Research Associate Assistant

CURRICULUM VITAE

Name Annayya Rao Aroor

Address: Department of Medicine

Division of Endocrinology, Diabetes and Metabolism

Center for Diabetes and Cardiovascular Research

One Hospital Drive

Diabetes Center D109 HSC

Columbia MO 65212

Phone 573-***-**** (Mobile)

573-814-6000_ext 53729 (Office)

E. Mail: ******@******.********.***

Home 112, Cedar Falls Ct, Columbia MO 65203

Date of Birth 09-10-1952

Marital Status: Married, two children

Visa Status US Citizen

EDUCATION

Mysore Medical College M.B.B.S. 1976 Medicine

Mysore University, India

Kasturba Medical College, M.D. 1979 Biochemistry Residency program in Clinical Biochemistry

Mysore University, India Passed with Distinction

Kasturba Medical College MNAMS 1982 Biochemistry Clinical Biochemistry

Mysore University, India National Board of Examinations

Kasturba Medical College, Ph.D 1984 Biochemistry Thesis: Studies on human

Mysore University, India protease inhibitors

Academic credentials are evaluated by International Education Research Foundation, California. All the degrees are equivalent to degrees offered in Accredited Institutions in USA.

American Board of

Clinical Chemistry DABCC 2014 Clinical Chemistry

HONORS AND AWARDS

1976-1979 Senior Research Fellowship from Indian Council of Medical Research, Government of India

1979-1982 Research Associateship from Indian Council of Medical Research, Government of India

1988 Awarded Distinguished Kasturba Medical College Alumni award for academic achievement

2004 Fellow, Association of Clinical Biochemists of India (FACB)

2004-2007 Associate member (corresponding member), Curriculum Development Program for International

Federation of Clinical Chemistry (2004-2007)

2014 Fellow of the American Academy of Clinical Chemistry (FAACC)

ACADEMIC APPOINTMENTS

1978 -1980, Tutor/ Lecturer, Department of Biochemistry, Kasturba Medical College, Manipal, India.

1980 – 1982 Assistant Professor, Department of Biochemistry, Kasturba Medical College, Manipal, India.

1982 – 1983 Reader, Department of Biochemistry, Kasturba Medical College, Manipal, India.

1983 – 1985 Reader and Head, Department of Clinical Biochemistry and Nutrition,

Director, Clinical Biochemistry Laboratory, Kasturba Medical College Hospital, Kasturba Medical College, Manipal, India.

1985 - 1988 Associate Professor and Head, Department of Clinical Biochemistry and Nutrition,

Director, Clinical Biochemistry Laboratory, Kasturba Medical College Hospital,

Kasturba medical College, Manipal, India

1988 - 1995 Professor and Head, Department of Clinical Biochemistry and Nutrition,

Director, Clinical Biochemistry Laboratory, Kasturba Medical College Hospital,

Manipal, India (1990-1995, study leave)

1996-1997 Instructor, Department of Pharmacology and Toxicology, University of Mississippi

Medical Center, Mississippi, Jackson, U.S A.

1997- 2005 Professor and Head, Department of Biochemistry,

Director, Division of Clinical Biochemistry Laboratory, Central Laboratory, Kempegowda Institute of Medical Sciences Hospital, Bangalore, Karnataka, India (2000-2001, study leave)

2006- 2011 Research Assistant Professor, Department of Medical Pharmacology and Physiology

University of Missouri School of Medicine, Columbia, USA

2011- 2020 Research Assistant Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes

and Metabolism, Center for Diabetes and Cardiovascular Research, Division of Nephrology, University of

Missouri, School of Medicine, Columbia, USA.

2020- to date Research Associate Professor, Department of Internal Medicine, Division of Endocrinology, Diabetes

and Metabolism, Center for Diabetes and Cardiovascular Research, Division of Nephrology, University of

Missouri, School of Medicine, Columbia, USA.

POST DOCTORAL TRAINING/VISITING RESEARCH FELLOWSHIP IN UNITED STATES

1990-1991 Research Associate, Department of Pharmacology and Toxicology, University of

Mississippi Medical Center, Mississippi, Jackson, U.S A.: Hepatobiology and molecular toxicology.

