Dr. INDU BALA KOUL

#FF-***, First floor, Ittina Neela, Near Gold Coin Club Road, Electronic city phase II, Bangalore, Karnataka-560100, India

Contact No.: 096******** E-Mail: adz20f@r.postjobfree.com Doctorate in Biochemistry with extensive research experience in vitro and in vivo systems

• Experience of working on animals (in vivo) for >5 yrs and Cell based and cell free systems

(in vitro) for >10 yrs.

• Experienced in method development, standardization, validation

• Preliminary screening primary screening of test compounds for therapeutic activities

• Experience of working in ISO/NABL accredited laboratory. HONOURS AND AWARDS RECEIVED

• Young Scientist Award from the Scientist & Technology Department for significant contribution in the field of Medical Sciences; 1994

• Gold medal for obtaining first class first in B.Sc. Final (1982).

• Dr. Ghulam Mohi-ud-din Falahi-Aam Prize of being Best Female Graduate of the year 1982.

• PGIMER Merit Scholarship holder (24th Feb. 1987 to 31st March1990)

• National Scholarship Holder (1983-1984)

• Merit Scholarship Holder (1979-1982)

FELLOWSHIPS AWARDED

• 1985-1986 Junior Research Fellowship, Postgraduate Institute of Medical Education and Research (P.G.I.M.E.R), Chandigarh, India.

Project: “Effect of High Caloric Intake through Fat on Benzo(a)Pyrene Induced Chemical Carcinogenesis in Rat”.

• 1987-1990 PGI Merit Fellowship

Project: “Study on the Effects of Interaction between Dietary Deficiencies of Fat and Vitamin A or both on Burden and Incidence Pulmonary Tumours Induced by Benzo(a) Pyrene on Male Wistar Rats and by N-Nitrosodiethylamine in Male Swiss Mice. (Ph.D. Thesis)

• 1991–1992: Research Fellowship, Regional Research Laboratory (CSIR), Jammu. Project: “AICRP (All India coordinated Research Project on Ethanopharmacology)”

• 1992-1997 Post Doctoral Research Assosciateship from The Council of Scientific and Industrial Research, New Delhi India.

Project: Development and Screening of Hepatoprotective Potentials of Plant Derived/Synthetic Agents against Model Hepatotoxicants”.

• 1997-2000: Post Doctoral Pool Officership from The Council of Scientific and Industrial Research, New Delhi.

Project: “Identification of Radical Scavengers from Medicinal Plants and Evaluation of their Antihepatotoxic Potential” at: Regional Research Laboratory, Jammu; Dr. B.R. Ambedkar Center for Biochemical Research, Delhi University (North Campus); Postgraduate Institute of Medical Education and Research, Chandigarh, India. RESEARCH EXPERIENCE

• Jan 92-Jan 97: Regional Research Laboratory (CSIR), Jammu as Research Associate

• May 97-May 98 : Regional Research Laboratory (CSIR), Jammu as Pool Officer

• May’98–July’99: Dr. B.R. Ambedkar Center for Biochemical Research, Delhi University (North Campus) as Pool Officer

• Jul’99 –May 2000: Dept of Biochemistry, Post Graduate Institute of Medical Education and Research Chandigarh, India as Pool Officer

• Sep’ 04 – Apr’ 09: Sami Labs Limited Peenya, Bangalore as Junior Principal Scientist Biological Research Department.

• Oct 2010 –Jan’13 : I-AIM, Yelahanka Bangalore, as Principal Scientist (Biology)

• DST Project: Establishment of National R&D facility for Rasayana Products from Traditional System of Medicine

• Jan’2016- Sept’ 2016 : Liveon Biolabs Pvt Ltd, Tumkur, Karnataka, as Head Technical Operations and Deputy Test Facility management.

