Jeffrey H. Ruth, PhD

Associate Research Scientist of Internal Medicine

University of Michigan Medical School

**** ********, ****** ******** *****

Phone: 312-***-****

Email: adkm9d@r.postjobfree.com

Education and Training

09/83-06/88 University of Michigan-Ann Arbor; B.S. in Biological Sciences

09/91-12/96 University of Michigan School of Public Health-Ann Arbor; Ph.D. in Epidemiologic Science (Hospital and Molecular Epidemiology - H.M.E.): primary research evaluated the expression and function of Interleukin-1 Receptor Antagonist Protein (IL-1ra/IRAP) in rodent type-1 and type-2 pulmonary hypersensitivity granuloma models.

Committee Members: Hunein F. Maassab, PhD

Steven Meshnick, MD, PhD

Steven L. Kunkel, PhD

Stephen W. Chensue, MD, PhD (Chair)

10/97-01/99 Post-Doctoral Fellowship in Molecular Biology; University of Wisconsin-Madison: primary research involved examining chemokine mRNA decay mechanisms and mRNA binding protein kinetics in eosinophils.

02/99-02/02 Post-Doctoral Fellowship in Rheumatology Research; Northwestern University Feinberg School of Medicine, Chicago, Illinois: primary research involved examining chemokine and chemokine receptor expression in rheumatoid arthritis (RA) patient tissues and rodent models of RA.

Academic, Administrative, and Clinical Appointments

09/13-present Associate Research Scientist of Internal Medicine, University of Michigan Medical School, Division of Rheumatology, Ann Arbor, Michigan.

09/03-08/13 Research Assistant Professor of Internal Medicine, University of Michigan Medical School, Division of Rheumatology, Ann Arbor, Michigan.

03/02-06/03 Research Associate, Northwestern University Feinberg School of Medicine, Arthritis Division, Chicago, Illinois.

03/93-09/97 Biologist-GS5, Veterans Administration Medical Center, Department of Pathology and Laboratory Medicine, Ann Arbor, Michigan.

08/88-08/91 Health Science Research Assistant I, University of Michigan School of Public Health, Department of Epidemiology, Ann Arbor, Michigan.

05/92-09/92 Laboratory Technician, State of Michigan Department of Public Health, Lansing, Michigan: primary responsibility was to screen infants in Michigan for human immunodeficiency virus (HIV) infection.

Grants

Active grants

Sponsor: Kickstart University of Michigan, Fast Forward Medical Innovation (FFMI)

Title: Evidence for targeting NK cell CD6 as a breast cancer immunotherapy

PI: Fox

Inclusive Dates : 04/01/20 - 03/31/21

Role: Co-Investigator

Total Costs: $42,500

Sponsor: National Institutes of Health

Title: Physiology of Inflammatory Arthritis in High Resolution

PI: Xueding Wang, Ph.D.

Inclusive Dates: 07/01/2017-06/30/2022

Role: Co-Investigator

Total Costs: $ 4,559,312

Summary of Major Previous Grants

Sponsor: Kickstart University of Michigan, Fast Forward Medical Innovation (FFMI)

Title: Attenuation of checkpoint inhibitor autoimmune toxicity by anti-CD6

PI: Fox

Inclusive Dates : 07/01/19 - 06/30/20

Role: Co-Investigator

Total Costs: $42,500

Sponsor: Rogel Cancer Center Research Grant

Title: CD6 targeting as a novel strategy for breast cancer

PI: Ruth/Fox: Co-PIs

Inclusive Dates : 01/01/19 - 12/31/19

Role: Co-PI

Total Costs: $75,000

Sponsor: Gilead Sciences, Inc

Title: Effects of filgotinib on JAK signaling and functional behavior of RA synovial fibroblasts

PI: David A. Fox, M.D.

Inclusive Dates: 06/01/2017-05/31/2019

Role: Co-Investigator

Total Costs: $426,454

Sponsor: Regeneron Pharmaceuticals, Inc

Title: Response of Synovial Fibroblasts to Interleukin 6

PI: David A. Fox, M.D.

