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Mass Spectrometry Drug Development

Location:
Los Angeles, CA
Posted:
January 15, 2024

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Resume:

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Andrew Mead, PhD

***** ******* ** ** *********

Pacific Palisades, CA 90272

+1-310-***-****

ad2syg@r.postjobfree.com

Resume objective

Qualified scientist with five years of research experience in the Pharmaceutical Science field, seeking position that will allow me to apply skills in Liquid Chromatography and Mass Spectrometry, Molecular and Cell Techniques, Drug Development, Preclinical Studies, Immunology, and Assay Development

Educational achievements

USC, PhD, Experimental Clinical Therapeutics, GPA 3.96, Dean’s Fellow, Aug 2017-May 2023 USC, MS, Regulatory Science/Affairs, GPA 3.86, Aug 2018-May 2021 UC BERKELEY, B.A. Molecular/Cell Biology, GPA 3.67, Aug 2013-May2017 Research experience

Pharmaceutical Science, Experimental Clinical Therapeutics, 2017-2023

● Constructed liquid chromatography-mass spectrometry (LC-MS/MS) lipidomics and solid-phase extraction methods for liquid biopsy of disease

● Experienced in aseptic cell culture (stem cells), qPCR, western blot, DNA/RNA extraction, ELISA, immunostaining, fluorescent microscopy, and flow cytometry

● Established a drug-carrier platform of bioconjugated cyclic, cell-penetrating peptides evaluated with PK/PD preclinical studies

● Developed an orally bioavailable small molecule lipoxin analogue for the treatment of retinal dystrophy targeting chronic inflammation

● Created a sub-buccal polymer formulation for sildenafil and tempol therapeutics as a fast-acting alternative to enteric-coated oral formulations

● Extensive animal handling experience applying oral gavage and subcutaneous administrations, caliper measurements, and end of study tissue

● Generated a mutant scFv targeting the CD22 epitope on B-cell malignancies for an antibody-drug conjugate therapeutic

● Instituted quality assurance and quality control (QA/QC) standards to maintain regulatory quality standards of GMP/GLP

● Knowledgeable in software and hardware during HPLC and LCMS method development, device calibration, and maintenance

● Designed plasmids, transformed E. Coli, purified/refolded protein inclusion bodies using FPLC and SEC, and checked fractions with SDS-PAGE

● Propelled new therapeutic candidates through the drug development pipeline with innovative technical writing in grant proposals and posters/presentations

● Collaborated effectively with fellow colleagues, including serving in leadership positions Technical skills

● Chromatography and Mass Spectronomy

● Cell Culture

● Microscopy/Imaging

● Biochemical Assays/Molecular Techniques

● Regulatory affairs expertise

● Software and Database knowledge



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