Medicinal Chemistry and Pharmacology (Ph.D.)

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CURRICULUM VITAE

Solomon Girmay Berehe, Ph.D.

Email: ************@*****.***

Tel: +821*********

Education

Doctor of

Philosophy

September 2019–August 2024

Medicinal Chemistry and Pharmacology, University of Science and Technology, Republic of Korea.

Thesis topic part I: Discovery of Novel Hydroxypyridone Derivatives as Potent LpxC Inhibitors Targeting Multidrug-Resistant Pseudomonas Aeruginosa Thesis topic part II: Discovery of Novel Isoxazole-Based Small Molecules Targeting Zika Virus Infections

Advisor: Prof. Young-Sik Jung

Master of Science September 2011–April 2014

Organic Chemistry, College of Natural and Computational Sciences; Haramaya; University, Ethiopia

Thesis topic: Isolation and characterization of antimicrobial compounds from seed extract of Lepidium sativium herb

Advisor: Prof. Aman Dekobo

Bachelor of Science September 2008 – July 2011

Chemistry; College of Natural and Computational Sciences, University of Gondar, Ethiopia.

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Research Experiences

Research Student

(Ph.D. Scholar)

September, 2019 – August 2024

Infectious Diseases Therapeutic Research Center, Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology Supervisor: Prof. Young-Sik Jung

Development of HIF-2α inhibitor for treating chronic hepatocellular carcinoma

(HCC).

Development of HBx-DDB1 interaction inhibitors for treating chronic Hepatitis B virus (HBV).

Discovery and Synthesis of Novel Non-Hydroxamate-based LpxC Inhibitors as Antibiotic Agents.

Discovery and SAR Study of Isoxazole Derivatives as Novel Antiviral Agents for the Treatment of Zika Virus Infections

Discovery of a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase.

Research Interest

Development of Antiviral for Hepatitis B Virus (HBV) treatment Targeting protein kinases for cancer therapy

Developments in Antibiotics for multidrug-resistant (MDR) bacterial infections Antiviral drug discovery for the treatment of COVID-19 infections Development of small-molecule inhibitors against ZIKV and DNV infections Teaching Experiences

Senior Lecturer

June 2017–August 2018

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Ethiopia

Lecturer April 2014–May 2017.

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Ethiopia

Chairman

Applied

Chemistry

Feb 2015–August 2018.

Chairman of Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Ethiopia

Course Taught (Under Graduate)

Senior Lecturer

June 2017–August 2018

Organic Chemistry II, Organic Synthesis, Physical Organic Chemistry, Protein Chemistry,

Lecturer April 2014–May 2017.

Organic Chemistry I, Organic Chemistry II, Organic Synthesis, Physical Organic 3 / 5

Chemistry

Academic Honors

1. UST-KRICT Graduate Research Fellowship: Sep 2019–present 2. Haramaya University Post Graduate Fellowship: 2011–2014 3. University of Gondar under Graduate Fellowship: 2008–2011 Research Honors

1. Award for Presentation Excellence in recognition of outstanding achievements at the Thesis Presentation Contest of UST-KRICT school, Spring semester of 2024. 2. Oral Presentation award in the 31

st

Annual Congress of the Chemical Societies of Ethiopia (CSE) entitled “Fatty acids, metal composition, nutritional value and physicochemical parameters of Lepidium sativium seed oil collected from Ethiopia.” on March 02, 2015, held at Addis Ababa University, Addis Ababa, Ethiopia.

3. Oral Presentation award in the 30

th

Annual Congress of the Chemical Societies of Ethiopia (CSE) entitled “Isolation and characterization of antimicrobial compounds from seed extract of fetto

(Lepidium sativium) herb.” from Feb, 28 - Mar 2, 2014, held at Mekelle University, Mekelle, Ethiopia (Master degree Thesis research)

Professional Membership

1. Member of Korean Chemical Society (KCS), Oct 2019-present 2. Member of Chemical Society of Ethiopia (CSE), Feb 2014-present 3. Member of Ethiopian Teachers Association (ETA), May 2014-present List of Publications

1. 1

Berehe Solomon Girmay, Sileshi Abera Ayele, Abbas Azeem Syed, Su San Jang, Enhhye Jung, Jin Soo Shin, Soo Bong Han, Hyejin Kim. Discovery and structure-activity relationship study of novel isoxazole-based small molecules targeting Zika virus infections. RSC Med., Chem, 2024,15, 2792- 2805.

