CHANDRIKA SENTHILKUMARAN

Toronto, ON M*R *X* ***- 277-8590 addeaa@r.postjobfree.com

EDUCATION

PhD. Pathobiology, Ontario Veterinary College, University of Guelph - Guelph, Ontario. 08/2013 MSc. Animal and Poultry Science, University of Guelph - Guelph, Ontario. 03/2006 BVSc. Veterinary Science, University of Peradeniya - Sri Lanka. 12/2002 GMP & GLP. University of Toronto (continuing education) - Toronto, Ontario. 12/2019 Registered Lab Animal Technician (RLAT/Research), Canada. 2008 PROFESSIONAL SUMMARY

Results-oriented worker with superior problem-solving and critical thinking skills, as well as meticulous attention to detail and methodical nature. Skilled in tackling problems in unique ways to develop innovative solutions.

Awards received for professional achievements

• Visiting Fellowships in Canadian Government Laboratories (NSERC), 2015 & 2018

• President's National Award for Innovation and Best Practices (Team award, CFIA), 2017

• Edmond J. Safra Fellowship, University of Toronto, 2014 SKILLS

• Project management

• GLP & GMP

• Quality control

• Risk Assessment

• Scientific writing

• Lab operations

• Laboratory testing and analysis

• Team Leadership

• Biosafety and Biosecurity

• Animal testing and surgery

• Laboratory animal husbandry

• Record keeping

WORK HISTORY

Research Associate, Present

Microbiology, Sunnybrook Research Institute – Toronto, ON Development of animal models and therapeutics for COVID-19 Research Associate, 12/2018 to 07/2019

Odette cancer center, Sunnybrook Research Institute – Toronto, ON

• Designed and conducted Pre-clinical (animal) experiments, performed techniques including handling, anesthesia, injections, euthanasia and dissections

• Managed Biosafety Level 2 research facility, developed safety protocols and reports, helped team meet regulatory requirements by coordinating documentation and filings

• Prepared animal utilization protocols, collaborated in preparation of grant proposals, presented proposed work at meetings, trained and supervised graduate students and summer students

• Leveraged highly effective communication and active listening skills to work effectively scientists of diverse backgrounds and accomplish common research goals

• Took active role in departmental meetings, engaging with all parties and transcribing detailed notes of plans, decisions and options discussed

Visiting Scientist, 03/2018 to 08/2018

BSL4 lab, National Microbiology Laboratory, Public Health Agency of Canada – Winnipeg, Manitoba

Chandrika Senthilkumaran

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• Designed experiments and prepared animal utilization protocols for the preclinical vaccine efficacy studies with risk group 4 viruses (Ebola, Nipah and Lassa)

• Complied with safety and hazardous material handling, storage regulatory requirements and internal procedures affecting bio-safety level 4 research operations

• Evaluated biosafety and biosecurity problems and performed risk analysis to identify potential risk associated working with risk group four pathogens in the containment level four lab

• Developed standard operating procedures and document workflows for current and future techniques utilized in research projects

Research Scientist, 09/2016 to 03/2018

BSL 4 Lab, Canadian Food Inspection Agency – Winnipeg, Manitoba

• Designed and coordinated efficacy studies for anti-viral therapeutics against Ebola and Nipah virus

• Performed relevant experiments/technique in highly regulated and controlled (BSL4) environment and gathered, arranged and corrected research data to create representative graphs and charts highlighting results for presentations

• Applied for export/import permits for biologicals and assisted senior scientists with paperwork and documentation in both lab and office environments

• Created research summaries, manuscripts, project proposals and presented them to supervisors, collaborators and directors to advocate further research funding

• Disseminated research findings to various personnel in different formats, including white papers, presentations and spreadsheets

Biologist, 03/2015 to 09/2016

BSL 3 Lab, Canadian Food Inspection Agency – Winnipeg, Manitoba

• Handled diagnostic specimens and conducted tests according to established protocols, keeping efficient records on all experiments according to ISO 9000 and ISO/IEC 17025 in controlled environment

• Played key role in designing and conducting animal inoculation experiments with high consequences viruses in BSL3 containment lab, that resulted in two published manuscripts

• Collaborated with stakeholders, including lab managers and project leaders to identify new diagnostic techniques to detect emerging and re-emerging viral diseases in animal species

• Managed and archived quality documentation and participated in internal and external audits

