Elias Georges Karroum M.D. Ph.D.

Date of birth: *1 / 18 / 1980

Place of birth: Beirut, Lebanon

Nationality: Lebanese

Emails:

adze7u@r.postjobfree.com

adze7u@r.postjobfree.com

adze7u@r.postjobfree.com

Tel: 202-***-****

Fax: 202-***-****

Office Address: 2150 Pennsylvania Ave, NW 9th Floor, Washington, DC 20037 Professional Positions

Associate Professor of Neurology, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA. July 2022-present.

Assistant Professor of Neurology, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA. September 2017-June 2022. Associate Program Director of the Sleep Medicine Fellowship, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA. September 2017-present. Medical Staff, Department of Neurology & Rehabilitation Medicine, The George Washington Medical Faculty Associates, Washington DC, USA. September 2017- present.

Medical Staff, Department of Neurology & Rehabilitation Medicine, The George Washington University Hospital, Washington DC, USA. September 2017-present. Post-Graduate Training

Fellowship in Clinical Neurophysiology, Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; graduated and certificate issued in June 2017.

Fellowship in Sleep Medicine, Emory Sleep Center, Emory University School of Medicine, Atlanta, Georgia, USA; graduated and certificate issued in June 2016. Residency in Neurology, Department of Neurology, Southern Illinois University, School of Medicine, Springfield, Illinois, USA; graduated and certificate issued in June 2015.

Internship/Preliminary Year in Internal Medicine, Department of Internal Medicine, Southern Illinois University, School of Medicine, Springfield, Illinois, USA; graduated and certificate issued in June 2012.

Educational Background

University Diploma in the History of Medicine, University of Paris (Université de Paris; currently Paris Cité University, Université Paris Cité), Paris, France; certificate issued in December 2021.

Ph.D. in Neurosciences, Pierre and Marie Curie University (UPMC or Paris 6; currently Sorbonne University), Paris, France; thesis defended in June 2011, and diploma issued in March 2012.

M.Sc. in Cognitive and Behavioral Neurosciences, Pierre and Marie Curie University

(UPMC or Paris 6; currently Sorbonne University), Paris, France; dissertation defended in June 2007, and diploma issued in February 2008. Inter-University Diploma in Neuroanatomy and Neuroimaging, Pierre and Marie Curie University (UPMC or Paris 6; currently Sorbonne University), Paris, France; certificate issued in September 2007.

M.D., Faculty of Medicine (FM), Saint-Joseph University (USJ), Beirut, Lebanon; thesis defended, and diploma issued in July 2005.

Master’s degree in Biological and Medical Sciences, Faculty of Medicine (FM), Saint- Joseph University (USJ), Beirut, Lebanon; diploma issued in November 2004. Certificate in Biostatistics and Epidemiology, Faculty of Medicine (FM), Saint-Joseph University (USJ), Beirut, Lebanon; certificate issued in July 2003. Certificate in Immunology, Faculty of Medicine (FM), Saint-Joseph University (USJ), Beirut, Lebanon; certificate issued in July 2001.

Certificate in Genetics, Faculty of Medicine (FM), Saint-Joseph University (USJ), Beirut, Lebanon; certificate issued in July 2001.

Lebanese Scientific Baccalaureate in Experimental Sciences; diploma issued in 1998. French Scientific Baccalaureate in Life and Earth Sciences; diploma issued in 1998. Honors

Summa cum laude, Ph.D. Thesis; June 2011.

Magna cum laude, M.Sc.; February 2008.

Magna cum laude, Lebanese Scientific Baccalaureate; 1998. Cum laude, French Scientific Baccalaureate; 1998.

Awards

American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Residency and Fellowship Member Award, 200 $ awarded for the work “Is Corticosteroid Treatment Associated with Sleep Related Breathing Disorders in Duchenne Muscular Dystrophy? A Preliminary Study” presented at the 63 nd

annual

meeting of the AANEM; New Orleans, Louisiana, USA. September 14-17, 2016. Wayne Hening Young Investigator Award, 1000 $ awarded for the work on the

“Genetic Characterization of the Painful Restless Legs Phenotype” presented at the annual meeting of the International Restless Legs Syndrome Study Group; Denver, Colorado, USA. June 12, 2016.

