Jim R. Kuykendall, PhD, PharmD, DABT

**** ******* *****

Erie, CO 80516

303-***-**** cell

ad1zwb@r.postjobfree.com

Education

B.S. Biology, B.S. Biochemistry, Virginia Polytechnic Institute, 1983

Ph.D., with honors, Biochemistry, University of Tennessee, 1988

Academic Post-doctoral Fellow, Harvard Medical School, 1989-91

Industrial Post-doctoral Fellow, E. I. DuPont de Nemours and Company, 1991-94

Doctor of Pharmacy, with honors, Idaho State University, 1998

Diplomat- American Board of Toxicology, 2005, recertified 2010, 2015

Work Experience (from most recent)

Relief Pharmacist, Highlands Behavioral Health, Comprehensive Pharmacy Services, Denver CO (12/22-present)

Relief Pharmacist, Specialty Medical Staffing, Everett WA 10/22-present.

Part-time Pharmacist, Byers Pharmacy, Byers CO (1/23-present)

Regional Pharmacy Consultant, Center at Northridge, Westminster CO, 11/2016-5/2022

Float Pharmacist, King Soopers Pharmacy, Boulder, CO, 8/2016-11/2016

Director of Pharmacy, Fort Logan State Psychiatric Hospital, Denver, CO, 5/2012-6/2016

Director of Pharmacy, Centennial Peaks Hospital, Louisville, CO, 5/2009-5/2012

Pharmacist, Safeway Corporation, Denver, CO 10/2007 – 5/2009

Senior Managing Health Scientist, ChemRisk Consulting, Boulder, CO 11/2005 - 8/2007

Assistant Professor of Biochemical Toxicology, Raabe College of Pharmacy, Ohio Northern University, Ada, OH 9/2003-10/2005

Adjunct Assistant Professor of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, ID 7/1999 - 8/2003

oClinical Pharmacist Indian Health Service, Fort Hall, ID

oLecturer- pharmacy, nursing and dental hygiene students

oClinical Pharmacist Veterans Administration Nursing Home

Staff Retail Pharmacist: Albertson’s Pharmacy, Blackfoot, ID 3/2001 - 8/2003; Wal-Mart Pharmacy, Blackfoot, ID 2/1999 - 3/2001; Super Save Pharmacy, Pocatello, ID 8/1998-5/1999.

Toxicologist, Toxigen Consulting, Pocatello, ID 1/1995 – present

oClients include Maxxus Energy Corporation, ChemRisk, Syngenetics, Elsevier Publishers

Owner and Head Instructor, American Tae Kwon Do of Pocatello, 1994 - 2000.

Research Toxicologist (Study Director), Genetic Toxicology Division, Haskell Laboratory for Toxicology and Industrial Medicine, E. I. Du Pont de Nemours and Company, Newark, DE, 1/1994 - 8/1994

Grants and Research Support

Maxxus Energy Corporation, Newark NJ. $15,000. DNA-Protein crosslinks in Burkitt’s lymphoma cells exposed to various industrial pollutants. Primary Investigator, 1994-1995.

EPSCOR Idaho State University. $10,000. DNA-protein crosslinks in fish exposed to environmental chromium. Co-Investigator, 1996-1997.

Bennett Endowed Chair for Pharmaceutical Research, Ohio Northern University. $22,222. DNA-protein crosslinks in fish exposed to chromium and nickel salts. Primary Investigator, 2005-2006.

University Teaching Responsibilities

Idaho State University 2000-2002 Nursing Pharmacology I and II (Course Director); Pharmacy Case Studies I, II, III, IV; Dental Hygiene Pharmacology (Course Director); Waste Management (Genetic Toxicology lectures); Staff Pharmacist co-preceptor for P-4 Students (7 Students).

