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Mohamed Merza Jahrami (PhD)

Telephone: +973-********

Email: adkdad@r.postjobfree.com

EXPERIENCE IN TOP-NOTCH QUALITY TEACHING & RESEARCH CENTERS IN DIFFERENT UK AND USA UNIVERSITIES SPANNING THREE DECADES

Objective: Seeking to steer operations in managing quality assurance and accreditation process of educational organizations as well as healthcare systems. Apart from my qualifications I have an extensive world class experience which enables me to convey the knowledge with the application background. Meanwhile, integrating expertise and leadership skills that drive organizational performance to world-class levels in the quality of teaching and research industry.

Additional Excellence: Analytical Quality minded personality with proven scientific and clinical laboratory experience. Proficient in upholding service standards and operational policies, planning & implementing effective control measures to increase the quality of organizational performance. PROFESSIONAL ABRIDGEMENT

Experienced in problem based and student- centered education.

My extensive experience in quality has enabled me to conceptualize and manage the process of quality assurance and accreditation of higher education in order to focus on educational issues leading to well- educated society demands tailored graduates.

Added Expertise

Multitask skills Creativity High through-put data mining Persuasion Collaboration Adaptability Emotional Intelligence Assay- Development Chimeric Antigen Receptor (CAR) T cells Flow Cytometry/FACS/Fluorescence Associated Cell- Sorting Analysis Immunoassays Project Management qPCR/RT-PCR T cell assays T cell culture Xenograft Models Cloning ELISA Gene Editing Meso Scale Discovery Electrochemiluminescence (MSD-ECL) Protein engineering Flow Cytometry/FACS/Fluorescence Associated Cell Sorting - Cell Sorting Research Fields

Immuno-Oncology Immuno-engineering Immunology Gene Therapy Oncology/Cancer Biology

CAREER HISTORY & HIGHLIGHTS

Quality Assurance Consultant, Daar Holoul, Kuwait (November 2019-Februuary 2010)

Senior Scientist, Dasman Diabetes Institute, Kuwait, ( June 2014 to July 2019)

Quality Coordinator 2ndary healthcare, Salmaniya Medical Complex (SMC) Administration, Bahrain

(September 2010-June 2014)

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Quality Control Coordinator, Pathology dept, SMC Bahrain (September 2007- August 2010)

Medical Technologist, Pathology SMC, Bahrain (August 2003-June 2007)

Clinical Research Fellow, Barbara Davis Center, Denver, CO, USA (September 2005 – June 2007)

Biochemistry Lecturer, Arabian Gulf University, Bahrain (September 2001 – August 2002)

Medicine Biochemistry PhD, Plymouth, UK (July 1997 - October 2000)

Technologist (volunteer), Manchester Royal Infirmary, Manchester, UK (July 1996 – May 1997)

Quality Control Supervisor, Bapco, Awali, Bahrain (April 1990 – August1995)

Quality Control Helper, Awal Food Factory (July 982- May 1984). TEACHING EXPERIENCE

Biochemistry and Cell Biology, University of Colorado, USA (June-August 2006)

Genetic and Inheritance, Community College of Denver, Co, USA (January-May 2006)

MSc in medical biochemistry, Arabian Gulf University, Kingdom of Bahrain (January-April 2002)

Tutoring 2nd year students on myocardial infarction, arrhythmia, rheumatic heart disease - Arabian Gulf University- Kingdom of Bahrain (January-June 2002)

Biochemistry and cell biology, Arabian Gulf University, Kingdom of Bahrain (September 2001- June 2002)

Problem Based Learning (PBL): Arabian Gulf University, Kingdom of Bahrain (September 2001- April 2002)

Assistance of two MD students throughout their projects and theses writing - University of Plymouth, UK (September 1998- March 2000)

Human genetics (University of Plymouth, UK (September-June 1998)

Biochemistry and molecular biology, University of Plymouth, UK (September 1998-March 1999)

Basic Biology, Laboratory Sciences, University of Manchester, UK (January -November 1996)

Educational Technology, University of Bahrain (September-December 1998)

An Ideal Strategic Plan to Control Sickle Cell Anemia in the Kingdom of Bahrain, proposal (August 2010).