2.

1

Avinash G. Vishakantegowda,

1

Berehe Solomon Girmay, Jin Soo Shin, Joo-Youn Lee, Sunjoo Ahn. Young-Sik Jung, Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl) acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters, 2023, 96,129504. (1 these authors

contributed equally).

3. GetachewBantihun, GenetAtsbeha, SolomonGirmay,YilkalDessie. Anti-Limnatisnilotica activity and kinetic study of Guizotia abyssinica hull crude extract in stream water body ecosystems of Ethiopia. South African Journal of Botany, 2023, 161, 568-574. 4. Tewabech Alemu, Kebede Shenkute, Rajalakshanan Eswaramoorthy, Solomon Girmay, Yadess Melaku, Milkyas Endale Molecular Docking Analysis of Antibacterial Indole Alkaloids from Roots of Brucea Antidysentrica Ethiop. J.Sci.Sustain.Dev. 2020, 7(2); 1-13 4 / 5

5. Fitsum Lemilemu, Solomon Girmay, Kebede Shenkute, Milkyas Endale. Antibacterial Steroids from Roots of Bersama Abyssinica, Ethiop.J.Sci.Sustain.Dev, 2020, 7(1); 27-34. 6. Tesfaye Nuru, Solomon Girmay, Yadessa Melaku, Milkyas Endale. Benzoylbetulin from Roots of Teclea nobilis. The Pharmaceutical and Chemical Journal, 2018, 5(4):56-62. 7. Shimekit Tadele and Solomon Girmay. Quantification of Bioactive Constituent D-Pinitol in Ethiopian Soybean. Nat Prod Chem Res, 2018, 6(2);1-4. 8. Yilkal Dessie Sintayehu, Abebe Belay Gemeta, Solomon Girmay Berehe. Optical Photocatalytic Degradation of Methylene Blue Using Lignocellulose Modified TiO2. International Journal of Photochemistry and Photobiology. 2017, 2(3): 81-84. 9. Solomon, G., Aman, D. and Bachheti, R.K. Fatty acids, metal composition, nutritional value and physicochemical parameters of Lepidium sativium seed oil collected from Ethiopia. International Food Research Journal. 2016, 23(2): 827-831.

10. Solomon Girmay, Preliminary Phytochemical Screening and in vitro Antimicrobial Activity of Datura stramonium Leaves Extracts Collected from Eastern Ethiopia. International Research Journal of Biological Sciences. 2015. 4(1):1-5.

11. Solomon Girmay Berehe and Aman Dekebo Boru. Phytochemical Screening and Antimicrobial Activities of Crude Extracts of Lepidium sativium Seeds Grown in Ethiopia. International Journal of Pharmaceutical Sciences and Research.2014, 5(10): 4182-4187. Technical Skills

• Target understanding and mode of actions

• Drug design and exploring structure-activity relationship (SAR)

• Synthetic route design and structural elucidation

• Gram scale reaction design and purifications

• Biological data analysis and interpretation

• Sample purification using different techniques

Recrystallization

MPLC

Pre-TLC

HPLC

• Sample analysis using different instruments

NMR

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LC-MS

HRMS

• Literature search: using specialized databases such as SciFinder, ChemSpider, PupMed, and Espacenet.

• Scientific skills: gained outstanding skills in preparing reports, writing research proposals, and drafting manuscripts.

• Presentation skills: effectively presenting research findings to scientific audiences

• Project management: efficiently managing research projects and timelines while collaborating with multidisciplinary teams.

References

1. Prof. Young-Sik Jung

Professor: Medicinal Chemistry and Pharmacology, University of Science and Technology, Republic of Korea

Principal Investigator: Infectious Disease Therapeutics Research Center Korean Research Institute of Chemical Technology, Republic of Korea Email: ******@*****.**.**

2. Prof. Aman Dekobo

Professor: Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Ethiopia

Email: *********@*****.***

3. Dr. Kesatebrhan Haile Asresu

Postdoctoral research associate: Structural Genomics Consortium (SGC), UNC Chapel Hill, USA. Email: ********@*****.***

DECLARATION: I hereby declare that all the above information is true to the best of my knowledge.

August 23, 2024

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