Alfaisal University

Major: Bachelor of Medicine and

Bachelor of Surgery

Attended: August 2016 – December 2016

Highschool Diploma

Al-Rowad International School

Riyadh, Saudi Arabia

Graduated: May 2016

Cumulative GPA: 4.0

Wyel Halimeh

Address: 2635 N Parkwood ln Wichita, KS 67220

Email: adc9y9@r.postjobfree.com

adc9y9@r.postjobfree.com

adc9y9@r.postjobfree.com

Phone: 316-***-****

Education

Bachelor of Science

Major: ACS Chemistry

Minors: Biology

Math

Wichita State University

Graduated: Spring 2020

Cumulative GPA: 3.75

Work Experience

Undergraduate Teacher Assistant (2018- 2020)

Institute: Wichita State University

Responsibilities: Teaching General Chemistry II Lab Grading Student Papers

Updating Lab Protocols

Updating Lab Manuals/Grading Rubrics/ Grading Spreadsheets Solution Preparation

Co-authored Lab Manual

SSS Student Tutor (2019- 2020)

Institute: Student Support Services

Responsibilities: Tutoring Students and adult learners on subjects they have difficulty in. Certification: CRLA Certified Level I Tutor

Arabic Translator (2017- Present)

Company: VN Translation Services

Responsibilities: Translating English to Arabic for most Major Hospitals and Clinics in the Wichita Area Research Experience

Physical Chemistry: (Summer 2018- Present)

Instructor: Dr. Douglas English Phone: 316-***-**** Email: adc9y9@r.postjobfree.com Project Title: Surfactant-Based Colloidal Systems to Promote Photo Induced Reduction of Silver Objective: This research focuses on the synthesis of silver nanoparticles by the photoreduction of silver ions in colloidal aqueous solution. This method provides a green approach for silver nanoparticle production since there is no need for organic solvents and the photoreduction reaction occurs at room temperature. This study investigates surfactant mixture composition and concentration and their effect on the silver nanoparticle yield, stability, uniformity, and size. This gives the ability to produce silver nanoparticles at different yields and sizes according to the required use or experiment. The silver nanoparticle solutions are monitored through UV/Vis absorption spectroscopy by monitoring a unique optical property of metal nanoparticles known as surface plasmon resonance band. Differences in these spectra and the reaction kinetics are used to evaluate the yield stability, uniformity, and size of nanoparticle.

Biochemistry: (Fall 2019- Present)

Instructor: Dr. James Bann Phone: 316-***-**** Email: adc9y9@r.postjobfree.com Project Title: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor Abstract: The death that can come within a few days after exposure to the anthrax toxin from Bacillus anthracis is due to the presence and effects of anthrax lethal factor (LF). LF is a zinc metalloproteinase whose function depends upon the translocation of LF from the endosome of a host cell into the cytosol, where it cleaves mitogen-activated protein kinase kinases and disrupting cell signaling pathways. The translocation requires LF to unfold as it transits through the narrow channel of the pore, formed by the anthrax protective antigen (PA). Unfolding of LF has been shown to be pH-dependent, but little is known regarding the kinetics of unfolding and refolding of LF. Specifically, refolding of LF must occur fairly rapidly within the cell cytosol to prevent degradation of the protein by cellular proteases. The N-terminal PA binding domain of LF, LFN, has a single cis-proline residue (Pro166), and we hypothesized that this cis proline must isomerize to trans during the unfolding and translocation process and that refolding would be slow, and perhaps dependent on cellular prolyl isomerases for refolding. To this end, we have performed a detailed kinetic refolding/unfolding study of LFN from urea solutions. Our preliminary experiments indicate that LFN refolding occurs rapidly (within 1 second), suggesting that Pro166 does not isomerize to an appreciable extent in the unfolded state, or if it does isomerize, that isomerization back to cis is a fast process. The implications of these experiments on the mechanism of anthrax toxin lethality will be discussed.

Instrumentation

Bomb Calorimeter

Circular Dichroism

Differential Scanning Calorimetry (DSC)

Fast Protein Liquid Chromatography (FPLC)

High Performance Liquid Chromatography (HPLC)

Inductively Coupled Plasma Optical Emission Spectrometry Infrared Spectroscopy

Nuclear Magnetic Resonance (NMR)

Spectrofluorometer

Stop-Flow Fluorescence Spectroscopy

UV/Vis Spectroscopy

Presentations and Awards

Presentations:

Undergraduate Research and Creative Activity Forum 2019 Poster: Surfactant-Based Colloidal Systems to Promote Photo Induced Reduction of Silver American Chemical Society Midwest Regional Meeting 2019 Oral Presentation: Surfactant-Based Colloidal Systems to Promote Photo Induced Reduction of Silver Poster: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor Heartland Undergraduate Biochemistry Forum 2019: KU Medical Center Department of Biochemistry/Molecular Biology Poster: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor First Place Poster Presentation

Great Plains Regional Annual Symposium on Protein and Biomolecular NMR 2019 Poster: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor K-INBRE Annual Symposium 2020

Poster: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor Award of Excellence for Outstanding Poster Presentation Undergraduate Research Day at the Capitol 2020

Poster: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor Certificate of Participation for Representing Wichita State University

Awards

H Dene Heskett Scholarship

Erach R. Talaty Endowed Scholarship in Chemistry

Roaslee and Alvin Sarachek Award for Scholarly Excellence in the Natural Sciences in the Natural Sciences K-INBRE Summer Scholar: 2019

Project: Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor Undergraduate Research and Creative Activities Grant: Year: 2019 -2020 Project: Surfactant-Based Colloidal Systems to Promote Photo Induced Reduction American Chemical Society Undergraduate Award in Physical Chemistry Activities and Volunteering

Heartland Hospice Care:

Responsibilities: Offer support, companionship and practical, compassionate help to terminal ill patients.

American Chemical Society:

An active member of ACS on campus since Fall of 2018. Vice President for academic year of 2019-2020

Volunteered at local elementary schools to teach and present chemistry experiments. Ran chemistry labs for events at Wichita State University Chemistry Department Coordinated Chemistry Lab for Expanding Your Horizon Event 2019 Started and ran a new event with Augusta Hiighschool where a few students got to come out and see a variety of labs including a bomb calorimeter lab, a biology lab, and an anthropology lab.

Contact this candidate