Laxman M. Alakonda, Ph.D.

Research Scientist @Issar Pharmaceuticals,

Contact: +91-901*******, (adenqg@r.postjobfree.com)

https://www.linkedin.com/in/laxmanma/

Skills

Synthetic & Analytical skills

• Practical knowledge of small molecule and peptide APIs.

• Extensive handling of prep-HPLC and purification method development on Hanbon DAC-50, 150 & 200mm columns.

• Literature (Scifinder & Reaxys), design, modification (C&N termini), synthesis (solid & liquid phases), purification (prep-HPLC & conventional), lyophilisation and characterisation (aHPLC, LCMS, NMR, UV

& IR) of small molecule and peptide APIs from mg to multi-gram scale.

• Asymmetric synthesis, organometallics, cross-couplings and multi-step organic synthesis.

• Handling of light and moisture sensitive compounds and reactions.

• Peptide structure determination using 2D-NMR spectroscopy.

• Familiar with Chemdraw, Topspin, LabSolutions, Clarity, Easychrom and MS Office. Managerial skills

• Excel at grasping essence and identifying opportunities that bring profitable growth to organization.

• Project management, leading a team and training the novices.

• GMP documentation (SOPs, STPs, BMRs, change controls, deviations, calibrations, validations) and coordination with cross-functional groups.

• Client interaction, decision-making and problem solving.

• Excellent communication (written & verbal) and interpersonal skills for productive-relationships.

• Essence of Regulatory guidelines WHO, GLP, GMP, GDP, ICH and Agencies (FDA, HC, EMA, CDSCO). Experience

06/2019 -

Present:

Research Scientist @Issar Pharmaceuticals, Hyderabad, India. Responsibilities: Planning, execution and troubleshooting.

• Synthesis (SPPS), purification (prep-HPLC), lyophilisation and purity (aHPLC) of peptide APIs.

• aHPLC & Prep-HPLC method development on Hanobn DAC-50, 150 & 200mm columns.

• Incharge of purification wing including equipments; prep-HPLCs and lyophilisers.

• Laboratory management and training the novices as per GMP.

• Weekly meetings with CMD on work progress.

Accomplishments: Developed cost-effective prep-HPLC purification methods for 1) Decapeptide: Reduced overall time and consumables to its half. 2) Degarelix acetate: Developed single purification method with 56% yield & >99.5% purity. 3) Genopep: Improving the yields by prep-HPLC and method development for peptide NCEs. 07/2018 -

05/2019:

Subject Matter Expert @Chegg India, India.

Responsibilities: Provided solutions for organic chemistry problems –Freelance. 03/2016 -

02/2018:

Post Doctoral Fellow @TCIS-TIFRH, Hyderabad, India. PI: Dr. V. Agarwal. Activities involved in:

• Synthesis laboratory establishment.

• Planing, synthesis (Auto-SPPS), purification (semiprep-HPLC), lyophilisation and structure determination (2DNMR) of peptides, small molecule inhibitors and zoledronic acid.

• Weekly group meetings and presentations.

Projects involved in:

• Synthesis of rhodanine based small molecule inhibitors to measure site specific changes at ps- ns dynamics of PDZ as a function of ligand binding affinity using NMR. CV Dr. Laxman M. Alakonda

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• Synthesis of zoledronic acid to study the dynamic properties of H2O molecules in different pseudo-polymorphs using ssNMR.

06/2013 -

12/2015:

Prepared for Indian Civil Services Examination (CSE) with chemistry as an optional subject. 01/2007 -

05/2013:

Doctoral Fellow @University of Hyderabad, Hyderabad, India. PI: Prof. M. Periasamy. Thesis title: “Development of Organic Synthetic Methods for N-Arylation and for Synthesis of Chiral Propargylamines and Chiral Allenes”

Projects involved in:

1. Studies on N-Arylation of NH-Heterocycles and Diphenylamine 2. Studies on N-Arylation of Chiral C2-Symmetric Diamines. 3. Synthetic Applications of Chiral C2-Symmetric Diamines: Enantioselective Synthesis of Chiral Propargylamines and Chiral Allenes.

01/2006 -

06/2006:

Project Fellow @University of Hyderabad, Hyderabad, India. PI: Prof. R. Nagarajan Project Title: Synthesis and characterization of 3,6-dipyrazollyl carbazole using Vilsmeier-Haack reaction.

