Dr. LAVANYA GOPALA

Post Doctoral Research Fellow

Department of Chemistry,

Sookmyung Women’s University,

Seoul, South Korea.

Email: adpxp0@r.postjobfree.com

adpxp0@r.postjobfree.com.

EDUCATION:

PDF. (Post Doctoral Research Fellow) in Chemistry 2021-Present Sookmyung Women’s University, Seoul, South Korea.

PDF. (Post Doctoral Research Fellow) in Medicinal Chemistry 2019-2021 Donghua University, Shanghai, China.

PDF. (Post Doctoral Research Fellow) in Medicinal Chemistry 2016-2018 Southwest University, Chongqing, China.

Ph.D., (Doctor of Philosophy in Chemistry) in Organic Chemistry 2010-2014 Sri Venkateswara University, Tirupati, India.

M.Sc., (Master of Sciences) in Organic Chemistry 2006 – 08 Sri Venkateswara University, Tirupati, India. Percentage: 72.3% B.Sc., (Bachelor of Sciences) in

Chemistry, Medical Lab Technology, Microbiology 2003 - 06 Sri Venkateswara University, Tirupati, India. University 1 st

Rank

AREAS OF EXPERTISE:

• Heterocyclic Chemistry.

• Organic Synthesis.

• Biological studies of compounds.

• Carbohydrate Chemistry.

KEY SKILLS:

• Designing and executing the multi-step synthesis of complex bioactive molecules and development of new methodologies for organic synthesis

• Capable of doing both collaborative and independent projects

• Experienced in milligram to gram scale reactions

• Expertise in purification techniques such as Column Chromatography, Preparative and thin layer chromatography

• Experience with IR and UV-VIS Spectrometer (Schimadzu)

• Apart from bench work, actively involved in literature search and manuscript preparation

• Well versed with the data interpretation:

1

H,

13

C-NMR, MS, UV and IR.

• Computer knowledge MS Word, Power point, ChemDraw, ISIS draw, Scopus and Sci-Finder.

ACHIEVEMENTS:

University 1

st

rank holder in Under Graduation from Sri Venkateswara University.

Indira Gandhi’s Fellowship, in MSc. from University Grants Commission, New Delhi (2006-2008).

University Research Fellow, (01-07-2010 to 31-03-2012).

University Grants Commission –Bachelor of Scientific Research Junior Research Fellowship, University Grants Commission, New Delhi (01-04-2012 to 31-03-2014).

University Grants Commission - Bachelor of Scientific Research (Senior Research Fellowship), University Grants Commission, New Delhi (01-04-2014 to 05-11-2014).

The Best Poster Award in International Seminar on Emerging Trends in Synthetic Organic Medicinal Chemistry (ESMC – 2013).

The Special Appreciation Poster Award in International Symposium on Environmental Pollution, Nutrition and Genetics Cancer Biology and Therapeutics - 2013).

Appreciation Award in workshop on Spectroscopy.

The Research Fellowship for International Young Scientists from International

(Regional) Cooperation and Exchange Program of China National Natural Science Foundation (NSFC) (No. 816********).

The Research Member in International (Regional) Cooperation and Exchange Program of China National Natural Science Foundation Project (NSFC) (No. 21672173).

The Research Fellowship for Post Doctoral Researchers from Chongqing Special Foundation Program in China for Young Talents (CSFP) (No. Xm2017185).

TECHNICAL SKILLS:

Operating System: Windows XP, Windows Vista, windows 8 Software Skills: SAS-Base and Advance,

SAS-Clinical, Clinical Research,

Clinical Data Management,

Oracle 10g, C, C++, VB. Net,

M.S. Office.

TECHING EXPERIENCE:

• Handled Classes for M.Sc., Organic, Medicinal and Five year Integrated Chemistry courses during the year 2010-2013.

• Working as Research Assistant in Hyderabad Central University (March-May-2015). RESEARCH EXPERIENCE:

In-vivo activity studies for the synthesized compounds like anti-inflammatory activity.

Antimicrobial activity and structure activity relationship of different heterocycles was studied. Some of the lead molecules have also been evaluated for their antimicrobial and antioxidant activities.

A variety Michael adducts were prepared to explore the Michael addition of various active methylene compounds to a variety of unsaturated sulfones.

The 1,3-dipolar cycloaddition methodology was used to develop mixed bisheterocycles viz., bis pyrroles, pyrazolines and isoxazolines.

Different ketene dithiolates were explored for the development of different five and six membered heterocycles.

Symmetrical and unsymmetrical oxadiazoles, thiadiazoles and triazoles were developed utilizing synthetic viability of different substrates.