Thesis Supervised:

PhD entitled “Novel MHC Analyses Allow Prediction of Extreme Genetic Risk for Type 1A Diabetes” by Theresa Ann Aly, Colorado University, USA (September 2005-June 2007)

MSc entitled “Effective Staff Involvement due to Performance Progam: case of SMC laboratory” by Ebtisam Abdulnabi Ali, France Arabian School Bahrain (September 2009-December 2010).

• PhD (Molecular Immunogenetics), University of Plymouth (July 1997-October 2000)

• MSc (Molecular Biochemistry), University of Manchester (September 1995-June1996)

• SDP (Management), Bapco Training Center (September 1993-June1994)

• BSc (Biology Minor Chemistry), University of Bahrain (September 1994-June 1989) Academic Affiliations & Awards:

1. Diabetes New Autoantibody Group (co-finder) (2012) 2. International Consortium to Identify Susceptibility Genes for Generalized Vitiligo (VitGene) (2008) 3. Postdoctoral Fellowship, Microarray Technology & Fine Mapping, University of Colorado, Colorado, United States of America, Mentor: George Eisenbarth (2007) 4. Type 1 Diabetes Genetic Consortium (T1DGC) (2007) 5. Fulbright Visiting Scholar Award (2005)

6. International Diabetes federation (2002)

7. American Diabetes Association (2000)

8. European Diabetes Association (1998)

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Research Grants:

i. RA 2015-013; August 2015

ii. RA 2016-015 A; November 2016

iii. RA 2016-015 B; November 2016

Submission to IPD-IMGT/HLA Database (ongoing)

• HLA-B*15:220:01:01 is possibly on the haplotype of HLA-A*32:01-C*04:01-B*15:220:01:01- DRB1*04:05-DQB1*02:02 in a Kuwaiti family; in January 2020 (HWS10058463, HWS10058465, HWS10058467)

• Identification of HLA-C*16:46 allele in a Kuwaiti individual; in September 2019 (HWS10055711).

• HLA-DQB1*04:02:13, anHLA-DQB1*04:02 variant, identified in a Kuwaiti individual; in August 2019

(HWS10055749).

• *Recognition of an HLA-C*04 variant, HLA-C*04:30, in two Kuwaiti families; in July and August 2019 (HWS10055605 and HWS10056165).

Computer Skills:

• Knowledge of relational databases

• Project, Word, Excel, Access, Power Point, FrontPage, Outlook

• Lotus Notes, Epi.6, EndNote, VG Laboratory Informational Management system (VGLIMS) Workshops Attended:

Stem Cell Biology, progress & potential

Immunology Treat 2006

Comparative Medicine Skills

Advancement and Future of Proteomics

Neuron Linguistic Programming (NLP)

Problem Based Learning

True & False Questions

Leadership and Teamwork

Leadership and Effectiveness

Interpersonal Communication and Assertiveness

Quality Control in Diagnostic Lab

Self and Staff Development

Performance Monitoring and Appraisal

Managing Change

Time Management

Integrated Management System

ISO 9000& Quality Control

Balanced Score Card

Organizer, Editorial Reviewer:

The First GCC Genetic Conference: Organizing Member

Pan-Arab Pediatric Conference: Academic Editorial Committee;

International Conference in sickle Cell Disease:

Member of Organizing Committee

Member of Academic Committee

Peer Reviewed Journals:

a) Diabetes Research and Clinical Practice

b) Journal of Public Health and Epidemiology

c) Cytokine and Interferon Research Journal

d) Journal of Clinical Biochemistry

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e) Diabetes Care

f) Journal of Immunological Investigations

g) Journal of Medical Biochemistry

h) Journal of Molecular Medicine

PERSONAL INFORMATION

Date of Birth: 1 Jan 1963

Languages Known: Arabic, English, Urdu

Address: 1-1183, 1122, Tubli, Bahrain

REFERENCES

Janelle A. Noble Liping Yu

Professor of Immunology Associate Professor & Head of Core lab HLA and Autoantibody Children's Hospital Oakland Res Institute Barbara Davis Center 5700 Martin Luther King Jr Way School of Medicine