Ohio Northern University 2003-2005 Biochemistry I and II; Biomedical Sciences I, II, III; Pharmacology- lectures in Oncology, Infectious Disease, Immunology; Pharmaceutical Calculations; Special Studies in Research (6 individual students); Student Seminar

Academic/Professional Societies

Society of Toxicology, 2007

American College of Toxicology, 2006

Society of Environmental Toxicology and Chemistry, 2006

Kappa Psi Pharmacy Fraternity, 2005

Environmental Mutagenesis Society, 2003

Genetic Toxicology Society, 2003

Rho Chi Pharmacy Honor Society, 1997

Sigma Xi Scientific Research Society, 1986

Gamma Beta Phi National Honor Society, 1985

Awards

Bennett Endowed Chair for Pharmaceutical Research, ONU 2005

Teva Pharmaceuticals 1988, Outstanding Achievement in the Study of Pharmacy

Rite-Aid Academic Pharmacy Scholarship 1997

Grey Charitable Foundation Pharmacy Scholarship 1996

Thrifty Payless Academic Pharmacy Scholarship 1995

ISU School of Pharmacy, Class President 1994-96

Academic Dean’s List 1981-83 VPI and 1994-1997 ISU

DuPont Scientific Publication Award, 1994

American Tae Kwon Do Association, Second Degree Black Belt 1994

NIH Post-doctoral Fellowship, Harvard Medical School, 1989 - 1991

NIH Pre-doctoral Fellowship, University of Tennessee, 1983 - 1988

Imhotep Student Leadership Award, University of Tennessee, 1988

University of Tennessee Student Government Executive Council 1986 – 1987

State Licensure/Board Certifications

Board-Certified Toxicologist, American Board of Toxicology, 2005, recertification 2010

Idaho Registered Pharmacist #P5388, 1998- present

Colorado Registered Pharmacist #17814, 2007- present

Delaware Registered Pharmacist, #A1-001563, 2021- present

Kansas Registered Pharmacist #1-113625, 2022-present

Reviewer/Editor for the Following Journals

Annals of Pharmacotherapy

Aquatic Toxicology

Archives of Environmental Contamination and Toxicology

Bioinorganic Chemistry and Applications

Clinical Ophthalmology

Environmental and Molecular Mutagenesis

ISRN Toxicology (Editorial staff)

Journal of Toxicology and Environmental Health

Oncogene

Toxicology In Vitro

Turkish Journal of Zoology

Research Publications (from most recent)

1.Kuykendall JR, Shaw, SL, Paustenbach, D, Fehling, K, Kacew, S, Kabay, V. (2009) Chemicals present in automobile traffic tunnels and the possible community health hazards: a review of the literature. Inhalation Toxicology 21:747-92.

2.Kuykendall, JR, Mellinger, KN, Miller, K.L, Cain, AV, Perry, MW, Bradley, M, Jarvi, EJ, and Paustenbach, DJ (2008) DNA-Protein cross-links in erythrocytes of freshwater fish exposed to hexavalent chromium or divalent nickel. Archives of Environmental Contamination and Toxicology 56: 260-267.

3.Kuykendall, JR, Cox, R, Kinder, DH. (2007) 1-Methylnicotinamide stimulates cell growth and inhibits hemoglobin synthesis in differentiating murine erythroleukemia cells. Toxicology In Vitro 21: 1656-1662.

4.Kuykendall, JR, Jarvi, EJ, Finley, BL, Paustenbach, DJ. (2007) DNA-Protein crosslink formation in Burkitt’s lymphoma cells cultured with benzaldehyde and the sedative paraldehyde. Drug and Chemical Toxicology 30:1-16.

5.Kuykendall, JR, Miller, KL Mellinger, KN and Cain, AV. (2006) Dietary hexavalent chromium exposure causes DNA-Protein crosslink formation in erythrocytes of largemouth bass (Micropterus salmonides). Aquatic Toxicology 28:27-31.

6.Rhodes, RS, Kuykendall, JR, Heyneman, CA, May, MA, Bushan, A. (2006) Stability of phenytoin sodium suspensions prepared for the treatment of open wounds. Int J Pharmaceutical Compounding 10: 74-78.

