Los Angeles, CA *****

310-***-****

Citizenship: USA

Education: -Bachelor of Arts (with Honors), History New York University, New York, N.Y.

-Doctor of Medicine

SUNY Stony Brook, Stony Brook, N.Y.

-Internal Medicine Residency

New York University-Bellevue Hospital Center

-Critical Care Medicine Fellowship

University of California at San Francisco Medical Center

-Cardiovascular Research Institute at UCSF

-Clinical Pharmacology Fellowship

University of California at San Francisco Medical Center

-Cardiology Fellowship

University of Michigan Medical Center

-Cardiac CT Imaging

Harbor UCLA Medical Center

Licensure: New York State

California

Michigan

Board Certification: American Board of Internal Medicine Critical Care Medicine (Board Eligible)

Subspecialty Board of Cardiovascular Disease

Certificate in Cardiac CT Imaging, Harbor UCLA Medical Center Professional

Experience: Staff Cardiologist, Cedars-Sinai Medical Center (1999-present) Clinical Assistant Professor of Medicine, UCLA (2000-2004) Fellow American College of Cardiology (2008-present) Director, Advanced Heart Failure Program

Cedars-Sinai Medical Center, Los Angeles (1998-1999) Assistant Professor of Medicine, UCLA (1998-2000)

Cedars-Sinai Heart Institute (2012-present)

Clinical Assistant Professor of Medicine, MWU/AZCOM (2014-2016) Professional

Activities: Heart Failure Society of America

CURRICULUM VITAE

Name: Simonini, Americo A MD, FACC

Personal History: 640 South San Vicente Suite 498

Honors and Special

Awards:

American College of Physicians

Society of Critical Care Medicine

American Heart Association

Council Member, Atherosclerosis and Thrombosis

Cedars-Sinai Heart Institute

Faculty Member, International Heart Failure Society Scientific Executive Committee, Intern’l Congress on Heart Disease Vascular Biology Working Group

American College of Cardiology, California Chapter Cedars-Sinai Heart Institute

Saban Free Clinic!Cedars-Sinai Heart Institute

Screen Actors Guild, Health and Safety Committee

Consultant to Industry:

Smith Kline Beecham:

Carvedilol Regional Advisory Board Consultant

Astra Merck: Hypertension Lipid Consultant

Consultant Nesiritide

Blue Cross of California: CHF Treatment Guidelines CHARM advisory panel

VALHeFT advisory panel

Medical Director: RegenoCELL Therapeutics 2008-2012 Medical Consultant: AVIIR Diagnostics

Medical Consultant: Biosciences

Speaker Faculty: Novartis

National Honor Society

New York University Scholars Program

Phi Beta Kappa-New York University

Founder’s Day Academic Award-New York University

John Parkes History Achievement Award-New York University Regent’s Scholarship-Medical College Admissions Test American Heart Association Training Grant

National Research Service Award (NHLBI)

Astra-Merck Young Investigator Finalist

Michigan ACC Investigator Award

Astra-Merck Young Investigator Award

Coronary Thrombosis and Atherosclerosis Symposium Award Astra-Merck Young Investigator Award (Lipids)

Featured Article: Los Angeles Business Weekly

Article: “Living with Heart Failure”, Los Angeles Times Featured Article on Angiogenesis : Los Angeles Times Invited Faculty: World Congress on Heart Failure

Invited Faculty: American College of Cardiology

Invited Faculty: International Congress on Heart Disease Research Grants/Fellowships Received:

American Heart Association, California Affiliate

National Heart Lung Blood Institute -NIH

SCIOS Grant

Merck Medical School Development Award

CHARM Investigators

Parke-Davis/Pfizer Investigation

OVERTURE Investigatiors

WATCH Investigators

VALHeFT Investigators

PRECEDENT Investigators

IMPACT Investigators

Lectures/Presentations:

Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Astra-Merck Young Investigator Symposium, San Francisco. September, 1995

