Maria Cristina Bravi, M.D., Ph.D

Current personal address:

Via dei monti di Creta 85,

***** ****, *****

E-mail: adm94b@r.postjobfree.com

Phone number +39-335*******

Current professional address:

Stroke Unit – Department of Neuroscience

San Camillo-Forlanini Hospital

Circonvallazione Gianicolense 87,

00152 Rome, Italy.

Education:

University of Rome La Sapienza- School of Medicine

Degree: M.D.,

University of Rome La Sapienza- Department of Internal Medicine

Specialist in Internal Medicine

University of L’Aquila, Italy – Department of Internal Medicine

Ph.D in Internal Medicine

Board-certified in Internal Medicine

Licensed physician in Italy and EU.

GMC registration

DHA registration

Position:

Consultant, Department of Internal Medicine -San Camillo-Forlanini Hospital, Rome, Italy.

Consultant, Stroke unit- Department of Neuroscience- San Camillo-Forlanini Hospital, Rome, Italy.

Professor of Internal Medicine, nursing school, University of Rome La Sapienza, Italy.

Accreditations:

BLS/ACLS,

Experience

Dr Maria Cristina Bravi has worked at San Camillo-Forlanini Hospital in Rome, Italy since 2002. She is specialist in Internal Medicine and Urgent Care. Firstly, she worked in Accidents and Emergency Department. During her stay at A&E she showed competence and empathy and also good interpersonal skills. Then she moved to Internal Medicine ward where she worked managing complex cases such as patients with cardiovascular, pulmonary, oncological, neurovascular and diseases of the endocrine system . She also worked as consultant at Gynecology Department managing cases of gestational hypertension, preeclampsia/eclampsia, HELLP syndrome and gestational diabetes. To complete her medical competence and experience, she moved from Internal Medicine Ward to Stroke Unit at Neuroscience Department where she has been working since 2015. In that context, she takes care of patients with cerebrovascular disease such as stroke, TIA, and intracranial hemorrhage treating them with intravenous thrombolysis when indicated according to European Stroke Organization guidelines. She also works in team with interventional neuroradiology supporting patients whom undergo to mechanical thrombectomy for artery occlusion or stenosis in Intensive Care Unit. She also works as consultant in Internal Medicine in Neuroscience Department where she takes care of patients in urgent care and out clinic patients treating complex cases of endocrine, cardiovascular and infectious diseases. During her hospital routine she also uses telemedicine to share complex medical cases with experts and to improve the quality of and access to care while lowering costs.

As infection of Covid-19 spread through the country, due to increases number of cases admitted to the hospital she also manage patients with mild acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Internal Medicine ward and in Stroke Unit according to the internal protocol of National Institute of Infection disease “Lazzaro Spallanzani” in collaboration with WHO and also referring to Coronavirus Disease 2019 (COVID-19) Treatment Guidelines of the National Institutes of Health ( https://www.covid19treatmentguidelines.nih.gov/) . To assess patients at high risk of evolution of the disease ( with an exaggerated immune/inflammatory response to the infection) she uses MEWS (Modified Early Warning Score) and a panel of lab test ( ABGs, Anion Gap, PCR, Ferritin, Albumin, AST, ALT, LDH, Troponin BUN/Creatinine ratio, D-dimer, FBC ), and clinical evaluation in daily routine.

Publications:

1.M.L. Boccuni, G. De Mattia, O. Laurenti, C. Bravi, R: Messina, M.R. Bruno, N. Visalli, P. Pozzilli. Recenti acquisizioni di patogenesi ed immunoterapia nel diabete di tipo I. Folia Allerg. Immunol. Clin. 37: 67-76, 1990.

2.O. Laurenti, F. Albi, M. Artini, C. Bravi, R. Hurd, G. De Mattia. Effects of HMGA* in non insulin-dependent diabetics with secondary dyslipidaemia. Clinical Trials Journal, Vol 27, No 3,1990.

3.G. De Mattia, O. Laurenti, C. Bravi, C. Ferri, C. Bellini, C. De Angelis, C. Giarrizzo, A. Santucci, F Balsano. Does mild autonomic neuropathy affect atrial natriuretic factor regulation in diabetic hypertensive patients? Am. J Hypertens 4, 832-835, 1991.

