Clinical Research Internal Medicine

Robert Weinberg Curriculum Vitae

Email: *********@*****.*** Cell: +1-781-***-****

Education

B.S. in Biology, Massachusetts Institute of Technology (M.I.T.), Cambridge, MA

M.M.Sc. in Immunology, Harvard Medical School, Boston, MA

M.S.. in Pharmacology, Massachusetts College of Pharmacy and Health Sciences, Boston

Academic Employment Record

2024 Science Teacher (Substitute), Chelsea School System, Chelsea, MA Teaching physics, chemistry, biology, calculus, algebra in Chelsea Schools

2020-24 Teaching Assistant II, TH Chan Harvard School of Public Health, Boston, MA Teaching clinical research to physicians, residents, interns, postdocs through global Principles & Practice of Clinical Research https://site.ppcr.org/

2010-20 Research Scientist, M.I.T., Biomaterials Science & Engineering Laboratory Investigation into the cellular and genetic mechanisms underlying the pathology of neuro-degenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Biophysical studies on the aggregation of β-amyloid peptide and how specific antioxidant polyphenols intercalate and interfere with the stacking of β-amyloid peptide thus inhibiting fibrillogenesis. Studies on the cytokines expressed by activated astrocytes and its modulation by these polyphenols. Computational genomic analyses investigating the transcriptomic changes induced in mice by oil palm phenolic compounds and investigating potential new Alzheimer’s drugs from phytochemical extracts.

2016-17 Graduate Thesis research MMSc in Immunology, Harvard Medical School (while working at MIT) Thesis on computational genomic analyses investigating the role of the zinc-finger transcription factor SALL4 on leukemogenesis during the development of acute myeloid leukemia in adults. Discovered that a unique set of transcription factors are induced in those acute B-cell leukemias which contain a t(8;14) chromosomal translocation, which is also often found in cases of EBV-induced Burkitt’s lymphoma

2008-09 Patent Research Analyst for biotechnology patents, Cardinal Intellectual Property, Evanston, IL Biotechnology and Medical Device Expert, Reviewed PCT applications of medical devices, biotechnology patents regarding the critical elements of novelty, non-obviousness and prior art in the field of the invention. My area of scientific expertise was in biotechnology and medical devices. Database searches were conducted in the U.S. (www.uspto.gov), European, World (www.wipo.int), and Japanese Invention databases.

2004-08 Medico-Legal Consultant, Medical Liability & Malpractice, Halstrom Law Offices, Boston Consultation and review of patients’ medical records from hospitals, surgery and physicians’ office practices Assessment of diagnoses, diagnostic work-ups, differential diagnoses, surgeries, invasive medical procedures Review of medical records with regards to regional Standard of Care, Deviation from SOC, proximate causation

2000-03 Emergency Medicine Attending Physician, Jones Memorial Hospital, Wellsville, NY Chief medical provider for pediatric, adult and trauma patients arriving in the ED. Certified in ACLS, ATLS, PALS. Rural community hospital in physician-shortage area with approximately 29,000 visits/yr

1997-99 Primary Care Family Medicine Physician, Parkhill Family Medical Practice, Fitchburg, MA Primary care physician for community medical practice with panel of approximately 4,000 patients – adult & pediatric, Provision of acute and non-urgent medical cases, outpatient surgery, referral to specialists

1991-97 Primary Care Family Medicine Physician, Boston Evening Medical Center, Boston, MA Primary care physician for community medical practice with panel of approximately 5,500 patients – adult & pediatric, Provision of acute and non-urgent medical cases, outpatient surgery, referral to specialists

Publications

1) Robert Weinberg, Vera Koledova et al.,“Palm Fruit Bioactives augment the expression of tyrosine hydroxylase in the basal ganglia of the Nile Grass Rat brain” Nature Scientific Reports

2) Robert Weinberg, Vera Koledova et al.,“Palm Fruit Bioactives modulate the reactivity of IL-1b-stimulated astrocytes in vitro and alter the cytokine/chemokine secretome with reduction of TNF-a, RANTES and IP-10” Nature Scientific Reports

