EDUCATION AND TRAINING

****-**** **, ** **** University of the Witwatersrand, Johannesburg, South Africa

MAJORS: ECONOMICS, ENGLISH (FIRST CLASS, SUMMA CUM LAUDE)

****-**** ** ***** ***** School of Medicine, New York, NY

2000-2005Brigham and Women’s Hospital and Harvard University, Boston MA Postdoctoral fellowship in infectious diseases

2005-2008Resident in Clinical Pathology, Brigham and Women’s Hospital, Boston, MA

SKILLS

Directing high complexity CLIA laboratories

Laboratory quality and regulatory compliance

Primary care

Addiction medicine

Occupational Health

Weight loss medicine

APPOINTMENTS AND POSITIONS

9/2023-1/2024 Physician, MDSI, Hayward and Fairfield, CA

9/2023-1/2024 Attending physician, Baymark Health Services, Oakland and San Mateo, CA

10/2022-12/2022 CEO, GilaRiverMD, an on-line weight loss clinic, Pleasant Hill, CA

8/2022-4/2023 Medical Director, Millennium Health, Inc, San Diego, CA

1/2021-7/2022 Laboratory and Medical Director, Perkin Elmer Genomics, CDPH Branch Laboratory, Valencia, CA

3/2020-10/2022 Part time laboratory director, COVID-19 lab, Color Genomics, Burlingame, CA

12/2017-1/2020 Medical Director, Millennium Health, San Diego, CA

1/2015-8/2017 Laboratory Director, Invitae, San Francisco, CA

1/2015-6/2016 Laboratory Director, Precision Diagnostics, San Diego, CA (part-time)

4/2013-1/2015 Consultant, Private Biotech.

8/2008-4/2013 Assistant Professor of Pathology, Department of Pathology, University of Pittsburgh,

Laboratory Medical Director, Clinical Laboratories, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA

Founder and Director, Hemoglobin Diagnostics Service, UPMC.

PROFESSIONAL CERTIFICATION AND LICENSURE

2013- NYS COQs in Clinical Chemistry and Toxicology

2013- California Medical License (C5591), expires 10/20/2024, renewable

2008- Board Certification, Clinical Pathology (08-425), no expiration date

2013 State of Arizona Medical License (Inactive)

2008 Pennsylvania Medical License (MD435621) (Inactive)

2008 Commonwealth of Massachusetts Medical License (Inactive)

DEA licensed

MEMBERSHIPS IN PROFESSIONAL SOCIETIES

2015- Association of Molecular Pathology

2008- American Society for Clinical Pathology (ASCP)

2008- College of American Pathologists (CAP)

2008- Society for Pediatric Pathology

2007- Academy of Clinical Laboratory and Physician Scientists (ACLPS)

PRIZES AND AWARDS

2009-2013 Howard Hughes Medical Institute Physician-Scientist Early Career Award

2002-2005 Leukemia and Lymphoma Society (LLS), Grant Awardee (Fellow),

2000 Morris B Bender Family Prize for Clinical Neurology,

1998-1999 Howard Hughes Medical Institute Research Training Fellowship

1992- Faculty of Arts Gold Medal, University of the Witwatersrand

1988- University Council Entrance Scholarship

INVITED REVIEWER ACTIVITY

2012- Ad-Hoc Reviewer, Current Microbiology

2012- Ad-Hoc Reviewer, Cellular Physiology and Biochemistry (Karger)

2011- European Journal of Immunology

2009- Ad-Hoc Reviewer, Journal of Pediatric Pathology

2008- Reviewer, CDC Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) grants, Atlanta, GA.

COMPLIANCE AND REGULATORY ACTIVITIES

2016- Prepared Medicare/Palmetto Molecular Diagnostics Technical Assessment

2015- FDA presentation at invitation of E Mansfield, Gaithersburg, MD: NGS testing at Invitae.

2015- Successful NYS, CLIA inspections, granting of NYS and CLIA licensure for Invitae.

UNIVERSITY ACTIVITIES

2012- Chair, Clinical Laboratory Standards Committee (CHP)

2010- Clinical Pathology Rotation Director:Pathology Residency (Junior Lab Director Program) and Pediatric Pathology Fellowship

2009- Physician representative, Executive Patient-Safety Committee (CHP)

2008- Member: Molecular Virology Program, UPCI

2008- Lecturer: Molecular Virology graduate course (Tumor Virology), UPCI and Hillman Cancer Center

2001-2005 Tutor, Infectious Diseases and Immunology course, Harvard Medical School

MEETINGS AND ABSTRACTS (2012)

2016- European Society of Human Genetics, May 21st-24th, Barcelona, Spain McCalmon et.al. “SMRTer Confirmation”: Scalable Clinical Read-through Variant Confirmation Using Pacific Biosciences’ SMRT Sequencing Platform.”