4.O.Laurenti, M.C. Bravi, M. Cassone Faldetta, G. De Mattia. Valutazione dell’efficacia del trattamento metformina-glibenclamide in pazienti diabetici non insulino-dipendenti in eccedenza ponderale. La Clinica terapeutica, 1991.

5.C. Ferri, G, De Mattia, C. Bellini, O.Laurenti, C. Bravi, R. Baldoncini, M. S. Bonavita, A. Santucci, F. Balsano. Octreotide, a somatostatin analog reduces insulin secretion and increases renal Na+ excretion in lean essential hypertensive patients. Am JHypertens 6, 276-281,1993.

6.F. Mangiagli, L. Madonia, M. C. Bravi, O. Laurenti, P. Innocenti, G. De Mattia. I potenziali evocati motori (PEM) e somatosensoriali (PES) nella neuropatia diabetica. La ClinicaTerapeutica, vol 143, 1993.

7.G. De Mattia, O. Laurenti, C. Bravi, A. Ghiselli, L. Iuliano, F. Balsano. Effects of aldose reductase inhibition on glutathione redox status in erythrocytes of diabetic patients. Metabolism, vol 43, No 8(August), 965-968, 1994.

8.O. Laurenti, A. Piccoli, C. Bravi, M. Cassone Faldetta, C. Bellini, L. Leoni, C. Ferri, G. De Mattia. Effect of aprotinin on insulin sensitivity in non insulin-dependent diabetes mellitus. Diabetic Medicine, 13: 642-645, 1996.

9.M. C. Bravi, P. Pietrangeli, O.Laurenti, S. Basili, M. Cassone-Faldetta, C. Ferri, G. De Mattia: Polyolpathwayactivation and glutathione redox status in non-insulindiabeticpatients. Metabolism, Vol 46, No 10. (October), 1194-1198, 1997.

10.G. De Mattia, M. Cassone-Faldetta, C. Bellini, M. C. Bravi, O. Laurenti, R. Baldoncini, A. Santucci, C. Ferri. Role of plasma and urinary endothelin-1 in early diabetic and hypertensive nephropathy. Am J Hypertens, Vol 11, No 8 (August), 983-988, 1998.

11.G. De Mattia, M. C. Bravi, O. Laurenti, M. Cassone-Faldetta, A. Armiento, C. Ferri, F. Balsano. Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin dependent diabetes mellitus. Metabolism,Vol 47, No 8 (August), 993-997, 1998.

12.G. De Mattia, M.C. Bravi, O. Laurenti, M. Cassone Faldetta, A. Proietti, O. De Luca, A. Armiento, C. Ferri. Reduction of oxidative stress by oral N-acetyl-L-cysteine treatment decreased plasma soluble vascular cell adhesion molecule-1 levels in non-obese, non-dyslipidemic, normotensive, non-insulin-dependent diabetic patients. Diabetologia, 41: 1392-1396, 1998.

13.G. De Mattia, M.C. Bravi, A. Costanzo, O. Laurenti, M. Cassone Faldetta, A. Armiento, O. De Luca, C. Ferri. Effects of insulin on in vitro vascular cell adhesion molecule-1 expression and in vivo soluble VCAM-1 release. Diabetologia, 42: 1235-1239, 1999.

14.L. Pastore, A. Tessitore, S. Martinotti, E. Toniato, E. Alesse, M.C. Bravi, C. Ferri, G. Desideri, A. Gulino, A. Santucci. Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo. Circulation, 100: 1646-1652, 1999.

15.M. Cassone Faldetta, O. Laurenti, G. Desideri, M. C. Bravi, o. de Luca, M. C. Marinucci, G. De Mattia, C. Ferri. L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Diabetologia 45: 1120-1127, 2002.

16.A. Costanzo, F. Moretti, VL. Burgio, C. Bravi, F. Guido, M. Levrero, PL. Puri. Endothelial activation by Ang II through NFkB and p38 pathways: involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin. J Cell Physiol Jun; 195(3):402-410, 2003.

17.G. Desideri, MC Bravi, M. Tucci, G. Croce, MC. Marinucci, A. Santucci, E. Alesse, C. Ferri. Angio II inhibits endothelial cell motility through an AT1- dependent oxidant mechanism. ArteriosclerThrombVascBiol 23:1218-1223, 2003.