Environmental toxicology. In vitro and in vivo studies.

1991-1993 Research Associate, Department of Biochemistry, University of Mississippi Medical Center, Mississippi, Jackson, U.S A : Translational control of gene expression, leukemic cell differentiation, Protein structure and function.

1993-1996 Research Associate, Department of Pharmacology and Toxicology, University

of Mississippi Medical Center, Mississippi, Jackson, U.S A.: Alcohol immunotoxicity and neurotoxicity,

reactive gliosis, and Immune cell apoptosis, Alcohol and NMDA mediated neurotoxicity.

2000-2001 Visiting Research Scholar, Department of Pharmacology, University of Missouri School of

Medicine, Columbia.: Alcohol, MAPK signaling, epigenetic histone modifications and liver injury.

Ethanol modulation of Angiotensin II signaling and proteome study.

PROFESSIONAL ORGANIZATION/ MEMBERSHIPS

American Association of Clinical Chemistry

Association of Clinical Biochemists of India

National Academy of Medical Sciences, India.

American Heart Association, Endocrine Society

EXPERIENCE IN CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY

I.ADMINISTRATION

Director of Undergraduate Teaching and Post graduate teaching program Involved in development of curriculum development and integrated and problem based teaching program in medical biochemistry from time to time based on revision of curriculum at University of Health Sciences and medical Council of India.

Director of Clinical Biochemistry division of central laboratory services of Medical Center attached to Kasturba Medical College (1983-1990) and Kempegowda Institute of Medical Sciences (1997-1999, 2002-2005). Vide operational and administrative experience of the clinical chemistry laboratory. Excellent knowledge of laboratory test and aid in diagnosis. Interphase effectively with clinicians, house staff and technical staff.

Member of educational, research and ethical committee of the Institution and University of Health sciences. Invited member of promotional committees of sister universities. Committee member for accreditation of graduate and research program at University of health sciences. Coordinator for PhD committee of University of health sciences. Expert member for examination related work at University of health sciences. Coordinator, life planning center and center for health promotion, Kasturba Medical College. Member, visiting team for evaluation of diagnostic and clinical services at International medical centers (1985).

II.ANALYTICAL SKILLS AND INSTRUMENTATION

Techniques Extensive experience in different areas of clinical chemistry and toxicology. Expertise in routine chemistry, special chemistry including immunoasays, polymerase chain reaction, proteomics, flow cytometry, imaging techniques, assays of neurotransmitters and their metabolites employing high pressure liquid chromatography, metal analysis, STAT laboratory operations and urine analysis.

Quality control program. Methodology including evaluation and introduction of new procedures for the clinical laboratory.

Instrumentation Operation and maintenance of various laboratory instruments including Technicon RA XT autoanalyzer system, scintillation counters, gamma counters, blood gas analyzers, electrolyte analyzers and immunochemistry analyzers, HPLC systems, atomic absorption spectrophotometer and ultracentrifugation. Familiarization with mass spectrometry and proteomics.

Special training

1983 Endocrinological techniques and their applications National Institute of Nutrition, Hyderbad India

1984 Technicon auto analyzer systems Technicon Instruments, Singapore

1987 Hormone and receptor assays and their applications (Four weeks) National Institute of health and Family Planning, New Delhi India

1991-1992 Molecular Biology Department of Biochemistry and Molecular Biology University of Florida,

College of Medicine as a part of post-doctoral training at Department of Biochemistry,

University of Mississippi Medical Center, Jackson, Mississippi).

III.TEACHING AND EDUCATION

Graduate Teaching Twenty years of teaching experience of lecturing, tutoring and practical class teaching in Biochemistry for students in Medicine, Dentistry and Medical Laboratory Technology.

Post graduate Teaching for Residents in Biochemistry ( similar to clinical chemistry fellowship

program), Medicine, Dentistry MS Biochemistry, and MS biotechnology. Active involvement in Continuing Medical Education program and Symposia in Clinical Biochemistry in India including problem based learning in biochemistry

Coordinator, Educational Cell for Curriculum Development in Clinical Biochemistry, Association of Clinical Biochemists of India.

