mailto:ad2mey@r.postjobfree.com%

SHAH NAWAZ KHAN

PhD (London)

ad2mey@r.postjobfree.com

POSITIONS HELD:

Professor of Pathology (Chemical Pathology),

Academic Supervisor for MPhil / PhD studie

, Peshawar Medical College, Peshawar..

Eminent Professor of Pathology, Higher Education Commission, Islamabad & Department of pharmacology- combined Project (2004 -2006,- University of Peshawar

Professor & HOD, Department of Pathology, Jinnah Medical College, Peshawar ( 2005 – 2006 )

Associate Professor of Biochemistry, Foundation University Medical College, RAWALPINDI, Advisor, Higher Education Committee, Member Academic Council, Foundation University. (2002- 2005)

Associate Professor of Pathology, Frontier Medical College, Abbott Abad (2002)

Assistant Professor / Research Scientist,, Department of Chemical Pathology, COURTAULD INSTITUTE, the UCL - Middlesex Hospital School of Medicine, London, University of London 1981 -1985

Consultant for Pathology / Clinical Labs at King Khalid Hospital and Maternity & Children, Ministry of Health, Tabuk; Kingdom of Saudi Arabia, (1990-1999).

Director, Continued Medical Education for doctors, KSA (1989-1999).

Chief of Department of Hospital-infection Control, MCH., KSA (1990- 1999)

Regional Chief for diagnosis and treatment for metabolic diseases in the New-Born, Tabuk Province, Ministry of Health, Saudi Arabia(1990 – 1999)

Director / Coordinator (R&D), Diagnostic & biomedical research products, Polytechnic Enterprises, Pompino Beach, Florida / Fountain Valley, California, USA (1999-2001)

Academic Positions

Chairman, Postgraduate Department of Biochemistry & Chemistry, Govt. Postgraduate College, Abbottabad, University of Peshawar, Pakistan ( 1976 -1981, 1986 – 1990)

Member, Board of postgraduate Studies, University of Peshawar (1986-1990)

Assistant Professor & Research Associate, Department of Chemical Pathology, University College & Middlesex Hospital Medical School, University of London. (1981—1985)

Research Fellow /Assistant Professor, Basic Medical Sciences Institute. Jinnah Postgraduate Medical Centre, Karachi (1976-1978)

Assistant Professor / Lecturer Postgraduate Biochemistry –Chemistry 1964 -1976

ORGANIZATION / PLANNING & ADMINISTERATIVE EXPERIENCE:

Experience in teaching, practical research, management and administration in multidisciplinary scientific fields

Chairman / Postgraduate Department (Biochemistry, Chemistry & Basic Applied Medical Sciences), Postgraduate College, Abbottabad 1978 – 1980, 1986 - 1992

Director (Technical), Clinical Pathology Division, King Khalid & Maternity & Children Hospital, TABUK (KSA) 1989 – 1999

Chief of Hospital Infection Control, Maternity & Children Hospital, TABUK, KSA, 1989-99

Chief of Project for the screening & treatment of Congenital Hypothyroidism in the new born in TABUK PROVINCE (KSA) 1989 –1999

Managing Director Coordinator (R & D), Polytech Enterprises, Fountain Valley, California (USA) 1999- 2001

Chairman, Postgraduate Education Planning Committee, Frontier Medical College, Abbotabad 2002 -2003

Secretary / Organizer, Higher Education Committee, Foundation University Medical College, Rawalpindi 2003 – 2005 Organized guidance to the Approval Authority, the PMDC inspection teams. Prepared feasibility reports for the establishment of higher auxiliary institutes (Higher Education – Training Courses for College of Pharmacy and the scientific research Laboratories) There was a successful outcome and the proposals were approved.

- Posses experience as Specialist / Consultant for Clinical Pathology &

Laboratory Medicine Got experience in U.K (The Middlesex Hospital Medical School, London W1,

National Hospital, Queen Square, London,,

Orange County Hospital, California, USA.

