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Adam R. Davis Sr., Ph.D.

US Citizen, Gulf War Veteran

*** ******* **., **********, ** 22602, 443-***-**** adyecy@r.postjobfree.com, https://www.linkedin.com/in/adam-davis-29aa822b/ Department of Defense Security Clearance Level: Secret -2019 Curriculum Vitae

Dr. Davis is a biomedical informaticist, molecular biologist, and information technology professional with 26+ years of experience leading laboratory research, computational biology, and data analytics for various disease and medical studies with 9+ years of practical experience in Combat Medic, then a Practical Nurse. He is an expert in utilizing correct technologies to conduct research and designing medical proposals for high-payout grants to support gene editing, omics, computational biology, computer science, human performance, and readiness. He has over ten years of experience building high-performing teams, directing strategic planning for research, and maintaining various stakeholder expectations. Proficient in many molecular biology techniques for RNA, DNA, and protein analyses. Highly skilled in designing and applying statistical and predictive algorithms for the human classification of diseases and other phenotypes. Academic Degrees:

• Ph.D. in Biology (Computational and Molecular Biology), Clark Atlanta University, Atlanta, GA, Graduated: July 2005

• BS in Biology, Morgan State University, Baltimore, MD, Graduated: May 1997 Certifications:

Certificate in Clinical Epidemiology, Program in Clinical Effectiveness, Harvard School of Public Health, Boston, MA, Completed: August 2006

Fellowships:

• Fellow in Bioinformatics, Cardiovascular Research Institute, Morehouse School of Medicine Atlanta, GA, May 2005 - June 2006

• Fellow in Biomedical Informatics, I2b2 National Centre for Biomedical Computing, Harvard Medical School Boston, MA, June 2006 - November 2009

US Army Military Education:

• Medical Specialist Course, Completed: August 1982

• Combat Medical Professional Course, Completed: July 1984

• Primary NCO Course, Completed: July 1985

• Practical Nurse Course, Completed: June 1987

• Patient Care Specialist Phase II, Completed: June 1988 Professional Development/Training

• Recombinant DNA Methodology Training Program, National Institutes of Health

• VASCULATA Training Program, Dartmouth College, USA

• Level I, II, III Microarray Data Analysis Workshop, Agilent Technologies

• Integrative Statistical Analysis of Genome-Scale Data, Cold Spring Harbor Laboratory, USA

• Genetics of Complex Human Diseases, Cold Spring Harbor Laboratory, USA US Army Practical and Development Training:

• Medical Non-Commissioned Officer (NCO)

• Air Assault Course

• Certificate of Participation TEAM SPIRIT

Adam R. Davis Sr., PhD – Page 2 of 8

• Lighter Fighter Certificate of Achievement

• NCO Academy Primary Leadership Development Course

• General transportation of Hazardous Material Course

• Jungle Warfare Training Course

Awards & Honors

• 4X winner of NIH Pathway to Independence Award (K99-R00) from Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, and Morehouse School of Medicine, Atlanta GA

• 3X recipient of the Outstanding Teaching Fellow Award from The Harvard-MIT Division of Health Sciences and Technology, Boston, MA

• 3X recipient of the NIH National Research Service Award (T-32) from i2b2 National Center for Biomedical Computing, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA

• 2X winner of NIH National Research Service Award (T-32) from Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA

• Recognized for Outstanding Scientific Presentation by Morehouse School of Medicine, Atlanta, GA

• 3X awardee of NIH National Research Service Student Award (F31) from Clark Atlanta University, Atlanta, GA

• Awarded Minority Scholar in Cancer Research Award from American Association for Cancer Research (AACR)

• 4X honoree of Beta Kappa Chi, Biology Honor Society Award from Morgan State University, Baltimore, MD

• Received Certificate of Outstanding Achievement in Biology from Morgan State University, Baltimore, MD US Army Honors:

• Kuwaiti Liberation Medal, Saudi Arabia Ribbon, United States

• Army Service Ribbon

• 3X Good Conduct Medal, United States Army.

