Ravu Vengala Rao, Ph. D.

Contact:+91-900******* e-mail: ad3emb@r.postjobfree.com

OBJECTIVE: To obtain a suitable position in chemical and pharmaceuticals industry where my experience and skills can be effectively utilized and excel my skill set to achieve organizational and individual career goals.

CAREER SUMMARY AND EXPERTISE:

Technical skills:

11+ years of industrial R&D experience in CRO and medicinal chemistry area apart from the Post-Doctoral research.

Strong background in total synthesis of natural products, medicinal chemistry and development of NCEs.

Well experienced in application of new synthetic methodologies for the synthesis of natural products and medicinal chemistry.

Well experienced in diverse areas of Asymmetric synthesis, Organo catalysis, Carbohydrates, Peptides, Sugar amino acids and phosphate chemistry.

Well versed in multi-step organic synthesis, route scouting and process optimization in laboratory scale. Experienced in planning and execution of large-scale projects.

Well experienced in the development of NCEs for the medicinal chemistry projects from mg scale to large scale (up to Kg scale).

Excellent technical proficiency, scientific creativity.

Proficient in writing scientific manuscripts and execution of industrial and academic projects.

Excellent skills in predicting the analytical data and 2D NMR interpretations. Managerial and leadership skills:

Excellent interpersonal and leadership skills.

Well experienced in hiring the talent, training people and team building.

Responsible for the designing schemes, providing the chemistry solutions and delivery of projects.

Planning of the projects from receiving to delivery by coordinating with external and internal stake holders.

Proven track record in successful delivery of projects in FTE and FFS mode within the stipulated timelines with quality. Handled multiple clients in parallel.

Well awareness of laboratory safety practices and implementation record and for various hazardous reactions.

Experienced in lab safety audits, LHA, risk assessment for hazardous reactions.

Training the team in writing eLN and scientific reports. Responsible for eLN audit and providing the feedback.

Well experienced in safety audits, client audits and experienced in preparing and settling audit CAPA reports.

Proven track record in solving the challenging targets and accomplishment of projects.

Good record keeping skills and maintain the laboratory standard in accordance with company practices.

Well experienced in handling the integrated Medicinal chemistry discovery projects.

Excellent record in retaining and growing the collaborations by understanding and meeting the client expectations.

INDUSTRIAL EXPERIENCE:

Syngene International Limited, Hyderabad, India: June 2023 – Aug 2023 Worked as a Senior Principal Investigator in Division of Discovery Chemistry, Syngene International Limited, Hyderabad, India

Leadership role in managing a team of research associates and Ph.Ds.

Responsible for the team productivity, planning the resources and execution of the FTE projects.

Propose, evaluate and develop synthetic routes in the laboratory to determine optimum/preferred conditions for novel molecules, which involved a variety of chemistry heterocyclic, aliphatic, asymmetric synthesis, peptides, sugars and phosphate.

The projects involve day to day problem solving, data analysis, shipment of compounds (mg to gram quantities), writing reports and day to day interactions with internal and external stake holders. Sai Life Sciences Limited, Hyderabad, India: July 2021 – May 2023 Working as a Principal Scientist in Division of Medicinal Chemistry division,

Leadership role in managing a team of research associates and Ph.Ds.

Responsible for the team productivity, planning the resources and execution of the FTE & FFS projects with cost efficiency.

Propose, evaluate and develop synthetic routes in the laboratory to determine optimum/preferred conditions for novel molecules, which involved a variety of chemistry heterocyclic, aliphatic, asymmetric synthesis, peptides, sugars and phosphate.

The projects involve day to day problem solving, data analysis, shipment of compounds (mg to gram quantities), writing reports and day to day interactions with internal and external stake holders. Syngene International Limited, Bangalaore, India: Dec 2018 – June 2021 Worked as a Principal Investigator in Division of Discovery Chemistry, Syngene International Limited, Bangalore, India

Leadership role in managing a team of research associates. Planning and execution of medicinal chemistry projects and library projects with excellent trouble shooting and problem-solving skills.

Propose, evaluate and develop synthetic routes in the laboratory to determine optimum/preferred conditions for novel molecules, which involved a variety of chemistry heterocyclic, aliphatic, asymmetric synthesis, peptides and sugars.

The projects involve day to day problem solving, data analysis, shipment of compounds (mg to gram quantities), writing reports and day to day interactions with clients. GVK Bio-Sciences Private Limited (currently Aragen Life Sciences), Hyderabad, India: July 2014 – Nov 2018

Worked as a Team leader (Scientific manager and Senior Scientific manager) in Division of Medicinal Chemistry,

Led a team of chemists for the Agro and Medicinal chemistry projects for different clients. The projects involving a wide variety of chemistry like hetero cyclic, aliphatic and multi component domino reactions.

The projects involve day to day problem solving, data analysis, shipment of compounds (mg to gram quantities), day to day interactions with cross functional teams and weekly updates and telecons with clients.

Handled for FFS projects with a small team (2-4 members) in parallel with FTE programs (12 members).

Managed different clients in parallel in FTE mode.

Designed alternative routes/strategies for the synthesis of new challenging chemical entities and scaled up the selected candidates in large scale.

Sai Life Sciences, Hyderabad, India: Jan 2013 – June 2014 Worked as an Associate Research Scientist-II in Division of Medicinal Chemistry,

Worked for execution of client based medicinal chemistry discovery projects.

Route scouting, alternative strategies and synthesis of challenging synthetic targets.

Planning the daily activities for junior colleagues and providing the scientific/ technical assistance for project leader.