Committee member (International), Core Curriculum Development for Medical Education, Koirala Institute of Medical Sciences, Nepal

Co-author of Manual for Medical Laboratory Technology ( Aroor AR, Keshavamourthy KK and Nayak SS Clinical Biochemistry section, Ed. R. Reweigh) published by National Council for Educational Research and Training, India.1987

Curriculum Development Program for International Federation of Clinical Chemistry (2004-2007). Contribution of clinical chemistry web based topics as a corresponding member, IFCC from India as a National Representative of Association of Clinical Biochemists of India.

Author of “Medical Biochemistry”. Text book for medical students containing four integrated sections: Cell biology and chemistry, Metabolism and nutrition, Molecular biology and genetics, Specialized tissue and clinical biochemistry. 914 pages First Edition, 2011 Published by Jaypee Brothers Medical Publishers, India. Selected for e book portal. Reprinted in 2013.

IV.RESEARCH EXPERIENCE

A.Mentoring PhD students

PhD Guide for eight graduate students (1988-2005) in clinical chemistry and toxicology research.

Most of the research work is related to endocrinology, metabolism and neuroscience.

1.Cholesterol efflux proteins in health and disease:1991

2.Studies on the role of proteinase inhibitors in inflammation:1993

3.Indigenous drugs in learning and memory: 1993

4.Natriuretic hormones in hypertensive states:1995

5.Atherosclerosis risk factors in diabetes mellitus:1996

6.Biomarkers of oxidative stress in diabetes mellitus:2005

7.Studies on lead and alcohol interactive hepatotoxicity;2005

8.Studies on lead and alcohol interactive neurotoxicity:2005

B.Mentoring Postgraduate Students

Mentor for post graduate students in MD program in Biochemistry. Supervision of postgraduate (co-guide) in Medicine, Pediatrics, Surgery, Dentistry, Obstetrics and Gynecology and Pharmaceutical Sciences on Research in the area of biochemical endocrinology, inflammation, neurochemistry, oncology and nutrition

C.Graduate advisory and examination committees

Member, Expert Committee for evaluation of progress report for PhD thesis, Rajiv Gandhi University of Health Sciences (2003-2005)

Examiner for PhD thesis in Biochemistry in different Universities in India

D.Editorial Board Member for scientific journals

Member, Editorial Board, Indian Journal of Clinical Biochemistry

E.Research Support.

1.National Institutes of Translational control of gene 1991-1993 Visiting

Health (RO1) expression Scientist

2.National Institutes Mechanisms of alcohol 1993-1997 Visiting

of Health (RO1) suppression of immune response Scientist

3.National Institutes Alcohol and MAP Kinase cascade 2000-2001 Visiting of Health (RO1) signaling cascade Scientist

4.National Institutes Ethanol and MAP Kinase Cascade 2006-2008 Investigator

of health (RO1) Key Personnel

5.National Institutes Histone modifications by ethanol 2007-2011 Investigator

of Health (RO1) Mechanism and consequence Key Personnel

6.Boehringer-Ingelheim Impact of Linagliptin Therapy on Cardiac 2011 – 2014 Co- Investigator

and Renal Function in Rodent Models of

the Metabolic Syndrome

7.National Institutes Ang II and Overnutrition and Insulin 2011-2015 Co- Investigator

of Health (RO1) resistance in Cardiovascular Tissue

8.National institutes of Ang II and aldosterone effects on 2012-2014 Co- Investigator

Health (RO1) insulin resistance

9.Takeda Pharmaceuticals Comparison of Azilsartan Medoximil and 2011-2013 Investigator

Olmesartan Medoximil on Aldosterone

Breakthrough in Hypertensive Rats during

Chronic Ang II Infusion

10.Merck Effects of MK-0626 on cardiac and renal 2011-2013 Investigator

insulin resistance with focus on proximal

tubule NHE3

11.Bristol Myers Squibb Saxagliptin intervention for RAS activation 2013-2014 Investigator

in kidney

12.VA Merit award Interactions of the RAAS and a Western 2012-2017 Co-Investigator

Diet on Insulin Metabolic Actions

13.Boehringer-Ingelheim Impact of Empagliflozin and Linagliptin 2016 – 2017 Co-Investigator

Combination Therapy on Cardiovascular

and Kidney Disease Progression in

Rodent Models of Diabetes

.

