Curriculum Vitae

Personal Information:

Name: Juanjuan Su

Hobbies: Reading, thinking, running, traveling, sight seeing Address: 7 Bradford Rd, Winchester, MA, 01890, USA E-mail: adbnvz@r.postjobfree.com

Telephone: 617-***-****

Work Experience

2018.3-2018 .6 Postdoc, Massachusetts General Hospital Main project is to study the mechanism of neurodegeneration in alzheimer's disease. Explored how elastin-like polypeptides (ELPs), a component of the brain extracellular matrix (ECM), affected the levels of AD-related amyloid-β peptides (Aβ) both in vitro and in vivo. Education:

2012.9-2017.5 PhD study in Biophysics, University of Groningen, The Netherlands My PhD research project is to study the interplay of peptides with membrane lipids using large scale and high-throughput Molecular dynamics (MD) simulations. We mostly use Coarse Grained (CG) models as the work horse, and refine our results using more detailed all-atom models. The mechanism of antimicrobial peptides (AMPs) in killing bacteria is not clear yet, especially in molecular detail. MD simulations step into this field to offer a view on the dynamic behavior of interactions of AMPs with lipids.

2009. 9-2012.6 Master Degree Study in Computing Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China My master degree is three years program, which requires two years academic work. My research project is by using the density functional theory (DFT) method to investigate the electronic structures and photophysical properties of transition metal complexes and obtain further insights into the phosphorescent efficiency mechanism.

2005. 9-2009. 7 Bachelor Study in Material Chemistry, Liaocheng University, China Languages: Chinese, English

Skills:

Speak and write in fluent English

Excellent in Microsoft Office including Excel and Powerpoint Working knowledge of Gromacs, Gaussian software

Problem solving

Working knowledge of python language

Excellent in written and verbal communication skills Able to use professional graphics softwares, such as VMD, Gnuplot, Inkscape, photoshop Honors and awards:

Excellent Communist Party Member CAS (2011)

Excellent University Graduate Student of Shandong Province (2009) The top ten excellent Students of Liaocheng University (2009) Annual Academic Scholarship of Liaocheng University (Second Class 2006, 2007, 2008) List of Publications:

1. Juanjuan Su, Siewert Jan Marrink, Ann Thomas, Chris Williams, Manuel Nuno Melo*,

“The Interplay of the Pex11-Amph Peptide with Peroxisomal Membranes” BBA Biomembranes, 2018, 1860, 1292-1300. (Citation: 4) 2. Jing Sun#, Juanjuan Su#, Chao Ma, Robert Göstl, Andreas Herrmann, Kai Liu*, Hongjie Zhang, “Fabrication and Mechanical Properties of Engineered Protein-Based Adhesives and Fibers”, Advanced Materials, 2019, 1906360. (# co-author) 3. Chao Ma#, Juanjuan Su#, Yao Sun, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann,* Rudolph E. Tanzi, Kai Liu,* and Can Zhang* “Significant Upregulation of Alzheimer s b-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides” Angewandte Chemie International Edition, 2019, 58, 2-9. (# co-author) 4. Chao Ma#, Juanjuan Su#, Bo Li, Andreas Herrmann, Hongjie Zhang, Kai Liu*, Solvent- free plasticity and programmable mechanical behaviors of engineered proteins, Adv. Mater. 2019. DOI:10.1002/adma.201907697 (# co-author) 5. Kai Liu, Dong Chen, Alessio Marcozzi, Lifei Zheng, Juanjuan Su, Diego Pesce, Wojciech Zajaczkowskid, Anke Kolbe, Wojciech Pisula, Klaus Müllen, Noel A. Clark and Andreas Herrmann, Thermotropic liquid crystals from biomacromolecules, Proc. Nat. Acad. Sci. USA 2014, 111, 185**-*****. (Citation: 20)

6. Kai Liu, Min Shuai, Dong Chen, Michael Tuchband, Jennifer Y. Gerasimov, Juanjuan Su, Qing Liu, Wojciech Zajaczkowski, Wojciech Pisula, Klaus Müllen, Noel A. Clark, Andreas Herrmann, Solvent-free Liquid Crystals and Liquids from DNA, Chem. Eur. J. 2015, 21, 4898-4903. (Citation: 12)

7. Kai Liu, Justin Varghese, Jennifer Y. Gerasimov, Alexey O. Polyakov, Min Shuai, Juanjuan Su, Dong Chen, Wojciech Zajaczkowski, Alessio Marcozzi, Wojciech Pisula, Beatriz Noheda, Thomas T. M. Palstra, Noel A. Clark & Andreas Herrmann, Controlling the volatility of the written optical state in electrochromic DNA liquid crystals, Nat. Commun. 2016, 7, 11476. (Citation: 15)

8. Juanjuan Su, Lili Shi, Xiaobo Sun, Wei Guan, Zhijian Wu*, “DFT/TD-DFT Study on the Electronic Structures and Optoelectronic Properties of Several Red-Emitting Osmium

(II) Complexes with different P^P Ancillary Ligands”, Dalton Trans., 2011, 40, 1–7 .