• March’ 2019: Labriut Nutrients Private Limited, as Consultant -Product Development AREAS OF EXPERTISE

Research and Development

Technical Expertise

• Animal (in vivo) studies on Drug Metabolism (Enzymes), Metabolic profiling, Induction of chemical Carcinogenesis, Evaluation of effects of chemoprotective agents on biotransformations and enzymatic as well as non-enzymatic Cellular Antioxidant Defence System. Cigarette Smoking, Toxicological studies in animals, Evaluation of Antihepatotoxic effects of plant derived agents ; Screening of Free Radical Scavengers. Studies on Drug-Drug interactions and Cytochrome P450 activity.

• Cell Culture Handling of Different Cell Lines: HaCaT, Swiss 3T3 & 3T3 L1 & L6, KB, B16F,SKNMC, MCF-7, HepG2, RAW. 264.7, Caco-2, Hela and THP-1 Cells.

• Cell Based (in vitro) Assays and Model Development related to screening various therapeutic activities like Anti-Inflammatory, Anti-Diabetic, Antihepatotoxic, Antioxidant, Angiogenesis, Skin and Haircare Markers, Bioavailability, Cyclic AMP and Soluble Antioxidants, Nitric Oxide Formation and Inducible Nitric Oxide Synthase Activity. Cytotoxicity studies in cell lines

• In vitro cell free models on Iron Bioavailability studies Essential Responsibilities

• Planning, implementing and evaluating laboratory procedures/systems on assigned projects. Supervise subordinates to train, review as well as guide all Junior Researchers, Scientists and

• Senior Scientists in the department.

• Prepare study designs, study plan, study reports and reviews reports as per requirement.

• Perform peer review of manuscripts under preparation.

• Analysing and interpretation of data,

• Coordinating with different teams for completion of studies from clients; in Assay development,

& making improvement in assays.

• Communicating with Clients for Business development.

• Perform additional duties as assigned.

TEACHING ASSIGNMENTS

Oct’ 10-Jan’13: Institute of Ayurveda and integrative medicine, Bangalore as Principal Scientist- Biology

Dec’ 02 – Sep’ 04: M-e-M Institutes of Health Sciences Jammu, J&K as Assistant Professor – Biochemistry.Teaching students of Bachelor in Physiotherapy, Pharmacy, Medical Laboratory Technology and General nursing.

May’ 98 – Jul’ 99: Dr. B. R. AmbedkarCenter for Biomedical Research, University of Delhi, India. As Pool Officer. Teaching and tutoring Biochemistry to students of Integrated M.Sc. -Ph.D.

(Biomedical) Course at Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, India. Feb 1987-Mar 90 : PGIMER Chandigarh, Teaching Biochemistry to graduate /postgraduate students. COURSES UNDERTAKEN

• Flowcytometry at BD Biosciences, Gurgaon

• Cell coculture at Taramani complex, univ od Madras, Chennai

• Internal Auditors Training Program on ISO 9001:2008 conducted by TUV India.

• Trained for NABL at Sami Labs Ltd.

• Safety Aspects of Radiations from BARC, Mumbai for becoming Radiation Safety Officer;2005.

• Manuscript writing by Edanze,Springer

• Research Methodology from Postgraduate Institute of Medical Education and Research

(PGIMER), Chandigarh, India.

• Biostatistics from Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

• Computer Course of Tata Unisys Education Centre.

• Medical transcription from Cyborg Technologies

• A certification course on Measurement of uncertainities under NABL Accreditation program SCHOLASTIC PURSUITS

• 1991: Ph.D. from Postgraduate Institute of Medical Education and Research, Chandigarh, India Thesis: A study on the effects of interaction between dietary deficiencies of fat and Vitamin A in Chemical Carcinogenesis.

• 1984: M.Sc. (Biochemistry) (Non Thesis) from Kashmir University, Kashmir, J&K, India.