7.Paustenbach DJ, Kuykendall JR, Warmerdam, JM, Moy, P, Finley, BL. (2006) Factors affecting the bioaccessibility and bioavailability of hexavalent chromium and dioxin contaminants in soil and their relevance to risk assessment. Epidemiology 17, Suppl 6:S41.

8.Kuykendall, JR. (2005) 5-azacytidine and decitabine as monotherapies of myelodysplastic disorders. The Annals of Pharmacotherapy 39:1700-1708.

9.Kuykendall JR. (2005) Is antidepressant drug discontinuation warranted prior to polygraph administration? Health Matrix: Journal of Law-Medicine 15: 235-237.

10.Kuykendall, JR, O'Neil, SJ and Jarvi, EJ (2004) Elevated DNA-Protein Cross-links in Red Blood Cells of German Carp, Cyprinus carpio, from the Lower Passaic River, New Jersey. Bulletins of Environmental Contamination and Toxicology 73:898-902.

11.Kuykendall, JR and Rhodes RS (2004) Letter to the Editor: Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime. The Annals of Pharmacotherapy 38: 1968-1969.

12.Kuykendall, JR, Houle, MD and Rhodes, RS (2004) Possible warfarin failure due to interaction with smokeless tobacco. The Annals of Pharmacotherapy 38: 595-597.

13.Bogdannfy, MS, Mathison, B, Kuykendall, JR, and Harman, A (1997) Critical factors in assessing risk from exposure to nasal carcinogens. Mutation Research 380: 125-141.

14.Costa, M, Zhitkovich, A, Gargas, M, Paustenbach, D, Finley, B, Kuykendall, J, Billings, R, Wetterhahn, K, Waalkes, M and Patierno, S. (1996) Interlaboratory validation of a new assay for DNA-protein crosslinks. Mutation Research 369: 13-22.

15.Kuykendall JR, Overman SK, Kerger BD, Finley BL, Paustenbach DJ. (1996) Testing for DNA-protein crosslinking after drinking water exposure to chromium (III and VI) in human volunteers. The Toxicologist.

16.Kuykendall, JR, Kerger, BD, Jarvi, EJ, Corbett, GE and Paustenbach, DJ (1996) Measurement of DNA-protein crosslinks in human leukocytes following acute ingestion of chromium in drinking water. Carcinogenesis 17: 101-107.

17.Kuykendall, JR, Trela, B. and Bodganffy, MS (1995) DNA-protein crosslink formation in rat nasal epithelial cells by hexamethylphoshoramide and its correlation with formaldehyde production. Mutation Research 343: 209-218.

18.Kuykendall, JR and Bogdannfy, MS. (1994) Studies of the toxicity of vinyl acetate and acetaldehyde and induction of DNA-protein crosslink formation in rat nasal tissues. Inhalation Toxicology 6 (Supplement): 443-445.

19.Kuykendall, JR and Bogdannfy, MS (1993) Formation and stability of acetaldehyde-induced crosslinks between poly-lysine and poly-deoxyguanosine. Mutation Research 311: 49-56.

20.Kuykendall, JR, Taylor, M, and Bogdannfy, MS. (1993) DNA-protein crosslink formation and cytotoxicity of vinyl acetate in rat nasal epithelial tissues are mediated by carboxylesterase. Toxicology and Applied Pharmacology 123: 283-292.

21.Kuykendall, JR and Bogdannfy, MS. (1992) Comparison of DNA-protein crosslink formation in vitro by monofunctional saturated and unsaturated aldehydes. Mutation Research 283: 131-136.

22.Kuykendall, JR and Bogdannfy, MS. (1992) Reaction kinetics of DNA-histone crosslinking by vinyl acetate and acetaldehyde. Carcinogenesis 13: 2095-2100.

23.Kuykendall, JR and Cox, R (1991) Rapid and quantitative separation of nicotinamide and its N1-methylated metabolite by Dowex AG50-X4 chromatography. J. Chromatography 585: 322-323.

24.Kuykendall, JR and Cox, R. (1990) 2-Aminobenzamide, an inhibitor of ADP-ribosylation, antagonizes DNA hypomethylation during differentiation of murine Friend erythroleukemia cells by N’-methylnicotinamide. Differentiation 44: 69-73.