Inclusive Dates: 01/01/2017-12/31/2018

Role: Co-Investigator

Total Costs: $528,256

Sponsor: University of Michigan MCubed 2.0

Title: Macrophage Targeted Contrast Agents for Photoacoustic Imaging of Joint Disease

PI: Xueding Wang, Ph.D., Gus Rosania, Ph.D. and

Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 11/23/2015-04/29/2017

Role: Co-Principal Investigator

Total Costs: $60,000

Sponsor: Department of Defense (DoD) PRMRP Investigator Initiated Research Award PR120641

Title: Citrullinated chemokines in rheumatoid arthritis

PI: David A. Fox, M.D.

Inclusive Dates: 09/30/2013-09/29/2016

Role: Co-Investigator

Total Costs: $1,166,250

Sponsor: Seattle Genetics, Inc.

Title: CD30 and CD30-ligand in Rheumatic Disease

PI: David A. Fox, M.D.

Inclusive Dates: 05/01/2015-04/30/2016

Role: Co-Investigator

Total Costs: $ 78,902

Sponsor: UCB, Inc.

Title: Is the mechanism of Cimzia in part due to deactivation of the vasculature?-Part II

PI: Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 06/18/2013-12/31/2014

Role: Principal Investigator

Total Costs: $250,000

Sponsor: Bristol-Myers Squibb, Inc.

Title: Abatacept (Orencia) in Models of Angiogenesis

PI: Alisa E. Koch, M.D.

Inclusive Dates: 06/01/2011-05/31/2012

Role: Co-Investigator

Total Costs: $180,000

Sponsor: Bristol-Myers Squibb, Inc.

Title: Use of CTLA4-Ig (Abatacept) in an in vitro model of angiogenesis

PI: Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 12/04/2009-12/03/2010

Role: Principal Investigator

Total Costs: $79,950

Sponsor: Roche Laboratories, Inc.

Title: Tocilizumab as an inhibitor of monocyte recruitment

PI: Alisa E. Koch, M.D. and Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 08/20/2009-08/19/2010

Role: Co-Investigator

Total Costs: $79,949

Sponsor: TAP Pharmaceuticals, Inc.

Title: In vivo model of gout pathology

PI: Alisa E. Koch, M.D.

Inclusive Dates: 02/15/2008-02/14/2010

Role: Co-Investigator

Total Costs: $296,309

Sponsor: University of Michigan Rheumatic Diseases Core Center (RDCC) and NIAMS/NIH

Title: Endothelial cell adoptive transfer in human rheumatoid arthritis synovial tissue SCID mouse chimera as an in vivo model of angiogenesis

PI of project: David A. Fox, M.D.

Inclusive Dates: 08/01/2006-07/31/2009

Role: Co-Investigator

Total Costs: $50,000

Sponsor: NIH 1 R03 AR049907-01A2

Title: Accelerated arthritis, cytokine and chemokine production in E/P selectin deficient mice

PI: Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 01/15/2005-11/30/2007

Role: Principal Investigator

Total Costs: $217,479

Sponsor: TAP Pharmaceuticals, Inc.

Title: Mechanisms of inflammation in gouty arthritis

PI: Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 04/01/2006-03/31/2007

Role: Principal Investigator

Total Costs: $77,956

Sponsor: Arthritis Foundation, Michigan Chapter

Title: The in vivo role of CXCL16 and its receptor CXCR6 in leukocyte homing in RA

PI: Jeffrey H. Ruth, Ph.D.

Inclusive Dates: 07/01/2005-06/31/2006

Role: Principal Investigator

Total Costs: $40,000

Sponsor: NIH 5 P03 CA79458-03 (Midwest Center for AIDS Research)

Title: In vivo leukocyte migration in a severe combined immunodeficiency (SCID) mouse model.

PI of project: Steven M. Wolinsky, M.D.

