CURRICULUM VITAE

Reza Mohammadi

Phone: 714-***-****

Email: adb08e@r.postjobfree.com

Education

Ph.D. Candidate Materials Science & Engineering – UC Irvine Sept 2016 – Jun 2020 M.S. Materials Science & Engineering – Sharif University Sept 2010 – Sept 2012 B.S. Materials Science & Engineering – Amirkabir University Sept 2005 – Sept 2010 Experience

Ph.D. Candidate Sep 2016 – Present

5 years experience drug discovery and biologics

Stem Cell Research Center, Department of Surgery and Biomedical Engineering University of California Irvine, Irvine CA

• Invented 3 products licensed by two biotech companies, co-authored 14 peer-reviewed publications and 3 due to submit manuscripts

• Developed a cell-free approach using stem cell-derived extracellular vesicles to treat multiple sclerosis (MS) animal model

• Showed immunosuppressive roles of exosomes in neuroinflammatory milieu of MS murine models focusing on Macrophage and T cells phenotypes and polarizations Mentor: Dr. Weian Zhao

• Constructed, for the first time, two therapeutic and immunomodulatory implants

(AlgXO®) for islet xenotransplantation, providing long-term normoglycemic for immunocompetent rodents with Type 1 Diabetes

• Characterized the immunophenotype of immune response against implants and modulated the macrophage activation and function in the vicinity of implants. Mentors: Dr. Jonathan Lakey and Weian Zhao

• Lead team and future research strategies to utilize extracellular vesicles as therapies to treat autoimmune diseases, cancer and neurodegenerative disorders.

• Devised a novel immunoregulator and angiogenic implant and bioink (XoInk®) using 3D bioprinting

• Established extracellular vesicle field at UCI with bringing the expertise and collaborating with leaders in the field

• Mentored graduate, undergraduate, and high-school students to develop professionally and to complete assigned project

Research Scientist Dec 2014 – Sep 2016

School of Medicine, Stanford University, Palo Alto CA

• Led a U.S. patent and co-authored four publications including two first author publications in peer-reviewed journals

• Developed “Magnosome” technology for guided delivery of stem cells, patented for Stanford University and UCSF

• Formulated a novel physisorbed double-layer coating around Iron Oxide Nanoparticles

• Protein purification using fractionation methods (ultra - centrifugation, ultra / diafiltration, etc.), and chromatographic techniques (affinity, ion exchange, hydrophobic interaction, immobilized metal, and mixed mode chromatography)

Communication

Lecturer – Stem Cell Techniques Course Sep 2014 – Sep 2015 Stem Cell Research Center, Core Facilities, University of California Irvine, Irvine CA

• Communicating stem cell-derived extracellular vesicles treatment strategies in regenerative medicine

Teaching Assistant –Human Physiology Sep 2017 – Dec 2018

–Molecular Pharmacology

Department of Pharmaceutical Sciences, University of California Irvine, Irvine CA

• Presented lectures to the audience of 200+ senior level students

• Hold weekly discussion sessions for the students Leadership

Project Leader Sep 2017 – Present

University of California Irvine, Irvine CA

• Lead team and developed multiple projects in 3 different institutions and strategies to harness extracellular vesicles potentials as therapeutics for autoimmune diseases, eye disease and cancer

• Generated novel ideas, secured extramural funding, and led a multi-disciplinary team to fabricate, analyze, and establish AlgXO, Disk-of-Life®, and pCM-Alg technologies patented for UCI and licensed for a local company

XoStem LLC, Irvine CA

• Lead team of 3 scientists for Exosome production, lyophilization, and quality control

• Lead the IND preparation team for biologics

DECADE PLUS Leadership Coach Mar 2017-Present

Department of Education, University of California Irvine, Irvine CA

• Mentored more than 10 First-Gen Chancellor’s Scholars

• Led a team of 10 graduate and undergraduate students in group meetings

• Mentoring Excellency Certificate Awarded

Introduction to Project Management Course Mar 2017 – May 2017 UCI Extension

University of California Irvine, Irvine CA

• Planning a project from start to finish using Project Management Body of Knowledge guidelines

• Directed project justification, requirements, milestones, budget, and deliverables Project Leader Jan 2016 – Sep 2017

Biomaterials and Advanced Drug Delivery, Stanford University

• Lead team and invented Magnosome and Non-Toxic Iron Oxide Nanoparticles President July 2003 – Sept 2006

Scientific community of students

Sharif University, Iran

• Organized three scientific symposiums in Biomaterials, Nanotechnology, and Metallurgy

• Mentored students for effective communication, teamwork and presentation skills Consulting

Scientific Advisory Board (Extracellular Concepts) Jan 2018 – Present Oklahoma, USA

Led team of scientists to develop step by step plans and projects to develop therapeutic biologics for autoimmune and neuroinflammatory disorders.

