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performed for a positive result

may find as the most clinically

significant

lesion: colorectal cancer [4.0%],

advanced adenoma (including

sessile serrated polyps greater

than or equal to 1cm diameter)

[20%] or non- advanced

adenoma [31%]; or no colorectal

neoplasia [45%]. These estimates

are derived from a prospective

cross-sectional screening study

of 10,000 individuals at average

risk for colorectal cancer who

were screened with both

Cologuard and colonoscopy.

(Imperiale T. et al, N Engl J Med

2014;370(14):1286-1297.)

Cologuard may produce a false

negative or false

positive result (no colorectal

cancer or precancerous polyp

present at colonoscopy follow