Education

12/2006 - 05/2013: Ph.D. (Organic Chemistry), University of Hyderabad, Hyderabad, Telangana, India. 06/2004 - 05/2006: M.Sc. (Chemistry-1st Division), University of Hyderabad, Hyderabad, Telangana, India. 07/2000 - 05/2003: B.Sc. (Chemistry-1st Division), Silver Jubilee College, SK University, AP, India. Awards

• Awarded Post Doctoral Fellowship (March 2016- February 2018) by TCIS-TIFRH, Hyderabad, India.

• Awarded JRF & SRF (December 2006-December 2011) by CSIR, India.

• Qualified CSIR-JRF-2005 exam & stood in top 20% to write SPM Fellowship test conducted by CSIR, India.

• Secured All India Rank 101 in GATE-2006 conducted by IIT Kharagpur, India.

• Secured 26th rank in M.Sc. Entrance-2004 University of Hyderabad, Hyderabad, India. Publications

1) Alakonda, L. M.; Periasamy, M. J. Organomet. Chem., 2009, 694, 3859; Copper (I) catalysis: Synthesis of N,N'-diarylated and N-aryl,N'-formylated chiral C2-symmetric diamines.

(https://doi.org/10.1016/j.jorganchem.2009.08.002). 2) Alakonda, L. M.; Periasamy, M. Synthesis, 2012, 44, 1063; Simple and Convenient Methods for N- Arylation of Heterocycles and Diphenylamine. (DOI: 10.1055/s-003*-*******). 3) Periasamy, M.; Reddy, P. O.; Edukondalu, Dalai, M.; Alakonda, L. M.; Udaykumar, B. Eur. J. Org. Chem. 2014, 6067; Zinc Salt Promoted Diastereoselective Synthesis of Chiral Propargylamines Using Chiral Piperazines and their Enantioselective Conversion into Chiral Allenes;

(https://doi.org/10.1002/ejoc.201402766).

4) Alakonda, L. M.; Periasamy, M. (Unpublished results); CuBr Promoted Diastreoselective Synthesis of Chiral bis-Propargylamines in One Pot Operation.

5) Periasamy, M.; Gurubrahamam, R.; Sanjeevakumar, N.; Dalai, M.; Alakonda, L. M.; Reddy, P. O.; Suresh, S.; Satishkumar, S.; Padmaja, M.; Reddy, M. N.; Anwar, S.; Muthukumaragopal, G. P.; Seenivasaperumal, M.; Vairaprakash, P; Chimia, 2013, 67, 23; Convenient methods for Synthesis of chiral aminoalcohols and amines. (https://doi.org/10.2533/chimia.2013.23).

6) Alakonda, L. M.; Prakash, S.; Agarwal, V.; Madhu, P. K.; Synthesis and characterization of small molecule inhibitors to measure site specific ps-ns dynamics of hAF6 PDZ-domain as a function of ligand binding affinity using NMR (to be communicated).

CV Dr. Laxman M. Alakonda

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7) Alakonda, L. M.; Agarwal, V.; Madhu, P. K.; Synthesis and characterization of zoledronic acid and study of dynamic properties of water molecules in different pseudo polymorphs of ZA using ssNMR (Manuscript under preparation).

Presentation

1) Oral presentation @TCIS, Hyderabad, March 08th, 2017; Title: Synthesis and characterization of small molecule inhibitors for AF6 PDZ-domain.

2) Oral presentation @TCIS, Hyderabad, February 12th, 2016; Title: Development of Organic Synthetic Methods for N-Arylation and for Synthesis of Chiral Propargylamines and Chiral Allenes. 3) Oral presentation @UoH, Hyderabad, April 26th, 2013; Title: Development of Organic Synthetic Methods for N-Arylation and for Synthesis of Chiral Propargylamines and Chiral Allenes. 4) Oral presentation in the “Chemfest 2012” in house symposium held at University of Hyderabad, Hyderabad, February 24-25, 2012; Title: Transition metal catalyzed C-N cross couplings and enantioselective synthesis of chiral allenes.

5) Poster presentation in the “Chemfest 2012” in house symposium held at University of Hyderabad, Hyderabad, February 24-25, 2012; Title: Transition metal catalyzed C-N cross couplings and enantioselective synthesis of chiral allenes; Alakonda, L. M.; Periasamy, M. 6) Attended all the talks and symposia held during my tenure at all the concerned institutes. Declaration

I hereby declare that the above particulars are true and correct to the best of my knowledge and belief. Dr. Laxman M. Alakonda

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