Macrophage-Derived Angiogenic Factor IL-8, CXC, and CC Chemokines Are Expressed in Acute Coronary Syndromes. Council on Atherosclerosis, Scientific Sessions American Heart Association, New Orleans. November, 1996

IL-8 Mediated Angiogenesis in Human Coronary Atheroma. Astra-Merck Young Investigator Symposium, Washington, DC.September, 1997 IL-8 Is a Major Angiogenic Factor in Atherosclerosis . Michigan American College of Cardiology Symposium, Shanty Creek, MI. October,1997 IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Council on Atherosclerosis, Scientific Sessions American Heart Association, Orlando. November, 1997

IL-8 Mediates Angiogenesis in Coronary Atherosclerosis International Symposium on Coronary Thrombosis and Atherosclerosis, Gavleston,TX. December, 1997 Molecular Mechanisms Behind the Neurohormonal Hypothesis. Cardiology Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. June 1998 Chemokines in Atherosclerosis. Cardiology Grand Rounds University of Michigan, Ann Arbor, MI. August 1998

Advanced Heart Failure Treatment. Community Lecture, Los Angeles, CA. September 1998

The Role of CXC Chemokines in Atherosclerosis World Congress on Cardiology, Florence, Italy. October 1998

Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis after Human Cardiac Transplantation and in the Rat Model. Scientific Sessions, American Heart Association. Dallas, November 1998

Management of Outpatient Heart Failure Merck Physicians, Seattle, WA. December 1998

Therapies in Advanced Heart Failure: Left Ventricular Assist Devices. Cardiology Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. December 1998 CHF Treatments in the 21st Century. American College of Physicians/American Society of Internal Medicine, Southern California Chapter, Los Angeles, CA. February 1999. Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. American College of Cardiology, New Orleans, LA. March 1999 5 Million Failing Hearts: Reaching Patients, Reaching Goals, Faculty for ACCEL Healthcare CME Program, University of Cincinnati. Santa Monica, CA May 1999 Current Advances in Cardiology, “Current Management in Heart Failure” Heart Institute of the High Desert, Apple Valley, CA May 1999 Cytokine Activation in Heart Failure;“The Inflammatory Hypothesis” Cardiology Grand Rounds UCLA Medical Center, Los Angeles, CA. June 1999 Inflammatory Angiogenic Chemokines Are Associated with iNOS Expression in Failing Human Hearts, American Heart Association: Scientific Conference on Molecular, Cellular, and Integrated Physiological Approaches to the Failing Heart, Snowbird Conference Center, Utah. August 1999

Living with Heart Failure, Los Angeles Times Annual Festival of Health, University of Southern California, Los Angeles, CA. October 1999 The Role of CXC Chemokines in Atherosclerosis, Cardiology Grand Rounds University of Minnesota Medical Center, Minneapolis, MN. December 1999 Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL, World Congress on Heart Failure, Vancouver, B.C., Canada. July 2000 Angiogenic Chemokines in Atherosclerosis, Cardiology Grand Rounds University of Washington Medical Center, Seattle, WA. July 2000

New Thoughts on Atherosclerosis: CXC Chemokines and the“Inflammatory Hypothesis,” Cardiology Grand Rounds Robert Wood Johnson Medical Center, New Brunswick, NJ. December 2000

Angiogenic Molecules in Cardiovascular Disease: the Role of CXC Chemokines, Cardiology Grand Rounds University of Chicago Medical Center, Chicago, IL. January 2001

Lessons from Sharks:The Role of CXC Chemokines in Atherosclerosis, Cardiology Grand Rounds New York Hospital, New York, NY. February 2001 Heart Failure Therapy in the Managed Care Environment, Educational Session, American College of Cardiology, Orlando, FL March 2001 Management in the Patient with Heart Failure. Internal Medicine Grand Rounds Cedars Sinai Medical Center, Los Angeles, CA. June 2005