King Khalid Hospital (tertiary care 450 bed recognized for MRCP, FRCP training ) Tabuk KSA

Was responsible for investigations involving clinical pathology, hematology, endocrinology, hospital infection control in 5 Hospitals of Tabuk province KSA

Director / Provincial Chief for Screening & treatment programme for the diagnosis and early treatment of New born Endocrine / metabolc disorders,, Tabuk province, Saudi Arabia. (1990 -19 99)/metabolic

Chief of Hospital Infection Control Programme (1990 – 1999)

Project Director / Coordinator, Polytech Research Labs, Fountain Valley CA,USA 1999 -2002

While in USA, as the Research Director directed, genetic studies using embryonic cell cultures and development of mutated tissue cell lines -- Tissue Cell cultures, & experimentation, Cryopreservation in quid nitrogen storage system for cell lines, tissues, RNA, DNA, plasmids, antibodies etc … the Project started with culture o f mouse embryonic cells to evolve techniques for future marketing of bio active original products

However the 9 -11 events in USA, disturbed the whole family, following intra communal disturbances resulted into the murder of a close friend & financial losses which forced to return back to Pakistan

Practical Scientific Skills:

Possess practical Skills in the fields of Chemical Pathology, biochemistry,pharmacology; microbiology; Immunology, endocrinology & pharmaceutical sciences.

Chemical Pathology research studies using embryonic cell cultures and development of mutated tissue cell lines -- Tissue Cell cultures, & experimentation, Cryopreservation, liquid nitrogen storage system for cell lines, tissues, antibodies,

Clinical Chemistry, clinical laboratory techniques

-Endicrinology / special pathology

--Pharmacology of drugs and experimental techniques,

Ischemic Heart disease- biochemical parameters

Immunology and practical techniques

Laboratory practical teaching Courses in clinical chemistry, Microbiology and Pharmacology all graduate & postgraduate levels.

Epidemiological and clinical research, Nosocomial Infections and their Control - teaching, training of doctors, Nursing and paramedical staff.

Experimental medicines and Cell-membrane-research

-Animal experiments (Rabbit, Guinea Pig, Mice, Rat) and In Vitro experiments on isolated tissues & Cell cultures.

- Protein analysis, Gel electrophoresis including SDS-PAGE, radio-labeling, Staining of Gels with different stains, auto radiography of the gels, Southern blot, Western-blot, Protein–phosphorylation studies, Chromatographic techniques including TLC. GCM, HPLC Photo Density measurement and uses in research. Hospital Infections and their Control - teaching, training of doctors, Nursing and paramedical staff.

-Cell-membrane- lipids & Proteins, Phospho-Lipids - release and activation reactions in cells, Signal-transduction, Phospho Inositol -response, Effect of experimental drugs on Protein Kinase C activity; Blood & tissue cell-fractionation, Protein analysis, phospholipid separation ……STIMULUS RESPONSE COUPLING IN LIVING CELLS.

-Thrombosis research- Blood Platelet-activation, Platelet - aggregation & desaggregation studies, In vivo and in vitro effects of drugs on platelet activation, anti-thrombotic and fibrinolytic agents. Platelet release reactions, coagulation chemistry.

-Cardiovascular diseases, metabolic disorders, diabetes, Multiple Sclerosis

- Hormonal deficiencies & biochemical defects.. Endcrine disorders --

Newborn & adult .

PHARMACOLOGY & TOXICOLOGY:

Pharmacology of drugs acting on CNS, GIT, Cardiovascular, Respiratory, Renal & Reproductive systems, Chemotherapy of Microbial and neoplastic diseases, drugs acting on the blood & blood forming organs, Hormones & their antagonists, prescription & orders, drug interactions, Side effects & toxicology drugs acting on CNS, GIT, Cardiovascular, Renal, Reproductive systems, microbiological assays, Cancer and carcinogens anticancer treatment, radiations & their hazards, quality control, quality assurance. Experimental Techniques in Pharmacology, biochemistry, pharmacology, genetic experiments Bleeding & Tissue collection, Study of metabolic disorders, diabetes and Cardiovascular research. Drug testing,

Practical pharmacology-, Animal experimentations (Rabbit, mice, Guinea pig) - ED50, LD50, Therapeutic index. bio-availability Effect of drugs on isolated organs & tissues perfusion experiments, extraction of metabolic products, concentration & lypholization...

Clinical Lab.

