Data Analyst Healthcare
Resume:
GUANGJIN ZHOU
Senior Biostatician Clinical Data Analyst
+1-216-***-**** ********@*****.***
https://www.linkedin.com/in/guangjin-zhou-b558a1132/ Cleveland Ohio SUMMARY
I have ample experience in clinical data science, bioinformatics, and laboratory research. Throughout my career, I have completed over 50 projects and published more than 50 scientific papers. I have honed my skills in study design, statistical methods, data visualization, and communication, ensuring the highest quality and delivery. EXPERIENCE
Senior Biostatistican
Case Western Reserve University
04/2023 - Present Cleveland, OH
Healthcare Data Analyst/Biostatistician
Case Western Reserve University
08/2018 - 03/2023 Cleveland, OH
Worked as a research consultant and biostatistician Played an acting role that involved relationship building and effective communication, resulting in secured five-year funding with contractors Developed models for the outcome of cardiovascular surgery, volume and trend
Developed the models of measuring the outcome of hip and knee revision Developed a risk model of orthopedic surgery
Proficiency in healthcare data management and analysis methods. Performing machine learning in large healthcare data Development of various nationwide surgical volume projection models Research Associate
Case Western Reserve University
08/2008 - 05/2018 Cleveland, OH
Completed five projects sponsored by multiple federal grants Establishment of multiple genetic models of cardiovascular diseases Proficiency in molecular genetics
Bioinformatics analysis of RNA and DNA sequencing
DATA MANAGEMENT & ANALYSIS
Real-World Data EHR Data Health Claim Data Survey Data Next Generational Sequencing Data Meta-analysis
R SAS Python SQL
BWA STAR Advanced Excel PowerPoint
Adobe Illustrator
HIGHLIGHTS
Experience on Large Data Analysis
Healthcare Cost & Utilization Project
Claim Data
Survey Data
U.S. Census Data
Electronic Health Records
Next Generational Sequence Data
Machine Learning
ACHIEVEMENTS
Scientific contribution
> 50 scientific papers.
https://pubmed.ncbi.nlm.nih.gov/?
term=zhou%2C+guangjin
Productivity
> 50 projects
Consulting Services
6 year consulting on statistical methods
and data analysis
EDUCATION
Ph.D. Clinical & Translational Science
Case Western Reserve University
08/2018 - 05/2024 Cleveland, OH
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Programming & Softwares
08/2018 05/2024
Nationwide Inpatient Sample
National Readmission Data
Nationwide Ambulatory Surgery
State Medical Data
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Led the design and analysis of five clinical study projects Collaborated with two clinical teams with multitasks projects Bioinformatic analysis on Next Generational Sequencing Data Development of cancer prevalence measurement model
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Medicaid
Medicare
Cancer Registry
Supervised Learning
Unsupervised Learning
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Data Visualization
Work Experience:
Senior Research Statistician
Case Western Reserve University
4/2023 - Present
Duties, Accomplishments and Related Skills:
As the senior member of the Population Health and Outcomes Research team, I worked independently to provide consultation and guidance for clinicians and other investigators. I assumed supervisory duties delegated by the Principal Investigator and was fully responsible for formulating study objectives, designing research protocols, and writing proposals. I oversaw the day-to-day operation of five clinical projects and the implementation of goals across multidisciplinary and multi-institutional international teams, which involved tracking all aspects of projects, identifying needs, and facilitating the execution of solutions. I developed standard protocols to evaluate findings and surveys related to public health and policy. Additionally, I mentored new team members and guided junior researchers on techniques, statistical methods, and procedures. I generated reports for public health and policy, providing valuable insights and recommendations based on research findings. Furthermore, I authored research findings for publications, papers, meeting presentations, grants, and other documentation.
