PhD Biochemistry
Resume:
CURRICULUM VITAE
SUMMARY
I am a cancer biologist with expertise in molecular, cellular and biochemical biology. My PhD thesis was focused on mechanisms of chemotherapeutic agents and on devising strategies to enhance their anti-tumor effects. I also garnered postdoctoral experience in several realms ranging from breast cancer therapeutics and ribosomal machinery to carcinogen-driven genetic instability mechanisms. I also acquired laboratory management skills during my predoctoral and postdoctoral training. Additionally, I was fortunate to collaborate with other investigators and contribute to team science-driven projects. I am very eager to going back to the “work force” and specially to work as scientist / researcher, a job that I am still passionate about.
Thank you for your consideration.
NAME (first, last, degrees)
Oula Mansour, Ph.D., M.S.
CITIZENSHIP
Australia / United States of America
WORK AUTHORIZATION
USA resident
HOME ADDRESS (current)
4130 Candle Cove Ct,
Sugar Land, TX 77479
PHONE
***********@*******.***
EDUCATION
Degree-Granting Education
Ph.D. in Biochemistry, 2009
The Biochemistry Department, La Trobe University, Bundoora campus, Melbourne, Australia.
M.S. in Biochemistry, 2003
Department of Biology, American University of Beirut, Beirut, Lebanon.
M.S. in Biology, 2001
Department of Biology, Lebanese University, Beirut, Lebanon.
B.S. in Biology, 2000
Department of Biology, Lebanese University, Beirut, Lebanon.
Lebanese Baccalaureate (Experimental sciences), 1996
Lycee St-Pierre, Amioun, Lebanon.
Postgraduate Training
Postdoctoral fellowship, November 2015 – June 2016
Department of Radiology
The Methodist Hospital Research Institute, Houston, Texas, USA
Postdoctoral fellowship, July 2011 - January 2013
Department of Radiology
The Methodist Hospital Research Institute, Houston, Texas, USA
Postdoctoral fellowship, January 2010 - July 2011.
The Breast Medical Oncology department
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Postdoctoral fellowship, February 2009 – January 2010.
The Biochemistry Department, La Trobe University, Bundoora campus, Melbourne, Australia.
EXPERIENCE/TEACHING
Instructor, November 2016 – March 2019, American University of Beirut, Lebanon.
Postdoctoral fellow, July 2011 - January 2013, The Methodist Hospital Research Institute, Houston, Texas, USA.
Postdoctoral fellow, January 2010 - July 2011, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Research fellow, February 2009 - December 2009, The Biochemistry Department, La Trobe University, Bundoora campus, Melbourne, Australia.
Graduate Teaching Assistant, 2003-2009, The Biochemistry Department, La Trobe University, Bundoora campus, Melbourne, Australia.
Graduate Teaching Assistant, 2001-2003, Biology Department, American University of Beirut, Lebanon.
SCHOLARSHIPS AND AWARDS
La Trobe University Institute for Advanced Study Postgraduate Write-Up Award, 2009.
La Trobe University, Bundoora campus, Melbourne, Australia.
La Trobe University Postgraduate Research Scholarship (LTUPRS), 2004.
La Trobe University, Bundoora campus, Melbourne, Australia.
PUBLICATIONS
Peer-Reviewed Original Research Articles
1.Thaiparambil J, Mansour OC, El-Zein R. Effect of Benzo[a]Pyrene on Spindle Misorientation
And Fidelity of Chromosome Segregation in Lung Epithelial BEAS-2B Cells, Toxicol Sci. (2018).
2.Chen H; Song R; Wang G; Yang C; Zhang J; Zeng Z; Rubio V; Wang L; Zu N; Weiskoff A; Ding Z; Minze L; Jeyabal P; Mansour OC; Bai L; Merrick W; Zheng S; Shi ZZ. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation, Sci Rep. (2015).
3.Lee J, Bartholomeusz C, Mansour OC, Humphries J, Hortobagyi GN, Ordentlich P, Ueno NT. A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression. Breast Cancer Res Treat. Jul;146(2):259-72. (2014).
4.Mao R, Rubio Calva V, Chen H, Bai L, Mansour OC, Shi ZZ. OLA1 protects cells in heat shock by stabilizing HSP70, Cell Death & Disease. (2013).
5.Rizk S, Baydoun EH, Mansour OC, Brett CT. Identification of EDTA-soluble polysaccharides from pea epicotyl cell walls and their interaction with xyloglucan, American J. of Plant Sci. (2011).
6.Mansour OC, Evison BJ, Sleebs BE, Watson KG, Nudelman A, Rephaeli A, Buck DP, Collins JG, Bilardi RA, Phillips DR, Cutts SM. New anthracenedione derivatives with improved biological activity by virtue of stable drug-DNA adduct formation. J Med Chem. 53(19):6851-66 (2010).