All clinical chemistry tests by manual and instrumental methods, immunoassays, Enzyme Assays, ELISA, Electrolytes, Visible & UV spectrometry, atomic-absorption spectrometric analysis. Radio-immuno Assays, Immuno Fluorescence assays,

Blood banking - blood–donor selection, phlebotomy, blood screening, grouping, cross matching, RBC, WBCl and Platelets preparations, etc

Lab- administration,

Clinical Chemistry, microbiology, immunology, endocrinology, & Research Laboratories. analysis, ELISA, IMFA,RIA, IR & Spectrometric techniques

Supervision of blood bank Hematology & clinical analysis. Chromatographic techniques, instrumental methods

Chemistry- Organic & pharmaceutical

Molecular structure, properties & state of matter, complex formation, thermodynamics, Solutions and phase equilibrium, ionic/electrolytic equilibrium, drug solubility, drug stability, drug activity, drug absorption, osmolality,osmolarity,osmoticity, tonicity, chemical kinetics, colloids, suspensions & emulsions, surfaceactants, micelle formation, Organic Pharmaceutical chemistry, hetrocyclic Compounds, Inorganic Pharmaceutical chemistry, Natural products-lipids, waxes and oils, alkaloids, drug nomenclature (British & USA), structure-activity relationship, Radio-nucleotides, biological assays, specialized analytical methods & equipment, of. Powders, Solutions, emulsions, suspensions and extracts, antibiotics, Infection Control.

Drug administration routs., bioavailability, topical, oral, ophthalmic preparations, aerosols, drugs acting on CNS, GIT, Cardiovascular, Renal, Reproductive systems, Chemotherapy, microbiological assays, Cancer and carcinogens, anticancer treatment, radiations & their hazards, quality control, quality assurance. (Reference Remington: The Science & Practice Of Pharmacy- AR Gennaro)

Laboratory / research techniques:

All analytical techniques and procedures, Physico-Chemical methods of analysis,

Synthetic and analytical methods of organic chemistry and Inorganic

-Drug formulation- preparatory methods including freeze-drying & lypholization.

-Protein Analysis and purification methods.

Chromatography- Thin layer chromatography, Column Chromatography,

High Performance Liquid Chromatography, Gas chromatography,

-Spectrometry, Visible spectrometry, Ultraviolet Spectrometry, Infrared Spectrometry

Atomic Absorption Spectrometry,

Immuno Florance measurements, IMFA

-Radio active tracers / materials in diagnostic procedures,

-Radiolabeling of living cells in vivo and in-vitro

- Use of radiotracers in chemistry, biochemistry and pharmacology research

-Effects of Radiation on human and animals, measurement of radioactivity in cell and in vitro experiments.

-Immunology and immuno reactions,

- Molecular biology techniques --Gel Elecrophoresis, Polyacrylamide Gel Electrophoresis, Immunofloresnce- Immunoflorometric Assays, Membrane research and protein purification methods,

Clinical Research for finding out cause of disease by gathering clinical and Laboratory data on patients, Drug trials, Designing the research study, Education of the hospital staff in the proper study procedures and gathering of information on patients, Investigating and clarifying Research .

Research Interests:-Ischemic heart Disease, Cancer, Multiple Sclerosis, hospital infections and control, Toxicology & effects of drugs. Clinical cases - missing or unclear information, Re-formation of data,statistical analysis and research proposals, Monitoring of hospital staff for proper procedures, Assisting with new patient enrollment, Coordination among staff, patients and sponsoring agencies, documentation,

Education of the hospital staff in the proper study procedures and gathering of information on patients, Investigating and clarifying missing or unclear information, Re-formation of data and statistical analysis, Monitoring of hospital staff for proper procedures, Assisting with new patient enrollment, Coordination among staff, patients and sponsoring agencies, documentation and records.

LABORATORY MANAGEMENT:

Laboratory set up, design, arrangement, procedures and methods for the preparation of solutions and reagents,

Quality control, provisions, requirements, catalogues, quotations and purchase-agreements Biochemistry, chemistry, microbiology, and pharmacology.

Hospital Infection Control, preventive medicine, Antibiotic Policy, Hospital Quality Control, Infection Control procedures, guidelines and policies.

Management (Executive); Have experience in administration and management as an Managing Director (R & D) for POLYTECH ENTERPRISES, a Bio-medical Product Company in USA (1999-2002)

Computer/Software Knowledge of healthcare information, systems environment working with end user to extract, document and optimize date flow, implement systems and support applications entry

SCIENTIFIC DISCOVERIES (Original Research - USA / UK )

1. Role of Trace Elements in Ischemic Heart Disease

2. Discovered for the first time the phenomenon of reversal of aggregation of blood platelets through drugs.

3. Signal transduction mechanisms in Living Cells involved in diseases and abnormalities

Projects Completed:

Ischemic Heart Disease and Level of Trace elements In PAKISTANI Patients 1976-1978

Etiology of Multiple Sclerosis –role of Platelet Activation……. Multiple Sclerosis Society Of Great Briton. 1982 -1984 50,000 Pond Sterlings