Inclusive Dates: 09/01/2001-08/31/2002

Role: Co-Investigator

Total Costs: $40,000

Intellectual Property

No anti-CD6 monoclonal antibodies are currently approved for clinical use in the U.S. A provisional patent application was submitted to The United States Patent and Trademark Office (USPTO) by Drs. David A. Fox, MD and Jeffrey H. Ruth, PhD entitled “Compositions and Methods for Treating Cancer” on October 5th, 2018 (Application Number: 62741650). In particular, we provided compositions and methods for blocking CD6 binding to ligands (CD318 and/or CD166) on cancer cells (e.g., breast cancer cells). This binding interaction enhances killing of cancer cells by lymphocytes and prevents autoimmunity. Recently, a patent application on this project, entitled “Compositions and Methods for Treating Cancer” was filed by Drs. Fox and Ruth to the USPTO on October 3rd, 2019 (Application Number: UM-37004.601).

Honors and Awards

1993, 1994, 1995 University of Michigan Rackham Block Grant Scholarship Award recipient.

1995, 1996 Veterans Administration Medical Center performance award recipient; recognized for substantially exceeding performance requirements.

2000, 2001, 2002 FASEB Conference Burroughs Wellcome American Federation for Medical Research (AFMR) travel award recipient.

Editorial Positions, Boards, and Peer-Review Service

Editorial Service

Journal reviewer:

1. The Journal of Rheumatology (2002-present)

2. Arthritis & Rheumatology (2002-present)

3. Annals of the Rheumatic Diseases (2006-present)

4. Clinical Medicine: Arthritis and Musculoskeletal Disorders (2007-present)

5. Journal of Insect Science (2010-present)

6. Nature Reviews Rheumatology (2015-present)

7. Journal of Clinical Investigation (JCI) (2019-present)

8. JCI Insight (2020-present)

Editorial Board for:

1. Clinical Medicine: Arthritis and Musculoskeletal Disorders (2007-present).

2. ISRN Immunology (2011-present).

3. Hindawi Publishing Corporation: Mediators of Inflammation (Special Issue on Inflammatory Mediators of Angiogenesis; Guest Editor 2012-2013).

Grant Reviews and Study Sections for:

1.State of Pennsylvania Department of Health final performance review: 06-07 Cycle B (June 2007-present).

2.Oak Ridge Associated Universities (ORAU) Georgia Research Alliance Collaboration Planning Grant-FY 2010 (June 2009-present).

3.University of Nebraska Collaboration Initiative, Seed Grants (April 2017)

4.DoD 2015, PRMRP FY16, AIBS Scientific Peer Advisory and Review Services-Arthritis-Post-traumatic Osteoarthritis-Rheumatoid Arthritis Panel (December 2016).

5.DoD 2015, PRMRP FY15, AIBS Scientific Peer Advisory and Review Services-Arthritis-Post-traumatic Osteoarthritis-Rheumatoid Arthritis Panel (December 2015).

6.DoD 2014 PRMRP FY14, AIBS Scientific Peer Advisory and Review Services-Arthritis-Post-traumatic Osteoarthritis-Rheumatoid Arthritis Panel (December 2014).

7.The Health Research Board (HRB) Ireland: Study Section (June 2014).

8.NASA and Oak Ridge Associated Universities (ORAU): Nazarbayev University Research Review - January 2014, held February 22 – March 24, 2014.

9.NIH/NIAMS Center for Scientific Review Special Emphasis Panel, Small Business: Dermatology, Rheumatology and Inflammation (February 28, 2011).

10.Department of Defense (DoD), U.S. Army Medical Research and Material Command (USAMRMC), Peer Reviewed Medical Research Program (PRMRP) FY08: American Institute of Biological Sciences (AIBS) Scientific Peer Advisory and Review Services-Scleroderma Review Panel (June 2008).

11.Peer Reviewed Medical Research Program (Arthritis). General Dynamics Information Technology (GDIT), June 2020.

12.Oak Ridge Associated Universities, Nazarbayev Research Review, Summer 2020.

13.Versus Arthritis Review, September 2020.

Consulting

1.Sacoor Medical Group: Opinion Leader, International Pharmaceutical Industry Consultants; West Byfleet, Surrey England (2008-present).

2.Reuters Insight: Thought Leader; Healthcare (2008-present).

3.Guidepoint Global Consulting: Consultant, 444 Madison Avenue, 26th Floor, New York, New York 10022 (2009-present).

