Yang, Ethan */**/****

Curriculum Vitae

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Yang, Ethan

Present Mailing Address Permanent Mailing Address

**** *********** **** **** *********** Road

Palo Alto, California 94301 Palo Alto, California 94301 Preferred Phone: 310-***-****

Preferred Email: adeybb@r.postjobfree.com

Education

07/2010 - 05/2017, University of Miami Leonard M. Miller School of Medicine, MSTP, Miami, Florida, MD, PhD, 05/2017 09/2007 - 06/2008, Bioengineering, Stanford University, Stanford, California, MS, 06/2008 09/2003 - 06/2007, Biological Sciences, Stanford University, Stanford, California, BS, 06/2007 Relevant Experiences

07/2019 - 04/2020, Chief Medical Officer, Micromedical Technologies, Inc., Shanghai, China Engineered first generation of flow disruptor device for intracranial aneurysms and percutaneous transcervical artery revascularization, created rabbit and canine models, performed animal studies and created standard operating procedures, successfully raised series A round funding.

07/2017 - 06/2019, Resident Physician, Vascular Surgery, University of California, Los Angeles, California Performed routine and complex surgery in the specialized area of medicine of Vascular Surgery, provided care, education and counseling to patients, performed rounds, developed assessment and treatment plan, coordinated care and services with other members of the health care team.

11/2015 - 05/2017, Co-Investigator, Department of Vascular Surgery, Miami, Florida Conducted a retrospective study on determining the primary success rate of percutaneous ultrasound guided thrombin injection in pseudoaneurysms with respect to pseudoaneurysm size, neck sizes and complexities, led as a principal investigator in a project on improving predictive risk factors for AAA rupture, examined various parameters based on finite element studies in order to improve surgical criteria for elective AAAs.

05/2011 - 06/2015, MSTP trainee, Diabetes Research Institute, University of Miami, Miami, Florida Generated bioactive, immunomodulatory coatings through bio-orthogonal chemistry that serve not only to mask the donor cell surface, but also to provide direct host immune responses, constructed a tethered TGF-beta1, which functions as an “infectious” Treg with the potential to direct tolerogenic responses and protect the foreign cells from antigen-specific immune responses, constructed a layer-by-layer antioxidant biomaterial from CONP-PAMAM constructs to protect islet transplants. 02/2014 - 05/2015, Biomedical Engineering Teaching Assistant, University of Miami, Miami, Florida Lectured about immunology, tissue engineering and biomaterials, helped writing questions for final exams. 07/2008 - 05/2010, Research Assistant, UCSF Center for Cerebrovascular Research, San Francisco, California Investigated hypoxic gene expression regulation in ischemic tissues, explored the influence of Int3 and HOXD3 on brain angiogenesis, performed in vivo and in vitro experiments, including sequencing, cloning, and transfection. 07/2003 - 06/2007, Research Assistant, Department of Dermatology, Stanford University, Stanford, California Investigated the consequences of silencing Ras-induced Senescence 1 on Keratinocytes using RNAi, the effects of Keratin 6 and 14 deficiencies on IkB/Ras induced Squamous Cell Carcinoma, the effects of Slug-induced epithelial mesenchymal transition on tumor progression and metastasis in conjunction with epidermal growth and differentiation, studied the mechanisms that underlie integrin blockade induced re-differentiation in keratinocytes, became proficient in molecular biology (sequencing, cloning, transfection), cellular biology (FACS, RT-PCR, Western blot, immunohistochemistry), cell culturing, xenografting, and transplanting grafts.

06/2001 - 06/2003, Research Assistant, Department of Anesthesia, Stanford University, Stanford, California Studied caspase regulation of programmed cell death in astrocytes in response to serum deprivation-induced apoptosis, determined cell-mediated response to serum deprivation using gene chip microarray, acquired skills in cell culturing, immunostaining, protein electrophoresis and brain dissection.

Yang, Ethan 6/28/2020

Curriculum Vitae

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Peer Reviewed Journal Articles/Abstracts

Xu L, Chock VY, Yang EY, Giffard RG. Susceptibility to apoptosis varies with time in culture for murine neurons and astrocytes: changes in gene expression and activity. Neurol Res. 2004, Sep; 26(6): 632-643. Cited in PubMed; PMID: 15327753.

Gao P, Shen F, Gabriel RA, Law D, Yang EY, Yang GY, Young WL, Su H. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke. 2009, Nov; 40(11): 3596-3600. Cited in PubMed; PMID: 19745179.

Ovadia SA, Landy DC, Cohen ER, Yang EY, Thaller SR. Local administration of beta-blockers for infantile hemangiomas: a systematic review and meta-analysis. Ann Plast Surg. 2015, Feb; 75(2): 256-262. Cited in PubMed; PMID: 25590249. Weaver JD, Song Y, Yang EY, Ricordi C, Pileggi A, Buchwald P, Stabler CL. Controlled Release of Dexamethasone from Organosilicone Constructs for Local Modulation of Inflammation in Islet Transplantation. Tissue Eng Part A. 2015, Aug; 21(15- 16): 2250-2261. Cited in PubMed; PMID: 26027872.

Yang EY, Kronenfeld JP, Gattás-Asfura KM, Bayer AL, Stabler CL. Engineering an "infectious" Treg biomimetic through chemoselective tethering of TGF-beta1 to PEG brush surfaces. Biomaterials. 2015, Oct; 67(N/A): 20-31. Salsamendi J, Ghosh S, Ko AC, Pereira K, Yang EY, Alabiad C. Percutaneous Ethanolamine Sclerotherapy of a Retrobulbar Cyst in a Child with Microphthalmos and Proptosis. J Vasc Interv Radiol. 2015, Nov; 26(11):1658–1659. Cited in PubMed; PMID: 26505936

Yang EY, Kronenfeld JP, Stabler CL. Engineering biomimetic materials for islet transplantation. Curr Diabetes Rev. 2016, Jan; 11(3): 163-169. Cited in PubMed; PMID: 25776871.