14.Novartis Impact of Dual Acting Angiotensin-Receptor/ 2016-2017 Co-Investigator

Neprilysin Inhibitor (ARNi) Therapy on

Abnormal Cardiac, Vascular and Renal

Function in Male Zucker Rats.

15. VA merit Endothelial cell minrealocrticoid receptor and 2017-2021 Co-investigator

tubulointerstitial fibrosis

16. VA merit Cell specific mineralocorticoid receptor signaling 2018-2022 Co-investigator

Insulin resistance and cardiovascular stiffness

F.Publications

1..Reddy SK, Ballal AR, Shailaja S, Raviraja NS, Raghu Chandrashekhar RH, Sankhe R, Pai K, Tender T, Mathew M, Aroor A, Shetty AK, Adiga S, Devi V, Manjunath SM, Upadhya D Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy Theranostics .2023. (in press)

2.Foote,C A, Soares RN, Ramirez-Perez,F, Ghiarone,T Aroor AR, Manrique-Acevedo C, Padilla J and Martinez-Lemus, Endothelial Glycocalyx Amer J Physiology Compr Physiol. 2022 Aug 23;12(4):3781-3811

3.Ramirez-Perez FI, Cabral-Amador FJ, Whaley-Connell AT, Aroor AR, Morales-Quinones M, Woodford ML, Ghiarone T, Ferreira-Santos L, Jurrissen TJ, Manrique-Acevedo CM, Jia G, DeMarco VG, Padilla J, Martinez-Lemus LA, Lastra G. Cystamine reduces vascular stiffness in Western diet-fed female mice. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H167-H180.

4.Zhang L, Yang Y, Aroor AR, Jia G, Sun Z, Parrish A, Litherland G, Bonnard B, Jaisser F, Sowers JR, Hill MA. Endothelial sodium channel activation mediatesDOCA-salt-induced endothelial cell and arterial stiffening. Metabolism. 2022 May;130:155165.

5.Aroor AR, DeMarco VJ, Whaley-Connell AT, Jia J, Yang Y, Sharma N, Hans C, Hayden MR, Hill MA 4,6, Sowers RJ, Manrique-Acevedo C Lastra G Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice. Amer J Physiol Am J Physiol Regul Integr Comp Physiol. 2023 Jan 1;324(1):R90-R101.

6.Aroor AR, Mummidi S, Lopez-Alvarenga JC, Das N, Habibi J, Jia G, Lastra G, Chandrasekar B, DeMarco VG. Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness. Cardiovasc Diabetol. 2021 Apr 21;20(1):80.

7.Ramirez-Perez FI, Cabral-Amador FJ, Whaley-Connell AT, Aroor AR, Morales-Quinones M, Woodford ML, Ghiarone T, Ferreira-Santos L, Jurrissen TJ, Manrique-Acevedo CM, Jia G, DeMarco VG, Padilla J, Martinez-Lemus LA, Lastra G. Cystamine reduces vascular stiffness in Western diet-fed female mice. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H167-H180.

8.Manrique-Acevedo C, Padilla J, Naz H, Woodford ML, Ghiarone T, Aroor AR, Hulse JL, Cabral-Amador FJ, Martinez-Diaz V, Hans CP, Whaley-Connell A,Martinez-Lemus LA, Lastra G. Mineralocorticoid Receptor in Myeloid Cells. Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice. Front Physiol. 2021 Mar 29;12:588358.

9.Sukhanov S, Higashi Y, Yoshida T, Mummidi S, Aroor AR, Jeffrey RusselBender SB, DeMarco VG, Chandrasekar B. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion. Cell Signal. 2021 Jan;77:109825.

10.Das NA, Carpenter AJ, Belenchia A, Aroor AR, Noda M, Siebenlist U, Chandrasekar B, DeMarco VG. Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition. Cell Signal. 2020, 68:109506. doi:10.1016/j.