• 2X Army Achievement Medal

• NCO Professional Development Ribbon

• 3X Southwest Asia Service Ribbon

• Combat Medical Badge

• Overseas Service Ribbon

• National Defense Service Medal

Professional Experience

Shenandoah University, Winchester, VA. 22601

Visiting Assistant Professor, Biology Department: Lecturing Anatomy & Physiology, Cancer 8/2022 to Present: Lecture Anatomy & Physiology and separately Mechanisms of Cancer for undergraduate students three hours, three times a week, a total of nine hours per week of lectures. Neurostat Analytical Solutions, LLC., Vienna, VA., 22182 Biomedical Informatics and Information Systems, Independent Consultant (Full Time 40 hours per week), 06/2020- 12/2020:

To empirically measure the host molecular interactions and gene regulatory processes associated with clinical and psychological measurements and interventions to identify biomarkers. Provided experimental design, developed and implemented psychogenomic precision medicine and epidemiology protocols utilizing various omics assays (nucleic acid, protein, and epigenomic). Develop AI statistical pipelines for the prediction of variously defined human psychological states. Additionally, set objectives and strategies overseeing the implementation of the technological infrastructure (networks and computer systems) to streamline all internal operations and IT-related projects for Adam R. Davis Sr., PhD – Page 3 of 8

optimal performance and strategic benefits for the organization. Including DOD FedRAMP cybersecurity requirements, data encryption for extensive data collection, and data sharing. Office of The Vice President for Research, Uniform Services University, Dept. of Defense, Bethesda, MD., 20814

Clinical Information System Director – HJF Contractor (Full Time 40 hours per week), 11/2017 – 05/2020: Conduct institutional assessment for research infrastructure and provide solutions to bring university computer infrastructure into DOD FedRAMP+ IL2 and IL4 compliance. Design processes and procedures to remove bottlenecks in research acquisition. Designed computer infrastructure to grow the university’s research portfolio. Assisted university faculty with biomedical informatics and epidemiology research designs, biomarker analysis, hardware, and software designs for cloud computing on Amazon Web Services, and establishing omics (genetics, genomics, and epigenomics) analytical and computational pipelines, designing and selecting cybersecurity solutions meeting FedRAMP requirements for data management and encryption and de-identifying methodologies for data sharing compliant with DOD FedRAMP for PHI and PII. Genomics of Metabolic, Cardiovascular & Inflammatory Disease Branch, National Human Genome Research Institute, Bethesda, MD., 20892

Senior Staff Scientist – Biomedical Informatics, Cardiovascular Disease Section, Federal Employee Band 2, Level III,

(Full Time 40 hours per week) 12/2012 – 11/2017:

Designed, developed, and implemented a research environment with standard operating procedures; configured computer cluster for computation and bio-specimen biobank and translational biorepository. Designed large-scale precision medicine studies and clinical trials. Developed standard operating procedures (SOPs) for ongoing studies. His research focused on identifying human genomic /phenomic omics biomarkers (genetic, genomic, epigenomic) for cardiovascular disease and new drug treatments. He has conducted/reviewed biomedical informatics, systems biology, and computational analyses and published peer-reviewed publications. Morehouse School of Medicine (MSM), Atlanta, GA., 30310 Assistant Professor, Department of Physiology and Cardiovascular Research Institute, Morehouse School of Medicine, (Full Time 40 hours per week) 11/2009 – 12/2012: Dr. Davis’ research focused on identifying human genomic /phenomic omics biomarkers (genetic, genomic, epigenomic) for cardiovascular disease and asthma to identify new drugs for treatment. Dr. Davis was instrumental in establishing, designing, and implementing the RCENTER research web portal. He created the MSM on-premises bioinformatics computer environment (computer cluster, high throughput network storage) for omics, clinical data processing, and analytical pipelines to support research. Additionally, he served on the committee to design, implement, and develop the MSM cryo-repository rooms and LIMS system integration for the MSM research community.

• Director of the Informatics Computation and Analytics Development (ICAD) Core, 06/2010 – 12/2012: As the ICAD Director, I designed and implemented a university-level computer infrastructure and bioinformatics pipelines for omics and other clinical data analyses for the MSM research community.

• Director Bioinformatics and Computational Biology (BCB), 12/2009 – 12/2012: As the BCB Director, he assisted MSM faculty in bioinformatics and precision medicine protocol designs and analytics.