Teaching

Students Supervised/Mentored

1.Jason P. Zachariah BS, MS, MBA: Graduate Student in Masters of Biotechnology Program, Northwestern University, Chicago, IL (2001).

2.Rina Mady, BSc.: Undergraduate Work-Study Student; Northwestern University, Chicago, IL (2002-2003).

3.Randa Lynn Duprie, BSc.: Undergraduate Research Opportunity Program (UROP) Student; University of Michigan, Ann Arbor, MI (2003-2005).

4.Delia Mota, BSc.: UROP Student; University of Michigan, Ann Arbor, MI (2003-2005).

5.Alex Ronen, BSc.: Undergraduate Summer Intern, University of Michigan, Ann Arbor, MI (2005).

6.Callie A. Corsa, BSc.: Undergraduate Work-Study Student; University of Michigan, Ann Arbor, MI (2004-2006).

7.Andrew Cosgrove, BSc.: Undergraduate Summer Intern, University of Michigan, Ann Arbor, MI (2006).

8.Monica D. Arendt, BS: UROP and Molecular, Cellular and Developmental Biology (MCDB) Student; University of Michigan, Ann Arbor, MI (2005-2007, 2009-present).

9.Virginia Calkins, BSc.: Undergraduate Summer Intern from Yale University; interned at the University of Michigan, Ann Arbor, MI (2007).

10.Alexander Thompson, BSE (Mechanical Engineering): UROP Student; University of Michigan, Ann Arbor, MI (2007-2008, 2011).

11.Raisa Razalan, BSc.: UROP Student; University of Michigan, Ann Arbor, MI (2007-2008).

12.Sol Hee Lee, BSc.: UROP and MCDB Student; University of Michigan, Ann Arbor, MI (2008-2011).

13.Krystal Rana: UROP and MCDB Student; University of Michigan, Ann Arbor, MI (2009-2011).

14.Paul Sykula: UROP Student; University of Michigan, Ann Arbor, MI (2010-2011).

15.Stephanie Shuman: UROP Student; University of Michigan, Ann Arbor, MI (2011 - 2012).

16.Christine M. Ha: MCDB Student University of Michigan, Ann Arbor, MI (2012-2014).

17.Gautam Edhayan: Undergraduate and graduate (Masters) Biomedical Engineering Student; University of Michigan, Ann Arbor, MI (2012-2015).

18.Joshua Kim: UROP Student; University of Michigan, Ann Arbor, MI (2013-2015).

19.Adrian Hanna: UROP Student; University of Michigan, Ann Arbor, MI (2014-2015).

20.Ray Ohara: UROP and MCDB Student; University of Michigan, Ann Arbor, MI (2013-2015).

21.Noah Chen: Undergraduate Student University of Michigan, Ann Arbor, MI (2014-2016).

22.Jerry Graham Jr.: UROP and MCDB Student; University of Michigan, Ann Arbor, MI (2013-2016).

23.Stephanie Rasmussen: UROP Student; University of Michigan, Ann Arbor, MI (2014-present).

24.Kate van Loveren: UROP Student; University of Michigan, Ann Arbor, MI (2015-2017).

25.Riley Engstrom: UROP Student; University of Michigan, Ann Arbor, MI (2016-2017).

26.Daniel Weber: UROP and MCDB Student; University of Michigan, Ann Arbor, MI (2016-2018).

27.Kalana Athukorala: UROP and MCDB student; University of Michigan, Ann Arbor, MI (2017-present).

28.Matthew Lind: UROP Student; University of Michigan, Ann Arbor, MI (2018-present).

29.Rosemary Gedert: UROP Student; University of Michigan, Ann Arbor, MI (2018-present).

30.Peggy Randon: MCDB 100 student; University of Michigan, Ann Arbor, MI (2018-present).

Recognition awarded to undergraduate students while under my mentorship

1.Callie A. Corsa, BS: Abraham Grant Award recipient: competitive internal medicine grant awarded to undergraduates who have excelled in laboratory research, 2006.

2.Monica D. Arendt, BS.: UROP Summer Biomedical and Life Sciences Fellowship funded by the Howard Hughes Medical Institute (HHMI) and the Genentech Foundation: peer reviewed competitive grant awarded to fund outstanding undergraduates to perform laboratory research, 2007.

