BIOMEDICAL RESEARCH SCIENTIST

Proven success driving groundbreaking advancement in the field of functional genomics and drug targets. Track record of research in the field of:

Biochemistry, Molecular Biology and Human genetics.

Cell signaling and Drug targets.

In-vitro experiments and experimental design for mechanistic study. EDUCATION

Jadavpur University, Kolkata, India, Ph.D in Life Science (2014) University of Kalyani, Kalyani, India, M.Sc in Biochemistry (2005) Vidyasagar University, Midnapur, India, B.Sc in Chemistry(2003) EXPERIENCES

Oklahoma Medical Research Foundation, Oklahoma City, OK. Assistant Staff Scientist from 2018 to March, 2023. Manage molecular biology research laboratory and projects focused on functional genomics to identify functional genetic variants associated with Lupus disease and its regulatory mechanism for development of better molecular targets. Research Project Highlights:

Led research and development of functionally characterizing the variants and generated data for NIH R21 and PHF grant.

Conducted research on in-depth mechanistic study of a gene SLC15A4 which was funded a R21 grant.

From the study, we identified a specific allele of a enhancer element which could enhance any mammalian gene expression by 100 to 200 fold higher in cell lines. Based on the data, a R01 grant has been submitted to NIH.

Developed a method to design, clone and teste any enhancer and promoter element by Luciferase assay.

Contributed for the development of method to clone genomic library and isolate large-scale plasmid.

Volunteer to the Editorial process in different reputed Journals and awarded Publon Peer Review Award-2018. University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, OK. Postdoctoral Fellow from 2016 to 2018

Designed, conducted and completed research on CLL B-cell biology and mechanism of drug resistance in relapsed patients.

Research Project Highlights:

Collected patients samples and data from clinics.

Led research to understand the mechanisms of development of drug resistance and aberrant signal transduction pathways of chronic lymphocytic leukemia (CLL) pathogenesis for developing better therapeutic targets. Guru Prasad Maiti, PhD

Oklahoma City, OK-73120.

806-***-****: ad1q1f@r.postjobfree.com: LinkedIn: https://www.linkedin.com guru-prasad-maiti-80205482

Participated in research project that identified mitochondrial metabolism and pro-survival signaling molecule AXL in CLL biology.

Contributed in a research project related to shedding of micro vesicles and exosome by CLL B-cells. Texas Tech University Health Sciences Center, Lubbock, TX Postdoctoral Fellow from 2015 to 2016

Manage and conducted research projects on Anesthetic preconditioning of Heart and lung injury in mouse model and in- vitro.

Project Highlights:

Led research to identify lung and heart toxicity for short duration of hyperoxia and its mechanism.

Directed R&D efforts for protection of lung and heart injury by anesthetic preconditioning.

Designed, tested and validated the invitro observation in in vivo mouse model.

Contributed for the development of adenovirus with cloned gene from vector. RESEARCH EXPERIENCES FROM INDIA.

University of Kalyani, Research Associate from 2014 to 2015, Conducted and completed research on biological properties of some synthetic Chemo sensor in vitro.

Chittaranjan National Cancer Institute, Research Fellow from 2006 to 2014 Led research and development of Molecular human genetics in the field of Squamous cell carcinoma.

Indian Institute of Chemical Biology (CSIR), Project Assistant from 2005 to 2006 Conducted research for development of herbal drug to treat Asthma. SKILLS AND TECHNIQUES:

Molecular Biology, Cell biology and Immunology, Western Blot and immuno-precipitation, cell signaling, cloning, DNA sanger sequencing, library preparation for next gen sequencing, luciferase assay, MTT assay, ELISA, enzyme activity assay, lipofectamine based, and neon based transfection, gene manipulation by siRNA, QRT-PCR and regular PCR, 3D chromosomal architecture and 3C, different cell culture (both suspensions and adhere cell line, EBV transformed primary cell, BMSC from patient’s bone marrow), single cell isolation and individual colony development from CRISPR pool cell, basic animal handling, microscopy, immunohistochemistry and immunocytochemistry, valid primer designing for any PCR, recombinant protein expression and purification, adeno virus based cloning and virus particle generation, DNA methylation and demethylation, drug sensitivity assay, drug resistance assay, autophagy, intra cellular and intra lysosomal PH measurements, precision solutions and different buffer preparation for molecular biology and chemistry. ACHIEVEMENT AND AWARD:

Total number of publication-28

Publon Peer Review Award-2018

Awarded by Rotary Club of Calcutta for excellence in cancer research 2013.

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