Oakland, California 94609; USA University of Colorado, USA adkdad@r.postjobfree.com adkdad@r.postjobfree.com

Mark Atkinson Richard Spritz

Professor and head of Diabetes Center Director

University of Florida Human Genetics & Genomics

Medical Genetics School of Medicine

Cambridge, United Kingdom University of Colorado, USA PUBLICATIONS

Published

1. Mohamed M.Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair

, Medhat A-Halim, Parul Aggarwal, Sacha A. De Serres, Jamil R. Azzi,. Analysis of the frequency of single nucleotide polymorphisms in cytokine genes in patients with New Onset Diabetes After Transplant. Scientific Reports (under publication).

2. Jahromi M, Zahra Rahma, Nehad Taha, Lin PY, Yang KL.Detection of the HLA-DR4*01:44 allele in a Kuwaiti individual. HLA 2020, https://doi.org/10.1111/tan.13981 3. Tanideh N, Zarifi F, Rafiee S, Khastkhodaei M, Koohi-Hosseinabadi O, ZarifiF, Kherad Z, Jamshidzadeh A, Jahromi MA, Mousavi F,Mojahed Tagh M, Kamali M, Shekarkhar G, Jahromi M, Tarkesh F. Ziziphus jujube protects against cisplatin-induced nephrotoxicity in rats. . Comp Clin Pathol (2019). https://doi.org/10.1007/s00580-019-03055- 4. Mohamed Jahromi, Ebaa Al Ozairi. Human Leukocyte Antigen (HLA) and autoantibodies are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasizing on Kuwait. Dis Markers. 2019; 2019: 9786078.

5. Younes N, Younes S, Alsharabasi OA, El Zowalaty ME, Mustafa I, Jahromi M, Uddin S, Al-Nesf M, Pintus G, Zayed H. Immunogenetics of Celiac Disease: A focus on Arab countries. Curr Mol Med . 2020;20(4):275-285. doi: 10.2174/1566524019666191024104930. 6. Jahromi M, Al-Khuwari M, Lin PY, Yang KL. HLA-DQB1*04:02:13, an HLA-DQB1*04:02 variant, identified in a Kuwaiti individual. HLA. 2019 Oct 7. doi: 10.1111/tan.13714. 7. Jahromi M, Jacob SP, Taha N, Lin PY, Yang KL. Identification of HLA-C*16:46 allele in a Kuwaiti individual. HLA. 2019 Oct 2. doi: 10.1111/tan.13705. 8. Mohamed Jahromi, Zahra Rahme, Rasheeba Nizam, Py-Yu Lin, Kuo-Liang Yang, HLA-C*04 variant, HLA-C*04:30, in two Kuwaiti families. Tissue Antigen (HLA)2019; 2019 Aug 16. doi: 10.1111/tan.13669.

9. Mohamed Jahromi, Torki Al-Otaibi, Nashwa Othman, Osama Gheith, Tarek Mahmoud, Prasad Nair, Medhat A-Halim, Narayanam Nampoory. Immunogenetics of New Onset Diabetes after Page 5 of 7

Transplantation in Kuwait. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2019; 731-742/doi.org/10.2147/DMSO.S195859.

10. Jahromi M, Al-Mulla F, Al-Ozairi E. Autoimmune signatures for prediction and diagnosis of autoimmune diabetes in Kuwait. Autoimmun Rev. 2019 Apr 5. pii: S1568-9972(19)30079-5. doi: 10.1016/j.autrev.2019.02.009.