• Co-Director, R-Center Biomedical Informatics Unit, 12/2009 – 12/2012: Coordinated inter-institutional clinical and translational research projects for MSM. Consultant for the electronic medical record data extractions, data transformations for research, and analytical reports on medical treatment and decision processes for improving patient health outcomes.

Harvard-MIT Health Sciences and Technology (HST) Summer Institute, Boston, MA., 02115 Assistant Director in Bioinformatics (Full Time Summers 40 hours per week) 06/2006 – 06/2012: Dr. Davis partnered with a team on electronic medical record data extraction for integration into the i2b2 data repository. His research focused on omics data from several studies to identify biomarkers for disease. He conducted omics analyses on various research datasets. Additionally, he worked with students in designing research projects as part of the HST BIG summer program.

Brigham and Women’s Hospital and Harvard Medical School, Boston, MA., 02115 Adam R. Davis Sr., PhD – Page 4 of 8

Research Fellow in Bioinformatics, i2b2/National Center for Biomedical Computing, (Full Time 40 hours per week) 06/2006 – 12/2009:

Dr. Davis conducted research utilizing omics data from several studies to identify biomarkers for disease and ancestry. Additionally, he performed analysis related to EMR extraction and data integration into the i2b2 data repository.

Morehouse School of Medicine, Atlanta, GA., 30310

Post-Doctoral Fellow in Bioinformatics, Cardiovascular Research Institute, (Full Time 40 hours per week) 06/2005 – 06/2006:

Dr. Davis has conducted mRNA analyses on Cardiovascular Disease patient data, comparing multiple different datasets for a combined analysis.

Clark Atlanta University, Atlanta, GA., 30314

Graduate Student Research Assistant, (Full Time 40 hours per week) 10/1997 – 01/2002: Molecular Biology: Conducted research for the development of a Cathepsin-K transgenic mouse. Construct oligonucleotides using DNASTAR and Oligo programs for PCR and DNA sequencing. Perform plasmid construction, amplification, and purification using digestion enzymes, bacterial cultures, and the following plasmid purification kits: Qiagen, Eppendorf, and 5prime 3prime. Perform mammalian cell culture transfection efficiency and promoter functionality studies. He has performed assays such as 14C labeled chloramphenicol acetyltransferase assay (CAT), beta-galactosidase assay (B-GAL), and green fluorescent protein (GFP). DNA isolation and purification from mammalian and cell culture samples to include human studies and mouse breading genotyping. DNA, RNA, and protein isolation using standard techniques such as sodium acetate/ethanol and chloroform/phenol DNA precipitation, Trizol RNA and Protein isolation methods, northern blotting, western blotting, SDS-PAGE, and agarose electrophoresis. He is experienced with tissue culture types, including DNA transfection of tissue culture cells using electroporation or lipofectamine ™.

Computational Biology: In addition to wet bench research, Dr. Davis conducted computational and bioinformatic research elucidating RNA secondary structure folding free energy analyses. He has a solid knowledge base with the NCBI Reference Sequence (RefSeq) whole transcriptome, experience with DNA and RNA sequence folding programs, and characterization of the data results into a biological functional computational database. Develop relational databases using SQL languishes, mining large data sets (Terabit) relating to Gene Ontology (GO) Consortium and constructing functional relationships between Biological Process, Molecular Function, and Cellular Component databases with experimental data set results. Develop .bat files to expedite extensive data manipulations and reduce some manual computer commands. He applied biostatistics, including One-Way ANOVA, Two-Way ANOVA, T-test, z-score, and statistical blocking methods to identify meaningful data results. He has configured a computer cluster of 18 computers to work together through a university-level network for mRNA folding permutations using genetic algorithms such as J-express, ArrayTools, and Gene Cluster. Morgan State University, Baltimore, MD., 21251

Student Research Assistant, (Full Time 40 hours per week) 09/1996 – 05/1997: Daily, conducted animal research assays utilizing cell culture semisolid (Bone and Spleen), I-125 radioimmunoassay. Statistical analysis, image analysis, Rat bone marrow & spleen extraction and preparation for light microscope, Benzidine, Wright’s, and Giemsa cell staining.