Interconversion of heterocycles viz., conversion of oxadiazoles to thiadiazoles and triazoles was successfully accomplished in the presence of appropriate nucleophiles.

A new class bis heterocycles pyrazolyl oxadiazoles were developed from multi functional synthetic intermediate adopting 1,3-dipolar cycloaddition and cyclocondensation methodologies.

One pot methodology for five membered heterocycles viz., 2-oxazolines and 2- thiazolines was developed exploiting Samarium chemistry. PUBLICATIONS:

1. G. Lavanya, L. Mallikarjuna Reddy, V. Padmavathi and A. Padmaja

“Synthesis and antimicrobial activity of (1,4-phenylene)bis(aryl sulfonylpyrazoles and isoxazoles)”

European Journal of Medicinal Chemistry, Volume 73, 2014, Pages 187-194. 2. G. Lavanya, V. Padmavathi and A. Padmaja

“Synthesis and antioxidant activity of 1,4-[bis(3-arylmethanesulfonylpyrrolyl and pyrazolyl)]benzenes”

Journal of Brazilian Chemical Society, Volume 7, 2014, Pages 1200-1207. 3. G. Lavanya, T. Bhanu Prakash, G. Sravaya, V. Padmavathi and A. Padmaja

“Synthesis and antioxidant activity of bis unsaturated sulfones, bis pyrroles and bis pyrazoles”

Research On Chemical Intermediates, Volume 41, 2015, Pages 1930-1938. 4. G. Lavanya, V. Padmavathi A. Padmaja and M. Balaji

“Synthesis and anti-inflammatory activity of bis pyrazoles and bis isoxazoles” Medicinal Chemistry Research, Volume 24, 2015, Pages 3785-3793. 5. N. Mahoob Basha, G. Lavanya, A. Padmaja and V. Padmavathi

“Synthesis and Antioxidant activity of acetamidomethylsulfonyl bis- heterocycles-oxazolyl / thiazolyl / imidazolyl-1, 3, 4-oxadiazoles” Archiv Der Pharmazie, Volume 346, 2013, Pages 511-520. 6. Muralikrishna, G. Mallikarjuna Reddy, G. Lavanya, V. Padmavathi and A. Padmaja

“Synthesis of a new class of sulfonamido bis heterocycles—pyrrolyl/ pyrazolyl-1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazoles” Journal of Heterocycles Chemistry, Volume 51, 2014, Pages: 179-190. 7. T. Bhanu Prakash, G. Lavanya, A. Padmaja and V. Padmavathi

“Synthesis and antioxidant activity of amidomethane sulfonyl-linked bis- heterocycles”

Medicinal Chemistry Research, Volume 51, 2014, Pages 4500-4505. 8. Padmaja, P. Malla Kondaiah, G. Lavanya, and C. Rajasekhar

“Synthesis of symmetrical bis(5-substituted oxadiazolyl / thiadiazolyl / triazolylmethyl)sulfones”

Journal of Heterocyclic Chemistry Volume 13, 2016, Pages 2231- 2239. 9. L. Mallikarjuna Reddy, G. Lavanya, A. Padmaja and V. Padmavathi

“Synthesis and antimicrobial activity of sulfur linked bis and tris heterocycles” Journal of Heterocyclic Chemistry Volume 54, 2017, Pages 00-00. 10. Han-Bo Liu, Lavanya Gopala, Srinivasa Rao Avula, Ponmani Jeyakkumar, Xin-Mei Peng*, Cheng-He Zhou*and Rong-Xia Geng*

“Chalcone-benzotriazole conjugates as new potential antimicrobial agents: Design, synthesis, biological evaluation and synergism with clinical drugs” Chinese Journal of Chemistry Volume 35, 2017, Pages 483-496. 11. Ponmani Jayakkumar, Han-Bo Liu, Lavanya Gopala, Yu Cheng, Xin-Mei Peng, Rong-xia Geng and Cheng-He Zhou*

“Novel benzimidazolyl tetrahydroprotoberberines:Design, synthesis, antimicrobial evaluation and multi-targeting exploration”

Bioorganic Medicinal Chemistry Letters Volume 27, 2017, Pages 1737-1743. 12. Quan-Cheng, Hui Wang, Vijai Kumar Reddy Tangadanchu, Lavanya Gopala, Cheng-He Zhou*

“Chalcone-benzotriazole conjugates as new potential antimicrobial agents: Design, synthesis, biological evaluation and synergism with clinical drugs”

Scientia Sinica Chimica Volume 47, 2017, Pages 844-858. 13. Jun-Rong Duan, Han-Bo Liu, Ponmani Jeyakkumar, Lavanya Gopala, Xin- Mei Peng*, Shou Li, Rong-Xia Geng and Cheng-He Zhou*

“Synthesis of a series of Schiff base-bridged tetra-hydroprotoberberine triazoles as a new type of Potential antimicrobial agents and preliminary interactions with DNA indicated the possible interaction mechanism.” Med Chem Comm, Volume, 2017, Pages 1-10.