11. Zahra Rahme, Nehad Taha, Hidaia Abdalla, Smitha Abraham, Asma Alhubail, Hala AlSanae, Maria AlMahdi, Fahed Aljaser, Majda Abdelrasoul, Mona Al Khawar, Mohamed Jahromi. Challenges and Strategies for Recruiting Type 1 Diabetes Families in Kuwait with Strong Beliefs in Familism. bioRxiv 570945; doi: https://doi.org/10.1101/570945. 12. Abdel-Motal UM, G A, Abdelalim EM, Ponnuraja C, Iken K, Jahromi M, Doss GP, El Bekay R, Zayed H. Prevalence of nephropathy in type 1 diabetes in the Arab world: A systematic review and meta-analysis. Diabetes Metab Res Rev. 2018 Oct;34(7):e3026. doi: 10.1002/dmrr.3026. Epub 2018 Jun 8.

13. Grace Messenger, Richard Masoetsa, Imtiaz Hussain, Sriraman Devarajan & Mohamed Jahromi. Diabetic foot ulcer outcomes from a podiatry led tertiary service in Kuwait. Diabet Foot Ankle. 2018 May 28;9(1):1471927. doi: 10.1080/2000625X.2018.1471927. eCollection 2018. 14. Aggarwal P and M. Jahromi. Significant ACE Gene Haplotype Stipulates Development of Type 2 Diabetes in Women with Gestational Diabetes Mellitus. BJMMR 15(2): 1-8, 2016, Article no.BJMMR.25383 ISSN: 2231-0614, NLM ID: 101570965. 15. Mohamed Jahromi. Olfactory Receptor Gene is a Possible MHC-linked Gene. Savant Journal of Medicine and Medical Sciences Vol 2(7) pp. 169-172 September 2016 http://www.savantjournals.org/sjmms ISSN: 2985-895X 16. Essam M. Janahi, Mariam Al-Mannai, Hemlata Singh, and Mohamed Jahromi. Distribution of Hepatitis C Virus Genotypes in Bahrain. Hepat Mon. 2015 December; 15(12): e30300. doi: 10.5812/hepatmon.30300

17. Jahromi M, Ahmed A, Behbehani K (2014) Networking Between Cytokine Gene Polymorphisms Profile and HLA in the Pathogenesis of Type 1 Diabetes (A Pilot Study). MOJ Immunol 1(4): 00023. DOI: 10.15406/moji.2014.01.00023

18. Jahromi M, Ahmed A, Behbehani K, Mohammad A (2014) Critical Association Study of Olfactory Receptor Gene Polymorphism in Diabetic Complications. Immunome Res 10: 079. doi: 10.4172/17457580.1000079

19. Jahromi M, Ahmed A, Behbehani K, Mohammad A (2014) Critical Association Study of Olfactory Receptor Gene Polymorphism in Diabetic Complications. Immunome Res 10: 079. doi: 10.4172/17457580.1000079.

20. Jahromi M, Ahmed A, Behbehani K (2014) Networking Between Cytokine Gene Polymorphisms Profile and HLA in the Pathogenesis of Type 1 Diabetes (A Pilot Study). MOJ Immunol 1(4): 00023. DOI: 10.15406/moji.2014.01.00023.

21. Jahromi M (2012). Updates: Genetics of Type 1 Diabetes, http://dx.doi.org/10.5772/55960. 22. Jahromi M (2011)"Genetic Determinants of Type 1 Diabetes Type 1 Diabetes / Book 1", ISBN 978- 953-307-362-0.

23. Mohamed Jahromi. HAPLOTYPE SPECIFIC ALTERATION OF DIABETES MHC RISK BY OLFACTORY RECEPTOR GENE POLYMORPHISM. Autoimmune Rev. 2012 May 8. 24. Jahromi M (2014). Immunogenetics of Type 1 Diabetes and its Associated Complications in Pearce Z (ED). Endocrinology Research and clinical development: 69-102 - (NBC-R); ISBN: 978-1-63117- 000-3.