Scientific Advisory Board (XoStem) Dec 2018 – Present Irvine, CA

Consult with research and development team for product improvements and market analysis. Biomaterials, exosomes, and stem cells area. Consulted on product development steps and cGMP production in a clean room

Consultant (CelleSe) Feb 2019 – Present

Irvine, CA

Consulted with the scientific team on possible molecular pathways and product development Technical Skills

Extracellular Vesicles: exosome isolation from in vitro cultures and ex vivo, uptake assay, nanoparticle tracking analysis, ultracentrifugation and polymer-based precipitation of exosomes, characterization using flow cytometry/western blotting/electron microscopy, exosome quantification, exosomal RNA extraction, bioanalyzer. Immunology: flow cytometry, experimental autoimmune encephalomyelitis (EAE, MS animal model), NOD and STZ diabetic mouse models, Treg induction and expansion, T cell proliferation/inhibition assays, T cells differentiation (effector, memory, and regulatory), splenocyte and human PBMCs isolation and characterization, Macrophage modulation assays Bioengineering and Tissue Engineering: (Bio)-Materials and Nanomaterials synthesis and characterization, Drug Discovery, Engineering immunomodulatory devices through coating and/or controlled release and drug eluting approaches, Targeted Drug and Cell delivery, 3D bioprinting of cells and biomaterials. Red blood cells isolation and nanovesicle formation, In vivo (Live animal IVIS imaging) and in vitro assays for biomaterials biocompatibility, Designed and produced nanofabricated scaffolds, scaffold cell seeding, bioreactor, scaffold biocompatibility & biodegradability tests, Scanning and Transmission Electron Microscopies Others: AAS, AFM, DLS, DSC, EDX, FTIR, Gel Electrophoresis, ICP (MS and OES), UV/VIS, Fluorescent and Confocal Microscopies, TGA, TURBIDIMETRY, VSM, Western blotting, XPS, XRD, WDX, Viscometer, Tension & Fatigue tests, Casting Cell Culture: isolation and culture of mesenchymal stem cells derived from humans (Wharton Jelly, Umbilical Cord, Cord Blood, and Bone Marrow), induced pluripotent stem cells (iPSCs) generation and differentiation, perform stem cell differentiation, retinal progenitor cells, neural stem cells, fibroblast, macrophage, PBMCs and Splenocytes isolation characterization and expansion, adipose-derived stem cells isolation and expansion, MTT and XTT assays, Prussian blue, Plate Reader, ROS and NO measurement, chemical and electrochemical transfection Molecular Biology: nucleic acid extraction, PCR (standard, reverse-transcription, and real time), primer design, bioinformatics, ELISA, MAGPIX Luminex assay, electrophoresis, western blotting, viral vector construction & transduction, bacterial transformation, immunohistochemistry, immunocytochemistry

Cytogenetic: chromosome harvest and slide preparation for karyotyping Animal Handling: Immunocompetent, Immunocompromised, and genetically modified mice, rat, and rabbit

Biomaterials Fibrosis: Techniques and protocols to quantitatively characterize the immune response against implanted biomaterials

Data Analysis and Scientific Writing: design and interpretation of biological experiments with associated statistical analysis; Python, Matlab, construction of scientific graphs using programs such as Microsoft Word, Excel, PowerPoint, EndNote, FlowJo, GraphPad Prism Honors and Awards

Key personnel in CHOC research grant ($70k) 2019-2020 University of California Chancellor’s Club Fellow ($12k) 2019-2020 SoCal Flow Cytometry Scholarship 2019

