Chemistry Lab Research Assistant

Maryam Zangi Email : ******.*****@*****.***

Phone : 618-***-****

SUMMARY

• I am a 5

th

year PhD candidate in organic/medicinal chemistry with an extensive experience in organic synthesis. Synthetic organic chemist with strong medicinal chemistry background. Skilled in independent design and implementation of organic syntheses. Enthusiastic, knowledgeable, self-motivated and skilled chemist with 5+ years of hands-on experience in designing and executing multi-step syntheses and optimizing chemical reactions. Highly organized experimental chemist, confident team player and trainer to undergraduate student in the lab. GENERAL TECHNIQUES AND SKILLS

• Synthetic Methods: Experienced in the production of multi-gram to milligram amounts of targets; adept at isolation and characterization of products using a full scope of instrumentation; strategic and efficient design of executable synthetic routes; multi-step synthesis (parallel and convergent synthesis) of complex organic molecules; microwave synthesis; lyophilization; purification and isolation of small molecules through extraction, distillation, trituration, and recrystallization.

• Computational Skills: Schr odinger Maestro software suite, SciFinder, ChemDraw, Microsoft Office (Word, Excel, PowerPoint), LATEX, PyMol, Gaussian, Chemical and Database Searching.

• Analytical Techniques: NMR (1D, 2D), qNMR, UV-Vis absorption, LC-MS, IR spectroscopy, prep-HPLC, automated flash chromatography systems.

RESEARCH AND PROFESSIONAL EXPERIENCE

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Intern at Biogen Cambridge, MA

06/2022 – 08/2022

Assess the qNMR method parameters, calculated purity, potency, specificity, linearity, instrument method precision and accuracy on therapeutic drug for Acute Ischemic Stroke at phase 2

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Research and Teaching Assistant St. Louis University St. Louis, MO 08/2018 – Present

Train and supervise undergraduate student, shared expertise, knowledge and skills to run experiments for Crypto project

Collaborating with St. Louis university Environmental Health and Safety Center

Responsible for laboratory chemical waste and hazardous materials removal

Teaching Assistant, Organic Chemistry Lab

Synthesized derivatives of Ciclopirox as an effective inhibitors of Cryptococcus neoformans

Synthesized derivatives of the anti-fungal drug Ciclopirox as an active compound against herpes simplex virus II

Developed structure-activity relationships for pyrazolopyrimidines as potential drug for cryptosporidiosis

Synthesized and assessed analogs for HNOs as anti-HBV compounds for their antiviral potency and potential as lead compounds

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Research and Teaching Assistant, SIUE Edwardsville, IL 01/2017 – 06/2018

Teaching Assistant, General Chemistry Lab

Worked on tandem Oxa-Michael Ugi-Smiles couplings with α,β-unsaturated aldehydes

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Research Assistant, Tehran University of Medical Sciences Tehran, Iran 06/2016 – 12/2016

Synthesized organic compounds, designed small organic molecules, developed methodology towards optimize reaction conditions and characterization of synthesized compounds

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Research Assistant, Sharif University of Technology Tehran, Iran 01/2008 – 08/2008

Worked on calculation of hydrogen bonding strength on the overall inter-molecular interactions between series of anions helping Gaussian software

PUBLICATIONS AND CONFERENCE PRESENTATIONS

• Lin, J.; Zangi, M.; Kumar, T. V. N. H.; Shakar Reddy, M.; Reddy, L. V. R.; Sadhukhan, S. K.; Bradley, D. P.; Moreira-Walsh, B.; Edwards, T. C.; O’Dea, A. T.; Tavis, J. E.; Meyers, M. J.; Donlin, M. J. Synthetic Derivatives of Ciclopirox Are Effective Inhibitors of Cryptococcus neoformans. ACS Omega 2021, 6 (12), 8477-8487.

• Zangi, M.; Donald, K. A.; Casals, A. G.; Franson, A. D.; Yu, A. J.; Marker, E. M.; Woodson, M. E.; Campbell, S. D.; Mottaleb, M. A.; Narayana Hajay Kumar, T. V.; Reddy, M. S.; Raghava Reddy, L. V.; Sadhukhan, S. K.; Griggs, D. W.; Morrison, L. A.; Meyers, M. J. Synthetic Derivatives of the Antifungal Drug Ciclopirox Are Active Against Herpes Simplex Virus 2. European Journal of Medicinal Chemistry 2022, 238, 114443.

• Thessing, A.; Ayres, R.; Jones, J.; Bauer, H.; Zangi, M.; Luesse, S. B. Oxa-Michael/Ugi-Smiles Cascade Reaction With α,β-Unsaturated Aldehydes. Results in Chemistry 2022, 4, 100416.

• Synthesis of Derivatives of the Antifungal Drug Ciclopirox for Evaluation Against Herpes Simplex Virus 2, Zangi, M., Morrison, L. A., Meyers, M. J., Midwest Regional Meeting (MWRM), Iowa City, IA October 2022

• Synthetic Derivatives of Ciclopirox as an Effective Inhibitors of Cryptococcus neoformans, Zangi, M., Lin, J., Meyers, M. J., Donlin, M. J., 34th Annual Organic Chemistry Day, University of Missouri-Columbia, MO April 2022

• Synthesis and evaluation of ciclopirox analogs as antiviral agents against herpes simplex virus 2, Zangi, M., Meyers, M. J., ACS National Meeting, San Diego, CA March 2022

• Exploration of Ugi-Smiles Reactions Involving Oxy-Michael Additions, Zangi, M., Luesse, S. B., 255th ACS National Meeting, New Orleans, LA March 2018 AWARDS AND AFFILIATIONS

• National Institutes of Health(NIH) funded project 2019 - Present

• Graduate Scholarship from Chemistry Department at SIUe 2017 - 2018

• Research Grants for Graduate Students (RGGS) award 2017

• Member of American Chemical Society(ACS) 2017 - Present EDUCATION

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Ph.D. Organic Chemistry Saint Louis University, St. Louis, MO 07/2018–Present

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M.S. Organic Chemistry Southern Illinois University Edwardsville, Edwardsville, IL 01/2017–06/2018

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B.S. Chemistry Sharif University of Technology Tehran, Iran 08/2004–08/2009

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