Second Prize M.D. Thesis Award, 500 $ awarded for the thesis on the “Congenital insensitivity to pain. General review. A study of a Lebanese family” presented to obtain the M.D. diploma at the Faculty of Medicine (FM), Saint-Joseph University (USJ); Beirut, Lebanon. July 2005.

Medical Licensing

Medical Board Maryland License, State of Maryland, Department of Health, Maryland Board of Physicians; issued on 04/15/2022; expires on 09/30/2024; License number: D0094036.

Medical Board Virginia License, Virginia Department of Health Professions, Board of Medicine; issued on 03/11/2022; expires on 11/30/2024; License number: 010*******. Medical Board DC License, DC Department of Health, Board of Medicine; issued on 06/15/2017; expires on 12/31/2024; License number: MD045226. Medical Board Illinois License, Illinois Department of Financial and Professional Regulation (IDFPR); issued on 05/20/2015; expired on 07/31/2017; License number: 036138042.

General Medicine License, Lebanese Order of Physicians-Beirut, Lebanon; issued on 03/01/2006; no expiration date; License number: 388/K. Medical Certifications and Examinations

Sleep Medicine Certification, American Board of Psychiatry and Neurology; passed and certified on 11/20/2017; Certificate number: 1544. Clinical Neurophysiology Certification, American Board of Psychiatry and Neurology; passed and certified on 10/16/2017; Certificate number: 2915. Neurology Certification, American Board of Psychiatry and Neurology; passed and certified on 09/14/2015; Certificate number: 59509. Step 3 final examination, United States Medical Licensing Examination (USMLE); passed on 12/21/2012.

Educational Commission for Foreign medical graduates (ECFMG) Certification for passing required examinations (Medical Science: USMLE Step 1, passed on 08/03/2009 and USMLE step 2 CK, passed on 12/17/2007; Clinical Skills: USMLE Step 2 CS, passed on 04/28/2010); issued on 06/28/2010. Clinical Experiences

Neurologist and Sleep Specialist: Sleep Disorders Clinic (two and a half to three full days per week); Sleep Studies (Diagnostic PSG; PAP Titration PSG; Home Sleep Apnea Testing, HST; Multiple Sleep Latency Test, MSLT) reading and interpretation

(one full day per week); General Neurology Clinic (One half day per month covering resident clinic; 2017-2020); Academic, Teaching, and administrative time (one to one and a half day per week); Outpatient EEG reading and interpretation (two weeks every six months; 2017-2020); and Inpatient Neurology Service coverage (Two weekends every twelve months; 2017-2020); Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, The George Washington Medical Faculty Associates, and The George Washington University Hospital, Washington DC, USA; September 2017-current. Clinical Neurophysiology Fellowship: Adult Epilepsy Monitoring Unit fourteen weeks; Adult Epilepsy Clinic eight weeks; Adult Inpatient and Outpatient EEG and Evoked potentials reading four weeks; Intraoperative Monitoring (IOM) three weeks; EMG/NCS intermixed with Neuromuscular Clinic every week for fifteen weeks; Pediatric Epilepsy Monitoring Unit (including one half day Epilepsy Clinic per week) four weeks; and Pediatric Inpatient and Outpatient EEG reading four weeks; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; July 2016-June 2017.

Sleep Medicine Fellowship: Adult Sleep Medicine eight months; Pediatric Sleep Medicine four months; Specialized and General Sleep Outpatient Clinics (two to four half days per week); Continuity Outpatient Sleep Clinic (one full day per week); and Sleep Studies Scoring and/or Interpretation (two to four half days per week); Emory Sleep Center, Emory University School of Medicine, Children's Healthcare of Atlanta, and Atlanta VA Medical Center and Clinic, Atlanta, Georgia, USA; July 2015-June 2016.

Chief Resident, Neurology Residency (Third year): General Neurology six months; Neurophysiology two months; Pediatric Neurology two months; Outpatient Sub- Specialty Clinics one month; Neuroradiology one month; and Outpatient Continuity Clinic (one half day per week); Southern Illinois University, School of Medicine, St. John’s Hopsital, and Memorial Medical Center, Springfield, Illinois, USA; June 2014- June 2015.

Sleep Medicine Elective Rotation, Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA; May 2014. Neurology Residency (Second year): Stroke one month; General Neurology two months; Night float two months; Neuropathology two weeks; Neuro-ophthalmology two weeks; Neurophysiology one month; Pediatric Neurology one month; Neuro- rehabilitation one month; Neurosurgery one month; External Sleep Medicine Elective one month; Research one month; and Outpatient Continuity and Sub-specialty Clinics

(one half day each per week); Southern Illinois University, School of Medicine, St. John’s Hopsital, and Memorial Medical Center, Springfield, Illinois, USA; June 2013- June 2014.