Update on Therapies in the Management of Heart Failure, Department of Medicine Grand Rounds, Cedars-Sinai Medical Center, Los Angeles, CA. February 2006 Use of Autologous Angiogenic Precursor Cells in the Treatment of Patients with Ischemic Cardiomyopathy. Controversies and Advances in the Treatment of Cardiovascular Diseaser, Los Angeles, CA. September 2010

Mechanism of Vulnerable Plaque: Lessons from Biomarkers and Imaging. Cardiovascular Disease Prevention: Novel Strategies and Emerging Therapies, Mayo Clinic College of Medicine, Cancun, Mexico. February 2014.

Coronary Artery Disease Prevention for the Primary Physician, Department of Medicine Grand Rounds, Glendale Memorial Hospital, Glendale, California. March 2014 Immune Response Biomarkers Characterize Endothelial Injury and Predict Acute Coronary Syndrome, Atherosclerosis Thrombosis Vascular Biology meetings, Minneapolis, MN. April 2014

Novel Biomarker Algorithmic Panel Measuring Permutations of Immune Response to Cardiac Endothelial Injury and Global Risk Factors Identifies Patients at Risk of Acute Coronary Syndrome, European Society of Cardiology meetings, Paris, FR. September 2019 Carotid Plaque Lipid Content is Reduced After 6 Months of Proprotein Convertase Subtilisin Kexin Type 9 Inhibition With Alirocumab: an Interim Analysis of a Serial Magnetic Resonance Imaging Study. Scientific Sessions, American Heart Association, Philadelphia. November, 2019 Bibliography/Publications:

Research Papers (Peer Reviewed)

Massie BM, Simonini A, Minotti JR, Sahgal P, Wells L, Dudley GA: Specific Myopathy of Skeletal Muscle in Congestive Heart Failure. J. Am. Coll. Cardiology. 1996; Jan 27(1): 140-5.

Simonini A, Massie BM, Long CS, Qi M, Samarel AM: Alterations in Skeletal Muscle Gene Expression in the Rat with Chronic Congestive Heart Failure. J. Mol. and Cell. Cardiol. 1996; 28(8): 1683-91.

Simonini A, Long CS, McElhinny J, Yu P, Dudley GA, Massie BM: Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Circ. Research.1996; 79:128-136. Simonini A, Chang K, Yue P, Long CS, Massie BM:Expression of Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase Is Reduced in Heart Failure. Heart 1999; 81:303-307

Simonini A, Moscucci M, Muller DWM, Pagani FD, Burdick MD, Strieter RM: IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Circulation 2000; 101:1519-1526

Lepor NE, Sun J, Canton G, Hippe DS, Balu N, Simonini A, Hatsukami TS, Contreras L, Isquith DA, Kedan I, Yuan C, Zhao XQ: Regression in Carotid Plaque Lipid Content and Neovasculature with PCKS9 inhibition: A Time Course Study. Atherosclerosis 2021; 327:31-38

Research Papers (Peer Reviewed) Submitted:

Simonini A, Dudley GA, Long CS, Xu Y, Prior B, Massie BM: Heart Failure in Rats Attenuates the Increase of Skeletal Muscle Oxidative Enzymes Induced by Mechanical Loading. J. Appl. Physiol.

Simonini A, Wang HM, Czer LSC, Trento A, Blanche, C, Burdick MD, Strieter RM: Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis After Human Cardiac Transplantation and in the Rat Model. J. of Cardiac Failure

Simonini A, Pitt BS, Aviram M, Burdick MS, Strieter RM: Angiotensin II Receptor Blockade Attenuates the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. Circ. Research

Simonini A, Luthringer D, Strieter RM: Inflammatory Angiogenic Chemokines Are Associated with iNOS Expression in Failing Human Hearts. J. Am. Coll. Cardiology

Abstracts:

Simonini A, Schwartz DE, Carlisle AS: Adenosine in the Critically Ill Patient. Chest Medicine. October, 1992