14. Hui-Zhen Zhang, Shi-Chao He, Yan-Jun Peng, Lavanya Gopala, Vijai Kumar Reddy Tangadanchu, Lin-Ling Gan, Cheng-He Zhou*

“Design, Synthesis and antimicrobial evaluation of novel benzimidazole- incorporated sulphonamide analogues.”

European Journal of Medicinal Chemistry Volume 136, 2017, Pages 165- 183.

15. Jie Kanga, Vijai Kumar Reddy Tangadanchua, Lavanya Gopala, Wei-Wei Gaoa, Yu Chenga, Han-Bo Liua, Rong-Xia Genga, Shuo Lib,* Cheng-He Zhou,*

“Novel potentially antibacterial naphthalimide-derived metronidazoles: Design, synthesis, biological evaluation and supramolecular interactions with DNA, human serum albumin and topoisomerase II”

Chinese Journal of Chemistry Volume 28, 2017, Pages 1369-1374. 16. Xian-Fu Fang, Di Li, Vijai Kumar Reddy Tangadanchua, Lavanya Gopala, Wei-Wei Gaoa, Cheng-He Zhou,*

“Novel potentially antifungal hybrids of 5-flucytosine and fluconazole:Design, synthesis and bioactive evaluation”

Bioorganic Medicinal Chemistry Letters Volume 27, 2017, Pages 4964-4969. 17. Zhen-Zhen Li, Lavanya Gopala, Vijai Kumar Reddy Tangadanchua, Wei-Wei Gaoa, Cheng-He Zhou,*

“Discovery of Novel Nitroimidazole Enols as Pseudomonas Aeruginosa DNA Agents”

Bioorganic Medicinal Chemistry Letters Volume 136, 2017, Pages 165- 183. 18. Guo-Biao Zang, Swetha kameswari Malladi, Vijai Kumar Reddy Tangadanchua, Lavanya Gopala, Gao, Wei-Wei, Gui-Xin Cai,* and Cheng- He Zhou,*

“Discovery of natural berberine-derived nitroimidazoles as potentially multi- targeting agents against drug-resistant Escherichia coli” Science China Chemistry Volume 61, 2018, Pages 557-568. 19. Gao, Wei-Wei, Lavanya Gopala, Rammohan R. yadav, Guo-Biao, Li,Shou, and Cheng-He Zhou,*

“Discovery of 2-Aminothiazolyl Berberine Derivatives as Novel Effectively Antibacterial Agents toward Clinical Drug-resistant Gram-negative Acinetobacter baimanii”

European Journal of Medicinal Chemistry Volume 146, 2018, Pages 15-37. 20. Chen Ying-Ying, Lavanya Gopala, Rammohan R. yadav, Liu Han-Bo, Cheng Yu, Rong-Xia and Cheng-He Zhou,*

“Novel Naphthalimide Aminothiazoles as Potential Multi-Targeting Antimicrobial Agents”

ACS-Medicinal Chemistry Letters Volume 8, 2018, Pages 1331-1335. 21. Jie Kanga, Lavanya Gopala, Vijai Kumar Reddy Tangadanchua, Gao, Wei- Wei and Cheng-He Zhou,*

“Novel Naphthalimide nitroimidazoles as multitargeting antibacterial agents against resistant Acinetobacter Baumannil”

Future Medicinal Chemistry Volume 10 (7), 2018, Pages 711-724. 22. Lavanya Gopala*

“An Outline In Vitro Investigation Of The Antimicrobial Efficacy Of Novel PDT- Naphthalimide Derivatives”

ACS-Medicinal Chemistry Letters (Under Revision).

23. Peng-LiZhang, LavanyaGopala, Shao-LinZhang, Gui-XinCai, Cheng-HeZhou*,

“An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a.”

European Journal of Medicinal Chemistry Volume 229, 2022, Pages 1140-1150. REVIEW ARTICLES:

1. Lavanya Gopala,* Zhi-Long Chen

“Detail Synthetic Study of Infrared Fluorescent Dyes: Design, Synthesis and Chemical Properties of their Photodynamic Therapy Probes.” Chemical Review and Letters (In Press).

PATENTS:

1. Lavanya Gopala, Bheemanaboina Rammohan Rao Yadav, Kangjie, Chen Ying- Ying, Zhou Cheng-He*.

“Naphthalimide Derivatives- Preparation Methods and its Applications.” China Patent –By Case Number- CQF170811597.