11.Aroor AR, Whaley-Connell A, Sowers JR. Renal resistive index as a novel biomarker for cardiovasankidney risk reduction in type II diabetes. Clin Hypertens (Greenwich). 2020 22:231-233.

12.Xiong Y, Aroor AR, Ramirez-Perez FI, Jia G, Habibi J, Manrique-Acevedo C,Lastra G, Chen D, DeMarco VG, Martinez-Lemus LA, Hill MA, Jaisser F, Sowers JR, Whaley-Connell A. Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na channel. Am J Physiol Renal Physiol. 2020;318:F1220-F1228.

13.Sowers JR, Habibi J, Jia G, Bostick B, Manrique-Acevedo C, Lastra G, Yang Y,Chen D, Sun Z, Domeier TL, Durante W, Whaley-Connell AT, Hill MA, Jaisser F,DeMarco VG, Aroor AR. Endothelial sodium channel activation promotes cardiac stiffness and diastolic dysfunction in Western diet fed female mice. Metabolism.2020,109:154223.

14.Sukhanov S, Higashi Y, Yoshida T, Mummidi S, Aroor AR, Jeffrey Russell J, Bender SB, DeMarco VG, Chandrasekar B. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation\ and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion. Cell Signal. 2021;77:109825.

15.Aroor AR, Whaley-Connell A, Sowers JR. Renal resistive index as a novel biomarker for cardiovascular and kidney risk reduction in type II diabetes. J Clin Hypertens (Greenwich). 2020 Feb;22(2):231-233

16.Nistala R, Meuth AI, Smith C, An J, Habibi J, Hayden MR, Johnson M, Aroor A, Whaley-Connell A, Sowers JR, McKarns SC, Bender SB. DPP4 inhibition mitigates ANG II-mediated kidney immune activation and injury in male mice. Am J Physiol Renal Physiol. 2021;320:F505-F517

17.Aroor AR, Whaley-Connell A, Sowers JR. Renal resistive index as a novel biomarker for cardiovascular and kidney risk reduction in type II diabetes. J Clin Hypertens (Greenwich). 2020; 22:231-233.

18.Aroor AR, Whaley-Connell A, Sowers JR. Renal resistive index as a novel biomarker for cardiovascular and kidney risk reduction in type II diabetes. J Clin Hypertens (Greenwich). 2020 ;22:231-233.

19.Das NA, Carpenter AJ, Belenchia A, Aroor AR, Noda M, Siebenlist U, Chandrasekar B, DeMarco VG. Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition. Cell Signal. 2019;68:10950

20.Grunewald ZI, Jurrissen TJ, Woodford ML, Ramirez-Perez FI, Park LK, Pettit-Mee R, Ghiarone T, Brown SM, Morales-Quinones M, Ball JR, Staveley-O'Carroll KF, Aroor AR, Fadel PJ, Paradis P, Schiffrin EL, Bender SB, Martinez-Lemus LA, Padilla J. Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation. Hypertension. 2019;74:1409-1419.

21.Padilla J, Woodford ML, Lastra-Gonzalez G, Martinez-Diaz V, Fujie S, Yang Y, Lising AMC, Ramirez-Perez FI, Aroor AR, Morales-Quinones M, Ghiarone T, Whaley-Connell A, Martinez-Lemus LA, Hill MA, Manrique-Acevedo C. Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice. Endocrinology. 2019;160:2918-2928.

22.Aroor AR, Whaley-Connell A, Sowers JR. Utility of obesity and metabolic dyslipidemia (a non-insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness. J Clin Hypertens (Greenwich). 21:1071-1074.

23.Shukla SD, Restrepo R, Aroor AR, Liu X, Lim RW, Franke JD, Ford DA, Korthuis RJ. Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles. J Pharmacol Exp Ther. 2019;370:390-398.

24.Jia G, Aroor AR, Jia C, Sowers JR. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2019;1865:1802-1809.

25.Habibi J, Aroor AR, Das NA, Manrique-Acevedo CM, Johnson MS, Hayden MR, Nistala R, Wiedmeyer C, Chandrasekar B, DeMarco VG. The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat. Cardiovasc Diabetol. 2019;18:40.