Samarel AM, Minotti JR, Simonini A: Skeletal Muscle Protein Synthesis in Congestive Heart Failure. Circulation. November, 1993

Simonini A, Chang K, Yue P, Long CS, Massie BM: Expression of Skeletal Muscle Sarcoplasmic Reticulum Ca2+-ATPase Is Reduced in Heart Failure. Circulation. November, 1995

Massie BM, Simonini A, Minotti JR, Sahgal P, Wells L, Dudley GA: Specific Myopathy of Skeletal Muscle in Congestive Heart Failure. Circulation. November, 1995 Simonini A, Long CS, McElhinny J, Yu P, Dudley GA, Massie BM: Heart Failure in Rats Causes Changes in Skeletal Muscle Which Are Not Explained by Reduced Activity. Circulation. November, 1995

Simonini A, Muller DWM, Moscucci M, Pagani FD, Strieter RM:Macrophage-Derived Angiogenic Factor IL-8, CXC, and CC Chemokines Are Expressed in Acute Coronary Syndromes. Circulation. November, 1996

Simonini A, Dudley GA, Long CS, Xu Y, Prior B, Massie BM: Heart Failure in Rats Attenuates the Increase of Skeletal Muscle Oxidative Enzymes Induced by Mechanical Loading. Circulation. November, 1996

Simonini A, Moscucci M, Bates ER, Burdick MD, Strieter RM: Expression of CXC Chemokine IL-8 Is Associated with Smooth Muscle Cell Proliferation in Human Coronary In-Stent Restenosis. Circulation. November, 1997

Simonini A, Moscucci M, Muller DWM, Pagani FD, Burdick MD, Strieter RM: IL-8 Is a Major Angiogenic Factor in Human Atherectomy Tissue . Circulation. November, 1997 Simonini A, Bossone E, Aaronson KD, Armstrong WF: Doppler Indices of Diastolic Function Predict Peak Exercise Oxygen Consumption in Heart Failure. J. Am. Coll. Cardiology. March, 1998

Simonini A, Wang HM, Czer LSC, Trento A, Blanche, C, Burdick MD, Strieter RM: Expression of ELR-CXC Chemokines Are Associated with Allograft Atherosclerosis After Human Cardiac Transplantation and in the Rat Model. Circulation. November 1998 Simonini A, Pitt BS, Aviram M, Burdick MS, Strieter RM: Angiotensin II Receptor Blockade Antagonizes the Proliferative Effects of Oxidized LDL on Coronary Smooth Muscle Cells Via Inhibition of Angiogenic Chemokines. J. Am. Coll. Cardiology. March, 1999 Harrington DS, Zhao Y, Simonini A, Wong ND: Novel Biomarker Algorithmic Panel Measuring Permutations Of Immune Response To Cardiac Endothelia Injury And Global Risk Factors Identifies Patients At Risk For Acute Coronary Syndrome. J. Am Coll. Cardiology. March 2017

Simonini A, Harrington DS, Shiu V, Wong ND : Immune Response Biomarkers Characterize Endothelial Injury and Predict Acute Coronary Syndrome. ATVB Journal. May, 2017 Harrington DS, Zhao Y, Simonini A, Wong N: Novel Biomarker Algorithmic Panel Measuring Permutations of Immune Response to Cardiac Endothelial Injury and Global Risk Factors Identifies Patients at Risk of Acute Coronary Syndrome. European Heart Journal. October 2019

Sun J, Lepor NE, Canton G, Contreras L, Hippe DS, Isquith D, Balu N, Kedan I, Simonini A, Yuan C, Zhao XQ, Hatsukami TS: Carotid Plaque Lipid Content is Reduced After 6 Months of Proprotein Convertase Subtilisin Kexin Type 9 Inhibition With Alirocumab: an Interim Analysis of a Serial Magnetic Resonance Imaging Study. Circulation. November 2019

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