ALI MANOUCHEHRI

MD. MPHC.

**** ******* ***. *********, ** 37207

615-***-****

adk5jc@r.postjobfree.com

adk5jc@r.postjobfree.com

LinkedIn Profile: https://www.linkedin.com/in/ali-manouchehri-md-mphc-13a18815a/ SUMMARY

A scientist clinician and hardworking postdoctoral researcher dedicated to clinical and translational research projects in the fields of oncology and cardiovascular disease with a focus on pharmacovigilance, drug toxicity, and drug safety, delivering valuable insight via data analytics and methods. Achieved high-quality scientific papers in peer-reviewed journals.

Self-motivated and multi-tasking professional with methodical and detail-oriented approach. Managed challenging environments with complex schedules in different projects. Highly organized creative problem solver who educates, refines, and drives himself to be a better person. Proactive and punctual with team-oriented mentality. Eager to learn and advance collective discipline knowledge, adept at managing concurrent objectives to promote efficiency and influence positive outcomes.

Besides the medical knowledge and clinical research capabilities, the MPH program at Vanderbilt University

(Epidemiology Track) provided me a strong backbone in biostatistics and epidemiology skills with proficiency in using the software Stata and familiarity with SAS, Python, and R.

Significant experience in cross-function, multi-cultural and multi-lingual settings

Open to relocate and travel.

SKILLS

Project coordination and management

Research protocols design and evaluation (GCP,

HIPPA),

Problem resolution

Data management and analysis

Patient screening for recruitment

Epidemiological studies, and clinical trials.

Proficient in Stata and GraphPad; operator level for R, Python, SAS, and SPSS.

Organization and multi-tasking.

EXPERIENCE

VANDERBILT UNIVERSITY MEDICAL CENTER

Nashville, TN

Postdoctoral Clinical Pharmacology Research Fellow 07/2019 to Current

Management of several research projects at the same time with time management and multi-tasking.

Collected and analyzed data to maintain computer database of research inputs and statistics.

Implemented design safety procedures to enable effective collection methods.

Presented findings using graphics and statistical software at research conferences.

Communicated findings to grow research efforts, enabling improved workflows.

Produced well-written and thoroughly vetted research papers for industry journals.

Advanced knowledge of pharmacovigilance and cardiovascular toxicity related to novel cancer therapies through effective and correctly conducted research studies.

Proposed and implemented research focused on pharmacovigilance, and cardio-oncology.

Searched pertinent scientific literature to support efforts with empirical data.

Designed research protocols to perform instrumentation relative to research procedures.

Adhered to all regulatory standards and university regulations for reporting.

Conducting clinical research, Recruiting the patient, Documentation of the trial (IRB, Protocol, Consent, GCP,

…), Processing the samples from the patient (endothelial cells - isolate, immunopurify and perform comparative low cell count transcriptomics using endothelial cells from cancer patients)

Data management, entering, sorting, cleaning, analysis, and visualization.

Coordination and communication with the patients, and providers and the Pis.

Working on the genetic database of Vanderbilt University (BioVU): Running GWAS, PheWAS, Mendelian Randomization, Polygenic Risk Score studies.

VANDERBILT UNIVERSITY MEDICAL CENTER

Nashville, TN

Clin/Tran Research Coordinator II 02/2018 to 07/2019

Developed protocols, prepared equipment and purchased materials to coordinate administrative functions in support of planned studies.

Coordinate and manage the clinical trial subjects and collect the data from the certain databases for patients who were visited

Identified issues and provided timely resolutions.

Detailed results and conclusions in professionally prepared documents, reports and presentations.

Created high-quality graphical representations of study results by leveraging skills in PowerPoint.

Collected and documented data as part of field research in cardiology and novel oncology drugs.

Recognized issues and developed immediate resolutions to address and alleviate concerns.

Designed survey instruments and questionnaires to obtain desired research data.

Compiled and organized research data to produce reports and graphs.

Supported project leads in preparing regulatory documentation and presentations highlighting findings.

Screened potential subjects to determine suitability for studies.

Outlined key research in documents, spreadsheets and reports.

Managing several projects and communication with the research subjects and the providers and PIs. VANDERBILT UNIVERSITY MEDICAL CENTER

Nashville, TN

Graduate Research Intern 03/2017 to 02/2018

Supported project leads in preparing regulatory documentation and presentations highlighting findings.

Screened potential subjects to determine suitability for studies.

Checked incoming data for accuracy and integrity to identify and resolve problems.

Kept organized records, maintained inventory equipment and materials.

Compiled and organized research data to produce reports and graphs.

Identified relevant questions and determined best methods of collection.

Analyzed collected data by implementing scientific processes and observing all safety protocols.

Participated in events, including meetings and presentations.

Collaborated with researchers in preparing study results for publication or presentation

Managed critical paperwork such as informed consent forms and personal waivers. SHIRAZ UNIVERSITY OF MEDICAL SCIENCES

Shiraz, Iran

Physician – Emergency Room/Ward Executive Manager 09/2010 to 01/2016

Management of the emergency room with high load of patients needed critical thinking and being multitask problem solver.

Responsible for examination, diagnosis, and treatment of the full range of patients seen in the ER (Chamran Hospital) and Cardiac Surgery ICU (Namazi Hospital) . Makes immediate critical decisions involving difficult emergency cases (e.g., heart attacks, injuries, lacerations, fractures, dislocations, seizures) and initiates treatment or required minor procedures.