25.Kuykendall, JR and Cox, R (1989) Inhibition of DNA methylation by actinomycin D in differentiating Friend erythroleukemia cells. Biochemistry International 19: 811-820.

26.Kuykendall, JR and Cox, R (1989) Detection of 5-methylcytosine removal in Friend erythroleukemia cells following exposure to several differentiating agents. Cancer Letters 47: 149-152.

27.Kuykendall, JR (1988) Induction of hemoglobin biosynthesis in murine erythroleukemia cells by nicotinamide and its derivatives (Ph.D. thesis, University of Tennessee).

28.Magalhaes, FM, Baldini, JI, Souto, SM, Kuykendall, JR, and Doberiner, J (1983) A new acid tolerant Azospirillum species. An. Acad. Brasil. Cien. 55: 417-430.

Book chapters

1.Kuykendall, NS and Kuykendall, JR. (2023) Ketones in the Life Sciences- biochemistry, metabolism and medicinal significance. In: Metabolism Annual Volume 2023 (Y. Karamanos, Ed.), IntechOpen Publishing, London, UK (accepted).

2.Kuykendall, JR. (2010) Respiratory Toxicology: Aldehydes. In: Comprehensive Toxicology, 2nd Ed. (CA McQueen, Ed.) Elsevier Limited, Oxford, UK, pp. 291-330.

2. Kuykendall, JR and Paustenbach, DJ. (2008) Ecotoxicology: Benzene. In: Encyclopedia of Ecology. Jorgensen, S.E. and Fath, B., Eds. Oxford Press.

3. Kuykendall, JR and Cox, R. (1992) 2-Aminobenzamide antagonizes DNA de-methylation which precede induced differentiation of Friend erythroleukemia cells by N’-methylnicotinamide. In: ADP-Ribosylation Reactions (G Porier and P Moreau, Eds.), Springer-Verlag, New York, pp 233-237.

4. Kuykendall, JR and Cox, R. (1992) 1-Methylnicotinamide stimulates cell growth, causes DNA hypermethylation and inhibits induction of differentiation in Friend erythroleukemia cells. In: ADP-Ribosylation Reactions (G Porier and P Moreau, Eds.), Springer-Verlag, New York, pp 228-232.

5. Kuykendall, JR and Cox, R (1989) Niacin analogs that induce differentiation of Friend erythroleukemia cells are able to cause DNA hypomethylation. In: ADP-ribose Transferase Reactions: Mechanisms and Biological Significance. (Jacobson, M.K. and Jacobson, E.L. Eds.) Springer-Verlag, New York, pp 339-344.

Continuing Education Publications

1.Farag, S and Kuykendall, JR (2004) New treatment options for multiple myleoma. Council of Ohio Colleges of Pharmacy, Disease State Management Live Continuing Education Series, Columbus, OH.

2.Kuykendall, JR (2005) New Drug Developments- 5-azacytidine and decitabine as monotherapy of myelodysplastic disorders. Annals of Pharmacotherapy 29:1707-1708.

Meeting Presentations and Abstracts

“PBPK Modeling of benzene metabolites in bone marrow of humans with varied workplace exposure patterns and CYP2E1 activity,” Knutsen, JS, Kerger, BD, Kuykendall, JR, Paustenbach, DJ. 48th Annual Meeting of the Society of Toxicology, Baltimore, MD, March 17, 2009.

“Comparing Equal Delivered Doses of Airborne Benzene for 8 hr/day Steady Exposure vs. Peak Exposure Regimens Using a PB-PK Model,” Knutsen J, Kuykendall, JR and Paustenbach, D. Presented at American Industrial Hygiene Conference and Exposition, Minneapolis, MN. May 31-June 5, 2008.

“The possible community health hazards posed by emissions from automobile traffic tunnels: a review of the literature,” Abstract #1794, poster #331. Fehling K, Kuykendall, JR, Shaw, S, Paustenbach DJ, and Collins, D. 47th Annual Meeting of the Society of Toxicology, Seattle, WA, March 19, 2008.

