Organic Chemistry Synthetic

David J. Galler

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Education

Doctor of Philosophy – Synthetic Organic and Physical Organic Chemistry May 2019

Stony Brook University Stony Brook, NY

Advisor: Kathlyn A. Parker

Dissertation: A Six Part Exploration into Synthetic and Physical Organic Chemistry

Bachelor of Science – Chemistry with Honors May 2011

Stony Brook University Stony Brook, NY

Skills

Bench Skills: Synthesis of Complex Small Molecules, Air-Free Technique, Glove Box, Flash Column Chromatography, Recrystallization, Extraction, Distillation, Catalysis

Instrumentation: NMR, FTIR, KF, HPLC, Mass Spec, GC

Software: ChemDraw, MestReNOVA, TopSpin, SciFinder, Reaxys, OMNIC Spectra IR, Lab Solutions

Soft Skills: Problem solving, Teamwork, Creativity, Attention to detail, Adapting, Communication

Relivant Experience

Senior Chemist 2023-Present

Chemist 2020-2023

US Food and Drug Administration

Developed HPLC methods with wide application for assay analysis of combination drugs and their components to streamline drug analysis

oCreated HPLC method for the analysis of common OTC drug components under a unified method

Validated NMR methods at the regulatory testing site for biomolecules and small molecules for the implementation of a new national survey for drugs of interest

oGenerated NMR protocols for the active pharmaceutical product (API) to verify percent of label claim as an alternative method to HPLC to eliminate the need for a reference standard.

Created and developed SOPs regarding the continued operation, maintenance, and verification of technical equipment including HPLC, MS, IR, KF, & NMR

Mentored and trained junior scientists in FDA regulations and analytical chemistry techniques

Operated a GMP compliant laboratory environment by maintaining accountable documentation

Investigated pharmaceutical firms and manufacturing facilities to ensure compliance with GMP regulations

Synthesized drug impurities to spike analytical reference standards for purity verification, in line with FDA’s mission of public health protection

NMR Structure confirmation and elucidation of chemical impurities

Visiting Research Scholar 2022-2022

CUNY, York College

Designed strategies toward a novel variant of the silyl-prins reaction as a precursor to the synthesis of more complex natural products

Postdoctoral Researcher 2019-2020

Medicinal Chemistry

Under Prof. Junyong Choi, Queens College, City University of New York

Conducted medicinal chemistry research by synthesizing analogs for potential inhibitors of matrix metalloprotease and PI3 kinase for cancer research.

oSynthesized 4 compounds of the modified the aromatic group with lactams, 6 and 7 membered nitrogen heterocycles or substituted furans

oSynthesized 12 compounds of the modified carbon linker with varies chain lengths

Designed and performed concise synthesis of peptide oligomers as the core basis for analog synthesis by utilizing metal catalyzed coupling reactions, air-free manipulation and microwave assisted reactions

Analyzed spectroscopic and spectrometric data to determine structure of synthesized material including IR, MS, and 1D, 2D, and heteroatom NMR for structural confirmation

Fulfilled responsibilities of Safety Officer for compliance with NYC regulations of chemicals and chemical waste

Graduate Research Assistant

Total Synthetic Organic Chemistry/Physical Organic Chemistry/Polymer Chemistry

Under Prof. Kathlyn A. Parker, Stony Brook University 2011-2019

Completed the synthesis of two natural products, Phosphoiodyn A and plactoylene A, as a possible treatment of metabolic diseases and osteoporosis respectively.

oDeveloped a new synthetic route to forming conjugated diynes and iodo-olefins in the same molecule, with conjugation as a challenge.

Developed synthetic strategies for cost effective and efficient versatile chiral polyketide building blocks from achiral starting materials

oSynthesis and modeling of a versatile stereopentad via a key cyclic hydroboration

oDecagram scale synthesis of a syn/anti polyketide from an achiral starting material

Designed and synthesized novel monomers for alternating ring-opening metathesis polymerization

oSynthesized a series of cyclobutene esters for polymerization reactions with cyclohexene and cyclohex-2-en-1-ol

Gaussian modeled the thermodynamic reaction coordinate of an 8 /6 electrocyclic ring closing

Authored detailed and coherent manuscripts for publication and summarized abstracts for presentation

Administratively managed lab financial accounts, chemical purchasing, and maintaining inventory

Mentored and coached undergraduate students in lab safety and operations

Maintained safety regulations and procedures for the laboratory

Undergraduate Research Assistant

Polymer Chemistry

Under Prof. Barney Grubbs, Stony Brook University 2009-2011

Synthesized three-arm star block co-polymers for drug delivery

oWorked toward drug polymer conjugates for in vivo delivery at site specific regions

Teaching Experience

Adjunct Assistant Professor 2019-2023

CUNY, Queens College

Classes: Organic Chemistry 1 and 2, Organic Chemistry Lab 1 and 2, General Chemistry

Lectured to classes ~30 students by breaking down complex theories into simple ideas

Interacted with students through challenging practice problems by encouraging critical thinking

Designed lectures and exams to teach and assess students’ knowledge

oInteractive lectures were written to engage students and provide feedback of progress during class to reenforce learning outcomes

Welcomed regular student questions via email

Adjunct Assistant Professor

Nassau Community College 2016-2019

Long Island University 2017

Suffolk Community College 2015

Publications

1)Galler, D.J.; Parker, K.A., Molecular Studies on Palladium Mediated Electrocyclization, In Preparation

2)Calder, M.E.; Galler, D.J.; Parker, K.A., Synthesis of a Stereopentad via Cyclic Hydroboration, In Preparation

3)Galler, D.J.; Bermudez, G.; Parker, K.A., Multi-Gram Scale Synthesis Of A Versatile Syn-Anti Stereotriad By A Short And Cost-Effective Route, ARKIVOC, 2019, part iii, 93-102

4)Galler, D.J. & Parker, K.A. Five Easy Pieces: The Total Synthesis of Phosphoiodyn A and Placotylene A, Organic Letters, 2015, 17(22), 5544-5546

Presentations

1)2017 ACS National Meeting San Francisco, CA

Calder, M.E.; Galler, D.J.; Parker, K.A., Synthesis of Polypropionate Building Blocks for Complex Natural Products

2)2016 ACS National Meeting Philadelphia, PA

Galler, D.J. & Parker, K.A. Five Easy Pieces: The Total Synthesis of Phosphoiodyn A and Placotylene A

3)2016 National Meeting Philadelphia, PA

Galler, D.J.; Bermudez, G.; Parker, K.A., Large Scale Synthesis of Polyketide Building Blocks

4)2011 Undergraduate Honors Seminar Stony Brook University, NY

Kai, Y,. Galler, D., Grubbs, R.B., Synthesis of Tri-Arm Star Co-Polymers for Drug Delivery

Honors and Awards

Special Award for Excellence in Undergraduate Teaching 2011

Teaching a Graduate Course as an Undergraduate

Couse: Mechanisms and Strategies in Organic Synthesis

Certifications

Certificate of Fitness for Non-Production Chemical Laboratories (C-14) Issued by FDNY Sept 2019

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