Ordered laboratory testing, physical assessments and specialist consults to help diagnose and treat patients.

Educated patients on diagnoses, treatments and medications, and self-management to drive recovery and outcome goals.

Documented patient's visit, including medical history, physical exam, diagnoses and plan of action.

Participating in clinical research projects, review literature, examination and follow up of patients who enrolled in.

Participate and present at department ground rounds, mortality reports and conferences. EDUCATION AND TRAINING

M.D.: Doctor of MEDICINE 09/2008

Hormozgan University of Medical Sciences, Bandar Abbas, Iran MASTER OF PUBLIC HEALTH (MPH): EPIDEMIOLOGY TRACK Expected in 08/2021 Vanderbilt University, Nashville, TN

PUBLICATIONS AND PRESENTATIONS

Identification of Cardiovascular Adverse Effects Associated with Midostaurin-A WHO Pharmacovigilance Database Analysis. Circulation 142 (Sup_3), A12978-A12978 (2020) A Choudhary, A Manouchehri, J Moslehi, J

Immune checkpoint inhibitor-induced myositis, the earliest and most lethal complication among rheumatic and musculoskeletal toxicities. Autoimmunity Reviews, 102586 (2020) Yves Allenbach, Céline Anquetil, Ali Manouchehri, Olivier Benveniste, Olivier Lambotte, Bénédicte Lebrun- Vignes, Jean-Philippe Spano, Stéphane Ederhy, David Klatzmann, Michelle Rosenzwajg, Bruno Fautrel, Jacques Cadranel, Douglas B Johnson, Javid J Moslehi, Joe-Elie Salem

Solid organ transplant rejection associated with immune-checkpoint inhibitors. Annals of oncology: official journal of the European Society for Medical Oncology (2020) S Saberianfar, LS Nguyen, A Manouchehri, B Lebrun-Vignes, JJ Moslehi, DB Johnson, A Hertig, JE Salem

Tyrosine kinase inhibitors in leukemia and cardiovascular events: from mechanism to patient care. Arteriosclerosis, thrombosis, and vascular biology 40 (2), 301-308 (2020) A Manouchehri, E Kanu, MJ Mauro, AW Aday, JR Lindner, J Moslehi

Phénotype et pronostic des atteintes systémiques induites sous inhibiteurs de check-points immunitaires. La Revue de Médecine Interne 40, A72 (2019)

C Anquetil, JE Salem, A Manouchehri, O Lambotte, B Lebrun-Vignes, JP Spano, D Klatzmann, M Rosenzwajg, B Fautrel, J Cadranel, DB Johnson, JJ Moslehi, O Benveniste, Y Allenbach

Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study. Journal for immunotherapy of cancer 7 (1), 134 (2019)

Douglas B Johnson, Ali Manouchehri, Alexandra M Haugh, Henry T Quach, Justin M Balko, Bénédicte Lebrun- Vignes, Andrew Mammen, Javid J Moslehi, Joe-Elie Salem

Cardiovascular toxicity of ibrutinib: a pharmacovigilance study. EUROPEAN HEART JOURNAL 40, 893-893

(2019)

JE Salem, A Manouchehri, M Arie Bretagne, B Lebrun Vignes, JD Groarke, DB Johnson, T Yang, NM Reddy, C Funck-Brentano, JR Brown, DM Roden, JJ Moslehi

Cardiovascular toxicities associated with ibrutinib. Journal of the American College of Cardiology 74 (13), 1667- 1678 (2019)

Joe-Elie Salem, Ali Manouchehri, Marie Bretagne, Bénédicte Lebrun-Vignes, John D Groarke, Douglas B Johnson, Tao Yang, Nishitha M Reddy, Christian Funck-Brentano, Jennifer R Brown, Dan M Roden, Javid J Moslehi

Renin-angiotensin-aldosterone system modulates blood pressure response during vascular endothelial growth factor receptor inhibition. JACC: CardioOncology 1 (1), 14-23 (2019) Wendy J Bottinor, Megan M Shuey, Ali Manouchehri, Eric H Farber-Eger, Meng Xu, Devika Nair, Joe-Elie Salem, Thomas J Wang, Evan L Brittain

Spectrum of cardiovascular toxicities of immune checkpoint inhibitors: A pharmacovigilance study. The Lancet. Oncology 19 (12), 1579-1589 (2018)

Joe-Elie Salem, Ali Manouchehri, Melissa Moey, Bénédicte Lebrun-Vignes, Lisa Bastarache, Antoine Pariente, Aurélien Gobert, Jean-Philippe Spano, Justin M Balko, Marc P Bonaca, Dan M Roden, Douglas B Johnson, Javid J Moslehi

ACEI and ARB Use Modulates Blood Pressure Response During Initiation of Vascular Endothelial Growth Factor Receptor Inhibition. Circulation 138 (Suppl_1), A15890-A15890 (2018) Wendy Bottinor, Ali Manouchehri, Megan M Shuey, Eric Farber-Eger, Joe-Elie Salem, Javid J Moslehi, Thomas J Wang, Evan L Brittain

LANGUAGE SKILLS

Fluent in English, Farsi and intermediate proficiency in Arabic and elementary level in German.

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