Health Science Research Analyst/Statistician
Case Western Reserve University
8/2018 - 3/2023
Duties, Accomplishments and Related Skills:
At the Population Health and Outcome Research Core of the university, I assumed a leadership role in study design, data collection, analysis, and reporting. I provided statistical support for research projects across various departments within the School of Medicine, as well as partner institutes like the Cleveland Clinic and MetroHealth Hospitals. Data sources encompassed the Healthcare Cost and Utilization Project (HCUP), Medicaid and Medicare data, Ohio Medicaid Assessment Survey, Cancer registry data (e.g., Surveillance, Epidemiology, and End Results
(SEER), Ohio Cancer Incidence Surveillance System (OCISS), U.S. Census data, Health Retirement Study, and other relevant studies.
During this period, I completed over 30 clinical research projects, exploring topics such as the opioid epidemic, cancer prevalence in HIV patients, and outcomes of various cardiovascular and orthopedic surgeries. I collaborated closely with team members from multiple academic and health institutions in Ohio, participating in conference calls with clinicians across different specialties and regions for various studies. I developed study algorithms and flowcharts for each research project and successfully secured five-year funding with two groups from our partner institute. Additionally, I played an integral role in monitoring study quality assurance and maintaining effective communication with investigators. As a Biostatistician, I specialized in data management through programming SAS codes, developing macros, and processing data with R packages for complex statistical methods and machine learning. I utilized advanced Excel and Tableau for data visualization and interpreted results for investigators. Furthermore, I meticulously documented all steps involved in preparing different versions of the analytic file, generated data dictionaries, and curated archival datasets for future use by investigators.
One of my notable achievements was the development of a new statistical model for analyzing disease prevalence, leading to the discovery of high cancer prevalence among men living with HIV. This work was featured on Science Daily News
(https://www.sciencedaily.com/releases/2022/03/22-031*******.htm). Research Associate
Case Western Reserve University
8/2008 - 7/2018
Duties, Accomplishments and Related Skills:
At the Cardiovascular Research Institute of the university, I had the privilege of working under the mentorship of Dr. Mukesh Jain, an internationally renowned physician-scientist. I established various genetic animal models of cardiovascular diseases, leading to fundamental discoveries in the field. During this period, I played a key role in the functioning of one of the nation's top-funded laboratories. I initiated, managed, and executed goal- oriented projects that laid the groundwork for three NIH grants totaling $3,000,000. Thriving within a fast-paced collaborative environment, I mentored three graduate students and five undergraduates, and published more than 20 research articles. Notable findings from these publications include the discovery of a key genetic factor influencing blood vessel health (First author, 2012, Journal of Clinical Research: PMID: 23160196; Journal of Clinical Research Insights, co-first author, 2017:PMID: 28239661), and the identification of a conserved pathway controlling aging (Nature Communications, 2017, co-first author, PMID: 29030550). Through this experience, my interest in translational science grew, paving the way for my next professional goal. Research Fellow
Case Western Reserve University
8/2005 - 7/2008
Duties, Accomplishments and Related Skills:
At the Department of Genetics and Genome Sciences of the university, I focused on the study of genetic control of colorectal cancer. Under the mentorship of geneticist Dr. Guangbin Luo, I developed strong skills in molecular biology and computational biology. The findings from this work were highlighted in the discovery of a key protein involved in DNA replication and repair
(First author, International Journal of Biochemistry and Molecular Biology, 2010: PMID: 21968968).
