research fellow

Curriculum Vitae

Name:YIZHOU QUAN, Ph.D.

Gender:Male

Date of Birth:Oct-14-1987

E-mail address: **********@*******.***

Mobile: 857-***-****

Currently work: Research fellow in Massachusetts Eye&Ear Infirmary/Harvard Medical School

Brief Introduction:

9 years of experience in clinical translational studies/tissue regeneration/cell research.

Achieved robust cochlear hair cell regeneration in adult mice in situ and published Nature Communications in Dec.2019 ( achieved a holy grail in the field commented by the reviewer of the paper.)

He has published 9 peer-reviewed high-qualified articles, which have been cited for 151 times, with 3 articles as a first (co-first author) including Nature Communications; Scientific Reports;Oncotargets and 3 articles as a second author including 2 stem cell reports.

He has been invited to peer review articles for different journals: Open medicine; Biomedicine&Pharmacotherapy; Oncotarget; Oncotarget&therapy; Journal of Medicine Discovery.

An expert in testing AAVs/Ad.virus/Chemicals with the novel adult mice cochlea explant culture model in vitro.

An expert in testing Chemicals with round window niche delivery/middle ear delivery in adult mice in vivo.

Education:

Sep 2016-now Research Fellow

Massachusetts Eye&Ear Infirmary/Harvard Medical School

Supervisor: Professor Zheng-Yi Chen

Thesis:

Clinical translational study 1: Adult cochlear hair cell regeneration from transgenic animals to WT animals via Chemicals/AAVs/Ad.Virus in vitro.

Clinical translational study 2: Hearing function recovery via chemicals compounds in NIHL/ARHL model in vivo.

Sep 2011-Jul 2016 Ph.D. student, Bio-Medical Engineering

Stem cell Group, Department of Biomedical Engineering,

Shanghai Jiaotong University, Shanghai. (ranked 3rd in the nation, ranked 59 in the world)

Supervisor: Professor Wei-qiang Gao (World-renowned scientist who discovered Math1 (Atoh1) in hair cell regeneration)

Thesis: Cochlear hair cell regeneration/protection/cancer research

(Granted the “Golden Arawana Scholarship” in 2016, with only 2 graduate students (out of about 100 students) in the department.)

Publications

A novel in vitro model delineating hair cell regeneration and neural re-innervation in adult mouse cochlea; Wenyan Li, Yizhou Quan, Mingqian Huang, Yilai shu, Huawei Li, Zheng-Yi Chen, 2020, (Preparation)

Yilai Shu*, Wenyan Li*, Mingqian Huang*, Yi-Zhou Quan*, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li & Zheng-Yi Chen; Renewed proliferation in adult mouse cochlea and regeneration of hair cells. (2019). Nature Communications. Co-first author. https://doi.org/10.1038/s41467-019-13157-7.

RongLi, Yizhou Quan, Weilaing Xia; SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/β-catenin pathway. (2018). https://doi.org/10.1016/j.yexcr.2018.01.036

Chen, Q, Yizhou Quan, Wang, N; Xie, C; Ji, Z.; He,H.; Yin, S.; Chin, Y.E.; Wei, X.; Gao, W. Q. "Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea." Stem Cell Reports 9(1): 231-246. (2017)

Naitao Wang*, Bai-Jun Dong*, Yizhou Quan, Qianqian Chen, Mingliang Chu, Jin Xu, Wei Xue, Yi-Ran Huang, Ru Yang, and Wei-Qiang Gao; Regulation of prostate development and benign prostatic hyperplasia by autocrine cholinergic signaling via maintaining the epithelial progenitor cells in proliferating status; Stem Cell Reports. (2016). Http://dx.doi.org/10.1016/j.stemcr.2016.04.007

Yizhou Quan, Naitao Wang, Qianqian Chen, Jin Xu, Wei Cheng, Meijuan Di, Weiliang Xia,Wei-Qiang Gao; SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Oncotarget (2015,6(28):264**-*****); DOI:10.18632/oncotarget.4764 (2015).

Yizhou Quan, Li Xia, Jiaxiang Shao, Shankai Yin, C.Yan Cheng, Weiliang Xia, Weiqiang Gao; Adjudin protects rodent cochlear hair cell against gentamincin ototxicity via the SIRT3-ROS pathway. Sci Rep. 5, 8181; DOI:10.1038/srep08181 (2015).

Naitao Wang, Ming Yao, Jin Xu, Yizhou Quan, Kaiqing Zhang, Ru Yang and Wei-Qiang Gao; Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt; (2015). Clinical cancer research DOI: 10.1158/1078-0432.CCR-14-3163.

Cheng, Yan-Ho; Xia, Weiliang; W.P. Wong, Elissa; R. Xie, Qian; Shao, Jiaxiang; Liu, Tengyuan; Quan, Yizhou; Zhang, Tingting; Yang, Xiao; Geng, Keyi; Silvestrini, Bruno; Cheng, Chuen-Yan; Adjudin-a male contraceptive with other biological activities; Recent patents on endocrine, metabolic&immune drug discovery. (2015); 9(2):63-73.

Jia-xiang Shao, Ting-ting Zhang, Teng-yuan Liu, Yi-zhou Quan, Fan Li, Jie Liu, Xiao Yang, Qian Xie & Wei-liang Xia; Sirtuin functions in the brain: From physiological to pathological aspects; Journal of Shanghai Jiaotong University (Science) volume 19, pages651–662(2014)

Conference:

Regeneration of cochlear hair cells in adult mice by direct trans-differentiation of rejuvenated cochlear epithelial cells. Wenyan Li; Yi-Zhou Quan; Mingqian Huang; Yilai Shu; Yong Tao; Xuezhong Liu; Zhengmin Wang; Huawei Li; Zheng-Yi Chen (PD 70, ARO Conference 2018).

Induction of proliferation in adult and aged mouse cochlea. Yilai Shu; Wenyan Li; Yi-Zhou Quan; Mingqian Huang; Zhengmin Wang; Huawei Li; Zheng-Yi Chen (PS 215, ARO Conference, 2018)

Induction of proliferation and robust hair cell regeneration in adult mouse cochlea; Yizhou Quan, HUang, Mingqian, Shu Yilai, Li Wenyan, Chen, Zheng-Yi (World Congress on Endoscopic Ear Surgery 3.0, 2019)

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