Kennedy Krieger Research Institute, Baltimore, MD., 21205 Research Assistant, (Full Time 40 hours per week) 05/1994 – 09/1996: He performed clinical research assays using chromatography, high-speed centrifugation, sonication, gel electrophoresis, dialysis, southern & western blots, 14C16 & 14C24 synthetase, Lowry Bradford, Beta-oxidation, Catalase, and SDH assays for clinical patients. Organelle preparation of yeast Pichia Pasoris peroxisomes and mitochondria subcellular fractionations using sucrose and nicodence gradients. United States Army, USA

Medical Nurse and Combat Medic, (Full Time 40 hours per week) 08/1982 – 08/1992: Supervised Aid-Station and Emergency Facility for over 2000 soldiers, cared for patients with chronic and acute disorders, and prepared patients pre/post-surgery. Performed minor emergency surgical procedures (examples: suturing of lacerations, removing subcutaneous lipomas and hemorrhoids). Performed cardiopulmonary resuscitation Adam R. Davis Sr., PhD – Page 5 of 8

using artificial respiration (chest tubes and O2). Administered intravenous fluids, applied tourniquets, and immobilized fractures. During Wartime, he administered morphine, treated for numerous types of shock, and triaged casualties.

Grants/Funding

HG200393 (Senior Scientist, Davis), 11/08/12 - 11/04/17, NIH/NHGRI, $15M Cardiovascular Disease Cluster (CVD), Biomedical Informatics Objectives: Establish infrastructure to support a team of 11 bioinformatics staff. Design, develop, and execute precision health clinical trials utilizing current and new clinical trial data to elucidate biomarkers for cardiovascular diseases. Collaborate with NHGRI information technology staff to create computational and storage environments to support CVDS systems biology and bioinformatics.

R00350067-224001-21 (Principal Investigator, Davis), 06/25/09 - 11/08/12, NIH/NHLBI, $611,249 Phenome-Genome Characterization of Asthma in African Americans Objectives: To distinguish the genetic basis of differences in asthma susceptibility and the course of asthma (e.g., risk of exacerbations) between African American (AA) and Caucasian (CA) populations 1RC4MD005964-01 (Co-Investigator, Davis), 09/30/10 - 11/08/12, NIH/NIMHD, $11,628,781 Minority Health-GRID Network: A Genomic Resources for Health Disparity Research Objectives: To create a minority-focused research network to link health information with genetic data and assess genetic, personal, and environmental factors associated with severe hypertension (HTN) or high blood pressure 2G12RR003034-26 (Co-Investigator, Davis), 07/07/12 - 11/08/12, NIH/NCRR, $1,407,264 The Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center Objectives: Develop a critical level of biomedical research capability, productivity, and training that expands MSM’s research portfolio, allowing MSM to pursue multidisciplinary approaches to discovery science that translate into the amelioration of health disparities.

Research & Presentations

• Adam R. Davis, Presentation July 2019: MarkLogic Distributed Computing Meets AI Mining in an Integrated Biorepository: A Bioinformatics Ecosystem for New Discovery, XXXVIth International Congress on Law and Mental Health, Rome, Italy.

• Adam R. Davis, Ryan A. Neff, Jose Vargas, Rakale Quarells, Minority Health-GRID Network, and Gary H. Gibbons, Presentation December 2014. Alignment to an Ancestry Specific Reference Genome Discovers Additional Variants among the MH-GRID Cohort, National Institute on Minority Health and Health Disparities Grantees’ Conference, Washington, DC., USA.

• Ryan Neff, Gary Gibbons, Adam Davis, Presentation, October 2014. Alignment to an Ancestry Specific Reference Genome Discovers Additional Variants Among 1000 Genomes ASW Cohort, American Society for Human Genetics, San Diego, CA, USA.

• Davis Adam and Isaac S. Kohane, Presentation August 2008. Investigation of Gene Expression Specific to Continent of Origin, National Center for Biomedical Computing, 2008 All Hands Meeting, http://www.ncbcs.org/pdf/ahm2008/1110_Davis.pdf., Boston, MA, USA.