3.Monica D. Arendt, BS.: Abraham Grant Award recipient: competitive internal medicine grant awarded to undergraduates who have excelled in laboratory research, 2007.

4.Monica D. Arendt, BS.: UROP Symposium blue ribbon award recipient, recognized for best poster and presentation, 2007.

5.Alexander Thompson, BSE: UROP Symposium co-blue ribbon award recipient, recognized for best poster and presentation, 2008.

6.Raisa Razalan, BS.: UROP Symposium co-blue ribbon award recipient, recognized for best poster and presentation, 2008.

7.Sol Hee Lee, BS.: Summer Biomedical and Life Sciences Fellowship funded by the HHMI and the Genentech Foundation: peer reviewed competitive grant awarded to fund outstanding undergraduates to perform laboratory research, 2010.

8.Sol Hee Lee, BS.: University of Michigan Cardiovascular Center (CVC) Summer Undergraduate Fellowship. The CVC Fellowship specifically supports exemplary students interested in research in vascular biology and vascular disease, 2013.

9.Jerry Graham: Accepted into the Yale School of Medicine Summer Medical and Dental Education Program (SMDEP), a national program of The Robert Wood Johnson Foundation, 2014.

10.Gautam Edhayan: Student Achievement Award from the Rheumatology Research Foundation (RRF) to attend the 2014 ACR/ARHP Annual Meeting held in Boston, MA 2014.

11.Jerry Graham: The Minority Health and Health Disparities International Research Training (MHIRT) Program Center for Human Growth and Development Summer Research internship abroad (Chile) funded by NIH, 2015.

12.Gautam Edhayan, MSC.: Selected to present “Inflammatory Properties of Inhibitor of DNA Binding 1 As a Unique Fibroblast Derived Nuclear Protein” as a Plenary speaker for the 23rd Annual Department of Internal Medicine Research Symposium, University of Michigan Medical School, 2015.

13.Gautam Edhayan, MSC.: Abraham Grant Award recipient: competitive internal medicine grant awarded to undergraduates who have excelled in laboratory research, 2015.

14.Christine M. Ha, BS: Medical and Graduate Student Preceptorship Award Recipient. RRF, 2016.

15.Stephanie Rasmussen: Summer Biomedical and Life Sciences Fellowship funded by the HHMI and the Genentech Foundation: peer reviewed competitive grant awarded to fund outstanding undergraduates to perform laboratory research, 2016.

16.Daniel Weber: Summer Biomedical and Life Sciences Fellowship funded by the HHMI and the Genentech Foundation: peer reviewed competitive grant awarded to fund outstanding undergraduates to perform laboratory research, 2017.

17.Kalana Athukorala: Summer Biomedical and Life Sciences Fellowship funded by the HHMI and the Genentech Foundation: peer reviewed competitive grant awarded to fund outstanding undergraduates to perform laboratory research, 2018.

18.Kalana Athukorala: Undergraduate Summer Research Grant Program funded by Texas A&M Engineering: designed to provide an opportunity for undergraduate students to immerse themselves in research under the guidance of College of Engineering faculty, postdoctoral fellows and advanced graduate students.

19.Peggy Randon: UM-SMART Undergrad Summer Program recipient. M-SMART is designed for undergraduate students who are potentially interested in obtaining a combined MD/PhD degree leading to a career in academic medicine focused on basic research relevant to human disease, 2019.

Post-Doctoral Fellows Supervised/Mentored

1.Christian S. Haas, M.D.: Post-Doctoral Research Fellow; Northwestern University, Chicago IL; and University of Michigan, Ann Arbor, MI (2001-2005).

2.Hernon Castrorueda, M.D.: Visiting Scholar; Northwestern University, Chicago, IL; and University of Michigan, Ann Arbor, MI (2002-2004).

3.Bansari Shah, M.D.: Visiting Scholar; University of Michigan, Ann Arbor, MI (2003-2004).

4.Takeo Isozaki, M.D., Ph.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2010-2014).

5.Qiang Shu, M.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2010-2011).

6.Ken Yoshida, M.D., Ph.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2011-2014).