3) Robert P Weinberg et al, “Oil Palm Phenolics inhibit the in vitro aggregation of beta-amyloid peptide into oligomeric complexes”, International Journal of Alzheimer’s Disease, January 2018

4) Robert P Weinberg “Identification of Cell Surface Markers which correlate with Sall4 in a B-cell Acute Lymphoblastic Leukemia with t(8;14) discovered through Bioinformatic Analysis of Microarray Gene Expression Data” MMSc in Immunology thesis, Harvard Medical School, Harvard University Dissertation Archives, 2017

5) Raif S. Geha and Robert P. Weinberg, “Anti-Idiotypic Antisera in Man. I. Production and Immunochemical characterization of anti-idiotypic antisera to human antitetanus antibodies,” Journal of Immunology, Vol.121, No.4, October 1978

6) Robert Weinberg, Vera Koledova et al.,“Palm Fruit Bioactives modulate the secretion of plasminogen activator inhibitor type I from human adipocytes (manuscript under preparation)

7) Robert Weinberg, Vera Koledova et al.,“Palm Fruit Bioactives modulate the intracellular REDOX potential and reduce oxidative stress in CNS Glial cells via a NRF2-dependent mechanism” (manuscript under preparation)

Industry Employment Record

Phenolaeis Sdn. Bhd., Kuala Lumpur, Malaysia web site: https://www.phenolaeis.com/ Co-Founder and Equity Partner, helped develop patent portfolio for Malaysian corporation

Medical consultant and equity partner in biotechnology company focused on production of nutraceutical foods and beverages. Played key role in incorporation process and legal advising. IP portfolio includes 24 patents on bioactive and pharmaceutical properties of the Palm Oil Bioactives (Oil Palm Phenolics)

Medico-Legal Consultants - Provided medical consulting services to attorney firms involved with medical malpractice litigation. Reviewed medical records for deviation from the Standard of Care along with Proximate Causation. Identified high-reward malpractice cases which returned two 3-million dollar judgments

Leadership and Managerial Positions

2013-19 Board Member & Co-Chair, Hummingbird IRB (web site http://www.hummingbirdirb.com ) per diem Review of research & clinical trials involving human subjects requiring IRB approval per regulations (NIH, DHHS,FDA)

2015-18 Committee Member, Disaster Response and Preparedness Committee, ACEP American College of Emergency Physicians, Committee Membership

1998-2008 Founder and CEO of Flights for Humanity, Inc. - 501(c)(3) non-profit foundation Mission aim was to provide medical care and assistance in areas in need. Carried out several humanitarian missions in Mexico and the Caribbean as an instrument-rated certified Pilot (IFR, FAA). Missions were written up and reported in the Tufts Medical School Alumni Journal, MIT Technology Today, and the Fitchburg Sentinel daily newspaper

1991-97 Emergency Medical Director, Boston Evening Medical Center, Boston, MA Oversaw and implemented emergency medical protocols in a neighborhood community health center, now run by the Massachusetts General Hospital

1991-93 Medical Director, CBC Medical Clinic, Lowell, MA Provided primary medical care to the refugee Cambodian community of 35,000 who immigrated from Cambodia in the 1970s to escape the Khmer-Rouge Pol Pot reign of terror genocides

Academic Appointments

2012-2014 Instructor, Dept of Medicine, Boston University School of Medicine, Boston Teaching first- and second-year medical students Integrated Pathology (IP) and Introduction to Physical Diagnosis (ICM)

2009-2010 Adjunct Faculty, Dept of Health Sciences, Bay State College, Boston, MA Taught Anatomy & Physiology, Biology, Medical Office Procedures

2002-2017 Tutoring college and professional students 5-Star rating by over 200 tutee-students taught courses in: Anatomy, physiology, microbiology, calculus, physics, chemistry, biochemisty, tutor for Wyzant

1990-98 Instructor, Department of Community Health & Family Practice, Tufts University School of Medicine, Boston Taught Intro to Clinical Skills, Differential Diagnosis & Problem-based Learning