• Updated quality control standard methods and procedures to meet organization and compliance requirements

Postdoctoral Fellow, 03/2014 to 03/2015

University of Toronto – Toronto, Ontario

• Developed and executed experiments to optimize techniques and stereotaxic surgeries in mice to deliver AAV9 vector in discrete regions of brain for Parkinson disease research

• Supervised research lab by managing technical staff, performing data verification and providing technical support for staff and students

• Coordinated with vendors, sales reps and machine shops for aid in project completion

• Created and implemented safety protocols and procedures to reduce accidents attributed to radiation exposure and chemical spills

• Updated quality control standards, methods and procedures to meet university and compliance requirements

Chandrika Senthilkumaran

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PhD Candidate, 05/2009 to 08/2013

PhD Candidate, Ontario Veterinary College, University of Guelph – Guelph, Ontario

• Conducted research which led to development of bio marker for shipping fever pneumonia in beef calves and applied for patent for the findings

• Simultaneously managed three complex projects, meeting all pertinent milestones

• Authored two professional scientific papers for publishing in peer-reviewed journals and several conference proceedings

• Delivered several internal and external presentations to scientific community and public groups to showcase findings of research

• Managed high-value existing and new collaborations to deliver on objectives and maximize research funding, support and awareness

Anatomic Pathology Trainee, 01/2010 to 01/2011

Ontario Veterinary College, University of Guelph – Guelph, Ontario

• Attended training courses in Veterinary Anatomic gross pathology and histopathology to build understanding of disease diagnosis

• Perform routine necropsies and biopsies submitted to Ontario veterinary college teaching hospital and completed documentation and reports for health records

• Informed and supported senior pathologists through consistent communication and administrative support duties

• Enhanced collaboration between clinical team members by preparing meeting materials and taking clear notes to distribute to staff

• Learned new materials, processes and programs quickly to maximize performance Veterinary Technician, 02/2007 to 08/2007

Animal Resource Center, Ontario Cancer Institute, University Health Network – Toronto, Ontario

• Bred mouse colonies and fostered pups

• Inspected mice and rats for disease and collected diagnostic samples for testing

• Administered treatments and performed euthanasia on mice and rats

• Inspected and audited records of sale yards to monitor movement of animals

• Performed animal husbandry involving choice and preparation of appropriate housing and nutrition Laboratory Animal Technician III, 07/2006 to 02/2007 University of Toronto – Scarborough, Canada, Ontario

• Served as liaison to veterinarian in providing healthcare to animals

• Administered daily treatments and medications for animals as instructed or required

• Assisted in or provided routine and emergency medical treatment

• Induced and maintained anesthesia and assisted in stereotaxic surgeries in rats

• Performed and participated in routine and standardized technical tasks such as feeding and monitoring of health status to maintain animal health MSc Candidate, 09/2003 to 04/2006

University of Guelph, Ontario – Guelph, Ontario

• Played key role in developing surgeries in chickens for implanting cardiac catheters to collect serial blood samples that resulted in three international scientific publications

• Designed laboratory experiments to test hormone levels in chickens by Radio Immune Assay (RIA) Chandrika Senthilkumaran

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• Handled radioactive isotopes and conducted tests according to established protocols, keeping efficient records on all experiments

• Coordinated with research team in developing project plans for prioritized initiatives

• Supervised three summer students and assist in optimizing techniques and data analysis Graduate Teaching Assistant, 10/2005 to 01/2006

University of Guelph, Ontario – Guelph, Ontario

• Oversaw classes of up to 130 students in mammalian anatomy and physiology course

• Prepared lessons according to course outline to convey all required material and deepen student understanding of subject matter

• Mentored students through office hours and one-on-one communication

• Checked assignments, proctored tests, and provided grades according to university standard Peer reviewed publications

• Submitted

1) Senthilkumaran C, Collignon B, Smith G, Marszal P, de los Santos T, Weingartl HM. Use of IFN- expressing vectors in control of Ebola virus disease in swine