Research Fellow
Mayo Clinic
7/2004 - 7/2005
Duties, Accomplishments and Related Skills:
I immigrated to the United States and worked as a research fellow at Mayo Clinic. I studied the genetic control of colorectal cancer under the mentorship of geneticist Dr. Wanguo Liu. During this time, I acquired excellent skills in molecular genetics. Our research findings were featured in a scientific publication (Co-first author, PLOS, 2009: PMID: 19956716). Education:
Case Western Reserve University
GPA: 3.84 of a maximum 4
Credits Earned: 68 Semester Hours
Major: Clinical & Translational Science
Fudan University
Doctorate degree
Credits Earned: 54 Semester Hours
Major: Genetics and Human Genome
Jiamusi Medical College
Master's degree
Credits Earned: 38 Semester Hours
Major: Human Genetics
Northwestern Normal University
Bachelor's degree
Credits Earned: 166 Semester Hours
Major: General Biology
Job Related Training:
-- Translational Bioinformatics Training
-- National Institute of Health (NIH) Human Subjects Research Participants Course
-- The Collaborative Institutional Training Initiative (CITI Program) Training
-- Healthcare Cost and Utilization Project (HCUP) Data Use Agreement Certificate
-- Introduction to the Use of Medicare Data for Research Workshop
-- The Surveillance, Epidemiology, and End Results (SEER) -Medicare Training Workshop
-- SAS Certified Base Programmer for SAS 9
-- The National Center for Biotechnology Information (NCBI) Bioinformatics Course Language Skills:
Language Spoken Written Read
Chinese Advanced Advanced Advanced
English Advanced Advanced Advanced
Affiliations:
American Statistical Association (ASA) - Member
The Cleveland R User Group, for users of the R Statistical language - Member North American Vascular Biology Organization (NAVBO) - Member Sigma Xi, The Scientific Research Honor Society - Member Professional Publications:
Maigrot JA, Zhou G, Koroukian S,Gillinov M Bakaeen F, Svensson L, Edward G. Soltesz E. JTCVS Open. Nationwide Analysis of Case Volume and Outcomes in Cardiac Surgery during the COVID-19 Pandemic. 2024 May
An F, Zhou G* Harland M Hussain W Strainic Jain M Medof E.KLF4 and CD55 expression and function depend on each other. Front. Immunol. 2023 (* Co-first author). Rullán PJ, Zhou G, Emara AK, Klika AK, Koroukian S, Piuzzi NS. Understanding rates, risk factors, and complications associated with manipulation under anesthesia after total knee arthroplasty (TKA): An analysis of 100,613 TKAs. Knee. 2022 Sep 1;38:170-177. Zhou G, Koroukian SM, Navale SM, Schiltz NK, Kim U, Rose J, Cooper GS, Moore SE, Mintz LJ, Avery AK, Mukherjee S, Markt SC. Cancer burden in women with HIV on Medicaid: A nationwide analysis. Womens Health (Lond). 2023 Jan- Dec;19:17455057231170061.
Rullán PJ, Zhou G, Emara AK, Klika AK, Koroukian S, Piuzzi NS. Understanding rates, risk factors, and complications associated with manipulation under anesthesia after total knee arthroplasty (TKA): An analysis of 100,613 TKAs. Knee. 2022 Oct;38:170-177. Koroukian SM, Zhou G*, Navale SM, Schiltz NK, Kim U, Rose J, Cooper GS, Moore SE, Mintz LJ, Avery AK, Mukherjee S, Markt SC. Excess cancer prevalence in men with HIV: A nationwide analysis of Medicaid data. Cancer. 2022 May 15;128(10):1987-1995 (* Co- first author).
Rullan PJ, Emara AK, Zhou G, Pasqualini I, Klika AK, Koroukian SM, Barsoum WK, Piuzzi NS. National Inpatient Datasets May No Longer Be Appropriate for Overall Total Hip and Knee Arthroplasty Projections after Removal from Inpatient-Only Lists. J Knee Surg. 2023 Feb 17.
Rullán PJ, Zhou G, Emara AK, Klika AK, Koroukian S, Piuzzi NS. Understanding rates, risk factors, and complications associated with manipulation under anesthesia after total knee arthroplasty (TKA): An analysis of 100,613 TKAs. Knee. 2022 Sep 1;38:170-177. Rhoads C, Emara AK, Pumo T, Pan X, Zhou G, Koroukian S, Krebs VE, Piuzzi NS. What Are the Drivers of Readmission for Serious Venous Thromboembolic Events after Primary Total Knee Arthroplasty? An Analysis of 862,915 Patients. J Knee Surg. 2022 Jul 7.
Erossy M, Emara AK, Zhou G, Kourkian S, Klika AK, Molloy RM, Piuzzi NS. Simultaneous bilateral total knee arthroplasty has higher in-hospital complications than both staged surgeries: a nationwide propensity score matched analysis of 38,764 cases. Eur J Orthop Surg Traumatol. 2022 Mar 31.