• Davis A., Didgby D., Seffens W., Presented November 2005. Whole Transcriptome Variance Analysis of mRNA Secondary Structure Free Energies in Human, Mouse, and Arabidopsis, Proceedings of The Fifth Georgia Tech International Conference on Bioinformatics, Atlanta, GA, USA. Adam R. Davis Sr., PhD – Page 6 of 8

• Davis A., Didgby D., Seffens W., Presentation October 2005, Human Transcriptome Database Reveals clustering of Apoptosis Genes by mRNA Secondary Structure, The Second Annual Biotechnology and Bioinformatics Symposium, Colorado Springs, CO, USA.

• Adam Davis and William Seffens. Presentation May 2005, Whole Transcriptome Variance Analysis of mRNA Secondary Structure Free Energies in Human, Mouse, and Arabidopsis, Proceedings of The Fifth Georgia Tech International Conference For Bioinformatics, Atlanta, GA, USA.

• Davis A., Didgby D., Seffens W., Presented December 2004. Whole Human Transcriptome Pattern Analysis Using GO Vocabulary Terms and mRNA Secondary Structure Free Energies, Proceedings of RCMI International Symposium on Health Disparities, Baltimore, MD, USA.

• Davis A., Didgby D., Seffens W., Presented September 2004. Comparison of mRNA Secondary–Structure Folding Properties Across Whole Transcriptomes, Georgia Life Sciences Summit, Atlanta, GA, USA.

• Davis A., Kimbro S. Presented March 2001. Cathepsin K Expression in Prostate Cancers. AACR 2001 Symposiums, New Orleans, LA, USA.

• Davis A., Kimbro S. Presented September 2000. The Characterization of Osteoblast-specific Estrogen Receptor- alpha Expression in Osteoblast-like Cells, The American Association for Bone and Mineral Research, Toronto, Ontario, Canada.

• Davis A., Carmichael R., Presented April 1997. Evidence Suggesting Erythropoietin Transfer to Suckling Rats Via the Maternal Milk. FASEB Experimental Biology 97 Research Symposium, New Orleans, LA, USA. Publications

• Zilbermint, M., Gaye, A., Berthon, A., Hannah-Shmouni, F., Faucz, F. R., Lodish, M. B., Davis, A. R., Gibbons, G. H. and Stratakis, C. A. “ARMC 5 Variants and Risk of Hypertension in Blacks: MH- GRID Study”, J Am Heart Assoc. 2019: 8(14): p. e012508.

• Cihan Oguz, Shurjo K. Sen, Adam R. Davis, Yi-Ping Fu, Christopher J. ODonnell, Gary H. Gibbons. “Genotype- driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq and Framingham Heart Study cohorts,” BMC Systems Biology, 2017. 11(1): p.99

• Gebreab, S.Y., Riestra, P., Gaye, A., Khan, R. J., Xu, R., Davis, A. R., Quarells, R. C., Davis, S. K, Gibbons, G. H. Perceived neighborhood problems are associated with shorter telomere length in African American women. Psychoneuroendocrinology, 2016. 69: p. 90-7.

• Horbal SR, Seffens W, Davis AR, Silvestrov N, Gibbons GH, Quarells RC, Bidulescu A “Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH- GRID Study”. American Journal of Hypertension, 2016. 29(7): p. 814-20.

• Zilbermint M, Xekouki P, Faucz FR, Berthon A, Gkourogianni A, Schernthaner-Reiter MH, Batsis M, Sinaii N1, Quezado MM, Merino M, Hodes A, Abraham SB, Libé R, Assié G, Espiard S1, Drougat L, Ragazzon B, Davis A, Gebreab SY, Neff R, Kebebew E, Bertherat J, Lodish MB, Stratakis CA, “Primary Aldosteronism and ARMC5 Variants”. The Journal of Clinical Endocrinology & Metabolism, 2015 Jun;100(6): E900-9. ISSN (online): 1945- 7197.

• Quarshie, A.; Davis, A.; Strayhorn, G.; Weaver, C.; Delano, C.; Winters, K.; Rice, R.; Ofili, E.; “Establishing the Morehouse School of Medicine (MSM) R-Center Clinical and Translational Research Web-Portal: The Role of Focus Groups,” Journal of Health Care for the Poor and Underserved 22. 2011: Pages 165-173.

• Carey VJ, Davis AR, Lawrence MF, Gentleman R, Raby BA. Data structures and algorithms for analysis of genetics of gene expression with Bioconductor: GGtools 3.x. Bioinformatics. 2009;25(11):1447-1448.