NEWKIRK Foundation Fellow, UC Irvine ($10k) 2018-2019 Cure-It Category Lemelson-MIT prize-Massachusetts Institute of Technology, USA 2018 DECADE Plus Mentor Fellow, UC Irvine ($7k) 2018-2020 BioADD Annual Award conferred by Dr. Irving Weissman, Stanford University 2017 https://engineering.uci.edu/news/2017/2/grad-student-recognized-collaboration Graduate Fellowship, University of California Irvine, USA 2016-2019 Awarded funding by Lyme Disease Foundation, Stanford University, USA 2015 Awarded by Persian Nanotechnology Initiative Council for Outstanding Master Thesis 2013 Placed 29th among 7,375 participants in the national university entrance exam for M.S. degree entrance, held in Iran 2010

Publications

1. M. Rezaa Mohammadi, Samuel Rodriguez, Rui Cao, Jennifer Cam Luong, Shiri Li, Hien Lau, Ashlyn Wheeler, Hamad Alshetaiwi, Eric Teh, Hayk Davtyan, Mathew Blurton Jones, Mahtab Jafari, Kai Kessenbrock, Weian Zhao, Mark Danniels, Paul de Vos, Jonathan RT Lakey, Islet xenotransplantation in diabetic mice using stem cell derived immunomodulatory biomaterials, Nat. Biomed. Eng., Due to Submit

2. M. Rezaa Mohammadi, Jennifer Cam Luong, Rui Cao, Ashlyn Elizabeth Wheeler, Samuel Mathew Rodriguez, Hien Lau, Shiri Li, Paul de vos, Weian Zhao, Jonathan RT Lakey, Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response Against Implanted Biomaterials, Adv. Healthcare Mat., 2020, In Revision. 3. M. Rezaa Mohammadi, Farideh Dehkordi-Vakil, Joni Ricks-Oddie, Robert Mansfield, Himala Kashimiri, Mark Daniels, Weian Zhao, and Jonathan RT Lakey, Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation, Sci. Rep., 2020, Submitted

4. M. Rezaa Mohammadi, Milad Riazifar, Egest J.Pone, Ashish Yeri, Kendall Van Keuren-Jensen, Cecilia Lässer, Jan Lotvall, Weian Zhao, Isolation and characterization of microvesicles from mesenchymal stem cells, Methods, 2019 5. JRT Lakey, Samuel Rodriguez, M. Rezaa Mohammadi, Greg G Kojayan, Michael Alexander, Cryopreservation of Pancreatic Islets, Appl Cell Biol, 7(2), 2019

6. M. Riazifar*, M. Rezaa Mohammadi*, et al., W. Zhao, Stem Cell-derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders, ACS Nano, 2019. (* Co-first authorship). Featured on: https://physicsworld.com/a/nanoparticles-regulate-harmful-immune-response-in-multiple-sclerosis/ and https://www.eurekalert.org/pub_releases/2019-06/uoc--nts060519.php 7. M. Rezaa Mohammadi, C. Corbo, R. Molinaro, JRT Lakey, Biohybrid Nanoparticles to Negotiate with Biological Barriers, Small, 2019, 1902333

8. Hien Lau, Nicole Corrales, Michael Alexander, Shiri Li, M. Rezaa Mohammadi, Sandra Smink, Paul de Vos, Jonathan Lakey, Necrostatin-1 Supplementation Enhances Young Porcine Islet Maturation and In vitro Function, Xenotransplantation, 2019, Accepted.

9. M. Rezaa Mohammadi, Cao, Rui; Rodriguez, Samuel; Tolsma, Danielle; Lakey, Jonathan, Immunomodulatory Stem Cells to Alleviate the Foreign Body Response Against Implanted Biomaterials, Transplantation, 2019, 103, 9S2 - p S9–S10 10. M. Rezaa Mohammadi, Jennifer Cam Luong, Gahyun Grace Kim, Hien Lau, Jonathan RT Lakey, Scaffolds Implanted: What Is Next? Handbook of Tissue Engineering Scaffolds, Elsevier (2019) 11. M. Rezaa Mohammadi*, et al., W. Zhao, Isolation and Characterization of Microvesicles from Mesenchymal Stem Cells, Methods, 2019

