Research Fellow stem cells, pharmacogenetics, molecular and cell biol

Dr. Rima Hamdan

Stem Cells Consultant

Beirut, Lebanon

*********@*****.***

+961 (3) 025696

www.linkedin.com/in/rimahamdan (Publications: Check LinkedIn) Dual Nationalities: French and Lebanese

OVERVIEW A tenacious Stem Cells Consultant and University Professor with over eight (8) years of work experience with extensive knowledge in stem cell differentiation, laboratory research and development with a leading Lebanese American research center, and teaching students of different universities in Lebanon. Being trilingual with dual nationalities (French and Lebanese) and dealing with people from different cultures and backgrounds helped me develop high social adaptability and build strong public relations. And it all makes me able and motivated to join any respectable institution that valorizes diversity, fairness, and continuous development. ACHIEVEMENTS Succeeded in publishing twelve (12) biological sciences publications about different topics such as Crohn's disease, Xenogenic bone matrix, and genetic polymorphism and wrote a chapter of a book about the pathophysiology of gap junctions in the brain throughout my years of study and work at AUB, and conducted three (3) presentations at national and international meetings.

Publications :

- R Hamdan-Khalil, D Allorge, J-M Lo-Guidice, C Cauffiez, D Chevalier, N Houdret, C Libersa, M Lhermitte, J-F Colombel, J-L Gala and F Broly. In vitro characterization of four novel non- functional variants of the thiopurine S-methyltransferase (TPMT). Biochem Biophys Res Commun 309:1005-10,2003.

- D Allorge, R Hamdan-Khalil, Groupe d’Etudes Thérapeutiques des Affections Inflammatoires Digestives (GETAID), F Broly and J-F Colombel. ITPA genotyping test does not improve detection of Crohn’s disease patients at risk of azathioprine/6-mercaptopurine-induced myelosuppression. Gut. 2005 Apr;54(4):565.

- R Hamdan-Khalil, J-L Gala, D Allorge, J-M Lo-Guidice, Y Horsmans, N Houdret, F Broly,. Identification and functional analysis of two rare allelic variants of the thiopurine S- methyltransferase gene, TPMT*16 and TPMT*19. Biochem Pharmacol. 2005 Feb 1;69(3):525- 9. Epub 2004 Dec 10

- C Cauffiez, J-M Lo-Guidice, Quaranta S, D Allorge, D Chevalier, Cenee S, R Hamdan-Khalil, M Lhermitte, JJ Lafitte, C Libersa, J-F Colombel, I Stucker, F Broly. Genetic polymorphism of the human CYP2A13 in a French population: implication in lung cancer susceptibility. Biochem Biophys Res Commun. 317:662-9,2004.

- C Cauffiez, J-M Lo-Guidice, D Chevalier, D Allorge, R Hamdan-Khalil, M Lhermitte JJ, Lafitte, J-F Colombel, C Libersa, F Broly. First report of a genetic polymorphism of CYP3A43 gene: identification of a loss-of-function variant. Hum Mutat. 23:101,2004.

- D Chevalier, J-M Lo-Guidice, F Klingzig, D Allorge, C Cauffiez, R Hamdan-Khalil, E Rat, L Humbert, M Imbenotte, Broly F. Quantitative LC-MS analysis of thromboxane B2 in yeast microsomes expressing the human thromboxane synthase enzyme (CYP5A1). Prostaglandins Other Lipid Mediat, 2004

- A. Khalil, D lucidarme, P Desrumont, R Hamdan Khalil, B Filoche. Crohn's disease associated with interferon and ribavirin treatment for chronic hepatitis C. Gastroenterol Clin Biol. 2005 Feb;29(2)

- Marwan E El-Sabban,, Rima Hamdan-Khalil, Hilda El-Khoury,Steen Sindet-Pedersen & Ali Bazarbachi. Xenogenic bone matrix extracts induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Regenerative medecine, 2007 Jul;2(4):383-90

- Garat A, Cauffiez C, Hamdan-Khalil R, Glowacki F, Devos A, Leclerc J, Lionet A, Allorge D, Lo- Guidice JM, Broly F.IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element. Genet Test Mol Biomarkers. 2009 Dec;13(6):841-7.