Dewan KC, Zhou G, Koroukian SM, Petterson G, Bakaeen F, Roselli EE, Svensson LG, Gillinov AM, Johnston D, Soltesz EG. Opioid Use Disorder Increases Readmissions After Cardiac Surgery: A Call to Action. Ann Thorac Surg. 2022 Mar 11:S0003- 4975(22)00328-9.
Zuke WA, Chughtai M, Emara AK, Zhou G, Koroukian SM, Molloy RM, Piuzzi NS. What Are Drivers of Readmission for Readmission-Requiring Venous Thromboembolic Events After Primary Total Hip Arthroplasty? An Analysis of 544,443 Cases. J Arthroplasty. 2022 May;37(5):958-965.e3
Samuel LT, Sultan AA, Zhou G, Navale S, Kamath AF, Klika AK, Piuzzi NS, Koroukian SM, Higuera-Rueda CA. In-Hospital Mortality Is Associated With Low-Volume Hip Revision Centers After Septic Revision Total Hip Arthroplasty. Orthopedics. 2022 Jan- Feb;45(1):57-63.
Anis HK, Warren JA, Klika AK, Navale SM, Zhou G, Barsoum WK, Higuera CA, Piuzzi NS. Greater Prevalence of Mental Health Conditions in Septic Revision Total Knee Arthroplasty: A Call to Action. J Knee Surg. 2022 Jan;35(2):190-197. Dewan KC, Zhou G, Koroukian SM, Gillinov AM, Roselli EE, Svensson LG, Johnston DR, Bakaeen FG, Soltesz EG. Failure to Rescue After Cardiac Surgery at Minority- Serving Hospitals: Room for Improvement. Ann Thorac Surg. 2021 Nov 25:S0003- 4975(21)01987-1.
Emara AK, Zhou G, Klika AK, Koroukian SM, Schiltz NK, Higuera-Rueda CA, Molloy RM, Piuzzi NS. Is there increased value in robotic arm-assisted total hip arthroplasty? : a nationwide outcomes, trends, and projections analysis of 4,699,894 cases. Bone Joint J. 2021 Sep;103-B(9):1488-1496.
Emara AK, Zhou G, Klika AK, Koroukian SM, Schiltz NK, Krebs VE, Molloy RM, Piuzzi NS. Robotic-arm-assisted Knee Arthroplasty Associated With Favorable In-hospital Metrics and Exponentially Rising Adoption Compared With Manual Knee Arthroplasty. J Am Acad Orthop Surg. 2021 Dec 15;29(24):e1328-e1342. Zhou L, Lapping S, Liao X, Lu Y, Zhou G, Matoba K, Vasudevan N, Wang L, Nayak L. The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti- inflammatory activity by suppression of NF-κB pathways. PLoS One. 2020 Nov 12;15(11):e0241607.
Sangwung P, Zhou G*, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK. KLF2 and KLF4 control endothelial identity and vascular integrity. JCI Insight. 2017 Feb; 2(4):e91700. (* Co-first author).
Hsieh P, Zhou G*, Yuan Y, Zhang R, Prosdocimo D, Sangwung P, Borton A, Boriushkin E, Hamik E, Fujioka H, Fealy C, Kirwan J, M, Lu Y, Liao X, Bergeron D, Feng Z, and Jain M. A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction. Nature Communications 2017 Oct;8(1):914. (* Co-first author).
Shatat MA, Tian H, Zhang R, Tandon G, Hale A, Fritz JS, Zhou G, Martínez-González J, Rodríguez C, Champion HC, Jain MK, Hamik A.Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2014 Mar; 50(3):647-53.
Lu Y, Zhang L, Liao X, Sangwung P, Prosdocimo D, Zhou G, Vortruba A, Brian L, Han Y, Gao H, Wang Y, Shimizu K, Weinert-Stein K, Khrestian M, Simon D, Freedman N, Jain M. Kruppel Like Factor 15 is critical for vascular inflammation. J Clin. Invest. 2013. Oct;123(10):4232-41.
