System Integration Engineer, PhD

YUNTIAN XUE

Sunnyvale, CA ***** 949-***-****

ad5wwc@r.postjobfree.com https://www.linkedin.com/in/yuntianxue/

CAREER SUMMARY

R&D Engineer • System Integration Engineer • Process Engineer

A critical-thinking and diversely skilled R&D engineer with 7 years of professional experience developing medical device and driving efficient system integration solutions through innovative approaches.

A proactive project leader who excels in fostering cross-functional collaboration among colleagues, research institutions, and vendors to deliver creative solutions and achieve project goals efficiently.

A focused and unflappable problem solver who adeptly manages multiple tasks simultaneously and thrives in fast-paced and challenging environments with minimal supervision.

AREAS OF EXPERTISE

In Vitro Diagnostic (IVD)

Data Analysis

Fluorescent Microscopy

Stem Cell Technology

Next Generation Sequencing

Microfluidics

SolidWorks / AutoCAD

DNA Library Construction

Process Improvement

qPCR

Project Management

Python

PROFESSIONAL EXPERIENCE

Axbio Inc., Santa Clara, CA July 2022 – Present

Axbio Inc. is a pioneering company specializing in high throughput nanopore sequencing platform, in vitro molecular diagnostics, and biochips for cancer screening, pathogen detection, and drug development.

System Integration Engineer II

Initially hired as a Process Engineer I then quickly promoted to a project leader as R&D Engineer II in Jan. 2023. Serve as a key member in the System Integration team, leading and managing sequencing product development projects from proposal through project launch.

Spearheaded and managed a quality control and assurance project integrating the sequencer with a Zeiss fluorescent microscope for DNA sequencing mechanism validation. Collaborated with vendors and engineers to optimize mechanical parts and develop imaging analysis algorithms.

Chosen to develop the 4th generation nanopore sequencer product, ensuring software and hardware functionality per SOP. Documented performance, provided feedback for improvements, and communicated regularly with development teams, enhancing product reliability and market readiness.

Constructed and validated sequencing libraries through PCR amplification, end repair, A/T ligation, and purification, successfully validated DNA product using gel electrophoresis and fluorescent imaging.

Optimized the surface chemistry of silicon chips by streamlining SOP, cutting procedure time by 50% through detailed process analysis and experimental design.

University of California – Irvine, Irvine, CA Sep. 2017 – June 2022

Graduate Student Researcher

Led and accomplished the "Retinal Organoids On-a-Chip" project that aimed to overcome the challenges of long-term culture, quality control, and functional characterization of stem cell-derived retinal organoids.

Engineered and invented a specialized microfluidic bioreactor via finite element analysis (FEA), SOLIDWORKS, AutoCAD, 3D printing, and soft lithography techniques for the purpose of long-term tissue culture. Employed diverse biological tests such as qPCR, single-cell RNAseq, SEM, TEM, immunohistology, flow cytometry to assess tissue culture quality.

Conducted discovery research on non-invasive monitoring of retinal organoids using two-photon FILM and hyperspectral microscopy, revealing a metabolic shift and structural development over four months. Partnered across labs and introduced a deep learning algorithm that reduced phototoxicity.

Authored 4 journal papers and 10 conference abstracts. Holder of 1 patent. Proficient in technical writing, data analysis, documentation, and presentations. Experienced with project management tools.

EDUCATION

Doctor of Philosophy, Biomedical Engineering

University of California - Irvine, Irvine, CA

3.97/4.00 GPA, Entering Fellowship, UROP Mentor, TA, ARVO Travel Grant Winner, Bench to Bedside Poster Award Winner

Bachelor of Engineering, Materials Science and Engineering

Southern University of Science and Technology, China

3.82/4.00 GPA, Merit Scholarship, Volunteer at Language Learning Center, Principal Performer of Ruan in SUSTech Folk Orchestra

CERTIFICATIONS

Google Project Management, Coursera, 2024

Data Analytics Boot Camp, University of California - Irvine, Irvine, CA, 2022

SELECTED PUBLICATIONS

oXue, Y., Seiler, M.J., Tang, W.C., Wang, J.Y., Delgado, J., McLelland, B.T., Nistor, G., Keirstead, H.S. and Browne, A.W., 2021. Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance. Lab on a Chip, 21(17), pp.3361-3377. (US Patent app: 17903458)

oXue, Y., Browne, A.W., Tang, W.C., Delgado, J., McLelland, B.T., Nistor, G., Chen, J.T., Chew, K., Lee, N., Keirstead, H.S. and Seiler, M.J., 2021. Retinal Organoids Long-term Functional Characterization Using Two-Photon Fluorescence Lifetime and Hyperspectral Microscopy. Frontiers in Cellular Neuroscience, 518.

oXue, Y., Lin, B., Chen, J. T., Tang, W. C., Browne, A. W., & Seiler, M. J. (2022). The prospects for retinal organoids in treatment of retinal diseases. The Asia-Pacific Journal of Ophthalmology, 11(4), 314-327.

oMcAleer, S., Fast, A., Xue, Y., Seiler, M.J., Tang, W.C., Balu, M., Baldi, P. and Browne, A.W., 2021. Deep Learning–Assisted Multiphoton Microscopy to Reduce Light Exposure and Expedite Imaging in Tissues With High and Low Light Sensitivity. Translational vision science & technology, 10(12), pp.30-30.

VOLUNTEERISM

Seed Consulting Group, Los Angeles, CA Mar. 2021 – May 2021

A nonprofit organization provides consulting to organizations working toward an environmentally sustainable planet.

Consultant

Volunteered with a dedicated team on providing strategic marketing solutions for a wetland protection organization to bolster the organization’s outreach and impact.

Launched a social media platform operation plan for the client through identifying market segmentation, analyzing historical data, and providing recommendations on content creation.

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