26.Sharma N, Dev R, Belenchia AM, Aroor AR, Whaley-Connell A, Pulakat L, Hans CP.Deficiency of IL12p40

(Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm. Arterioscler

Thromb Vasc Biol. 2019;39:212-223.

27.Hayden MR, Grant DG, Aroor AR, DeMarco VG. Empagliflozin Ameliorates Type 2Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse. Brain Sci. 9.2019.

28.Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G,Whaley-Connell A. Diet-Induced Obesity Promotes KidneyEndothelial Stiffening and Fibrosis Dependent on the EndothelialMineralocorticoid Receptor. Hypertension.73:849-858. 2019.

29.Aroor AR, Das NA, Carpenter AJ, Habibi J, Jia G, Ramirez-Perez FI,Martinez-Lemus L, Manrique-Acevedo CM, Hayden MR, Duta C, Nistala R, Mayoux E,Padilla J, Chandrasekar B, DeMarco VG. Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury. Cardiovasc Diabetol.17:108,2018

30.Jia G, Aroor AR, Hill MA, Sowers JR. Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness. Hypertension.72:537-***-****

31.Jia G, Habibi J, Aroor AR, Hill MA, Yang Y, Whaley-Connell A, Jaisser F, Sowers JR. Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction. Hypertension. 72:731-***-****.

32.Hayden MR, Grant D, Aroor AR, and DeMarco VG. Ultrastructural Remodeling of The Neurovascular Unit in The Female Diabetic db/db Model – Part I: Astrocyte. Neuroglia 1(1), 220-244; 2018.

33. Hayden MR, Grant D, Aroor AR, and DeMarco VG. Ultrastructural Remodeling of The Neurovascular Unit in The Female Diabetic db/db Model – Part II: Microglia and Mitochondria. Neuroglia 1, 311-326; 2018.

34. Hayden MR, Grant D, Aroor AR, and DeMarco VG. Ultrastructural Remodeling of The Neurovascular Unit in The Female Diabetic db/db Model – Part III: Oligodendrocyte and Myelin. Neuroglia 1(2), 351-364;2018.

35.Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR. Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening. Curr Hypertens Rep.20:76.2018

36.Aroor AR, Manrique-Acevedo C, DeMarco VG. The role of dipeptidylpeptidase-4inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin. Cardiovasc Diabetol.17:59.2018.

37.Aroor AR, Jia G, Sowers JR. Cellular mechanisms underlying obesity-induced arterial stiffness. Am J Physiol Regul Integr Comp Physiol.314:R387-R398.2018.

38.Jia G, Habibi J, Aroor AR, Hill MA, DeMarco VG, Lee LE, Ma L, Barron BJ, Whaley-Connell A, Sowers JR. Enhanced endothelium epithelial sodium channel signaling prompts left ventricular diastolic dysfunction in obese female mice. Metabolism. 78:69-79. 2018

39.Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M, Barron B, Mayoux E, Rector RS, Whaley-Connell A, DeMarco VG. Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes. Cardiovasc Diabetol. 16:9, 2017.

40.Bostick B, Aroor AR, Habibi J, Durante W, Ma L, DeMarco VG, Garro M, Hayden MR, Booth FW, Sowers JR. Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels. Metabolism. 66:14-22.2017.

41.Brown SM, Smith CE, Meuth AI, Khan M, Aroor AR, Cleeton HM, Meininger GA,Sowers JR, DeMarco VG, Chandrasekar B, Nistala R, Bender SB. Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice. Endocrinology.158(10):3592-3604.2017.

42.Jia G, Aroor AR, Sowers JR. The role of mineralocorticoid receptor signaling in the cross-talk between adipose tissue and the vascular wall. Cardiovasc Res. 113:1055-1063. 2017.

43. Aroor AR, Jia G, Habibi J, Sun Z, Ramirez-Perez FI, Brady B, Chen D, Martinez-Lemus LA, Manrique C, Nistala R, Whaley-Connell AT, Demarco VG, Meininger GA, Sowers JR. Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice. Metabolism.;74:32-40. 2017.