“Meta-analysis of asbestos-related disease among skilled craftsmen in various occupational settings,” Abstract #1991. Kuykendall, JR, Chapman, PC, Williams, PRD and Paustenbach, DJ. 46th Annual Meeting of the Society of Toxicology, Charlotte, NC, March 29, 2007.

“Factors affecting the bioaccessibility and bioavailability of hexavalent chromium and TCDD contaminants in soils, and their relevance to risk assessment,” Paustenbach, DJ, Kuykendall, JR and Finley, BL. International Conference for Environmental Epidemiology and Exposure. Paris, France, Sept 4, 2006.

“DNA-protein crosslinks as a potential biomonitor of hexavalent chromium exposure in Rainbow trout” Abstract #1264. Mellinger KN, Miller KL, Kuykendall JR, Cain, AV, Finley BL, and Paustenbach DJ. 45th Annual Meeting of the Society of Toxicology, San Diego, CA, March 7, 2006.

“Persistence of DNA-Protein Cross-links in Erythrocytes Of Channel Catfish After Acute Hexavalent Chromium Exposure.” Abstract # 1265. Perry MW, Kuykendall JR, Miller KL, Mellinger KN, Finley BL and Paustenbach DJ. 45th Annual Meeting of the Society of Toxicology, San Diego, CA, March 7, 2006.

“Comparison of Nickel-Induced DNA-protein Crosslink in Several Freshwater Fish Species After Acute Exposure.” Abstract # 1266. Cain AV, Miller KL, Mellinger KN, Mullen MW and Kuykendall JR. 45th Annual Meeting of the Society of Toxicology, San Diego, CA, March 7, 2006.

“Dietary hexavalent chromium exposure causes DNA-protein crosslink formation in erythrocytes of Largemouth bass,” Abstract # 1267. Miller, KL, Mellinger KN, Cain AV and Kuykendall JR. 45th Annual Meeting of the Society of Toxicology, San Diego, CA, March 7, 2006.

"Elevated DNA-protein crosslinks in erythrocytes of German carp from the Lower Passaic River, Newark, NJ." 9th International Conference of Environmental Mutagens,” Kuykendall, JR, O’Neil, SJ and Jarvie, EJ. 6th Annual Meeting of the Environmental Mutagenesis Society, San Francisco CA. Sept 4, 2005.

"DNA-protein crosslinks in erythrocytes of Goldfish following acute exposure to hexavalent chromium in tank water." 9th International Conference of Environmental Mutagens. Kuykendall, JR. 6th Annual Meeting of the Environmental Mutagenesis Society, San Francisco, CA. Sept 6, 2005.

“Use of fish red blood cells as a biomonitor for DNA damage by DNA-protein crosslinking carcinogens,” Kuykendall, JR and Jarvie, EJ. Idaho Epscor Grant Program. Pocatello, ID. June 1996.

“Formation and stability of acetaldehyde-induced crosslinks between poly-lysine and poly-deoxyguanosine,” Kuykendall, JR and Bogdanffy, MS. Annual Mid-Atlantic Meeting of the Society of Genetic Toxicology. Princeton, NJ. June 1994.

“DNA-protein crosslink formation in rat nasal epithelial cells by hexamethylene-phosphoramide and its correlation with formaldehyde production,” Kuykendall, JR and Bogdanffy MS. Society of Toxicology 1994 Annual Meeting. Orlando, FL. May 1994.

“DNA-protein crosslink formation in isolated rat nasal epithelial cells exposed to vinyl acetate and acetaldehyde.” Kuykendall, JR and Bogdanffy MS. 84th Annual AACR Meeting, Orlando, FL, May 19-22, 1993. Proceed. Amer. Assoc. Cancer Res. Annu. Meet., 34, 156.

“Reaction kinetics of DNA protein crosslink formation by acetaldehyde and vinyl acetate,” Kuykendall, JR and Bogdanffy MS. 83rd Annual AACR Meeting, San Diego, CA, May 20-23, 1992. Proceed. Amer. Assoc. Cancer Res. Annu. Meet., 33, 145.