2. Lavanya Gopala, Chen Ying- Ying, Zhou Cheng-He*.

“Study on the preparation and application of the Schiff base bridged polyimide derivatives.”

3. Kangjie, Lavanya Gopala, Bheemanaboina Rammohan Rao Yadav, Zhou Cheng-He*.

“Cycloaliphatic amine naphthyl imide derivatives of metronidazole an its preparation method and application.”

China Patent –By Case Number- CQF17061121.

4. Bheemanaboina Rammohan Rao Yadav, Lavanya Gopala, Kangjie, Chen Ying- Ying, Zhou Cheng-He*.

“Sulfonyl benzimidazole compounds and their preparation and application.”

China Patent –By Case Number- CQF171012136.

CONFERENCE PAPERS:

1. Lavanya Gopala, Ying-Ying Chen, Rammohan R. Yadav Bheemanaboina,Jie Kang, Cheng-He Zhou*.

Design and Synthesis of Napthalimide-derived Fluconazole Analogues. (Page 162).

2. Ying-Ying Chen, Lavanya Gopala, Cheng-He Zhou*. Synthesis of potential MRSA DNA-targeting naphthalimide aminothiazoles as novel antimicrobial agent. (Page 160).

3. Ying-Ying Chen, Lavanya Gopala, Jie Kang, Cheng-He Zhou*. Novel aminothiazole-based naphthalimides: Design, synthesis and biological evaluation (Page 164).

CONFERENCES:

1. National Seminar- Recent Research Trends in Synthetic Organic and Natural Products Chemistry – February -2008-Sri Venkateswara University-Tirupati. 2. National Seminor-Seminar on Spectroscopy – August-2008-Hyderabad. 3. National Seminar–Vedic Science in Relevance to Modern Science-September- 2010-Sri Venkateswara University -Tirupati.

4. National Seminar-Trends 2011 in Biochemistry-Conference on Biochemistry and Molecular biology Concepts- November-2011- Sri Venkateswara University -Tirupati.

5. National Seminar-Current Trends and Development in Organic Synthesis- December-2011-Sri Venkateswara University -Tirupati. 6. National Seminar- Recent Research Trends in Chemical Sciences-December- 2011- Poster Presentation- Sri Venkateswara University -Tirupati. 7. National Seminar-Biotic and Abiotic- Their Health and Therapeutic Applications-February-2012- Poster Presentation- Sri Venkateswara University- Tirupati.

8. National Seminar-Recent Research Trends in Synthetic Organic and Natural Products Chemistry-March-2012- Poster Presentation- Sri Venkateswara University -Tirupati.

9. International Seminar-Current Trends in Environmental Toxicology and Experimental Therapeutics-December-2012- Poster Presentation- Vikrama Simhapuri University-Nellore.

10. International Seminar-Emerging Trends in Synthetic Organic Medicinal Chemistry- November-2013- Bester Poster Award-III- Vikrama Simhapuri University-Nellore.

11. International Seminar-Environmental Pollution, Nurition and Genetics a Special Symposium on Cancer Biology and Therapeutics-December-2013-Appreciation Award for Poster Presentation- Vikrama Simhapuri University -Nellore. 12. International Seminar-Nature Inspired Initiatives in Chemical Trends-March- 2014- Poster Presentation- Indian Institute of Chemical Technology- Hyderabad.

WORKSHOPS:

1. One day workshop on Spectroscopy-Vikrama Simhapuri University -Nellore

-February-2014.

2. A Workshop on – Science Academies-Lecture workshop on Advances in Biology and Biotechnology-Sri Venkateswara University -Tirupati -March-2014. 3. A Workshop on – Radiochemistry and radioisotope applications-Vikrama Simhapuri University -Nellore-April-2014.

REFERENCES:

1. Dr. B.V.Subba Reddy,

Sr Principal Scientist,

Organic Division-1,

Indian Institute of Chemical Technology (IICT)

Uppal Road,

Hyderabad – 500 007.

Email: adpxp0@r.postjobfree.com

2. Prof. Cheng He-Zhou

Laboratory of Bioorganic & Medicinal Chemistry,

School of Chemistry and Chemical Engineering,

Southwest University, Chongqing 400715, P. R. China. Email: adpxp0@r.postjobfree.com

3. Dr. A. Padmaja

Associate Professor

Department of Chemistry

Sri Venkateswara University, Tirupati, India

Email: adpxp0@r.postjobfree.com.

4. Prof. V. Padmavathi

Department of Chemistry

Sri Venkateswara University, Tirupati, India

Email: adpxp0@r.postjobfree.com.

5. Dr. P. Srinivas

Senior Scientist

Department of Catalysis

IICT Hyderabad, India

Email: adpxp0@r.postjobfree.com.

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