Chemical Synthesis Laboratory, ICES, Singapore: Aug 2011 – September 2012 Worked as a Scientist-I in Division of Organic Chemistry,

Worked for medicinal chemistry discovery projects in collaboration with Experimental Therapeutic Centre, Singapore.

Route scouting and synthesis of designed molecules, targeting the activation of P53 tumor suppressor and potential poly amine antibiotics to treat superbug infections. ACADEMIC EXPERIENCE:

Postdoctoral research fellow: Aug 2009 – July 2011 at Chemical Synthesis Laboratory, ICES, Singapore. Supervisor: Prof. Chen Yukai David (Collaboration with Prof. K. C. Nicolaou). Accomplishments of Postdoctoral research

Accomplished the synthesis of second-generation analogues of Palmerolide A, a potent natural product against melanoma cancer cells.

Doctoral Research, Sep 2003 –Jul 2009: Indian Institute of Chemical Technology, Hyderabad, India Supervisor: Dr. T. K. Chakraborty.

Accomplishments of Doctoral research

Synthetic studies towards Phorbhaside A: Developed a short and efficient asymmetric synthetic route for the construction of C1-C9 fragment (Key THP core) by using Crimmins aldol strategy and developed highly accessible route for the synthesis of glycoside moiety starting from L-rhamnose.

Total synthesis of Aspinolide B: Developed an efficient and accessible route for the synthesis of Aspinolide B from a commercially cheap chiralpool starting material D-mannitol by using Grubbs RCM as a key synthetic reaction.

Completed total synthesis of -Microcarpalide: Synthesized an anti-microfilament disrupting agent from a commercially cheap chiralpool starting material D-mannitol by using Grubbs RCM as a key step.

Conformational studies of peptides containing cis-3-hydroxy proline.

Synthesis and conformational analysis of various sugar amino acid based peptidomimetics. INDUSTRIAL PROJECTS HANDLED DURING Ph. D

Dupont crop protection, USA.

Zydus-Cadila research centre, India.

Dabur Research Foundation, India.

EDUCATION:

Ph. D. in Chemistry, 2003 to 2009. Indian Institute of Chemical Technology, Hyderabad, India. Worked under supervision of Dr. T.K. Chakraborty. Thesis entitled “Total synthesis of Microcarpalide, Aspinolide B and synthetic studies towards the top half of Phorbaside A”

M.Sc. (Master of Science in Chemistry, June 2003, First division with distinction) Osmania University, Hyderabad, India

B.Sc. (Bachelor of Science in Chemistry, Botany and Zoology, June 2000, First division). Osmania University, Hyderabad, India

FELLOWSHIPS:

Research Fellowship by Council of Scientific and Industrial Research (CSIR), Government of India.

Post-Doctoral Research Fellowship by A*STAR, Singapore. COURSES ATTENDED:

Drug discovery training course conducted by Experimental Therapeutic Centre, A*STAR (Agency for Science, Technology and Research, Singapore).

MCADDI 2019- Medicinal Chemistry and Drug Discovery and Development India 2019 (Training program conducted by Biocon academy)

CONFERENCES ATTENDED:

Attended 2nd International conference on “Organic Synthesis and Process Chemistry”, at IICT, Hyderabad, India, April 1-3, 2005.

Joint International conference on “Advances in Organic Chemistry and Chemical Biology” AOCCB 2006, Hyderabad, India, January 11-12, 2006.

UK-Singapore symposium on Contemporary strategies and practices in Medicinal chemistry 8th September 2011.

PUBLICATIONS:

1. Chemical synthesis and biological evolution of second generation Palmerolide A analogues Rao, R. V.; Leung, G. Y. C.; Lim, C. S.; Ng, S. Y.; Sum, R. J.; Chen. D. Y. K. Eur. J. Org. Chem, 2011, 463-468.

2. Total synthesis of Aspinolide B: a ring closing metathesis approach (cited as top 25 hottest article of TetrahedronLetters in 2007) Ghosh, S.; Rao, R. V. Tetrahedron letters, 2007, 48, 6937-6940. 3. Total synthesis of -Microcarpalide from D-mannitol (cited as top 5 hottest article of TetrahedronLetters in 2005); Ghosh, S.; Rao, R. V.; Jakkepally, S. Tetrahedron letters, 2005, 46, 5479-5481. 4. Conformational studies of peptides containing cis-3-hydroxy proline Chakraborty, T. K.; Pothukanoori, S.; Rao, R. V.; Kumar, S. K.; Kunwar, A. C. Journal of Organic Chemistry, 2004, 69, 7399-7402.

5. ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae

David T. Davies,* Simon Leiris, Nicolas Sprynski, Jérôme Castandet, Clarisse Lozano, Justine Bousquet, Magdalena Zalacain,1 Srinivas Vasa, Praveen K. Dasari, Ramesh, Pattipati, Naresh Vempala, Swetha Gujjewar, SyamKumar Godi, Raju Jallala, Rajashekar Reddy Sathyap, Narasimha A. Darshanoju, Vengala R. Ravu, Ramakrishna R. Juventhala, Narender Pottabathini, Somesh Sharma, Srinivasu Pothukanuri, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Jean- Denis Docquier, Marc Lemonnier, Martin Everett. ACS Infect. Dis. 2020. 6, 9, 2419-2430 REFERENCES:

Dr. Tushar Kanti Chakraborty

Department of Chemistry

Indian Institute of Science,

Bangalore, India-560012

E-mail: ad3emb@r.postjobfree.com

Prof. David Yu-Kai Chen

College of Natural sciences

Gwanak campus, Seoul National University

South Korea. Tel. +822*******

E-mail: ad3emb@r.postjobfree.com

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