- Yamout B, Hourani R, Salti H, Barada W, El-Hajj T, Al-Kutoubi A, Herlopian A, Baz EK, Mahfouz R, Khalil-Hamdan R, Kreidieh NM, El-Sabban M, Bazarbachi A.Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol. 2010 Oct 8;227(1-2):185-9. Epub 2010 Aug 21

- Zibara K, Hamdan R, Dib L, Sindet-Pedersen S, Kharfan-Dabaja M, Bazarbachi A, El-Sabban M. Acellular bone marrow extracts significantly enhance engraftment levels of human hematopoietic stem cells in mouse xeno-transplantation models. PLoS One. 2012;7(7):e40140. Epub 2012 Jul 2.

- Rima Hamdan, Maissa Yehia, Rabih S. Talhouk, Marwan E. El-Sabban . Pathophysiology of Gap Junctions in the Brain. Book chapter. Elsevier . SKILLS Organization skills, high level of accuracy, interpersonal skills, scheduling, cost management, numeracy, trend awareness, flexible adaption to work, persuasion, public relations, analytical skills, decision-making, active listening, team management, time management, task management, problem-solving, conflict management, Microsoft office, SPSS, Adobe Acrobat Writer, Adobe Acrobat Reader, Photoshop, writing papers and articles in the biological sciences. WORK

EXPERIENCE AMERICAN UNIVERSITY OF BEIRUT (AUB) - FACULTY OF MEDECINE 01/2005 – 12/2012 Postdoctoral Research Fellow Beirut, Lebanon

Performed in vitro stem cell differentiation following basic science research disciplines, utilizing specific techniques and equipment for targeted differentiation to desired cell lineage and more specialized cell types such as cells of the pancreas, liver, cartilage, nervous system, bone, blood and performing routine logging and testing of samples

Worked on platelet therapy, or platelet-rich plasma (PRP) therapy, to relieve pain by promoting long-lasting healing of musculoskeletal conditions using the healing power of the body

Effectively executed mesenchymal stem cell (MSC) therapy to treat neural damage in patients with multiple sclerosis (MS)

Conducted clinical researches following cell culture and molecular biology techniques such as PCR, qPCR, western blot analysis, immunohistochemistry, confocal microscopy, transfection, and other techniques and screened different mutations through DNA & RNA extraction and purification, PCR-SSCP, PCR –RFLP, sequencing

Collected experiments data, processed, organized, and summarized them, and reported results using a variety of scientific, word processing, spreadsheet, and even statistical software applications and published them

Designed laboratory experiments, techniques, and protocols and instructed research assistants (Master Students) in laboratory techniques LEBANESE UNIVERSITY (LU) - FACULTY OF DENTISTRY 04/2010 – 04/2012 Molecular Biology Professor Beirut, Lebanon

LEBANESE INTERNATIONAL UNIVERSITY (LIU) – ONE SEMESTER 10/2012 Genetics and Biology Professor Beirut, Lebanon

EDUCATION Lille 1/2 Universities 2003 – 2004

PhD, Pharmacogenetics Lille, France

Honor: Passed with high honors and first level of distinction. Title: Genetic Polymorphism of TPMT, IMPDH2 and ITPA. Description: Involvement in the myelotoxicity of thiopurine drugs. Lille University 1999 – 2000

DEA or Degree of in-Depth Studies, Biology and Health Lille, France Lebanese University (LU) 1999 – 2000

Master’s degree, Biochemistry Beirut, Lebanon

CERTIFICATIONS Radiation safety orientation on the use of radioactive material, Environmental Health Safety and Risk Management, Health Physics Services – AUB, 2006. INTERESTS Interested in attending conferences and workshops that would continuously help me grow in the field, as well as attending suitable events to build on my existing Network and establish relevant connections for my scope of work. LANGUAGES Arabic (Native Language), English (Professional Working Proficiency), French (Native Language)

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