Study of phenomenon of Reversal of cell stimulation (First time discovery) and mechanisms of control through drugs 15 million pounds sterling / 4years

Role of Borna Virus in patients of multiple Sclerosis (USA) 2 years Poly Tech Research Enterprises, Florida / California 92804 (2001- 2002 5 million $

Early diagnosis and treatment of mental retardation in the New - borns, Tabuk Province, Ministry of Health, Kingdom of Saudi Arabia (1990 - 1999 )

INTERNATIONAL PRESENTATIONS

International meeting of British Pharmacology Society at London in December, 1981

National Conference of Pakistan Cardiology Society, 1979

International Conference of Japanese Biochemical Society meeting held at Sendi, Japan, 1981

III International Congress of Inflammation -1984 Paris (3-7 September)

First International Conference on PAF-acether in PARIS –August 1983

British INVENTORS CLUB, London meeting, 1985

International Conference of Fatty Acids and Prostaglandins in London, June.1984

International conference of Pakistan Cardiology Society of held in Swat, 1987

.International Conference (1999) on Hospital acquired infections and their control held at Al-Qaseem,, Saudi Arabia April, 1998,1999 many others

PUBLICATIONS & PRESENTATIONS

Guidance & traininig to MSc Students of Biochemistry / Chemical Pathology, University of Peshawar (Pakistan) :-

Bano, S & Khan, S.N. (1988) Serum Electrolytes & enzymes in Diabetes Mellitus; MSc Thesis, University of Peshawar.

Shah, A.W & Khan, S.N. (1988) Analysis of lipids in brain of goat.MSc Thesis, University of Peshawar.

Mehmood, T & Khan, S.N. (1989) Trace elements level in soil and water of tehsil Abbottabad MSc. Thesis, University of Peshawar.

Anwar, J & Khan, S.N. (1989) commercially available antibiotics and their effectiveness against bacteria - MSc Thesis, University of Peshawar.

Mehmmod, K & Khan, S.N. (1989) Infantile Diarrhea - Bacteria involved and their sensitivity to drugs - MSc Thesis, University of Peshawar

Rahman, M.A. & Khan, S.N.(1989) Lactate Dehydrogenase Activity in cerebrospinal fluid from patients of Meningitis; MSc Thesis, University of Peshawar

Shah, S. & Khan, S.N. (1989) Biochemical and pharmacological study of Centella Asiatica. MSc Thesis, University of Peshawar

Khan, A. & Khan, S.N. (1989) The study of Staphylococci and Streptococci in upper respiratory tract infections. MSc Thesis, University of Peshawar.

Mughal, M.A & Khan, S.N. (1989) Detection of Narcotic Alkaloids in blood and urine and effects on liver function; MSc Thesis, University of Peshawar.

Zaheer, M & Khan, S.N. (1989) Determination of trace elements level in food constituents at different heights of Abbottabad District. MSc. Thesis, University of Peshawar

Shah, S & Khan, S.N. (1990) Serum Zinc, Copper, Iron and Manganese in relation to female fertility; MSc Thesis, University of Peshawar.Iqbal, Q.K. & Khan, S.N. (1990)

Mustafa, A. & Khan, S.N. (1990)Unsaturated fatty acids and trace elements in Garlic & Onion;, MSc. Thesis, University of Peshawar. Nutritional components of horse chestnut seeds; MSc Thesis, University of Peshawar.

Ahmed, J & Khan, S.N. (1990) Serum level of trace elements in normal and narcotics addicts; MSc Thesis, University of Peshawar.

Ayaz, M. & Khan, S.N. (1990) Serum levels of copper and Zinc in patients of renal diseases; MSc Thesis, University of Peshawar

Bashir, Abida & Khan, S.N. (1990) Serum level of Zinc, copper, Chromium and Manganese in Diabetes Mellitus; MSc. Thesis, University of Peshawar.

KhanS N & Kazmi H A 1964 Kinetics Features of Oxidation of Alcohols 1964 MSc Thesis, University of Peshawar

Khan, S.N. & Rahman M.A Serum Trace Elements in Iscxhemic Heart Disease, Mphil thesis, University of Karachi 1978

Khan, S.N. & Smith AD, Platelet Aggregation Induced by PAF acether A biochemical & morphological study of blood platelet aggregation & desaggregation 1985 PhD Thesis University of London.=

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-Only shortlisted candidates will be contacted.

-Applications should be submitted latest by November 23, 2

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