Neurology Residency (First year): Stroke three months; General Neurology three months; Night float three months; Neuroradiology one month; Neuropathology one month; Psychiatry one month; and Outpatient Continuity and Sub-specialty Clinics

(one half day each per week); Southern Illinois University, School of Medicine, St. John’s Hopsital, and Memorial Medical Center, Springfield, Illinois, USA; June 2012- June 2013.

Internal Medicine Internship (Preliminary year): General Internal Medicine three months; Intensive Care Medicine one month; Infectious Diseases one month; Neurology one month; Pulmonary one month; Gastroenterology one month; Medicine- Psychiatry one month; Emergency Medicine one month; Nephrology one month; and Hematology-Oncology one month; Southern Illinois University, School of Medicine, St. John’s Hopsital, and Memorial Medical Center, Springfield, Illinois, USA; June 2011-June 2012.

Sleep Disorders Observership, Sleep Health Centers, Brigham & Women’s Hospital, Division of Sleep Medicine, Harvard Medical School, Brighton, Massachusetts, USA; March 2010.

Movement Disorders Observership, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine (BCM), Houston, Texas, USA; August 2008.

Epilepsy Internship, Epilepsy Unit, Paul Castaigne Clinic, Pitié-Salpêtrière Hospital, Paris, France; July-August 2005.

Medicine and Surgery Internship: General Surgery two months; Emergency Medicine one month; Intensive Care Medicine one month; and General Internal Medicine two months; Bhannes Medical Center, Dahr el Sawan, North Metn, Lebanon; January-June 2005.

Medicine and Surgery Internship: Pulmonary one month; Intensive Care Medicine one month; Neurology one month; Cardiology one month; and Cardiac Intensive Care Unit one month; Hôtel-Dieu de France Hospital, Beirut, Lebanon; August-December 2004.

Medicine Internship, Ain Wazein Hospital, Ain Wazein, Chouf region, Lebanon; July 2004.

Medicine and Surgery Clerkship: General Surgery two months and Emergency Medicine two months; Hôtel-Dieu de France Hospital, Beirut, Lebanon; March-June 2004.

Neurosurgery Clerkship: Neurosurgery Department, Sainte-Anne Hospital, Paris, France; February 2004.

Medicine and Surgery Clerkship: Rheumatology two months; Nephrology two months; Neurology one month; Neurosurgery one month; and Ophthalmology one month; Hôtel-Dieu de France Hospital, Beirut, Lebanon; July 2003-January 2004. Research Experiences

Supervising research as a mentor

Prevalence and impact of muscle cramps in patients affected by the restless legs syndrome, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA; July 2020-current. Research Supervisor/Mentor for:

- Khaled Albazli M.D. (neurology chief resident 2020-2021). Characterization of Sleep disorders (particularly restless legs syndrome and sleep apnea) in Myasthenia Gravis patients, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA; July 2019-current. Research Supervisor/Mentor for:

-Kellen Mulhern D.O. (sleep fellow 2019-2020).

-Mohanad AlGaeed M.D. (neurology chief resident 2019-2020).

-Sahira Sekhon M.D. (sleep fellow 2021-2022).

Gender differences and gaps in sleep medicine and sleep research scholarship

(authorships, recognition awards, academic sleep medicine, etc.), Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA; July 2018-current. Research Supervisor/Mentor for: -Karina M. Jordan M.D. (sleep fellows 2018-2019).

-Hwan D. Kim M.D. (sleep fellows 2018-2019).

-Samira Naime M.D. (sleep fellow 2019-2020).

-Jeremy S. Landeo Gutierrez M.D. (sleep fellow 2020-2021). Education research on the evaluation of Adult Neurology Residency Program and Sleep Fellowship Program Websites contents, Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA; July 2020-February 2023. Research Supervisor/Mentor for:

-David Daniel M.D. (fourth year medical student 2020).

-Cayla Vila M.D. (fourth year medical student 2020).

-Shanti Shenoy M.D. (sleep fellow 2020-2021).

-Wahida Akberzie M.D. (sleep fellow 2020-2021).