“1-Methylnicotinamide stimulates cell growth, causes DNA hypermethylation and inhibits induction of differentiation in Friend erythroleukemia cells,” Kuykendall, JR and Cox, R. 9th International Symposium on ADP-ribosylation. Quebec, Canada. April 1991.

“2-Aminobenzamide antagonizes DNA de-methylation which precedes induced differentiation of Friend erythroleukemia cells by N’-methylnicotinamide,” Kuykendall, JR and Cox, R. 9th International Symposium on ADP-ribosylation. Quebec, Canada. April 1991.

“Niacin analogs that induce differentiation of Friend erythroleukemia cells are able to cause DNA hypomethylation,” Kuykendall, JR and Cox, R. 8th International Symposium on ADP-ribosylation. Fort Worth, TX. June 1987.

“Hypomethylation of DNA accompanies induction of differentiation of Friend erythroleukemia cells by nicotinamide,” Kuykendall, JR and Cox, R. FASEB Meeting, Philadelphia, PA. May 1987.

“Detection of 5-methylcytosine removal in Friend erythroleukemia cells following exposure to several differentiating agents,” Kuykendall, JR and Cox, R. International Forum on DNA Methylation Research. Rome, Italy. April 1987.

“Nicotinamide Adenine Dinucleotide (NAD+) alteration of DNA methylase activity from Friend erythroleukemia cells,” Kuykendall, JR and Cox, R. American Society of Biological Chemistry Meeting, Washington, DC. June 1986.

“Altered DNA methylation as part of the mechanism of Actinomycin D differentiation of Friend erythroleukemia cells,” Kuykendall, JR and Cox, R. 77th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA. May 1986.

“Genetic drift in hemaglutinin-neuraminidase antigens in Type C Influenza collected from 1908-1982.” Jim Kuykendall. Annual Meeting of the Kentucky-Tennessee Chapter of the American Microbiology Society. Memphis, TN, June 1984.

Other Professional Presentations

“PBPK Modeling of benzene metabolites in bone marrow of humans with varied workplace exposure patterns and CYP2E1 activity” School of Pharmacy, Husson University, Bangor, ME April 15, 2009.

“Inhalation medications for the treatment of COPD and asthma” Rose Medical Center, Denver, CO. September 2007.

“Factors affecting adherence to tuberculosis preventive therapy among Native Americans living in Idaho.” Indian Health Service, Fort Hall, ID. Nov. 2003.

“Use of Catapress® patches for the control of hypertension in the elderly.” Veterans Administration Hospital, Pocatello, ID. April 2002.

“Management of hypertension in the diabetic elderly.” Veterans Administration Hospital, Pocatello, ID. Sept. 2000.

“Insulin therapy in management of type II diabetes.” Indian Health Service. Fort Hall, ID. Nov. 1999.

“Cervadil® versus Cytotec® for cervical ripening.” College of Pharmacy, Idaho Stae University, Pocatello, ID. April 1998.

“Reaction Kinetics of vinyl acetate induced DNA-protein crosslinks.” Glaxo, Genetic Toxicology Division. Research Triangle Park, NC. July 1994.

“DNA–crosslink formation in rat nasal tissues by volatile aldehydes.” Exxon Corporation, Toxicology Division. Princeton, NJ. June 1994.

“DNA damage by neocarzinostatin” Berwick Industries. Boston, MA. April 1994.

“DNAse I footprinting studies of sequence-specific binding of neocarzinostatin to pBR322 DNA.” Beth Israel Hospital, Harvard Medical School, Boston, MA. June 1992.

“Murine erythroleukemia differentiation: Interactive role of ADP ribosylation and DNA hypomethylation.” BASF Corporation. Cambridge, MA. March 1994.

“Induction of hemoglobin biosynthesis in murine erythroleukemia cells by nicotinamide and its derivatives.” Veteran’s Administration Hospital Faculty Lecture Series, VA Hospital Memphis, TN. May 1988.

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