Engineer Chemical Engineering

REBECCA TRINH

** ******* **. #*, *******, MA ****4 – 978-***-**** – **********@*******.***

PROFESSIONAL SUMMARY

Chemical engineer with experience in pharmaceutical, and biotechnology. Special expertise in purification, filtration and process development. Detail oriented with strong skills in trouble shooting, and problem solving.

Deal with disposable filters, disposable bags, tubes and fittings at Millipore, Wyeth, MGI, and Aeris Therapeutics.

Deal with API (Taxol) at Bind Biosciences and Boston Scientific Corp.

Deal with organic solvents at Aeris Therapeutics, Bind Biosciences and Boston Scientific Corp.

Work in purification area at Wyeth, MGI, and Aeris Therapeutics Inc.

Support commissioning activities at Wyeth

Deal with TFF at Millipore, Wyeth, MGI, and Aeris Therapeutics.

Familiar with cGMP and US regulation by taking the “Biotechnology and the regulatory environment class”.

SKILLS

Research and analysis

Solution preparation

Aseptic technique

Filtration, TFF, NFF, UF/DF, VRF.

Chemistry

Polymers

Filling and Finish

Materials

Quality, 5S

Microsoft Word, Excel, PowerPoint, Visio

Glove box, Biosafety Cabinet

Lyophilize

Results interpretation

Process Engineer

WORK HISTORY

Chemical Engineer

02/2019 – 04/2020

Desktop Metal, Inc.

Developed new binders for 3D printing machines based on viscosity, pH, and surface tension requirements.

Filtered the binders using NFF system.

Performed primitive test to evaluate the absorption of new metal powders.

Made biscuits to measure the strength and for sintering purpose.

Used the instron to measure the TRS for biscuits

Prepared standard operating procedures (SOPs) documents for new experiments.

Compiled test results, generated graph, reports and presented results to Manager.

Cleaned and organized laboratory and kept supplies well-stocked to save time, money and promote laboratory efficiency.

Laboratory Technician

01/2018 – 01/2019

Rousselot

Characterize Gel by performing physical tests such as FAT, bloom, pH, conductivity, moisture, ash, reducing substance, sulfite, UV and viscosity.

Prepare samples to detect staph, pseudomonas, BTGN, eco li, salmonella, yeast and mold, total plate count, and Acinetobacter.

Test the environment samples for microbiological contamination.

Perform ICP metal analysis for gel samples.

Research Associate

02/2017 – 12/2018

Millennium Research Laboratory

Making solutions for HPLC.

Collected raw data to determine the molecular weight of polymers using the HPLC SEC method.

Development Chemist

07/2008 – 10/2008

Aeris Therapeutics, Inc.

Scaled up and developed the aPVA synthesis process from lab scale to clinical manufacturing scale.

Used UF/DF system to synthesize aPVA.

Developed the MBR for aPVA, phosphate buffer at different concentration and pH, which were used in human clinical trial.

Prepared Phosphate buffer by following the MBR.

Qualified the MBR for aminated polyvinyl alcohol, phosphate buffer, and Glutaraldehyde dilution.

Executed polymeric hydrogel synthesis process for human clinical trial under cGMP environment according to the MBR.

Lab Technician

03/2008 – 06/2008

MGI Pharma, Inc.

Performed DOE experiments, which helped to develop the clinical manufacturing amolimogene process.

Performed reagent preparation, lyophilize, crimping and labeling samples for R & D.

Operated the bio safety cabinet for filling.

Used the aseptic technique for filling and finish.

Operated the UF/DF system under cGLP environment.

Used and calibrated pH meter, conductivity meter to measure the pH, and conductivity of reagents.

Process Technician

11/2007 – 03/2008

Wyeth Biotech.

Developed, wrote and modified the SOPs, MBR, which had supported the purification commercial manufacturing BAP protein drug.

Operated and trained other technicians in purification group using the Chromatography, UF/DF, VRF (virus retain filtration) systems under cGMP environment.

Perform CIP, SIP for UF/DF and VRF system.

Using the aseptic technique to fill vials.

Research Associate

07/2007 – 11/2007

Bind Biosciences, Inc.

Worked in inert atmosphere and dry glove box to conduct chemical synthesis.

Performed technology transfer from MIT to Bind Biosciences.

Supported vitro and vivo study by synthesized nano particles PLGA -PEG- GL using many different methods such as:.

Coupling PLGA-COOH to NH2-PEG-COOH. Then Coupling PLGA-PEG-COOH to GL1 or GL2.

Coupling NH2-PEG-COOH to GL2 protected. Then Coupling NH2-PEG-GL2P to PLGA -COOH.

Coupling PLGA-COOH to NH2-PEG-Me.

Coupling PLGA-COOH to NH2-PEG-OH.

Lyophilized samples.

Characterized nano particles by using the GPC, measuring size, and zeta potential.

Engineer Technician

05/2004 – 09/2006

Millipore

Set up UF/DF, mini and micro system to test different types of TFF membrane.

Used Bovine Serum Albumin (BSA) protein solution and Phosphate Buffer Saline (PBS) to evaluate the performances of membranes by air integrity, hydraulic permeability, and BSA excursion.

Modified and improved the PETS system to test the robustness of two different types of membranes.

Ran membranes at low pressure, high temperature and high pressure, low temperature condition.

Performed air integrity and hydraulic test for each membrane after every run.

Recorded pressure drop, feed flow, permeate flow, feed, retentate, and permeate pressure.

Charged membranes by using CUF 1M system.

Mixed solutions for charging and measure the pH of these solutions before used.

Improved the rise in turbidity of MAB protein solution by testing different feed pumps, flow rate, and back pressure.

Associate Engineer

08/2000 – 09/2003

Boston Scientific Corp.

Wrote and executed laboratory experiments validating new concepts for evaluation sustain release profiles with multiple polymers (SMMA, SAN, SMA, SEBS, sulfonated SEBS, SIBS, PVP, PCL-PIB, PCL-PIB-PCL, EVA, EVAL, PMMA-PIB-PMMA, PE-g-PEO, Cellulose acetate, PS-DMSi, CAB, PS-HEMA, PEO, 4VP-co-S, 2VP-co-S, Gantrez AN, Poly (etherimide), PEMA, PEBA, BMA-g-methoxy PEGMA, PtBVE-PIB-PtBVE, EMACAA, PLGA, PCL,PLA etc.).

Formulated solutions by either blending 2 different polymers with drug or mixing a polymer with drug.

Determined new coating solutions by varying the percentage of Taxol or the percentage of polymers in solution to obtain a good sustain release profile.

Coated stents for content, SEM and kinetic drug release analysis.

Analyzed SEM and kinetic drug release results by comparing data to other systems where applicable.

Drew conclusions from data and make recommendations for further experimentation.

Reported results at group meetings.

Lab Technician

09/1999 – 12/1999

GSI Lumonics

Tested the foils by running them through the printing machine.

Graded these foils and entered results in excel.

Analyzed the results by graphing and comparing data to identify the good foils.

EDUCATION

University of Maryland University College

Master of Science: Biotechnology Studies

2011

University of Massachusetts - Lowell

Bachelor of Science: Chemical Engineering

1999

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