Ray JJ, Meizoso JP, Allen CJ, Teisch LF, Yang EY, Foong HY, Mundra LS, Namias N, Pizano LR, Schulman CI. Admission Hyperglycemia Predicts Infectious Complications After Burns. J Burn Care Res. 2016, Jun; Epub ahead of print Cited in PubMed; PMID: 27355659.

Yang EY, Tabbara MM, Sanchez PG, Abi-Chaker AM, Patel J, Bornak A, Jones KM, Rey J. Comparison of Ultrasound-Guided Thrombin Injection of Iatrogenic Pseudoaneurysms Based on Neck Dimension. Ann Vasc Surg. 2018 Feb; 47: 121-127. Epub 2017 Sep 5. Cited in PubMed; PMID: 28887253.

Xue S, Tang X, Zhao G, Tang H, Cai L, Fu W, Zhang W, Yang EY, Guo D. A Systematic Review and Updated Meta-analysis for Carotid Near-Occlusion. Ann Vasc Surg. 2019, Nov. Cited in PubMed; PMID: 31706996. Xue S, Tang X, Zhao G, Tang H, Shen Y, Yang EY, Fu W, Guo D. Contemporary Outcomes of Open and Endovascular Intervention for Extracranial Carotid Artery Aneurysms: A Single Centre Experience. Eur J Vasc Endovasc Surg. 2020, Jul. Cited in Pubmed; PMID: 32631711.

Li Y, Frei AW, Yang EY, Labrada I, Sun C, Rong Y, Samojlik MM, Bayer AL, Stabler CL. In Vitro Platform Establishes Antigen- Specific CD8+ T Cell Cytotoxicity to Encapsulated Cells via Indirect Antigen Recognition. Biomaterials, 2020 October. Poster Presentations

Cai T, Yang EY, Khavari PA. (2003). Class II PI3-Kinase mediates cell cycle inhibition and terminal differentiation in epidermis. Poster presented at: The 64th Meeting of the Society for Investigative Dermatology; Miami, Florida. Ridky TW, Yang EY, Leachman S, and Khavari PA. (2005). The structural integrity of individual keratin filament networks is dispensable for epidermal tumorigenesis. Poster presented at: Society for Investigative Dermatology; Stanford, California. Teisch LF, Ray JJ, Meizoso JP, Allen CJ, Foong HY, Yang EY, Narasimman M, Pizano LR, Namias N, Proctor KG, Schulman CI.

(2015). The role of hyperglycemia and diabetes on clinical outcomes after thermal injury. Poster presented at: South Florida ACS Surgical Research Forum Paper Presentations; Miami, Florida. Yang EY, Frei AW, Stabler CL. (2014). Engineering infection-mimicking materials targeting EGFR mutationpositive NSCLC Poster presented at: TERMIS meeting; Washington, District of Columbia. Yang, Ethan 6/28/2020

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Yang EY, Kronenfeld JP, Gattas-asfura K, Bayer AL, Stabler CL. (2015). Engineering an "infectious" Treg biomimetic through chemoselective tethering of TGF-beta1 to PEG brush surfaces Poster presented at: TERMIS World Congress; Boston, Massachusetts.

Oral Presentations

Yang EY, Frei AW, Stabler CL. (2015). Engineering an in vitro platform for characterization of antigen recognition for encapsulated islets. Oral Presentation presented at: IPITA/IXA/CTS Joint Congress; Melbourne, Australia. Yang EY, Gattas-asfura K, Stabler CL. (2014). Engineering tolerogenic biomaterials for islet transplants Oral Presentation presented at: Nanoflorida; Miami, Florida.

Other Experiences

08/2007 - 02/2008, Market Research, Startup/speeddate.com, Palo Alto, California Evaluated strengths and points of differentiation of competitors’ launch, prepared press to create and manage buzz for product offering, recommended marketing campaign to advertise brand image to customers, countering competition to reach networked 22-29-year-old students and working professionals for critical traffic. 09/2006 - 06/2008, Delegate Liaison, Asia-Pacific Student Entrepreneurship Society, Stanford Chapter, Stanford, California Invited top Silicon Valley venture capitalists as well as international and Stanford students to discussion forum, organized delegate conferences, mock pitch rounds, and entrepreneurial speaker series. 09/2006 - 06/2007, Marketing Research and Strategy, Balsam Hill (online retailer of premium trees), Venture Evaluation, eAngels, Graduate School of Business, Stanford University, Stanford, California Conducted ethnographic and one-on-one interviews with customers and prepared qualitative report on findings, designed and analyzed survey, performed quantitative analysis to validate results from qualitative report, recommended actions to achieve higher conversion rates, assessed China market entry opportunity, analyzed product portfolio and potential risk from competition, created pricing strategy, built detailed revenue projection model and designed marketing and sales campaign. Awards and Accomplishments

Engineering an “infectious” Treg biomimetic was featured as an Editor’s Choice in Science Translational Medicine 7, 301ec143301ec143, 2015. The article, entitled “Contagious Biomaterials” highlights the potential impact of our studies in generating tolerance microenvironment.

BS, Biological Sciences with Honors in Molecular and Cell Biology Stanford Undergraduate Research Grant 2006

Intel Science Talent Search Semifinalist 2003

Intel International Science and Engineering Fair Award Winner 2002, 2003

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