7.Evison BJ, Mansour OC, Menta E, Phillips DR, Cutts SM. Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent, Nucleic Acids Res. 35 (11):3581-9 (2007).
8.Mansour OC, Evison BJ, Menta E, Phillips DR, Cutts SM. The synergistic interaction of Pixantrone with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9). Mol Cancer Ther. (2019). Submitted.
Book chapters
1. Phillips DR, Swift L, Coldwell K, Spencer D, Bilardi R, Evison B, Mansour OC, Nudelman A,
Rephaeli A, Koch TH, Cutts SM. Drug-DNA adducts formed by formaldehyde activation of
anthracycline and related anticancer agents. In: DNA Adducts; Formation, Detection and
Mutagenesis (Alvarez, E. and Cunha, R., Eds) Nova Science Publishers, NY, ISBN 978-1-60741-
433-9, 2009.
Books
1. Enhancing the activity of the anti-cancer drug Mitoxantrone. La Trobe University Borchardt
Library, Melbourne, Australia, April 2009.
2. Identification of EDTA-soluble polymers of PEA epicotyl cell walls and their interaction with
xyloglucan. American University of Beirut JAFET library, Beirut, Lebanon, January 2003.
3. The in-vitro culture of Lilium in Lebanon: interest and economical aspect. Lebanese University
Library, Beirut, Lebanon, September 2000.
Abstracts
1.Mansour, OC., Evison, B.J., Sleebs, B.E., Watson, K.G., Rephaeli, A., Nudelman, A., Phillips, D.R. and Cutts, S.M. Facilitating pixantrone-induced DNA damage and subsequent cell kill through formaldehyde activation and improvements in drug design. 101st American Association for Cancer Research Annual Meeting 2010, Washington, USA
2.Medan, J., Sleebs, B.E., Evison, B.J., Mansour OC, Phillips, D.R. and Cutts, S.M. DNA Adduct forming derivatives of the anticancer agents mitoxantrone and pixantrone. 7th AFMC International Medicinal Chemistry Congress 2009, Cairns, Queensland.
3.Medan, J., Sleebs B.E., Watson K.G., Evison B.J., Mansour OC., Cutts S.M. and Phillips, D.R. DNA adduct forming derivatives of the anticancer agents mitoxantrone and pixantrone. 21st Lorne Cancer Conference 2009, Lorne, Australia.
4.Evison, B.J., Mansour OC., Sleebs B.E., Watson K.G., Phillips D.R. and Cutts, S.M. The development of novel anthracenediones with enhanced biological and therapeutic activities. 20th Lorne Cancer Conference 2008, Lorne, Australia.
5.Mansour OC., Evison, B.J., Sleebs B.E., Watson K.G., Cutts S.M., Phillips D.R. Formaldehyde activation of mitoxantrone derivatives. Aurora Symposium, September 27-28, 2007, Melbourne, Australia.
6.Mansour OC., Evison, B.J., Cutts S.M., Phillips D.R. Enhancing the activity of mitoxantrone by formaldehyde activation. The 19th Lorne Cancer Conference, February 08-10, 2007, Lorne, Australia.
7.Mansour OC., Cutts S.M., Phillips D.R. The interaction of mitoxantrone and herceptin. The 97th Annual Meeting of the American Association for Cancer Research (AACR) meeting, April 01-05, 2006, Washington DC, USA.
8.Mansour OC., Cutts S.M., Phillips D.R.. Enhancing the activity of mitoxantrone. The 18th Lorne Cancer Conference, February 09-12, 2006, Lorne, Australia.
PROFESSIONAL MEMBERSHIPS
Member of the American Association of Cancer Research (AACR) 2010-present
SKILLS
- Fluent in three languages (English, French and Arabic).
- Broad range of computer skills.
- Experienced in working in multidisciplinary team-oriented and academic settings in major clinical and
research centers such as MD Anderson Cancer Center and The Methodist Hospital.
REFEREES
Name: Prof. Don R. Phillips
Position: Emeritus Professor
Address: La Trobe University, Victoria 3086, Australia
Phone (work): +61 3 9479 2182
E-mail: *.********@*******.***.**
Name: Dr. Suzanne M. Cutts
Position: ARC Future Fellow
Address: La Trobe University, Victoria 3086, Australia
Phone (work): +61 3 9479 1517
E-mail: *.*****@*******.***.**
Name: Dr. Zheng Zheng Shi
Position: Assistant Professor
Address: Radiology Department
The Methodist Hospital Research Institute
Phone (work): 713-***-****
E-mail: ****@****.***
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