Zhou G, Hamik A, Nayak L, Tian H, Shi H, Lu Y, Sharma N, Liao X, Hale A, Boerboom L, Feaver RE, Gao H, Desai A, Schmaier A, Gerson SL, Wang Y, Atkins GB, Blackman BR, Simon DI, Jain MK. Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin. Invest. 2012 Dec 3;122(12):4727-31. Sharma N, Lu Y, Zhou G, Liao X, Kapil P, Anand P, Mahabeleshwar GH, Stamler JS, Jain MK. Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2836-8. Zhou H, Hinman M, Barron V, Geng C, Zhou G, Luo G, Siegel R, Lou L. Hu Proteins Regulate Alternative Splicing By Inducing Localized Histone Hyperacetylation In An RNA-Dependent Manner. Proc Natl Acad Sci USA. 2011 108(36):E627-35. Liao X, Sharma N, Kapadia F, Zhou G, Lu, Y, Ganapathi MH, Dalmas E, Venteclef N, Flask C, Kim J, Jain MK. Myeloid Krüppel-like factor 4 regulates macrophage polarization. J Clin. Invest. 2011; 121(7):2736-49 Zhou G, Liu Y, Wu S, Tie F, Lou H, Chiang C, Luo G. Purification of a novel RECQL5- SWI/SNF- RNAPII super complex. Int J Biochem Mol Biol 2010; 1(1):101-111. Yori JL, Johnson E, Zhou G, Jain MK, Keri RA. Kruppel-like factor 4 inhibits epithelial-to- mesenchymal transition through regulation of E-cadherin gene expression. J Biol Chem. 2010; 285(22):168**-*****.
Guo J*, Cagatay T*, Zhou G*, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One. 2009; 4(11): e7982 (*, Co-first author). Hu Y, Lu X, Zhou G, Barnes EL, Luo G. Recql5 Plays an Important Role in DNA Replication and Cell Survival Following Camptothecin Treatment. Mol Biol Cell. 2009; 20(1):114-123
Chen Y, Zhou G, Yu M, He Y, Tang W, Lai J, He J, Liu W, Tan D. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. Biochem Biophys Res Commun. 2005; 337(4):1112- 1118.
Zhou G, Zhao Y. Genetics and pathogenesis: Tuberous Sclerosis Complex. Section of Genetics/Foreign Medical Science 2005; 33(8): 213-217. Zhou G, Wang J, Zhang Y, Zhong C, Ni J, Wang L, Guo J, Zhang K, Yu L., Zhao S. Cloning, expression and subcellular localization of Human HN1 and HN1 like gene as well as Characterization of their orthologs define an evolutionary conserved gene family. Gene 2004; 331: 115–123.
Zhou G, Zhang Y, Wang J, Guo J, Ni J, Zhong Z, Wang L., Dang Y, Yu L. Cloning, Expression and Characterization of novel human RNA binding protein gene PNO1. DNA sequence 2004; 15(3): 219-224.
Zhou G, Yu L, Zhao S. The pseudogenes of human genome. Chinese Bulletin of Life Sciences 2004, 16(4): 206-209.
Zhou G, Yu L, Zhao S. Nucleolus and nucleolar proteins. Chinese Journal of Cell Biology 2004, 26(3): 261-265.
Zhou G, Xiao Y, Wang W. Human T-cell Leukemia Virus type I and diseases. Section of Genetics/Foreign Medical Sciences 1996; 19(6): 299-303. Additional Information:
Programming level:
• R: Advanced level
• SAS: Advanced level
• Python: Basic level
• Tableau: Medium level
• Excel: Advanced level
• Bioinformatics package: BWA STAR
Journal Reviewer:
• Journal of Acquired Immune Deficiency Syndromes
• Oncology Reports
• Oncology Letters
• Molecular Medicine Reports
• Molecular and Clinical Reports
• Experimental and Therapeutic Medicine Awards:
• 20 X Awards from Spandidos Publications excellence in reviewing, 2017-2018
• Xinsheng Scholarship, Fudan University, 200
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