2015- American Society of Human Genetics (ASHG) (forthcoming) October 6-10, Baltimore, MD Lincoln et. Al. “To confirm or not confirm, That is the Question: A rigorous approach to evaluating the importance of Sanger confirmation of NGS findings”

2015- NIST/ Genome in a Bottle (GIAB) Consortium Working Group, August 27-28th (participant)

2015- ACMG Annual Clinical Genetics Meeting, Salt Lake City, Utah, March 25-28th (attendee).

2012- International Conference on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, PA, August 1-4, 2012) Epstein-Barr virus (EBV) ZTA interacts with histone modifying proteins MLL2 and JMJD2C to create an epigenetic footprint favoring lytic replication Taylor GM and Rosendorff A

2012- Proteomics, Interactomes. May 7-May 12, 2012, Stockholm, Sweden (Keystone Conferences) Epstein-Barr virus (EBV) ZTA interacts with histone modifying proteins MLL2 and JMJD2C to create an epigenetic footprint favoring lytic replication Taylor GM and Rosendorff A

2012- AACR “Mass Spectrometry in the Clinical Lab: Best Practices and Current Applications” September 6-7, Chicago, IL.

GRANT FUNDING

2008-2014 Howard Hughes Medical Institute, Physician-Scientist Early Career Award

2002-2005 Leukemia and Lymphoma Society Early Career Award

PUBLICATIONS

(1) Ami P. Shah, M.D., M.P.H; Benjamin T. Cobb; Darla R. Lower, MT(ASCP); Nader Shaikh, M.D.; Jayne Rassmusen, MPM, MT(ASCP); Alejandro Hoberman, M.D.; Ellen R. Wald, M.D.; Adam Rosendorff, M.D.; Robert W. Hickey, M.D. Enhanced vs. Automated Urinalysis for screening of Urinary Tract Infections in Children in the Emergency Department. (submitted NEJM)

(2) Adam Rosendorff, Comparison of CEDIA FK506 assay with HPLC/MS/MS in a large cohort of pediatric patients (Am J Clin Pathol. 2013 Jun;139(6):788-92)

(3) Maurer S, Rosendorff A Hemoglobin Pittsburgh: Spurious hypoxemia by pulse oximetry due to a novel alpha-chain hemoglobin variant in a 12 year-old boy (submitted, American Journal of Clinical Pathology)

(4) Activated Partial Thromboplastin Time is a Better Trending Tool in Pediatric ECMO Timothy M. Maul TM, Wolff EL, Rosendorff A, Morell VO and Wearden PD, Pediatr Crit Care Med. 2012 Nov;13(6):e363-71. doi: 10.1097/PCC.0b013e31825b582e.

(5) Taylor GM, Raghuwanshi SK, Wadowsky R, Rowe DT Rosendorff, A Endoplasmic Reticulum Stress Causes EBV lytic replication Blood August 17, 2011

(6) Davies ML, Xu S, Lyons-Weiler J, Rosendorff A, Webber SA, Wasil LR, Metes D, Rowe DT. (2010) Cellular factors associated with latency and spontaneous Epstein-Barr virus reactivation in B-lymphoblastoid cell lines. Virology. 400:53-67

(7) Garrido J, Maruo S, Takada K, Rosendorff A EBNA3C interacts with Gadd34 and counteracts the unfolded protein response. Virol J. 2009 Dec 29;6(1):231.

(8) Rosendorff, A and Dorfman, DD Factor VLeiden: a review Arch Pathol Lab Med. 2007 Jun;131(6):866-71.

(9) Portal D, Rosendorff A, Kieff E Epstein-Barr nuclear antigen leader protein co-activates transcription through interaction with histone deacetylase 4. Proc Natl Acad Sci USA 2006 103(51): 19278-83.

(10) Rosendorff A, Sakakibara S, Lu S, Kieff E, Xuan Y, DiBacco A, Shi Y, Shi Y and Gill G NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5308-13.

(11) Rosendorff A, David G, Lin J, Kieff E and Johannsen E. EBNA3C coactivation with EBNA2 requires a SUMO homology domain. J Virol. 2004 Jan;78(1):367-77.

(12) Rosendorff A, Ebersole BJ, Sealfon S. Conserved helix 7 tyrosine functions as an activation relay in the serotonin 5HT2C receptor Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):90-6.

(13) Chu JL, Ramos P, Rosendorff A, Nikolic-Zugic J, Lacy E, Matsuzawa A, Elkon KB. "Massive upregulation of Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome." J. Exp. Med. 1995;181:393-398.

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