-Jeremy S. Landeo Gutierrez M.D. (sleep fellow 2020-2021). Supervised research as a mentee

Fundamental research

Thermographical, pharmacological and behavioral study of the interaction between nociception and thermoregulation in the anesthetized rat, INSERM Unit U713, Pierre and Marie Curie faculty of medicine, Paris, France; September 2006-July 2007. Supervisor: Dr. Daniel Le Bars D.VM. D.Sc.

Clinical research

Genetic characterization of the painful form of the restless legs syndrome, Emory Sleep Center, Emory University School of Medicine, Atlanta, Georgia, USA; July 2015-June 2016. Supervisor: Pr. David B. Rye M.D. Ph.D. Periodic leg movements in Parkinson disease with and without restless legs, Emory Sleep Center, Emory University School of Medicine, Atlanta, Georgia, USA; July 2015-June 2016. Supervisor: Pr. Donald L Bliwise Ph.D. Predictors of sleep disordered breathing in Duchenne Muscular Dystrophy, Emory Sleep Center, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, Georgia, USA; July 2015-June 2016. Supervisor: Dr. Han C. Phan M.D.

Sleep objective measures in the painful form of the restless legs syndrome, Sleep Disorders Center, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA; May 2014, and Southern Illinois University, School of Medicine, Department of Neurology, Springfield, Illinois, USA; June 2014. Supervisor: Pr. Richard P. Allen Ph.D.

Characterization of the sensations and pain in the restless legs syndrome, Sleep Disorders Unit, Pitié-Salpêtrière University Hospital, Paris, France; October 2007- March 2011. Supervisor: Pr. Isabelle Arnulf M.D. Ph.D. Congenital insensitivity to pain in a Lebanese family, Faculty of Medicine, Saint- Joseph University, Beirut, Lebanon; July 2004-June 2005. Supervisor: Pr. Salam Koussa M.D.

Clinical trials (Participated as Sub-investigator July 2016-June 2017) Protocol N01199. An open-label, multicenter, follow-up trial to evaluate the long-term safety and efficacy of brivaracetam used as adjunctive treatment at a flexible dose up to a maximum of 100 mg/day in subjects aged 16 years or older suffering from epilepsy. NCT00175916, Principal Investigator: Pr. Bassel Abou-Khalil M.D., Sponsor: UCB Biosciences.

Protocol #P261-401. A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intranasal Midazolam (USL261) in the Outpatient Treatment of Subjects with Seizure Clusters. NCT01390220, Principal Investigator: Pr. Bassel Abou- Khalil M.D., Sponsor: Upsher Smith Laboratories.

Protocol #P261-402. An Open-Label Safety Study of USL261 in the Outpatient Treatment of Subjects with Seizure Clusters. NCT01529034, Principal Investigator: Pr. Bassel Abou-Khalil M.D., Sponsor: Upsher Smith Laboratories. Protocol N01379. An Open-Label, Multicenter, Follow-up Study to Evaluate the Long- Term Safety and Efficacy of Brivaracetam Used as Adjunctive Treatment in Subjects Aged 16 Years or Older with Partial Onset Seizures. NCT01339559, Principal Investigator: Kevin F. Haas, M.D. Ph.D., Sponsor: UCB Biosciences. Protocol YKP3089C017. A Multicenter, Double-Blind, Randomized, Placebo- Controlled, Dose-Response Trial of YKP3089 as Adjunctive Therapy in Subjects with Partial Onset Seizures with Optional Opel-Label Extension. NCT01866111, Principal Investigator: Pr. Bassel Abou-Khalil M.D., Sponsor: SK Life Science. Protocol YKP3089C021. An Open Label, Multicenter, Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects with Partial Onset Seizures. NCT02535091, Principal Investigator: Pr. Bassel Abou-Khalil M.D., Sponsor: SK Life Science.

Research Grants

Research Grant of 30000 € in 2007 from the French Restless Legs Syndrome Association (Association Française des personnes affectées par le Syndrome des Jambes sans Repos: AFSJR ; renamed Association France Ekbom : AFE). Educational Grants and Scholarships to attend meetings and workshops The 10th annual American Academy of Sleep Medicine (AASM) Young Investigators Research Forum (YIRF); Bethesda, Maryland, USA; April 18-20, 2018. Scholarship to attend the International RLS Study Group (IRLSSG) and European RLS Study Group (EU-RLSSG) 2015 RLS/WED Science Summit; Pacific Grove, CA, USA. October 22-26, 2015.