7.Smriti Mohan, MD: House Officer, Pediatrics, University of Michigan Hospitals, CW H.O. Peds – Rheumatology; Mentoring Committee member (2014-2015).

8.Huadong (Sarah) Cui, M.D., Ph.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2015-2016).

9.Wenyi (Mabel) Fu, M.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2017-2018).

10.Mikel Gurrea Rubio, Ph.D.: Research Fellow, Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI (2019-2020).

Intramural Presentations

2004CXCR6 and its ligand CXCL16, expression and function in a synovial tissue-severe combined immunodeficient chimera. University of Michigan Department of Internal Medicine Research Day. University of Michigan Medical School, Ann Arbor, MI.

2006 Chemokines in rheumatoid arthritis. Rackham arthritis research unit (RARU) lecture series. University of Michigan Medical School, Ann Arbor, MI.

2006 CXCL16 expression and function in rheumatoid arthritis. Basic Science Research Conference lecture series. University of Michigan Medical School, Ann Arbor, MI.

2007CXCL16 expression and function in rheumatoid arthritis (update on: Endothelial cell adoptive transfer in human rheumatoid arthritis synovial tissue SCID mouse chimera as an in vivo model of angiogenesis for RDCC). University of Michigan Medical School, Ann Arbor, MI.

2016Internal Medicine Research Symposium: “Evidence for Citrullinated Inhibitor of DNA Binding-1 as a Novel Autoantigen Candidate in Rheumatoid Arthritis.”

2016 Rheumatology Research Conference: Biological function of DNA Binding-1 protein in rheumatoid arthritis

Visiting Professorships, Seminars, and Extramural Invited Presentations

National/Regional Extramural Invited Presentations

1996 Differential IL-1 receptor antagonist (IL-1ra) expression during Th-1-cell-mediated and Th2-cell mediated granuloma-formation. National Institutes of Health, National Eye Institute, Bethesda, MD.

1999 Cytokine mediated regulation of IL-1receptor antagonist protein. Biogen, Inc., Boston, MA.

2000 Cytokine mediated regulation of IL-1receptor antagonist protein. Eli Lilly Pharmaceuticals, Indianapolis, IN.

2000 Cytokine mediated regulation of IL-1receptor antagonist protein. Millenium Pharmaceuticals, Boston, MA.

2000 Chemokine expression and regulation in chronic disease. Northwestern University Rheumatology Grand Rounds. Chicago, IL.

2001 Selective lymphocyte chemokine receptor expression in the rheumatoid joint. Human Genome Sciences, Rockville, MD.

2002 Cellular chemokine receptor expression in rheumatoid arthritis. Genentech Inc., San Francisco, CA.

2002 Cellular chemokine receptor expression in rheumatoid arthritis. Genomics Institute of the Novartis Foundation, San Diego, CA.

2003 Accelerated collagen induced arthritis in E- and P-selectin mutant mice; and CXCR6 and its ligand CXCL16, expression and function in rheumatoid arthritis and in a synovial tissue-severe combined immunodeficient chimera. University of Michigan Rheumatology Grand Rounds. University of Michigan Medical School, Ann Arbor, MI.

2005 Cellular chemokine receptor expression in rheumatoid arthritis (the role of fractalkine). Midwestern University, Chicago, IL.

2011 Implications of chemokine expression in rheumatoid arthritis. University of Toledo School of Pharmacology, Toledo, OH.

2015 Citrullinated Id1 as a therapeutic target in RA. GlaxoSmithKline (GSK) Discovery Partnerships with Academia (DPAc) and University of Michigan presentation.

Professional Societies

American College of Rheumatology (2012-2018)

Bibliography

Peer Reviewed Publications (most recent listed first)

1.Ruth JH, Gurrea-Rubio M, Athukorala KS, Rasmussen SM, Weber DP, Randon P, Amin MA, Campbell PL, Tsou PS, Mao-Draayer Y, Wu Q, Lanigan TM, Keshamouni VG, Singer NG, Lin F, Fox DA: CD6 is a target for Cancer Immunotherapy. JCI Insight. In press.