25. Mohamed M Jahromi, B Ann Millward, Andrew G Demaine. Significant Correlation between Association of Polymorphism in Codon 10 of the TGF-b1 T (29) C with Type 1 Diabetes and Patients with Nephropathy Disorder. J Interferon and Cytokine Research 2010, 30: 59-66. 26. Aly TA, Baschal EE, Jahromi MM, Fernando MS, Babu SR, Gowan K, Kretowski A, Erlich HA, Fain PR, Rewers MJ, Eisenbarth GS. Haplotype Analysis of the MHC Identifies Major New Type 1A Diabetes Locus. Diabetes2008; 57:770-776.

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27. Zhang L, Gianani R, Nakayama M, Liu E, Kobayashi M, Baschal E, Yu L, Babu S, Dawson A, Johnson K, Jahromi M, Aly T, Fain P, Barker J, Rewers M, Eisenbarth GS. Type 1 diabetes: Chronic progressive autoimmune disease. Defining Optimal Immunotherapies for Type 1 Diabetes. Novartis Found Symp. 2008;292:85-94.

28. Mohamed M Jahromi and George S Eisenbarth. Cellular and Molecular Pathology of Type 1 Diabetes. Cell Mol Life Sci 2007; 64: 865-72.

29. Mohamed M Jahromi and George S Eisenbarth. Genetic Determinants of Type 1 Diabetes Across Populations. Ann NY Acad Sci 2006; 289-299.

30. Theresa A. Aly, Akane Ide, Mohamed M. Jahromi, Jennifer M. Barker, Maria S. Fernando, Sunanda R. Babu, Liping Yu, Dongmei Miao, Henry A. Erlich, Pamela R. Fain, Katherine J. Barriga, Jill M. Norris, Marian J. Rewers, and George S. Eisenbarth. Extreme genetic risk for type 1A diabetes. Proc Nat Acad Sci USA 103; 2006 : 140**-*****.

31. Mohamed M Jahromi. Towards Molecular Medicine (1): Cell and molecular biology in clinical medicine. JBMS 2004; 16: 35-39.

32. Mohamed M Jahromi, B Ann Millward, Andrew G Demaine. The 5¢ flanking G (-174) C region of the IL-6 gene polymorphism is highly associated with type 1 diabetes mellitus. J Interferon and Cytokine Research; 2000:885-888.

33. Mohamed M Jahromi, B Ann Millward, Andrew G Demaine. A CA repeat polymorphism of the interferon-g gene is highly associated with type 1 diabetes: IFNG and IL-4 gene polymorphism and type 1 diabetes. J Interferon and Cytokine Research; 2000; 20: 187-190. 34. Nicola Cartwright, Andrew Demaine, Mohamed Jahromi, Hilary Sanders, and Edward Kaminski. A study of cytokine protein secretion, frequencies of cytokine expressing cells and IFN-G gene polymorphisms in normal individuals. J Transplantation 1999; 68/10: 1546-1552. In Preparation

I. Mohamed M.Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory Significant protection of Angiopoietin-1 plasma level for post transplantation diabetes mellitus (PTDM), II. Mohamed M.Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory Significant protection of Angiopoietin-1 plasma level for post transplantation diabetes mellitus (PTDM), III. Mohamed Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory. A detailed analysis of angiopoietin-like proteins’ levels and NODAT Under revision by Scientific Reports. IV. Mohamed M.Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory, Shehab, Rasheed Ahmad. A pleotropic behavior of VEGF-α in association with NODAT and age at onset,evision by Scientific Reports. V. Mohamed M.Jahromi, Torki Al-Otaibi, Osama Gheith, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory. Strong association of BDNF expression in NODAT in Kuwait

VI. Mohamed Jahromi, Zahra Rahme, Nehad Taha, Hala AlSanae, Maria AlMahdi, Fahed Aljaser, Mona Al Khawari. Genetic variants predisposing most strongly to type 1 diabetes age at onset lie near candidate genes that function in the immune system and in pancreatic beta cells (The first HLA Imputation study in the Middle East)

Presentation

Osama Gheith, Torki Al-Otaibi,, Nashwa Othman, Tarek Mahmoud, Parasad Nair, Medhat A-Halim, Narayanam Nampoory,Mohamed M.Jahromi. T cells commands chief orchestras for New Onset Diabetes After Transplant (NODAT) in Kuwait. ESOT 2019, Spain. Mohamed Jahromi. Characterization of type 1 diabetes in Kuwaiti population using NGS-based HLA typing. EFI 2019, Lisbon.

