RYAN DESOUSA (Ph.D.)

**** ********* **., *** ***, Rockville, MD, 20852, USA adfgpl@r.postjobfree.com 1-323-***-****

OBJECTIVE

A challenging technical and leadership position with growth opportunities.

SUMMARY AND SKILLS

Experienced research professional in the chemical, polymer/material and characterization sciences.

Leadership/ supervisory experience, project management (Waterfall, Agile) and execution, communication, regulatory support- ISO13485, 21CFR820, business acumen.

DOE and statistical and regression data analysis, the Lean - Six Sigma process.

Product and early stage process research and development experience.

Patent search, Ideation, writing Invention Disclosures and Patent Applications.

Experience working with external collaborators and vendors.

MS-Office, Minitab, MS-Project (basic), Chemdraw, SciFinder, Matlab (basic), Documentum, LIMS.

NMR, LC, GPC, UV, FTIR, SEM/EDX, DSC, TGA, Rheology, XPS, DLS, Lyophilization.

CONTINUING EDUCATION

Certified Quality Engineer Certificate – Udemy (Apr 2020).

Lean Six Sigma Black Belt Certificate (Lean/DMAIC) – Villanova University (Jan 2020).

HBX - Credential of Readiness (Accounting, Economics and Analytics); Disruptive Strategy; Leading with Finance - Harvard Business School. (2016-2017)

Project Management Certificate - Emory University (2016).

Lean Six Sigma Green Belt Certificate (Lean/DMAIC) - University of Georgia (2015).

PROFESSIONAL EXPERIENCE

Senseonics Incorporated: Germantown, MD. USA.

October 2018 – Mar 2020: Principal Scientist – Materials Research & Process Development.

Development/evaluation of chemistries, hydrogels and polymers towards increasing longevity and reducing the calibration frequency of fluorescence based CGM sensor, in a Start-Up environment (ISO13485).

Developed composite hydrogel formulation, improving sensor optical stability by >50%; led process to clinical pilot scale, targeted at in-vivo (pre)clinical trials. PMA support. Patent Application in process.

Led chemistry team in the development and execution of FDA recommended processes, to characterize the effects of possible interferent substrates and serum proteins on the accuracy of the CGM sensor.

Led chemistry sub-team investigating the effects of critical parameters on current sensor algorithm and was instrumental in determining key chemical/physical parameters.

Collaborated on team involved in the development of polymeric underfill materials for the sensor and was key in the selection of an underfill material targeted at reducing ambient-light noise by >80%.

Analyzed sensor generated data sets, to evaluate the effects of the immune response oxidative cascade, photosensitization and process parameters on sensor chemistry and sensor performance.

Investigated degradant molecular entities and possible mechanistic pathways to the same.

Initiated material investigations into surface and bulk properties of sensor hydrogel.

Consulted on process improvement project teams, targeting improved sensor manufacturing yields.

Managed chemical inventory and county recertification submissions.

Alcon - Division of Novartis: Duluth, GA. USA.

October 2012 – January 2018: Senior Research Scientist – Materials, Vision Care.

Successfully delivered Class-II UV-Blocker modification to the $750 million (2016) DACP® lens brand; involving ideation, water soluble UV-Blocker syntheses, polymer modification, formulation development (DOE), lens fabrication, characterization, solving mechanistic challenges, and stability studies, of photocured contact lenses to meet PoC and manufacturing process conditions. 510k support.

RYAN DESOUSA adfgpl@r.postjobfree.com

RESEARCH and PROFESSIONAL EXPERIENCE (contd.)

Rapidly developed rheological methods to understand the behavior of dilatant aq. PMAA polymers, in support of the TFF purification of these polymers, to be used in contact lens lubricant surface coatings.

Compatibilization of GlucoseOxidase (GOx) enzyme for use in contact lens based glucose sensor.

Used DOE techniques to formulate silicone/non-silicone monomers, amphiphilic block copolymer PU/non-PU macromers, targeting improved co-continuous contact lens polymer networks.

Performed in-depth development studies to better understand the working of and failure modes associated with novel custom contact lens coating for enhanced lubricity and on-eye comfort.

Used DOE to evaluate the use of Rh based hydrosilation catalyst for hydrosilation of vinylic-amides.

Alcon - Division of Novartis: FortWorth, TX. USA.

March 2010 – October 2012: Senior Scientist II – Chemistry/Preformulation Research, Vision Care.

Formulated custom block-copolymer wetting agents for use in contact lens disinfection formulations that were then used in a commercial $80 million product (2013) OptiFree® PureMoist and later in Air Optix Hydraglyde®.

Executed on emulsions formulations in development of Systane Balance® DryEye OTC product.

Conceived, designed, developed, obtained resources and executed multiple physico-chemical studies aimed at taking red-ox disinfection chemical technologies from ideas to the bench to the MPDS market.

Alcon: Fort Worth, TX. USA.

July 2006 – March2010: Senior Scientist I – Chemical Research, Vison Care.

Designed and developed novel molecular design towards improving disinfectant efficacy and lowering toxicity.

Designed, obtained resources and performed physico-chemical experiments to better understand the effects of environmental parameters on various contact lens hydrogel bulk properties.

Oversaw related internal and external contract synthesis and scale up projects.

Mitsubishi Chemicals Research and Innovation Center Inc.: Goleta, CA., USA.

July 2004 – June 2006: Postdoctoral Research Chemist/Engineer.

Successfully delivered on project to design and develop polymer-electrolyte composite membranes, having >60% improved low %RH performance and comparable stability to Nafion®.

Collaborated on research projects between the MC group and UC-Santa Barbara.

Asian Paints India Limited: Mumbai, India.

March1998 - June 1999: Junior Chemist

Synthesis and evaluation of resins for wood coatings.

EDUCATION

1999 – 2004 University of Southern California, Los Angeles; PhD, Chemistry : GPA: 3.95 / 4.00

Advisors: Prof. G. K .Surya Prakash and Prof. G. A. Olah

1995 – 1997 University of Mumbai, India; Master of Science, Chemistry : First Class

1992 - 1995 University of Bombay, India; Bachelor of Science, Chemistry. : First Class

HONORS AND AWARDS

2002, 2003 Department of Chemistry Pre-doctoral Scholarship.

2001 Harold Moulton Graduate Fellowship for Excellence in Research.

2000 USC – College Graduate Merit Award.

U.S. IMMIGRATION STATUS: U.S. Permanent Resident/Green Card Holder.

PROFESSIONAL AFFILIATION: American Chemical Society.

PATENTS AND PUBLICATIONS: List available upon request or LinkedIn.

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