2.Lu C, Gurrea-Rubio M, Campbell PL, Tsou PS, Hervoso JL, Ali M, Hodish G, Model EN, Ruth JH, Robida AM, Alt AJ, Zhang C4, Urquhart AG, Lawton JN, Chung KC, Saunders TL, Groppi VE, Fox DA, Amin MA: Soluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1. Submitted.

3.Lanigan TM, Rasmussen SM, Weber DP, Athukorala KS, Campbell PL, Fox DA, Ruth JH: Real Time Visualization of Cancer Cell Death, Survival and Proliferation Using Fluorochrome-Transfected Cells in an IncuCyte Imaging System. J Biol Methods. 12;7(2):e133, 2020.

4.Akhtar N, Ruth JH, Rasmussen SM, Fox DA, Ahmed S: AT101, a BH3 mimetic inhibitor of MCL1/Bcl-2, suppresses synovial hyperplasia and tissue destruction in rheumatoid arthritis. Arthritis Res Ther (revisions submitted).

5.Li Y*, Ruth JH*, Rasmussen SM, Athukorala KS, Weber DP, Amin MA, Campbell PL, Singer NG, A. Fox DA, Lin F: Targeting CD6 Attenuates Murine Collagen Induced Arthritis. Arthritis Rheumatol. In press (*denotes equal contributors).

6.Ohara RA, Edhayan G, Rasmussen SM, Isozaki T, Remmer HA, Lanigan TM, Campbell PL, Urquhart AG, Lawton JN, Chung KC, Fox DA, Ruth JH: Citrullinated Inhibitor of DNA Binding 1 is a Novel Autoantigen in Rheumatoid Arthritis. Arthritis Rheumatol. 71:1241-1251, 2019.

7.O'Brien MJ, Shu Q, Stinson WA, Tsou PS, Ruth JH, Isozaki T, Campbell PL, Ohara RA, Koch AE, Fox DA, Amin MA: A unique role for galectin-9 in angiogenesis and inflammatory arthritis. Arthritis Res Ther. 12:31, 2018.

8.Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Fung J, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F: CD318 is a ligand for CD6. Proc Natl Acad Sci. 114:E6912-E6921, 2017.

9.Asif Amin M, Fox DA, Ruth JH: Synovial cellular and molecular markers in rheumatoid arthritis. Semin Immunopathol., 2017.

10.Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou PS, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD: Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. Bioorg Med Chem Lett. 27:1744-1749, 2017.

11.Edhayan G, Ohara RA, Stinson WA, Amin MA, Isozaki T, Ha CM, Haines GK III, Morgan R, Campbell PL, Arbab AS, Friday SC, Fox DA, Ruth JH: Inflammatory Properties of Inhibitor of DNA Binding 1 Secreted by Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis Res Ther. 18:87, 2016.

12.Morgan R, Endres J, Behbahani-Nejad N, Phillips K, Ruth JH, Friday SC, Edhayan G, Lanigan T, Urquhart A, Chung KC, Fox DA: Expression and Function of Aminopeptidase N/CD13 Produced by Fibroblast Like Synoviocytes in Rheumatoid Arthritis: Role of CD13 in Chemotaxis of Cytokine Activated T cells Independent of Enzymatic Activity. Arthritis Rheumatol. 67:74-85, 2015.

13.Amin MA, Campbell PL, Ruth JH, Isozaki T, Rabquer BJ, Alex Stinson W, O'Brien M, Edhayan G, Ohara RA, Vargo J, Domino SE, Koch AE: A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis. Ann Rheum Dis. 7:1459-66, 2015.

14.Yoshida Y, Korchynskyi O, Tak PP, Isozaki T, Ruth JH, Campbell PL, Baeten DL, Gerlag DM, Amin MA, Koch AE: Citrullination of ENA-78/CXCL5 results in conversion from a non-monocyte recruiting to a monocyte recruiting chemokine. Arthritis Rheumatol. 66:2716-27, 2014.

15.Isozaki T*, Amin MA*, Ruth JH*, Campbell PL, Tsou PS, Ha CM, Stinson WA, Domino SE, Koch AE: Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis. Arthritis Rheumatol. 66:2047-58, 2014 (*denotes equal contributors).