Resident Scholarship of 1000 $ to attend the 67

th

American Academy of Neurology

(AAN) Annual Meeting; Washington, DC, USA; April 18-25, 2015. Educational Grant to attend the Treatment of Dystonia & Spasticity: Residency Training Workshop Demonstrating the Use of Botulinum Toxin at Rush University Medical Center; Chicago, Illinois, USA; June 1, 2013. Resident Scholarship of 500 $ to attend the 6

th

Annual Focus on Common Movement

Disorders course at Vanderbilt University Medical Center; Nashville, Tennessee, USA; September 28-30, 2012.

European Sleep Research Society (ESRS)-European Union (EU) “Marie Curie” Project to attend the “Training in Sleep Research and Sleep Medicine” with three consecutive modules: 1. Training Course at the Residential Centre of the University of Bologna; Bertinoro, Italy; April 25-27, 2008; 2. Practical Training Period at the Sleep and Wake Disorders Center, Department of Neurology, University Hospital; Zürich, Switzerland; June 23-28, 2008; and 3. Final Symposium at the Kultur und Bildungszentrum des Bezirks Oberbayern; Kloster Seeon, Germany; July 2-6, 2010. Reviewer for Scientific Journals, Meetings Abstracts, Fellowships Applications, and Grants

Clinical Neurology and Neurosurgery (2013).

International Journal of Neuroscience (2012).

Journal of Clinical Sleep Medicine (2015-2022).

Scandinavian Journal of Pain (2018-2020)

Sleep Medicine (2013-2015, 2017-2018, 2020-2021).

Sleep (2015-2016)

Reviewer of Abstracts for SLEEP 2020, the 34th annual meeting of the Associated Professional Sleep Societies.

Reviewer of Abstracts for SLEEP 2021, the 35th annual meeting of the Associated Professional Sleep Societies.

Reviewer of Abstracts for SLEEP 2022, the 36th annual meeting of the Associated Professional Sleep Societies.

Reviewer of Abstracts for SLEEP 2023, the 37th annual meeting of the Associated Professional Sleep Societies.

Reviewer of Abstracts for ANA 2022, the 147th annual meeting of the American Neurological Association.

Reviewer of Abstracts for ANA 2023, the 148th annual meeting of the American Neurological Association.

W.T. Gill Summer Fellowship Student Application for 2020. To support select summer research internship opportunities for first year medical students at The George Washington University, Children’s National Health System, and the Washington DC Veteran’s Affairs Medical Center; Washington, DC, USA. External Expert grant reviewer in 2022 for the “Programme Hospitalier de Recherche Clinique National (PHRC)”, financed by the “Ministère des Solidarités et de la Santé”

(Ministry of Solidarites and Health); Paris, France. Reviewer for the RLS Foundation Research Grant Application for 2022 and 2023. Serving as a member of the Research Grant Committee and the Scientific and medical advisory board of the RLS Foundation.

Publications

Scientific Journal Articles

1. Shenoy S, Akberzie W, Landeo-Gutierrez JS, Leon Guerrero CR, Karroum EG. Evaluation of Sleep Medicine Fellowship Program Websites. J Clin Sleep Med. 2023 (In Press). Cited in PubMed; PMID: 36747495

2. Costa J, Lakkis R, Sleilaty G, Karroum EG, El Helou J. Validation of an Arabic version of the Cambridge-Hopkins diagnostic questionnaire for restless legs syndrome. Sleep Breath. 2022 (In Press). Cited in PubMed; PMID: 36208386. 3. Walters AS, Li Y, Karroum EG, Champion D, Weinstock LB, Bagai K, Afrin LB, Spruyt K. Exploring the role of the endogenous opiate system in the pathogenesis of anemia in an opiate receptor knock-out model of Restless Legs Syndrome. Medical Hypothesis. 2022 Oct; 167:110941. Cited in PubMed; PMID: 36505961 4. Bliwise DL, Karroum EG, Greer SA, Factor SA, Trotti LM. Restless Legs Symptoms and Periodic Leg Movements in Sleep Among Patients with Parkinson's Disease. J Parkinsons Dis. 2022; 12 (4): 1339-1344. Cited in PubMed; PMID: 35311713.