44.Martinez-Lemus LA, Aroor AR, Ramirez-Perez FI, Jia G, Habibi J, DeMarco VG,Barron B, Whaley-Connell A, Nistala R, Sowers JR. Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet. Front Physiol. 8:456. 2017

45.Lastra G, Manrique C, Jia G, Aroor AR, Hayden MR, Barron BJ, Niles B, Padilla J, Sowers JR. Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice. Am J Physiol Regul Integr Comp Physiol. 313: R67-R77. 2017.

46. Aroor AR, Habibi J, Kandikattu HK, Garro-Kacher M, Barron B, Chen D, Hayden MR, Whaley-Connell A, Bender SB, Klein T, Padilla J, Sowers JR, Chandrasekar B, DeMarco VG. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol. 16:61. 2017

47.Manrique-Acevedo C, Ramirez-Perez FI, Padilla J, Vieira-Potter VJ, Aroor AR, Barron BJ, Chen D, Haertling D, Declue C, Sowers JR, Martinez-Lemus LA. Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet-Fed Male Mice. Endocrinology. 2017 158:1875-1885. 2017.

48.Jia G, Aroor AR, Sowers JR. Glucagon-Like Peptide 1 Receptor Activation and Platelet Function: Beyond Glycemic Control. Diabetes. 65:1487-9.2016.

49. Nistala R, Meuth A, Smith C, Annayya A. Reliable and High Efficiency Extraction of Kidney Immune Cells. J Vis Exp. (114). 2016.

50.Padilla J, Ramirez-Perez FI, Habibi J, Bostick B, Aroor AR, Hayden MR, Jia G, Garro M, DeMarco VG, Manrique C, Booth FW, Martinez-Lemus LA, Sowers JR. Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet-Fed Female Mice. Hypertension. 68:123*-****-****.

51. Manrique C, Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M,Martinez-Lemus LA, Ramirez-Perez FI, Klein T, Meininger GA, DeMarco VG.Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. Cardiovasc Diabetol. 8;15:94. 2016.

52.: Aroor A, Zuberek M, Duta C, Meuth A, Sowers JR, Whaley-Connell A, Nistala R.Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal tubules. Int J Mol Sci. 17:5,2016

53. Jia G, Habibi J, Aroor AR, Martinez-Lemus LA, DeMarco VG, Ramirez-Perez FI,Sun Z, Hayden MR, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR. Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.Circ Res. 118:935-43.2016.

54.Manrique C, Lastra G, Ramirez-Perez FI, Haertling D, DeMarco VG, Aroor AR, Jia G, Chen D, Barron BJ, Garro M, Padilla J, Martinez-Lemus LA, Sowers JR. Endothelial estrogen receptor alpha does not protect against vascular stiffness induced by Western Diet in female mice. Endocrinology. en20151681.2016

55.Shukla SD, Aroor AR, Restrepo R, Kharbanda KK, Ibdah JA. In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses. Biomolecules. 5 :3280-94, 2015.

56.Jia G, Aroor AR, DeMarco VG, Martinez-Lemus LA, Meininger GA, Sowers JR. Vascular stiffness in insulin resistance and obesity. Front Physiol. 6:231, 2015.

57.DeMarco VG, Habibi J, Jia G, Aroor AR, Ramirez-Perez FI, Martinez-Lemus LA, Bender SB, Garro M, Hayden MR, Sun Z, Meininger GA, Manrique C, Whaley-Connell A, Sowers JR. Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice. Hypertension. 66:99-107, 2015.

58.Bostick B, Habibi J, DeMarco VG, Jia G, Domeier TL, Lambert MD, Aroor AR, Nistala R, Bender SB, Garro M, Hayden MR, Ma L, Manrique C, Sowers JR. Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice. Am J Physiol Heart Circ Physiol. 308:H1126-35, 2015.

59.Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension. 65:1082-8, 2015.

60.Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS. Dipeptidyl peptidase-4inhibition ameliorates western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function. Diabetes. 64:1988-2001, 2015.

61.Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR. Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome. Arch Toxicol. 89:147-53, 2015.

62.Jia G, Habibi J, Bostick BP, Ma L, DeMarco VG, Aroor AR, Hayden MR, Whaley-Connell AT,

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