16.Haak A, Tsou PS, Amin MA, Ruth JH, Campbell PL, Fox DA, Khanna D, Larsen SD, Neubig NR: Targeting the myofibroblast genetic switch: inhibitors of MRTF/SRF-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 349:480-486, 2014.

17.Isozaki T, Amin MA, Arbab AS, Koch AE, Ha CM, Edhayan G, Haines GK III, Ruth JH: Inhibitor of DNA Binding 1 as a secreted angiogenic transcription factor in rheumatoid arthritis. Arthritis Res Ther. 16:R68, 2014.

18.Isozaki T, Ruth JH, Amin MA, Campbell PL, Tsou PS, Ha CM, Haines GK III, Koch AE: Fucosyltransferase 1 mediates angiogenesis, cell adhesion and proliferation in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 16:R28, 2014.

19.Szewczyk G, Rak J, Ruth JH: Inflammatory mediators of angiogenesis. Mediators Inflamm. 2013:610543, 2013.

20.Isozaki T, Arbab AS, Haas CS, Amin MA, Arendt MD, Koch AE, Ruth JH: Evidence for CXCL16 as a potent angiogenic mediator and endothelial progenitor cell chemotactic factor. Arthritis Rheumatol. 65:1736-46, 2013.

21.Tsou PS, Ruth JH, Campbell PL, Isozaki T, Lee S, Marotte H, Domino SE, Koch AE, Amin MA: A novel role for inducible Fut2 in angiogenesis. Angiogenesis J. 16:195-205, 2013.

22.Isozaki T, Rabquer BJ, Ruth JH, Haines GK III, Koch AE: A disintegrin and metalloprotease (ADAM10) is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis. Arthritis Rheumatol. 65:98-108, 2013.

23.Rabquer BJ, Hou Y, Ruth JH, Luo W, Eitzman DT, Koch AE, Amin MA: H-2g, a glucose analog of blood group H antigen, mediates monocyte recruitment in vitro and in vivo via IL-8/CXCL8. Open Access Rheum. Res. Rev. 4:93-98, 2012.

24.Shu Q, Amin MA, Ruth JH, Campbell PL, Koch AE: Suppression of endothelial cell activity by inhibition of tumor necrosis factor-α. Arthritis Res Ther. 14:R88, 2012.

25.Amin MA, Rabquer BJ, Mansfield PJ, Ruth JH, Marotte H, Haas CS, Reamer EN, Koch AE: Interleukin-18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases. Ann. Rheum. Dis. 69:2204-12, 2010.

26.Rabquer BJ, Amin MA, Teegala N, Ruth JH, Lesch CA, Imhof BA, Koch AE: Junction adhesion molecule-C is soluble and mediates angiogenesis. J. Immunol. 185:1777-85, 2010.

27.Ruth JH, Park CC, Amin MA, Lesch C, Shahrara S, Koch AE: IL-18 as an in vivo mediator of monocyte recruitment in rodent models of rheumatoid arthritis. Arthritis Res Ther. 12:R118, 2010.

28.Ruth JH, Arendt MD, Amin MA, Ahmed S, Marotte H, Rabquer BJ, Lesch C, Lee S, and Koch AE: Expression and function of CXCL16 in a novel model of gout. Arthritis Rheumatol. 62:2536-44, 2010.

29.Marotte H, Ahmed S, Ruth JH, Koch AE: Blocking ERK reduces TNF-α-induced-IL-18 bioactivity in rheumatoid arthritis synovial fibroblast by induction of IL-18BPa. Arthritis Rheumatol. 62:722-731, 2010.

30.Marotte H, Ruth JH, Campbell PL, Koch AE, Ahmed S: Green tea inhibits chemokine production, but upregulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis. Rheumatology (Oxford). 49:467-79, 2010.

31.Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE: Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci. 105:14692-7, 2008.

32.Amin MA, Ruth JH, Haas CS, Pakozdi A, Koch AE: H-2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment in in vitro and in vivo via Src and phosphatidylinositol 3 kinase pathways. Arthritis Rheumatol. 58:689-695, 2008.

33.Haas CS*, Amin MA*, Ruth JH*,

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