5. Karroum EG. Trivialization of the restless legs syndrome during the “belle époque”. Sleep Med. 2021; 88: 169-170. Cited in PubMed; PMID: 34768131. 6. Naime S, Karroum EG. Women Are Underrepresented in Major US Sleep Societies Recognition Awards. J Clin Sleep Med. 2021; 17(8):1665–1673. Cited in PubMed; PMID: 33783346.

7. Daniel D, Vila C, Leon Guerrero CR, Karroum EG. Evaluation of Adult Neurology Residency Program Websites. Ann Neurol. 2021; 89(4): 637-642. Cited in PubMed; PMID: 33421179.

8. Karroum EG, Saini PS, Trotti LM, Rye DB. TOX3 gene variant could be associated with painful restless legs. Sleep Med. 2020; 65(1): 4-7. Cited in PubMed; PMID: 31706190.

9. Karroum EG. Painful Willis-Ekbom disease: unbearable and distinct form of restless legs? Scand J Pain. 2019; 19(3): 429-431. Cited in PubMed; PMID: 31256071.

10. El Bitar N, Pollin B, Karroum EG, Pincedé I, Le Bars D. Entanglement between Thermoregulation and Nociception in the rat: The case of Morphine. J Neurophysiol. 2016; 116(6): 2473-2496. Cited in PubMed; PMID: 27605533. 11. Trotti LM, Karroum EG. Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases. Curr Neurol Neurosci Rep. 2016; 16(7): 63. Cited in PubMed; PMID: 27180068.

12. Karroum EG, Phan HC, Torrez DM, Trotti LM. Perfect periodicity: to be or not to be periodic leg movements. J Clin Sleep Med. 2016; 12(3): 452-455. Cited in PubMed; PMID: 26857061.

13. Karroum EG, Arnulf I. Characterization of the painful restless legs syndrome. Sleep Med. 2015; 16 (7): 897. Cited in PubMed; PMID: 26002759. 14. Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I. Painful Restless Legs Syndrome: a Severe, Burning Form of the Disease. Clin J Pain. 2015; 31(5): 459- 466. Cited in PubMed; PMID: 25167326.

15. El Bitar N, Pollin B, Karroum E, Pincedé I, Mouraux A, Le Bars D. Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain. J Neurophysiol. 2014; 112(9): 2185-2198. Cited in PubMed; PMID: 25008410. 16. Karroum EG, Leu-Semenescu S, Arnulf I. Topography of the sensations in primary restless legs syndrome. J Neurol Sci. 2012; 320(1-2): 26-31. Cited in PubMed; PMID: 22704032.

17. Karroum EG, Golmard JL, Leu-Semenescu S, Arnulf I. Sensations in restless legs syndrome. Sleep Med. 2012; 13(4): 402-408. Cited in PubMed; PMID: 22296915. 18. Karroum EG, Raux M, Riou B, Arnulf I. [Acute exacerbation of restless legs syndrome during perioperative procedures: Case-reports and suggested management] (In French). Ann Fr Anesth Reanim. 2010; 29(12): 920-924. Cited in PubMed; PMID: 21112730.

19. Raux M, Karroum EG, Arnulf I. Case scenario: anesthetic implications of restless legs syndrome. Anesthesiology. 2010; 112(6): 1511-1517. Cited in PubMed; PMID: 20463578.

20. Limousin N, Konofal E,

Karroum E, Lohmann E, Theodorou I, Dürr A, Arnulf I. Rapid Eye Movement Sleep Behavior Disorder, Hypersomnia and Restless Legs Syndrome in Patients with Parkin Mutation. Mov Disord. 2009; 24(13): 1970-1976. Cited in PubMed; PMID: 19672985.

21. Leu-Semenescu S, Karroum E, Brion A, Konofal E, Arnulf I. Dopamine dysregulation syndrome in a patient with restless legs syndrome. Sleep Med. 2009; 10(4): 494-496. Cited in PubMed; PMID: 19410183.

22. Karroum E, Konofal E, Arnulf I. Karl-Axel Ekbom (1907-1977). J Neurol. 2009; 256(4): 683-684. Cited in PubMed; PMID: 19280107.

23. Konofal E, Karroum E, Montplaisir J, Derenne JP, Arnulf I. Two early descriptions of restless legs syndrome and periodic leg movements by Boissier de Sauvages

(1763) and Gilles de la Tourette (1898). Sleep Med. 2009; 10(5): 586-591. Cited in PubMed; PMID: 18752999.

