Curriculum Vitae

NATHAN A. WIGNER adaymi@r.postjobfree.com

(p) 206-***-****

Home Address: *** ***** *****

Columbus, Ohio 43235

Education:

**/**-**/** ***** Fellow, Department of Orthopaedic Surgery, University of Washington (Seattle, WA) 07/12-07/17 Resident, Department of Orthopaedic Surgery, University of Pennsylvania (Philadelphia, PA) 08/03-07/12 M.D.-Ph.D., Boston University School of Medicine (BUSM; Boston, MA) 08/08-08/09 Postdoctoral Research Fellow, Department of Orthopaedic Surgery, BUSM 08/05-08/08 Ph.D., Biochemistry, BUSM

08/97-12/01 B.S., Biological Sciences (summa cum laude), North Carolina State University (Raleigh, NC) B.A., Chemistry (summa cum laude)

Minor, Biotechnology

Awards, Honors, and Membership in Honorary Societies: 2011 Alpha Omega Alpha Honor Medical Society

2009 Ignition Award for Technology Development and Translational Research, “Targeting Anthrax Toxin Receptors for Improved Treatment of Osteoporosis”, $50,000 (total costs), Boston University 2003-2012 Dean’s Scholarship Merit Award (Full M.D.-Ph.D. tuition funding, BUSM) 2001 Phi Beta Kappa Society

2001 Golden Key International Honor Society

1997-2001 Gamma Beta Phi Honor Society (Chapter President, 2000-2001) Memberships in Professional Societies:

American Academy of Orthopaedic Surgeons Member

Orthopaedic Trauma Association Member

AO Trauma Member

AO Spine Member

Peer Reviewed Publications:

Wigner N, Kadam A, Saville P, Arlet V. Can posterior lumbar instrumentation and fusion be overpowered by anterior lumber fusion with hyperlordotic cages? A cadaver study. Global Spine Journal. 2017. PMID: 28989849. Kadam A, Wigner N, Saville P, Arlet V. Overpowering posterior lumbar instrumentation and fusion with hyperlordotic anterior lumbar interbody cages followed by posterior revision. J Neurosurg Spine. 2017 Dec;27(6). PMID: 28960160. Scolaro JA, Taylor RM, Wigner NA. Venous thromboembolism in orthopaedic trauma. Journal of the American Academy of Orthopaedic Surgeons. 2015 Jan; 23(1):1-6. PMID: 25538125.

Wigner, Nathan A., Donegan, Derek J. Current concepts in deep vein thrombosis and pulmonary embolism after trauma. Current Orthopaedic Practice. June 2014(25) p208–212.

Al-Sebaei MO, Daukas DM, Belkina AC, Kakar S, Wigner NA, Cusher D, Graves D, Einhorn TA, Morgan E, Gerstenfeld LC. Role of Fas and Treg cells in fracture healing as characterized in the Fas-deficient (lpr) mouse model of lupus. Journal of Bone and Mineral Research. 2014 Jun,29(6):1478-91. PMID: 24677136.

Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC. Functional role of Runx3 in the regulation of aggrecan expression during cartilage development. Journal of Cell Physiology. 2013 Nov;228(11):2232-42. PMID: 23625810. Carrol SH and Wigner NA, Johnston-Cox H, Kulkarni N, Gerstenfeld LC, Ravid K. The A2b adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo. Journal of Biological Chemistry. 2012 Mar 8. PMID:22403399. Wigner NA, Kulkarni N, Yakavonis M, Young M, Tinsley B, Meeks B, Einhorn TA, Gerstenfeld LC. Urine matrix metalloproteinases

(MMPs) as biomarkers for the progression of fracture healing. Injury. 2011 Jul. PMID: 21689817. Iftikhar M, Hurtado P, Bais MV, Wigner N, Stephens DN, Gerstenfeld LC, Trackman PC. Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. Journal of Biological Chemistry. 2011 Jan; 285(2): 909-918. PMID: 21071451.

Bauzá G, Miller G, Kaseje N, Wigner NA, Wang Z, Gerstenfeld LC, Burke PA. The effects of injury magnitude on the kinetics of the acute phase response. The Journal of Trauma. 2011 Apr; 70(4): 948-953. PMID: 20693926. Salisbury-Palomares KT, Gerstenfeld LC, Wigner NA, Lenburg ME, Einhorn TA, Morgan EF. Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model. Arthritis and Rheumatism. 2010 Apr; 62(4): 1108-1118. PMID: 20131271.

Wigner NA, Luderer HF, Cox MK, Sooy K, Gerstenfeld LC, Demay MB. Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2. Journal of Bone and Mineral Research. 2010 Apr; 25(4): 724-733. PMID: 19839770. Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA, Gerstenfeld LC. Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PloS One. 2009 May; 4(5): 1-16. PMID: 19415118. Bais MV, Wigner N, Young M, Toholka R, Graves DT, Morgan EF, Gerstenfeld LC, Einhorn TA. BMP2 is essential for post-natal osteogenesis but not for recruitment of osteogenic stem cells. Bone. 2009 May; 45(2): 254-266. PMID: 19398045. Morgan EF, Mason ZD, Bishop G, Davis AD, Wigner NA, Gerstenfeld LC, Einhorn TA. Combined effects of recombinant human BMP-7

(rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone. 2008 Aug; 43(6): 1031-1038. PMID: 18761113. Kakar S, Einhorn TA, Vora S, Miara LJ, Hon G, Wigner NA, Toben D, Jacobsen KA, Al-Sebaei MO, Song M, Trackman PC, Morgan EF, Gerstenfeld LC, Barnes GL. Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. Journal of Bone and Mineral Research. 2007 Dec; 22(12): 1903-1912. PMID: 17680724. Lee HS, Shockley KR, Schut GJ, Conners SB, Montero CI, Johnson MR, Chou CJ, Bridger SL, Wigner N, Brehm SD, Jenney FE Jr., Comfort DA, Kelly RM, Adams MW. Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus. Journal of Bacteriology. 2006 Mar; 188(6): 2115-2125. PMID: 16513741. Book Chapters:

Nathan A. Wigner, Neil P. Sheth, and Jaimo Ahn. Pelvic and Hip Fractures. Fractures in the Elderly: A Guide to Practical Management, Chapter 13. In press.