(Citation: 16)

9. Juanjuan Su, Lili Shi, Wei Guan, Zhijian Wu*, “Theoretical study on photo physical properties of cyclometalated cationic iridium(III) complexes containing dipyrido[3,2-f:2, 3 -h]quinoxaline ligand”, Synthetic Metals,2012,162, 1392–1399 . (Citation: 3) 10. Lili Shi, Juanjuan Su, and Zhijian Wu*, “First Principles Studies on the EfficientPhoto- luminescent Iridium(III) Complexes with C^N=N Ligands”, Inorg. Chem., 2011, 50, 5477. (Citation: 45)

11. Godefroid Gahungu, Juanjuan Su, Xiaochun Qu, Yuqi Liu, Yanling Si, Xiaohong Shang and Zhijian Wu*, “Shedding light on unusual photophysical properties of bis- cyclometalated iridium(iii) complexes containing 2,5-diaryl-1,3,4-oxadiazole-based and acetylacetonate ligands”, Dalton Trans., 2012, 41, 102**-***** .(Citation: 4) 12. Godefroid Gahungu, Juanjuan Su, Xiaochun Qu, Yuqi Liu, Yanling Si, Xiaohong Shang and Zhijian Wu*,”Combined Effects of Stereoisomeric and Steric Factors on Electronic and Photophysical Properties of Bis-cyclometalated Ir(III) Complexes Con- taining 2,5-Diaryl-1,3,4-oxadiazole Based and Picolinate Ligands”, J. Phys. Chem. C. 2012,116,27,145**-*****. (Citation: 5)

13. Yuqi Liu, Godefroid Gahungu, Xiaobo Sun, Juanjuan Su, Xiaochun Qu and Zhijian Wu, “Theoretical study on the influence of ancillary and cyclometalated ligands on the electronic structures and optoelectronic properties of heteroleptic iridium(iii) complexes”, Dalton Trans., 2012,41, 7595-7603. (Citation: 14)

14. Godefroid Gahungu,Yuqi Liu, Yanling Si, Juanjuan Su, Xiaochun Qu, Xiaohong Shang and Zhijian Wu* “Enhancing the blue phosphorescence of iridium complexes with a dicyclometalated phosphite ligand via aza-substitution: a density functional theory investigation”, J. Mater. Chem. C, 2014,2, 8364-8372 . (Citation:5) 15. Juanjuan Su, Siewert Jan Marrink, Manuel Nuno Melo*, “Localization Preference of Antimicrobial Peptides on Liquid-Disordered Membrane Domains” under review. 16. Juanjuan Su, Siewert Jan Marrink, Manuel Nuno Melo*, “A Molecular Dynamics View on the Segregation Effect of Antimicrobial Peptides on Anionic Lipids”,To be submitted. Summary for PhD research:

My PhD research project is to study the interplay of peptides with membrane lipids using large scale and high-throughput Molecular dynamics (MD) simulations. We mostly use Coarse Grained (CG) models as the work horse, and refine our results using more detailed all-atom models. The mechanism of antimicrobial peptides (AMPs) in killing bacteria is not clear yet, especially in molecular detail. MD simulations step into this field to offer a view on the dynamic behavior of interactions of AMPs with lipids. I have three chapters research work in my thesis. In Chapter 1 I focus on the AMP-mediated lateral segregation of anionic lipids in a membrane, one of the aforementioned disruptive factors in the mode of action of AMPs. I present a multiscale MD study of peptide binding and segregation, using the AMPs Magainin 2, BP100, and MSI-103 in interaction with a POPE/cardiolipin bilayer. In Chapter 2 I studied the partitioning of AMPs on Ld/Lo phase separated membranes. I address the question whether AMPs have a preferential binding mode to either Ld or Lo domains, and to what extent the AMPs can disrupt the phase segregation. In Chapter 3 I investigated the interplay of Pex11-Amph with peroxisomal model membranes. The simulations reveal how Pex11-Amph interacts with the membrane, and which residues are responsible for inducing membrane curvature. Scientific activity:

1) Autumn School (Essen and Nijmegen, Germany)-“Biomolecular Structure and Function- Computational Approaches”

Nov. 26-Dec. 7, 2012

2) Amsterdam Workshop (The Netherlands) – “Understanding Molecular Simulations” Jan. 7-18, 2013

3) Vlieland 2013 Conference (The Netherlands): Present a poster May 26-28, 2013

4) 25th Intl. BIOMOS Symposium on Biomolecular Simulation (Ausserberg, Switzerland )

Present a talk

Sept. 9-11, 2015

5) Annual Meeting of the German Biophysical Society (Erlangen, Germany) Present a talk

Sept.25-28, 2016

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