24. Karroum E, Konofal E, Arnulf I. [Restless-legs syndrome]. Rev Neurol (Paris). 2008; 164(8-9): 701-721 (In French). Cited in PubMed; PMID: 18656214. Scientific Monographs

1. Karroum EG. Pioneers in the Restless Legs Syndrome. A Historical Overview from Willis to Ekbom. Certificate in History of Medicine Dissertation; University of Paris, Paris; September 2021 (134 p.)

2. Karroum E. [Study of the sensory component in restless legs syndrome]. Doctor of Science (Ph.D.) Thesis; Pierre and Marie Curie University (UPMC, Paris 6), Paris; June 2011 (277 p.). (In French).

3. Karroum E. [Influence of thermoregulation on nociception: a preliminary study in the anesthetized rat]. Master of Science (M.Sc.) Dissertation; Pierre and Marie Curie University (UPMC, Paris 6), Paris; June 2007 (19 p.). (In French). 4. Karroum E. [Congenital insensitivity to pain. General review. A study of a Lebanese family]. Doctor of Medicine (M.D.) Thesis; Saint-Joseph University, Beirut; June 2005 (167 p.). (In French).

Regional, National, and International Scientific Presentations & Lectures Poster Presentations

1. Albazli K, Walters AS, Karroum EG. Prevalence and Impact of Muscle Cramps in Patients with Restless Legs. 36th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS); Charlotte, North Carolina, USA. June 4-8, 2022. Abstract published in Sleep. 2022; 45 (Abstract Supplement): A242. 2. Maniar N, Walters AS, Karroum EG. A Case of Familial Restless Legs Syndrome and Raynaud's Phenomenon. 36th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS); Charlotte, North Carolina, USA. June 4-8, 2022. Abstract published in Sleep. 2022; 45 (Abstract Supplement): A356-A357. 3. Shenoy S, Akberzie W, Landeo Gutierrez JS, Leon Guerrero CR, Karroum EG. Evaluation of Sleep Medicine Fellowship Program Websites. 36th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS); Charlotte, North Carolina, USA. June 4-8, 2022. Abstract published in Sleep. 2022; 45 (Abstract Supplement): A164-A165.

4. Champion D, Bui M, Aouad, Teng A, Walters A, Karroum EG, Jaaniste T, Hopper J. Restless legs syndrome is associated with multiple pain disorders in four studies in children and adults. Australian Pain Society 42nd Annual Scientific Meeting; Hobart, Tasmania, Australia. April 10-13, 2022.

5. Champion D, Bui M, Ng G, Aoaud, Curry-Hyde A, Teng A, Walters A, Karroum EG, Jaaniste T, Hopper J. A history of iron deficiency is associated with primary and chronic pain disorders in children and adolescents, and in adults. 13th International Symposium on Pediatric Pain; Virtual meeting, Auckland, New Zealand, March 24-27, 2022.

6. Shenoy S, Chen H, Karroum E. Ictal Central Apneic Events Detected on Polysomnogram: An Educational Case Report. 35th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS); Virtual meeting, USA. June 10-13, 2021. Abstract published in Sleep. 2021; 44 (Abstract Supplement): A325. This work was also accepted as an oral presentation at the above meeting (presented by Shenoy S) in the Oral Presentation Session: Trainee Challenging Cases. 7. AlGaeed M, McPherson T, Lee I, Feese M, Aban I, Cutter G, Kaminski H, Karroum E. Prevalence and Impact of Restless Legs in Patients with Myasthenia Gravis. 35th Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS); Virtual meeting, USA. June 10-13, 2021. Abstract published in Sleep. 2021; 44

(Abstract Supplement): A205-A206. This work was also accepted as an oral presentation at the above meeting (presented by AlGaeed M) in Oral Presentation Session: O-21: New Paradigms in RBD and RLS.

8. Naime S, Karroum EG. Women are underrepresented in major US sleep societies recognition awards. 34th Meeting of the Associated Professional Sleep Societies, LCC; Virtual meeting, USA. August 27-30, 2020. Abstract published in Sleep. 2020; 43 (Abstract Supplement): A138.

9. Karroum EG, Leu-Semenescu S, Amdur R, Arnulf I. “Uncovering my feet alleviates my restless legs”: impact of different activities and conditions on restless legs symptoms. 34th Meeting of the Associated Professional Sleep Societies, LCC;

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