Schenker, Mara L., Wigner, Nathan A., Lopas, Luke, Hankenson, Kurt D., Ahn, Jaimo. Fracture repair and bone grafting. Orthopaedic Knowledge Update 11, Chapter 2p15-26. March 2014.

Extramural Research Funding:

2015-present Foundations for Orthopaedic Trauma (FOT): Effects of fatigue on cognitive and psychomotor performance in orthopaedic house-staff, $20,000 (total costs).

Patents:

Gerstenfeld LC, Einhorn TA, Wigner NA. Methods for screening agents to treat bone diseases using anthrax toxin receptors and methods for treatment of bone diseases; Appl No.: 61/393,642. BU Ref. No.: BU08 16. 2010. Selected Conference Poster and Oral Presentations: Meeks BD, Haas AR, Wigner NA, Alpaugh KG, Morgan EF, Einhorn TA, Gerstenfeld LC, Schlezinger JJ. (2011, January). The environmental toxicant tributlytin induces osteoporosis via PPAR-gamma. Poster presented at: 57th Annual Meeting of the Orthopaedic Research Society; Long Beach, CA.

Young ML, Wigner N, Sagi HC, Gerstenfeld LC, Shah AR, Tornetta P. (2010, March). Comparison of bone graft from a reamer irrigator aspirator (RIA) and iliac crest (ICBG). Poster presented at: Annual Meeting of the American Academy of Orthopaedic Surgeons; New Orleans, LA.

Carroll SH, Wigner NA, Kulkarni N, Gerstenfeld LC, Ravid K. (2010, December). New regulatory mechanisms of bone marrow mesenchymal stem cell differentiation involving an adenosine receptor. Poster presented at: 52nd Annual Meeting of the American Society of Hematology; Orlando, FL.

Bais MV, Wigner N, Young M, Graves DT, Morgan EF, Gerstenfeld LC and Einhorn TA. (2009, February). Intramedullary bone formation shows that BMP2 is essential for post-natal osteogenesis but not for recruitment of osteogenic stem cells. Poster presented at: 55th Annual Meeting of the Orthopaedic Research Society; Las Vegas, NV. Bais M, Shabin Z, Marsell R, Kotton D, Wigner N, Morgan E, Einhorn T, Gerstenfeld L. (2009, September). Embryonic stem cell pluripotency factor Nanog has a functional role in post-natal bone regeneration and mesenchymal stem cell differentiation. Poster presented at: 31st Annual Meeting of the American Society of Bone and Mineral Research; Denver, CO. Kulkarni N, Wigner NA, Young M, Tinsley B, Yakavonis M, Meeks B, Einhorn TA, Gerstenfeld LC. (2009, September). Urinary matrix metalloproteinases as biomarkers for fracture healing. Poster presented at: 31st Annual Meeting of the American Society for Bone and Mineral Research; Denver, CO.

Marsell R, Bais M, Wigner NA, Chandler R, Spagnoli A, Mortlock DP, Gerstenfeld LC, Einhorn TA. (2009, September). Post-natal BMP2 expression differs between osteogenic and chondrogenic progenitors and displays a systemic increase as a response to bone trauma. Poster presented at: 31st Annual Meeting of the American Society for Bone and Mineral Research; Denver, CO. Wigner NA, Barnes GL, and Gerstenfeld LC. (2008, September). Runx transcription factors regulate aggrecan gene expression during chondrogenic differentiation. Poster/Oral presentation at: 54th Annual Meeting of the Orthopaedic Research Society; Honolulu, HI. Wigner NA, Gerstenfeld LC, Einhorn TA, and Demay MB. (2008, September). Hypophosphatemia impairs endochondral bone formation during fracture healing. Poster presented at: 54th Annual Meeting of the Orthopaedic Research Society; Honolulu, HI. Bais MV, Mclean J, Sabastiani P, Young M, Smith T, Wigner NA, Kotton DN, Einhorn TA, and Gerstenfeld LC. (2008, September). Induction of embryonic stem cell- related genes during fracture healing and the transcriptional analysis of fracture healing. Poster presented at: 54th Annual Meeting of the Orthopaedic Research Society; Honolulu, HI. Barnes GL, Kakar S, Vora S, Record N, Wigner NA, Morgan EF, Gerstenfeld LC, Einhorn TA. (2008, September). Enhanced chondrogenic maturation in PTH treated fractures. Poster presented at: 54th Annual Meeting of the Orthopaedic Research Society; Honolulu, HI. Bais MV, Wigner NA, Young M, Toholka R, Graves D, Morgan EF, Gerstenfeld LC, Einhorn TA. (2008, September). Dependence of post- natal osteogenic differentiation on BMP2: dissection of osteogenic lineage commitment by lentivirus BMP2 shRNA ex vivo and in vivo. Poster presented at: 30th Annual Meeting of the American Society for Bone and Mineral Research; Quebec, Canada.

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