1990-92 Advanced Cardiac Life Support Instructor, Beth Israel Hospital, Boston, MA Certified by American Heart Association to teach ER docs, residents & physicians. Protocols for resuscitationof persons succumbing to cardiac arrest, ventricular fibrillation, ventricular tachyardia, EMD, bradyarrhythmias

1991-92 Advanced Trauma Life Support Instructor-candidate, Longwood Area Trauma Certified by American College of Surgeons to teach trauma skills including Burr holes, chest tubes, pericardiocentesis

Inventions with Patents Granted

Title: “Protective Effects of Oil Palm Composition on Alzheimer’s Disease”, US20160250274, Primary Inventor: Robert P. Weinberg, Priority Date 2013-10-11

Title: “Composition “Oil palm phenolics composition for the protection of humans, organs, cells and tissues against the injurious effects of exposure to ionizing radiation”,WIPO WO2017116225, Inventor: Robert P. Weinberg, Priority Date 2015-12-31

5 Additional Invention Disclosures filed with the M.I.T. Technology Licensing Office pending decision for U.S. patent

Conference Presentations – International and National

October 2017 - Fourth International Conference on Palm Phytonutrients and Chronic Diseases, Hilton Hotel, Boston “The effects of oil palm phenolics on the production of cytokines by CNS glial cells and the development of Neuroinflammation”, Invitation from Office of Minister Counselor, Malaysian Palm Oil Board, Kuala Lumpur, Malaysia

April 2017 - Eighth Annual International Conference on the Biological and Clinical Applications of Oil Palm-derived Phytonutrients “Modulation of shear-induced signaling in vascular endothelial cells induced by oil palm phenolics”, Massachusetts Institute of Technology, Cambridge, MA

May 2016 – Seventh Annual International Conference on the Biological and Clinical Applications of Oil Palm-derived Phytonutrients “The effects of oil palm phenolics on angiogenesis and Vascular Endothelial Growth Factor signaling” Royal Shangrila Hotel, Kuala Lumpur, Malaysia

April 2015 – Sixth Annual International Conference on the Biological and Clinical Applications of Oil Palm-derived Phytonutrients “The effects of oil palm phenolics on the misfolding and aggregation of beta-amyloid peptide and potential implications for Azheimer’s disease”, M.I.T. Faculty Club, M.I.T., Cambridge, MA

May 2014 - Fourth Annual International Conference on the Biological and Clinical Applications of Oil Palm-derived Phytonutrients “The effects of oil palm phenolics on the activation of NF-κB and transcription of pro-inflammatory genes? M.I.T. Faculty Club, M.I.T., Cambridge, MA

Professional Organization membership (past and present)

College of American Pathologists, Massachusetts College of Emergency Physicians, American College of Emergency Physicians, Massachusetts Medical Society, American Medical Association, American College of Osteopathic Family Practitioners, American Association for the Advancement of Science, Institute of Electrical and Electronic Engineers, Biomedical Section

Clinical Laboratory Experience in Clinical Pathology

Boston Hospital for Women, Lying-In Division – Blood Bank Technologist

Nashua Rehabilitation Hospital – clinical laboratory Hematology, Clinical Chemistry, Microbiology, Coagulation

Brookside Park Family Life Center, Peter Bent Brigham Hospital – medical technologist

Riddle Memorial Hospital, Media PA – medical technologist

Hospital at Parker Hill – clinical chemistry and Hematology

Research Laboratory methodologies / Skills mastered

Nucleic Acid methods : DNA/RNA analysis on agarose gels; DNA & RNA isolation & purification; restriction endonuclease fragment analysis & gene mapping; DNA and RNA preps, cDNA libraries; Northern blots and Southern blots; cloning genes & rDNA using phage & viral vectors; genome editing with CRISPR-Cas, Zinc finger nucleases, use of riboswitches