• Davis AR; Kohane IS; “Expression differences by continent of origin point to the immortalization process,” Hum Mol Genet. 2009;18(20):3864-3875.

Adam R. Davis Sr., PhD – Page 7 of 8

• Yoo, J.; Digby, D.; Davis, A.; Seffens, W.; “Whole Transcriptome mRNA Secondary Structure Analysis Using Distributed Computation,” Proceedings of the 2006 IEEE International Conference on Granular Computing, USA. May 2006: Pages 647-650.

• Adam R. Davis, David Digby, and William Seffens, “Human Transcriptome Database Reveals Clustering of Apoptosis Genes by mRNA Secondary Structure,” Proceedings of the Second Annual Biotechnology and Bioinformatics Symposium, Colorado Springs, Colorado, USA. October 2005: Pages 59-62. Technical Proficiencies

• Proficient in Molecular Biology techniques, RNA, DNA, protein extraction, gel electrophoreses (SDS and 2D), Northern and Western blots, chromatography, high-speed centrifugation (cell organelle subcellular fractionations using sucrose and nicodence gradients), sonication (tissue, cells, DNA, and RNA), cell separation for most tissue and body fluids

• Proficient in most methods for biological specimen collection and long term cryo-repository storage for tissue, cells, organelles, analytes, and fluids

• Proficient in constructing oligonucleotides using DNASTAR and Oligo programs for PCR and targeted sequencing

• Proficient in CLIA level diagnostics testing for 14C16 & 14C24 synthetase, Lowry, Bradford, Beta-oxidation, Catalase, and SDH assays for clinical patients.

• Perform plasmid construction, amplification, and purification using digestion enzymes, bacterial cultures, and plasmid purification

• Proficient with DNA transfection of tissue culture cells using methods, e.g., electroporation or lipofectamine.

• Proficient in predicting and simulating mRNA folding analysis using genetic algorithms incorporated into array expression programs such as J-express, ArrayTools, Gene Cluster, and NCBI RefSeq database.

• Experienced in designing and implementing sequencing pipelines and data processing utilizing hisat2, bowtie2, samtools, bwa-mem, FastQC, Picard-tools, Cufflinks

• Data mining utilization of artificial intelligence supervised learning (e.g., Na.ve Bays, ANN, decision trees, random forest) and unsupervised learning (Hierarchical, k-means, affinity propagation)

• Proficient in statistical programming to include predictive modeling and AI utilizing RStudio and Bioconductor, Python and Perl on the LINX platform

• Expert in omics data analysis, dimensionality reduction, and visualization techniques

• Highly trained and proficient with most NCBI web-based applications for pathway and gene network research utilizing GEO, DbGap, DBVar, GeneCrad, and other gene-gene interaction network enrichment software, examples: Ingenuity, MediCore (GeneGo), Navigator, Kegg

• Capable of developing databases utilizing Microsoft SQL Server, Access, Hadoop, and PolyBase using Teradata and Oracle ETL tools

• Very knowledgeable of clinical protocol data system design and data integration i2b2, RedCap, NIH-Clinical Trials Database

• Knowledgeable of ITP analytics such as IBM Watson and Microsoft PowerBI, and others

• Hands-on experience designing network-attached storage (NAS), including RAID methodology, SAN high-speed InfiniBand storage network bandwidth requirements

• Familiar with Azure Stream Processing and Cloud-based warehouses, including IBM Netezza, HortonWorks, Azure DW

• Proficient in website and application development utilizing GoDaddy and OutSystems, Adam R. Davis Sr., PhD – Page 8 of 8

• Proficient in Microsoft Word, Excel, Access, PowerPoint

• GoDaddy and OutSystems

Professional Associations

Member, 2015 – Present, Council Member American Heart Association (AHA) Member, 2013 – Present, American Society of Human Genetics (ASHG) Member, 2010 – 2011, African and Southern African Societies of Human Genetics (SASHG) Member, 2000 – 2003, American Association for Cancer Research (AACR) Member, 2001 – 2002, American Association for Bone and Mineral Research (ASMBR) Member, 1997 – 1998, Federation of American Societies for Experiential Biology (FASEB)

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