Jalees Afzal

Apex, NC • 919-***-**** (c)

adbnwa@r.postjobfree.com

SENIOR METABOLISM SCIENTIST

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Senior-level Scientist with extensive experience in conducting and monitoring metabolism, residue, and environmental fate studies specializing in product safety science and registrations for global agrochemical industry. Gather, analyze, manage, and report large amounts of data with regulatory compliance oversight. Utilize a variety of databases and resources. Translate scientific evidence into digestible information, offer insightful and actionable recommendations, and collaborate with multidisciplinary teams. U.S. Citizen.

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—Areas of Expertise—

Monitor Plant, Rat, Goat, Poultry, and Fish Metabolism, Residue, efate and Animal Feeding studies

Participate as a Consumer Safety Expert in pre-submission and post-submission meetings with Regulatory Authorities

Organized and Chaired Metabolism Symposia at American Chemical Society National Meetings

Register Company Products with Regulatory Authorities

Dietary Burden, Import Tolerance Petitions, and Process JMPR Dossier and NAFTA Submissions

Saved Company thousands of dollars by drafting several scientific waiver documents for metabolism and feeding studies to Regulatory Authorities

Responded to and Defended Concerns from Regulatory Authorities

Education

Post-Doctoral Fellow

Department of Chemistry and Medicinal Chemistry, University of Oklahoma

Ph.D., Organic Chemistry

National Chemical Laboratory, University of Pune, India

Master of Science, Organic Chemistry

Osmania University, Hyderabad, India

Professional Experience

Chief Scientific Officer Isolera Extracts, Oxford, NC 2019-Present

Extraction, Isolation, Winterization, Decarboxylation, Crystallization of CBD as well as HPLC Profiling and quantification of Cannabinoids from Industrial Hemp

Senior Scientist II BASF Corporation 2013-09/28/2018

Strengthen and apply regulatory science competencies especially in the areas of plant, animal, and fish residue, fate and metabolism studies

Provide technical support and expertise in residue and metabolism studies to the Consumer Safety Group and others outside the group

Coordinate the planning and monitoring of resdiue and metabolism studies and promote knowledge sharing within the competency center

Support the development and registration of assigned developmental active ingredients and key Life Cycle Management projects (e.g. dietary burden calculations, dietary risk assessments, AIR re-registration, dRR dossiers, IT petitions, JMPR dossier and NAFTA submissions) executed, submitted, and registered as scheduled

Proactively identify areas of threat or growth and respond to questions/concerns from regulatory authorities

Senior Research Associate BASF Corporation 2000-2012

Coordinated as a consumer safety expert in the preparation of NAFTA and EU dossiers for the registration of BASF Corporation’s developmental and registered products

Monitored and conducted plant, rat, animal, and fish, residue and metabolism and animal feeding studies

Developed analytical methods for measurement of plant protection products residues in various biological matrices

Designed and implemented radiotracer methods to facilitate the isolation and identification of metabolites

Utilized stateoftheart chromatographic (TLC, CC, LC) and spectroscopic (NMR, LC/MS/MS) techniques

Conducted environmental fate and residue studies as needed to support registration of experimental compounds and developmental products

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Additional Experience

Senior Research Chemist American Cyanamid Company/ Wyeth Laboratories (10 years)

Conducted rat pharmacokinetic studies, plant, animal, and fish metabolism studies; developed analytical methods for the measurement of animal health care products and plant protection products in various biological matrices

Designed and implemented radiotracer methods to facilitate the isolation and identification of new metabolites of R&D products for the accomplishment of daily objectives in support of the company's R&D efforts in bringing new products to the market

Drafted technical reports necessary to support government registrations; supervised and trained technicians in the use of equipment and methods, and coordinated their work assignments

Served as Member of the Radioisotope Committee; achieved senior-level advancement

Supervisor, ABC Laboratories, Columbia, Missouri (2 years)

● Responsible for the training and supervision of a group of 8 Chemists

● Performed Custom Synthesis of organic compounds and derivatives

● Studied Plant and Animal Metabolism: Protocol development in keeping with EPA and GLP guidelines

● Analyzed Isotopic dilution, determination of specific activity, mass quantitation by generation of a standard curve using LC/MS

● Determined Radiopurity by TLC and HPLC

● Extracted, isolated, determined radioactivity profile in biological matrices

● Performed extraction of various plant and animal matrices, purification, derivatization and identification of metabolites by mass spectrometry and NMR

Scientific Publications

1.J. Afzal, A.B. Burke, P.L. Batten, R.L. Delay and P. Miller: “Metabolic Fate and Blood Pharmacokinetics of Carbon-14 Labeled Moxidectin in Horses.” J. Agric. FoodChem, 45, 3627-3633 (1997).

2.J. Afzal, S.J. Stout, A.R. daCunha, and P. Miller. "Moxidectin: Absorption, Tissue Distribution, Excretion and Biotransformation of Carbon-14 Labeled Moxidectin in Sheep." J.Agric.FoodChem., 42, 1767-1773 (1994).

3.S.J. Stout, A.R. daCunha, S.S. Wu, J. Zulalian, J. Afzal. "Moxidectin: Characterization of Cattle, Sheep, and Rat In Vitro and In Vivo Metabolites by Liquid Chromatography/Tandom Mass Spectrometry." J.Agric.FoodChem., 42, 388-392 (1994).

4.J. Afzal, R.A. Magarian, M. Griffin and J.T. Pento; "Synthesis of Air and Light Sensitive Cis-phenolic Cyclopropane Derivatives." SynthCommun.19, 3061 (1989).

5.B.M. Fung, D.L. Mamrosh, E.A. O'Rear, C.B. Frech and J. Afzal: "Unusual Micellar Properties of a New Class of Fluorinated Surfactants". J.Phys.Chem.92, 4405 (1988).

6.J. Afzal, B.M. Fung and E.A. O'Rear: "Synthesis of Perfluoroalky-N-polyethoxylated Amides." J.FluorineChem.34, 385 (1987).

7.J. Afzal and B.M. Fung: "Carbon-13 NMR of Liquid Crystal Solutions with Magic Angle Spinning. Hindered Rotation in 6-(dialkylamino)fulvenes". J.Chem.Phy.84, 6119 (1986).

8.J. Afzal, S.R. Ashlock, B.M. Fung and E.A. O'Rear: "Interaction between Perfluoro Chemicals and Oxygen in Phosphatidylcholine Vesicles." J.Phys.Chem. 90, 3019 (1986).

9.B.M. Fung and J. Afzal: "Carbon-13 NMR of Liquid Crystals. Spinning near the Magic Angle with Proton-proton Dipolar Coupling." J.Amer.Chem.Soc.108, 1107 (1986).

10.B.M. Fung, J. Afzal, T.L. Foss and M.H. Chau: "Nematic Ordering of 4-n-Alkyl-4'-Cyanobiphenyls Studied by Carbon-13 NMR with Off-Magic-Angle Spinning." J. Chem.Phys.85, 4808, (1986).

11.C. Duen poon, J. Afzal, M. Gangoda and B.M. Fung: "Carbon-13 and Proton NMR for two series of Mesogenic Compounds. Mag.Res.Chem.24, 1015 (1986).

12. J. Afzal, K. G. Das, B.G. Hazra and B.M. Bhawal: "A Novel Synthetic Route to 1-Aryltetralin Lignan Lactone via Intermolecular Cycloaddition with o-quinodimethane." Synth.Commun.13, 787 (1987).

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