Bioinformatics methods: Microarray and RNA-seq gene expression analysis using R, Bioconductor, Python, MATLAB; high-throughput DNA sequencing analysis; NGS; machine learning paradigms: hierarchical cluster analysis, random tree forest, neural nets

Protein methods: Western immunoblotting; PAGE electrophoresis; immunoassays including double-sandwiches with fluorescent markers and Coombs tests; Ochterlony gels, ELISA assays; immunoelectrophoresis; RIA assays, radio-iodinating peptides; protein isolation and purification by column chromatography using gel filtration, ion exchange, affinity columns; positive-pressure protein concentration via ultrafiltration; immunoprecipitation, Spectrophotometric assays, Fluorometric assays;

Immunology methods: Monoclonal antibody production including mouse immunization and hybridoma fusions; Flow cytometry cell sorting and analysis

Cell Biology / cytology methods: Immunofluorescent antibody staining of cell surface markers

Microscopy / Cell visualization: Transmission Electron Microscopy, Phase Contrast microscopy, Immunofluroescence staining

Cell and Tissue Culture methods: Flow Cytometry analysis & cell separations; in vivo cellular fluorescence REDOX analyses; cell culture of adherent & suspension cell types

In vivo animal work: mice, rats, rabbits, goats; small animal injections: SQ, IV, IM, IP; immunizing animals with/without adjuvant (CFA); necropsies and autopsies, small animal surgery; novel vaccine development

Electronics and Instrumentation: design of analog circuits on breadboard, signal analysis on oscilloscope; electric circuit fundamentals (R/L/C), Electronic Circuit & Instrument design, building and trouble-shooting: use of Op-Amps and IC chips, amplifiers

Surgery Experience: 6 months in OR experience as Surgical First Assistant, handling, retractors, assisting with sutures, multiple OR types, 1 month Neurosurgical Rotation at Westchester Medical Center, NY -assisted with craniotomies, meningiomectomies, hematoma evacuation

Employment in Clinical Medicine and Patient Care

2000-02 Attending Emergency Medicine Physician, Jones Memorial Hospital, Wellsville, NY Provided urgent and emergent medical care to adult and pediatric patients, performed ACLS, ATLS, PALS

1997-99 Attending Family Medicine Physician, Parkhill Family Practice, Fitchburg, MA Provided Family Medicine and Primary Care to a patient panel of approximately 3,500 patients

1990-97 Attending Family Medicine Physician, Boston Evening Medical Center, Boston, MA Provided Family Medicine and Primary Care to a patient panel of approximately 3,500 patients

1988-90 Attending Emergency Medicine Physician, Hale Haverhill Municipal Hospital, Haverhill, MA Provided urgent and emergent medical care to adult and pediatric patients, performed ACLS, ATLS, PALS

1987-88 PGY-1 Resident in Internal Medicine residency, St Vincent Hospital, Worcester, MA Resident training in MICU, General Medical Wards, Emergency Room, Electives in Dermatology, Ophthalmology

1986-87 PGY-1 Resident in Anatomic Pathology residency, Brown University, Providence, RI Resident training in post-mortem autopsies (performed 53 autopsies), grossing clinical path specimens, histopathology

Computer/Surgical/Foreign Language Skills

Computer programming with MATLAB, R, Python Computer programming on UNIX, Linux with BASH

Bioinformatics analysis of microarray and RNA-seq gene expression data Small animal surgery and necropsy on mice, rats, rabbits

6 months experience as Surgical First Assistant in the Dept of Surgery at Martha’s Vineyard Hospital, Oak Bluffs, MA assisting with C-sections, appendectomies, cholecystectomies

Foreign languages spoken: Russian, French, Spanish

Family/Living Background

Live in Medford, Massachusetts with my wife, two youngest sons and daughter-in-law, and parents-in-law

Enjoy the lakes and mountains of Western Maine, walks along the beach

Enjoyed motorcycling around on my BMW K1200LT; Also enjoy boating and fishing, hiking and camping

Enjoy Foreign travel and exploring new cultures of Europe, Russia, Caribbean, South America

Enjoy reading and exploring new areas of knowledge and scholarship

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