lecture and lab courses

Capable to manage Zoom full online and hybrid courses

Roger Williams Medical Center, Providence, RI 01/2010 –12/2011

Associate Research Scientist

Developed genetically modified therapeutic T cells for the treatment of Gastrointestinal stromal tumor

Human blood and mouse spleen T cell isolation

Tumor and T cell culture (mouse and human) and transduction

Cell proliferation assay, Cytotoxicity, ELISA (Direct, Indirect, Competitive and Sandwich), MTT assay, Cytometric bead array (CBA)

IP injections of therapeutic monoclonal antibodies

Albert Einstein College of Medicine, Bronx, NY 06/2006 –01/2010

Research Scientist

Discovery of new diagnostic and therapeutic markers (oncogenic proteins)

DNA/RNA purification by Phenol Chloroform. Plasmid DNA extraction by Miniprep and Maxiprep

Transfection of cells with desired plasmid construct(s)

RNA and protein extraction from human and mouse tissue and cell lines (Trizol, RNeasy)

PCR, Gradient PCR, Gill Bates mutant Assay and WT Assay for Knock-in Mice, qPCR (Sybr Green), Enzyme assays (Alkaline phosphatase), Western blot

Probe preparation for Affymetrix and Nimblegen micro array analysis

FACS analysis (PI staining and cell cycle analysis)

Immunohistochemistry (paraffin embedded and frozen sections)

Archival RNA extraction from archival formalin-fixed tissue

High-Throughput Tissue Microarray was developed and analyzed human biopsy sections

Mouse handling, coding, genotyping and sacrifice, Mouse injection for Brdu incorporation

sequencing method

SELECTED RESEARCH PUBLICATIONS

https://www.ncbi.nlm.nih.gov/pubmed/?term=Ahmed+N+Mariadason+JM

https://www.ncbi.nlm.nih.gov/pubmed/?term=Ahmed+N++Morris+Ge

https://pubmed.ncbi.nlm.nih.gov/21697460/

Nephrology and urology patients’ research publications are not included in the list

RELEVANT PROFESSIONAL TRAININGS

Completed extensive manufacturing, quality control and biostatistical analysis trainings 2022

Completed Sartoflow Advanced Sartorius Experts’ Onsite Trainings 2022

Completed Environmentally Controlled Spaces 2023

Completed Quality Notification Course 2023

ADDITIONAL PROFESSIONAL TRAININGS

Excel basic and Excel advanced 2022

Minitab I and Minitab II Statistical Data Analysis 2022

Statistical Process Control/SCOPE 2022

SOFWARE SKILLS

MS office ELN/Electronic notebook

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