• Secured 65%

• 1982: B.Sc. (Chemistry, Botany, Zoology) (Triple Major) from Kashmir University, Kashmir, J&K, India

• Academic Accolades:

Secured 1st Position in the University with 71%

Received Gold Medal for obtaining 1st Class First. PERSONAL DOSSIER

Date of Birth : 27th November 1963

LIST OF PAPERS PUBLISHED

1. Koul, I B and Kapil A. Evaluation of the liver protective potential of Piperine- An Active Principle of Black and Long Peppers. Plants med 59,4-13-417-****. 2. Koul I.B and Kapil, A Effect of Diterpences from Andrographics Paniculata on Antioxidant Defence System and Lipid Per Oxidation. Ind.J.Pharmacol, 26, 296, 300, 1994. 3. Koul, B., Koul A, Gandhi R.K Sharma, R.R and Khanduja. K.L Differential Effect of Fat Deficiency on Hepatic a Pulmonary Drug Metabolizing Enzymes in Rat and Mouse. Biochemistry International 20, 979-989, 1990.

4. Koul, I.B, Sharma, R.R. and Khanduja K.L. Effect of dietary fat ingestion on Extrahepatic Drug Metabolizing Enzymes in Rat. Medical Science Research 17,977-978,198. 5. Koul, I.B., Sharma, R.R Khanduja K.L. Plasma cholesterol and triglyceride levels in carcinogen- treated fat and Vitamin A deficient rodents. Medical science Research (accepted), 1990. 6. Kapil, A and Koul, I.B. In Vitro evaluation of Antiheapatotoxic Activity of Quinonzolines. Ind J.Pharma, Sci.57-148-150.1995.

7. Kapil, A and Koul, I.B. Antihepatotoxic Effects of Chlorogenic Acid from Anthocephalus Cadamba. Phytotheraphy Res 9, 189 193, 1995.

8. Khanduja, K.L, Koul, I.B and Sehgal, S Influence of combined deficiency of fat and vitamin A on benzo(a) Pyrene Induce Lung Carcinogensis in rats, Ind, J. Exptl. Biol 32,124-127,1994 9. Kapil. A, Koul I.B, Banerjee. S and Gupta B.D. Antithepatoxic Effect of Major Diterpenoid Constituents of Andrographis Paniculata. Biochem Pharmacol.46, 182-185, 1993. 10. Kapil, A and Koul, I.B Evaluation of Antihepatotoxic Potential of Natural Products by in Vitro Microsomal Lipid Peroxidation. Medical Science Research 20,449-450, 1992. 11. Khanduja, K.L., Koul, I.B, Gandhi, R.K, Sehgal, S and Sharma, R.R Effect of Combined Deficiency of Fat & vitamin A on N-nitrosodiethylamine-induced Lung Carcinogenesis in mice. Cancer letter, 62, 57-62, 1992.

12. Khanduja, K.L. Koul I.B, Gandhi R.K and Sharma R.R Status of Drug Metabolising Enzymes after Treatment of Fat-Deficient Mice with N-Nitrosodiethylamine. J.Clin.Biochem.Nutr.10, 113- 118, 1991.

13. Khanduja K.L, Koul, I.B and Gupta M.P and Effect of Large of Ascorbic Acid on the Hepatic and Extrahepatic Drug Metabolising Enzyme in Guinea Pig. Biochemistry international 13, 669- 670, 1986.

14. Koul, A., Gupta M.P., Koul, I.B, Majid S, .Sharma, RR.and Khanduja, K.L.Effect of ascorbic acid on inducibility of Pulmonary Arythydrocarbon Hydroxylase by Cigarette Smoke in Guinea Pig. Medical Science Research 16, 1119-1120, 1988.

15. Koul,A., Gupta M.P., Koul,I.B, Majid S, Sharma, RR and Khanduja K.L Lack of inducibility of pulmonary Arythydrocarbon Hydroxylase by Cigarette Smoke in Guinea Pig on Excessive Doses of Ascorbic Acid. Anticaner Res.8 (5B), 1056, 1988. 16. Koul, A., Gupta M.P., Koul, I.B, Majid S, .Sharma, RR and Khanduja, K.L. Effect of Ascorbic Acid on Antioxidant Defence in Guinea Pig. J. Clin. Biochem. Nutr, 21-27, 1989. 17. Gupta M.P., Khanduja, K.L Koul, I.B and Sharma, RR Effect of Cigarette Smoke Inhalation on Benzo9a) Pyrene Induced Lung Carcinogenesis in Vitamin A Deficiency in the Rat. Cancer Letters 55, 81-88, 1990.