• Published

1) Feihu Yan, Shihua He, Logan Banadyga, Wenjun Zhu, Huajun Zhang, Md Niaz Rahim, Brad Collignon, Chandrika Senthilkumaran, Carissa Embury-Hyatt, Xiangguo Qiu. Characterization of Reston virus infection in ferrets Antiviral Res. 2019 Mar 2. doi: 10.1016/j.antiviral.2019.03.001 2) Senthilkumaran C, Yang M, Bittner H, Ambagala A, Lung O, Zimmerman J, Giménez-Lirola LG, Nfon C. Detection of genome, antigen, and antibodies in oral fluids from pigs infected with foot-and-mouth disease virus. Can J Vet Res. 2017 Apr;81(2):82-90. 3) Senthilkumaran C, Bittner H, Ambagala A, Lung O, Babiuk S, Yang M, Zimmerman J, Giménez-Lirola LG, Nfon C. (2016), Use of Oral Fluids for Detection of Virus and Antibodies in Pigs Infected with Swine Vesicular Disease Virus. Transbound Emerg Dis. doi:10.1111/tbed.12563 4) Senthilkumaran C, Hewson J, Ollivett TL, Bienzle D, Lillie BN, Clark M, Caswell JL. Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those infected with Mannheimia haemolytica. Veterinary Research 2015, Feb 14; 46(1): 6 5) Senthilkumaran C, Clark ME, Abdelaziz K, Bateman KG, MacKay A, Hewson J, Caswell JL.. Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves. Veterinary Research 2013, Apr 8; 44(1): 24 6) Senthilkumaran C, Peterson S, Taylor M, Bédécarrats G. Use of a vascular access port for the measurement of pulsatile luteinizing hormone in old broiler breeders. Poult. Sci. 2006 85: 1632-640. 7) Chandrika Nadarajah & Ramiah Sivakanesan (2005). A preliminary study on serum calcium, phosphorous and magnesium concentrations in post parturienthypocalcaemic cows. In: Proceedings of the 14th Asian Commonwealth Veterinary Association Conference, pages 9-14. Chandrika Senthilkumaran

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SELECTED PRESENTATIONS

1) Use of IFN-Expressing Vectors in Control of Ebola Virus Disease in Swine, Biodefense World Summit 2018, Hyatt Regency Bethesda, Bethesda, Maryland USA, June 27 - 29, 2018. 2) Use of oral fluids for the surveillance of Swine viral diseases. Scientific seminar, National Center for Foreign Animal Diseases, CFIA, Winnipeg, MB, Dec 9 th

, 2016.

3) Annexins A1 and A2 as potential biomarkers of stress and respiratory disease susceptibility in beef calves. Scientific seminar, National Center for Foreign Animal Diseases, CFIA, Winnipeg, MB, May 8

th

, 2015.

4) Propagation of α-synuclein pathology in Parkinson’s disease. Technological Advances in Science, Medicine and Engineering (TASME) 18

th

Annual Conference and Workshop, PGCRL,

SickKids, Toronto, Ontario, July 5

th

, 2014

5) Annexins A1 & A2 are diagnostic markers for shipping fever in beef calves. ACVP and ASVCP Combined Annual Meeting, Washington State Convention Center in Seattle, Washington, December 1

st

, 2012.

6) Use of a vascular access port for the measurement of pulsatile luteinizing hormone secretion in old broiler breeders. Poultry Science Association 94th Annual meeting program. Auburn university, Auburn, Alabama, August 1

st

, 2005.

7) Gonadotropin inhibiting hormone does not affect circulating luteinizing hormone levels in the chicken. Association 94

th

Annual meeting program, Auburn University, Auburn, Alabama, August 1

st

, 2005.

PROFESSIONAL DEVELOPMENT

• Project management essentials for unofficial project manager, 2019

• WHMIS (Workplace Hazardous Materials Information System), 2019

• Project management workshop, GC campus, 2017

• ISO/IEC 17025:2017 (Canadian Food Inspection Agency), 2017

• First Aid and CPR, 2017

• Creating a respectful workplace, 2016

• Biosafety and Biosecurity, 2016

• General lab safety, 2016

• Chemical and biological spill cleaning, 2016

• Working with biosafety cabinets Class I, Class II A, Class II B, Class III AWARDS RECEIVED FOR ACCADEMIC ACHIEVEMENTS

• Ontario Veterinary College fellowship 2010

• Ontario Graduate Scholarship 2011

• D. G. Ingram Memorial Scholarship 2013

• Dr. J. Sherman Graduate Travel Grant 2012

• The Honorable John S. Martin Scholarship, Poultry Science, U of Guelph 2005

• University Graduate Scholarships, U of Guelph 2004 & 2005

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