18.G De Mattia, M.C. Bravi, O. Laurenti, O. De Luca, A. Calmieri, A, Sabatucci, G. Mendico, A. Ghiselli. Impairment of cell and plasma redox state in subjects professionally exposed to chromium. Am J IndMed 46: 120-125, 2004

19.M.C. Bravi, A. Armiento, O.Laurenti, M,Cassone-Faldetta, O,De Luca, G.De Mattia. Insulin decreases intracellular oxidative stress in patients with type 2 diabetes mellitus. Metabolism May; 55(5):691-5, 2006.

20.E. Guglielmelli, M.C.Bravi, G.M. Colombo, F.Culasso, M.Cicchinelli. Retrospective analysis of pulmonary embolism management in Emergency Department. Gazz Med Ital-Arch Sci Med 166:69-74, 2007

21.G De Mattia, M.C. Bravi, O. Laurenti, A. Moretti, R. Cipriani, A. Gatti, E. Mandosi, S. Morano. Endothelial dysfunction and oxidative stress in type 1 and type 2 diabetic patients without clinical macrovascular complications. Diabetes Res Clin Pract Feb; 79(2):337-42, 2008.

22.Bravi MC.,Salvadei S., Scarponi P, Loforte A, Musumeci F., Gasbarrone L. Intravascular lipoma of the superior vena cava. Intern Emerg Med DOI 10.1007/s 9/4 2011. I

23.Famularo G, Minisola G, Bravi MC, Colucci P, Gasbarrone L. Tetany, hypomagnesemia, and proton-pump inhibitors. Am J Med Oct;125(10), 2012.

24.Famularo G, Bravi MC, Gasbarrone L, Minisola G. Drug reaction with eosinophilia and systemic symptoms(DRESS): an atypical case during treatment with sulfasalazine. Clin Exp Rheumatol. Mar-Apr;31(2):326-7, 2013.

25.Anticoli S, Pezzella FR, Siniscalchi A, Gallelli L, Bravi MC. Pulmonary arteriovenous malformation as a cause of embolic stroke: case report and review literature. Intervent Neurol 3:27-30, 2014.

26.Anticoli S, Pezzella FR, Pozzessere C, Gallelli L, Bravi MC, Caso V, Siniscalchi A. Transient ischemic attack fast-track and long-term stroke risk: role of diffusion-weighted magnetic resonance imaging. J Stroke Cerebrovasc Dis. Sep;24(9):2110-6, 2015.

27.Anticoli S, Bravi MC, Pezzella FR. Stroke in the young adults:6-year case series of community hospital stroke unit. Open Journal of Emergency Medicine, 3,23-27, 2015.

28.Anticoli S, Bravi MC, Perillo G, Siniscalchi A, Pozzessere C, Pezzella FR, Tanzi P, Gallelli L, Cartoni D. Effect of cardioembolic etiology in intravenous thrombolysis efficacy for acute ischemic stroke. Curr Neurovasc Res 13(3):193-98, 2016.

29. Anticoli S, Bravi MC, Pezzella FR. Reversible cerebral vasoconstriction syndrome after intercontinental airplane travel. Intern Emerg Med DOI 10.1007s1173-90171659-z, published online 05/4/2017.

30.Anticoli S, Bravi MC, Mazza S, Pezzella FR, De Pandis MF. Vascular parkinsonism: motor and non-motor response on treatment with rotigotine. J Bioanal Biomed vol 9(2) 98-99, 2017.

31.Mangiardi M, Bravi MC, Pezzella FR, Ricci L, Anticoli S. Unsuccessful endovascular treatment in a patient with stroke onset of Takayasu arteritis and positive clinical outcome. Cureus 12(12): e11980. DOI 10.7759/cureus. 11980. December 08, 2020.

32.Ricci L, Mangiardi M, Lanzone J, De Liso A, Fallacara A, Bravi MC, Pezzella FR, Anticoli S. Ischemic stroke in very elderly : experience from a Italian Stroke Unit Hub over a period of 8 years in era of thrombectomy. J Stroke Crebrovasc Dis. June 2021. DOI: 10.1016/j.jstrokecerebrovasdis.2021.105754.

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