12. M. Rezaa Mohammadi, Andrey Malkovsky, Preetha Jothimuthu, Kwang-Min Kim, Mansi Parekh, Mohammed Inayathullah, Yan Zhuge, Jayakumar Rajadas, Double Layer PEG/Dextran Influences Fe ion release and Colloidal Stability of Iron Oxide Nanoparticles, Scientific Reports, 2018, 8 (1), 4286. Top 100 SciRep Chemistry papers 2018 13. A. Dubnika et al., M. Rezaa Mohammadi, Cytokines as therapeutic agents and targets in heart disease, Cytokine and Growth Factor Reviews 2018, 43, 54-68

14. M. Rezaa Mohammadi, Samuel Rodriguez, Rui Cao, Michael Alexander, JRT Lakey, Immune response to subcutaneous implants of alginate microcapsules, Materials Today: Proceeding, 5 (2018) pp. 155**-*****-**. M. Mozafari, M. Rezaa Mohammadi, et al., Synthesis and characterization of highly interconnected porous poly(ε- caprolactone)-collagen scaffolds: a therapeutic design to facilitate tendon regeneration, Materials Technology, 2018, 33 (1), 29-37

16. M. Jafarkhani, et al, M. Rezaa Mohammadi, M. Mozafari, Strategies for directing cells into building functional hearts and heart parts, Biomaterials Science, 2018 6(7):166*-****-**. C. Kopan et al, M. Rezaa Mohammadi, JRT Lakey, Emerging approaches in immunotherapy, regenerative medicine and bioengineering for type 1 diabetes, Frontiers in Immunology, 2018, 9, 1354 18. M. Karbassi, et al., M. Rezaa Mohammadi, Microemulsion-based synthesis of a visible-light-responsive Si-doped TiO2 photocatalyst and its photodegradation efficiency potential, Mat Chem and Phy 220 (2018) 374–382 19. M. Rezaa Mohammadi, Amirali Nojumi, Arita Dubnika, Masoud Mozafari, Mohammed Inayathullah, Jayakumar Rajadas, Nanomaterials Engineering for Drug Delivery: A Hybridization Approach, J Mat Chem B, 2017, 5, 399*-****-**. M. Rezaa Mohammadi, Wenchao Sun, M. Inayathullah, J. Rajadas, Nanoparticles hybridization to engineer biomaterials for drug delivery, Nanobiomaterials Science, Development and Evaluation, Elsevier (2017) 21. M. R. Mohamadi, J. Aghazadeh Mohandesi, M. Homayonifar, Fatigue behavior of polypropylene fiber reinforced concrete under variable amplitude loading, J Comp Mater, 2013, 47 (26), 3331-42 Patent

Jayakumar Rajadas, M. Rezaa Mohammadi, Mohammed Inyathullah, Geoffrey Gurtner, Tejal Desai, Magnosomes for Targeted delivery of Stem Cells to the skin, Heart, Brain and other Tissues, US Patent App. 15/884,736 PEER REVIEW

RSC Advances, American Journal of Transplantation, BioChimie, Methods. CONFERENCE TALKS

1. M.Rezaa Mohammadi, et al., JRT Lakey, Microencapsulation for Xentotransplantation, IXA 2019, Munich, Germany. 2. M.Rezaa Mohammadi, et al., JRT Lakey, Immunomodulatory biomaterials using stem cells, SFB 2019, Washington, USA. 3. A. Abbasi, S. A. Vitorino, M. R. Mohammadi, A. Lucas, C. Indralingam, W. Zhao, E. C. Breen, H. B. Rossiter, ERS International Congress, Spain 2019

4. M.Rezaa Mohammadi, Andrey V. Malkowsky, Preetha Jothimuthu, Jayakumar Rajadas, Magnosomes for Targeted Stem Cell Delivery to Ischemic Heart, Stanford Drug Discovery Symposium, Stanford University 2018 5. M.Rezaa Mohammadi, Andrey V. Malkowsky, Preetha Jothimuthu, Jayakumar Rajadas, Double Layer PEG/Dextran Influences Cell Viability, Colloidal Stability, and in vivo Fate of Iron Oxide Nanoparticles, Stanford Drug Discovery Symposium, Stanford University 2017

6. M.R. Mohammadi, C. Nazli, S. Kizilel, ‘Water-in-Water Emulsion Based Synthesis of Functional Poly(ethylene glycol) Microgels for Cancer Cell Targeting’, AIChE Annual Meeting, Atlanta

(U.S.A), 14-22 November 2014, accepted oral presentation

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