18. Khanduja, K.L., Gupta M.P., Koul, A., Koul, I.B and Sharma, RR .Effect of excessive intake of ascorbic acid on Hepatic and Extrahepatic Phase 1 and Phase 11 Drug Metabolism in Rat. Biochemistry International 14,135-***-****.

19. Khanduja, K.L., Kapur, S., Koul,A, Majid S Koul,I.B and Sharma,RR. Inhibition of arylhydrocarbon hydroxylase and cytchrome P450 by N-Nitrosodiethylamine in Guinea Pig on Excessive Doses Ascorbic Acid, Medical Science Research 18,109-110,1990. 20. Khanduja, K.L., Kapur,S., Koul,A, Majid S Koul,I.B and Sharma,RR inhibition of arylhydrocarbon hydroxylase and cytchrome P450 by 20-Methylcholanthrene and Phenobarbital in Guinea Pig on Excessive Doses Ascorbic Acid, Biochemistry International 21,715-724,1990. 21. Khanduja, K.L., Kapur,S., Koul,A, Majid S Koul,I.B and Sharma,RR Effect on N- Nitrosodiethylamine on the carcinogen activating and detoxifying enzymes in guinea pig on excessive doses ascorbic acid, .J.Clin.Biochem. Nutr 8,201-207, 1990 22. Khanduja,K.L., Vaidhyanathan,S., Koul,A, Pathak,C.M., Koul,I.B, Gupta,M.P., Majid S and Sharma,RR.A Comparative Study of the Reliability of Total Sialic Acid and Lipid Associated Sialic Acid as Makers for Translational Cell Carcinoma of the Bladder. Medical science Research 15, 1341-1342, 1987.

23. Khanduja, K.L., Gupta M.P, Pathak, C.M., Vaidhyanathan, S, Koul, A, Koul, I.B.Koul and Sharma R.R Effect of Phenobarbital and 3-Methylcholanthrene Treatment on Thyroid Hormones in Rat. Ind. J.Med. Res 86,361-375, 19874

24. Kapil A and Koul I.B Hepatoprotective Agents from Indian Traditional Plants. In: Glimpses of Indian Ethnopharmacology (Eds: P.Pushpangadan, Ulf Nyman and V.George); 1995. 25. Padmavenkat Subramanian, InduBala.Koul, ReejaKochuthekil Varghese, SrividyaKoyyala and Arun. Amla (Phyllanthusemblica L.) enhances iron bioavailability and uptake in in vitro models. Current Science 107,No 11, 10 Dec,2014.

Abstracts presented In National / international Conferences: 1. Koul,I.B., Khanduja, K.L Gupta M.P., and Sharma, RR.Effect of Dietary deficiency of fat on the status of drug metabolizing enzymes in mice. 7th Annual Convention of the Indian Association for Cancer Research at ITRC, Lucknow.

2. Koul IB, Bannerjee, Gupta BD and Kapil A.Antioxidant effects of diterpenoid constituents from Andrographis paniculata.64th annual Meeting Annual meeting, society of Biological chemists(India)

3. Koul,A., Gupta M.P., Koul,I.B, Majid S, Sharma, RR and Khanduja K.L Lack of inducibility of pulmonary Arythydrocarbon Hydroxylase by Cigarette Smoke in Guinea Pig on Excessive Doses of Ascorbic Acid. Anticancer Res.8 (5B), 1056, 1988.Annual International Cancer Conf. at Athens (Greece).

4. Koul IB, Saxena and Anand KK. N-Methylformamide induced toxicity-A model for the study of hepatoprotective agents.Platinum jubilee (1921-1996), The dept of Biochemistry, Indian Institute of Science and the 65th Annual meeting of the society of Biological Chemists (India) 5. Koul A, Gupta MP, Koul IB, Gupta MP, Majid S, Sharma RR & Khanduja Kl.: Effects of ascorbic acid on antioxidant defence system and lipid peroxidation in guinea pig. Anticancer research, 8 (5b) 1979, 1988. Annual International Cancer Conf. at Athens,( Greece).

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