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Hidaia Abdalla, Zahra Rahme, Nehad Taha, Mona Al Khawari, Mohamed Jahromi. Challenges and Strategies for Recruiting Type 1 Diabetes Families in Kuwait with Strong Beliefs in Familism. Diabetes Day 2019, Kuwait.

M. Jahromi, O. Ghaith, N. Othman, N. Nampoory, A. Ahmed. Significant association of TGF-β1 C-T Transition in codon 10 of the gene with Post-transplant Diabetes (ADA 78th) M. Jahromi. Post-transplant Diabetes in Arab population is a TH1 cell mediated disease (ADA 77th2017)] M. Jahromi. Association of TGF-β1 C (+869) T gene polymorphism with New Onset of Diabetes after Transplantation (IDF 2017)

M. Jahromi. Critical Association Study of Olfactory Receptor Gene in Diabetic Complications. Autoimmunity, 2014, Steno, France.

“Integrating Technological Advances into Molecular Diagnostic Practice” (Part I): presented in pathology Management meeting on September 2013

Medical Services Improvement, SMC-A&E (pathology services): presented to Pathology Management meeting on 5th April 2011

Medical Services Improvement, SMC-A&E (I): presented to SMC Executive management meeting on 31st January 2011

Genetic Counseling for High-Risk Patients, Seminar presented at RCSI-MUB-Bahrain Mohamed M. Jahromi, Theresa A. Aly, Sunanda R. Babu, Marian J. Rewers, George S. Eisenbarth. Strong Association of Ubiquitin D (UBD)/MAS1L Genes Distinct from DR/DQ with Type 1A Diabetes. ADA meeting, Chicago, USA (Talk)

Haplotype Sharing Increases Diabetes Risk, independent of high risk DR-DQ genotype. ADA meeting 2006, Washington, USA (Talk)

Pseudo-Mandelian Inheritance of Type ia Diabetes in Sibling by HLA DR/DQ Genotypes and Haplotype Sharing. Federation Of Clinical Immunolgy Society (FOCIS) meeting 2006, San Fransisco, USA (Talk and Poster)

Familial clustering of the interferon-y gene polymorphism in British Europid patient group and its importance in Arab population. Chronic Health Problem Congress 2004 (Talk) Cytokines Network in the Pathogenesis of Type 1 Diabetes. GCSD 1st Conference 2005, kingdom of Bahrain

(Talk)

A weak but significant association of the interleukin-4 C (-590) T gene polymorphism with type 1 diabetes. The Pan-Arab Pediatric Congress 11th 2003, kingdom of Bahrain (Talk) Interferon-γ and interleukin-4 gene polymorphism as immunogenetic markers for type 1 diabetes. The first GCC genetic conference 2003(Talk)

Strong Association of polymorphism in codon 10 of the TGF-β1 T (+869) C with type 1 diabetes. Immunoregulation in Health and Disease (2nd) United Arab Emirates (Poster) Association of intereron-γ genetic polymorphisms with susceptibility to chronic pancreatitis. Digestion 2000; 61: 111,pp 297, United Kingdom (Poster)

Investigation of interferon-γ and interleukin-4 gene polymorphism in type 1 diabetes. Diabatologia 1999; 42/1 (Suppl) A90 Spain (Poster)

A study of cytokine expressing cells and gene polymorphisms in normal volunteers. yHuman Immunology 1999; 60/1: S78 Belgium (Poster)

Polymorphisms of interferon-γ gene are associated with type 1 diabetes. Diabetologia 1998; 41/1: A79.

(Poster)

Is cell size marker of osteoblast activity! J Pathology 181 Supp 1997, 44A United Kingdom (Poster) Strong Association of the G (-174) C polymorphism in the human interleukin-6 promoter region with type 1 diabetes. BDA Professional Conference, March 2000, United Kingdom (Talk).

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